CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 28, 2014, Pages 10305-10310

  Flyøel, Tina ^a,b   Brorsson, Caroline ^a,b   Nielsen, Lotte B ^a   Miani, Michela ^c   Bang Berthelsen, Claus Heiner ^a,b   Friedrichsen, Martin ^d   Overgaard, Anne Julie ^a,b   Berchtold, Lukas A ^a,b   Wiberg, Anna ^e   Poulsen, Pernille ^f   Hansen, Lars ^a   Rosinger, Silke ^g   Boehm, Bernhard O ^g,h   Ram, Ramesh ⁱ   Nguyen, Quang ⁱ   Mehta, Munish ⁱ   Morahan, Grant ⁱ   Concannon, Patrick ^j   Bergholdt, Regine ^k   Nielsen, Jens H ^l   Reinheckel, Thomas ^m   Von Herrath, Matthias ^e   Vaag, Allan ^d   Eizirik, Decio Laks ^c   Mortensen, Henrik B ^a   Strøling, Joachim ^a,b   Pociot, Flemming ^a,b,l   more..

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d Rigshospitalet   (Denmark)

^e LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^f NOVO NORDISK A S   (Denmark)

^g UNIVERSITY OF ULM   (Germany)

^h NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

ⁱ UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^j UNIVERSITY OF FLORIDA   (United States)

^k HAGEDORN RESEARCH INSTITUTE   (Denmark)

^l UNIVERSITY OF COPENHAGEN   (Denmark)

^m UNIVERSITY OF FREIBURG   (Germany)

more..

Author keywords

EQTL; GWAS; Polymorphism; Remission; Susceptibility gene

Indexed keywords

BIM PROTEIN; CATHEPSIN H; DP5 PROTEIN; GAMMA INTERFERON; INS2 PROTEIN; INSULIN; INTERLEUKIN 1BETA; JNK PROTEIN; P38 PROTEIN; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FUNCTION; CLINICAL STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE CONTROL; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SENSITIVITY; LYMPHOBLASTOID CELL LINE; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

EQTL; GWAS; POLYMORPHISM; REMISSION; SUSCEPTIBILITY GENE;

ADOLESCENT; ALLELES; ANIMALS; APOPTOSIS; CATHEPSIN H; CELL LINE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; RATS;

EID: 84904353328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402571111     Document Type: Article

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