Beta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Kalis, Martins ^a   Bolmeson, Caroline ^a   Esguerra, Jonathan L S ^a   Gupta, Shashank ^c   Edlund, Anna ^a   Tormo Badia, Neivis ^a   Speidel, Dina ^a   Holmberg, Dan ^b,c   Mayans, Sofia ^b,c   Khoo, Nelson K S ^a   Wendt, Anna ^a   Eliasson, Lena ^a   Cilio, Corrado M ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; MESSENGER RNA; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; INSULIN; RIBONUCLEASE III;

AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DISRUPTION; CELL FUNCTION; CELL GRANULE; CELL MATURATION; CELL SELECTION; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; DICER1 GENE; DISEASE COURSE; FEMALE; GENE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; STRUCTURE ANALYSIS; ANIMAL; APOPTOSIS; CELL PROLIFERATION; EXPERIMENTAL DIABETES MELLITUS; FLOW CYTOMETRY; GENE SILENCING; GENETICS; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; METABOLISM; PANCREAS ISLET; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL PROLIFERATION; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, EXPERIMENTAL; FLOW CYTOMETRY; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MICE; RIBONUCLEASE III;

EID: 84455161954     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029166     Document Type: Article

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