메뉴 건너뛰기




Volumn 36, Issue 5, 2014, Pages 569-579

Insulitis in human type 1 diabetes: A comparison between patients and animal models

Author keywords

Autoimmunity; Insulin; Insulitis; Islets of Langerhans; Pancreas; Type 1 diabetes

Indexed keywords

ANIMAL; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; DISEASE MODEL; HUMAN; IMMUNOLOGY; INFLAMMATION; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PATHOLOGY;

EID: 84930791607     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-014-0438-4     Document Type: Review
Times cited : (102)

References (90)
  • 2
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. A chronic autoimmune disease
    • PID: 3517648, COI: 1:STN:280:DyaL283gtlCrsw%3D%3D
    • Eisenbarth GS (1986) Type I diabetes mellitus. A chronic autoimmune disease. New Eng J Med 314:1360–1368
    • (1986) New Eng J Med , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 3
    • 67649364114 scopus 로고    scopus 로고
    • The role of inflammation in insulitis and beta cell loss in type 1 diabetes
    • COI: 1:CAS:528:DC%2BD1MXjs1ymt7Y%3D
    • Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta cell loss in type 1 diabetes. Nat Rev 5:219–226
    • (2009) Nat Rev , vol.5 , pp. 219-226
    • Eizirik, D.L.1    Colli, M.L.2    Ortis, F.3
  • 4
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
    • COI: 1:CAS:528:DC%2BC3sXksFams7o%3D
    • Herold KC, Vignali DAA, Cooke A, Bluestone JA (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev 13:243–256
    • (2013) Nat Rev , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.A.2    Cooke, A.3    Bluestone, J.A.4
  • 5
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: etiology, immunology, and therapeutic strategies
    • PID: 21248163
    • Van Belle TL, Coppieters KT, von Herrath MG (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91:79–118
    • (2011) Physiol Rev , vol.91 , pp. 79-118
    • Van Belle, T.L.1    Coppieters, K.T.2    von Herrath, M.G.3
  • 6
    • 77953920802 scopus 로고    scopus 로고
    • Microscopic anatomy of the human islet of langerhans. The islets of Langerhans
    • PID: 20217491
    • In’t Veld P, Marichal M (2010) Microscopic anatomy of the human islet of langerhans. The islets of Langerhans. Adv Exp Med Biol 654:1–19
    • (2010) Adv Exp Med Biol , vol.654 , pp. 1-19
    • In’t Veld, P.1    Marichal, M.2
  • 7
    • 0027361654 scopus 로고
    • Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
    • PID: 8227346, COI: 1:CAS:528:DyaK2cXivFWqtQ%3D%3D
    • Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M, Kawata S, Tarui S, Kono N, Matsuzawa Y (1993) Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 92:2313–2322
    • (1993) J Clin Invest , vol.92 , pp. 2313-2322
    • Itoh, N.1    Hanafusa, T.2    Miyazaki, A.3    Miyagawa, J.4    Yamagata, K.5    Yamamoto, K.6    Waguri, M.7    Imagawa, A.8    Tamura, S.9    Inada, M.10    Kawata, S.11    Tarui, S.12    Kono, N.13    Matsuzawa, Y.14
  • 9
    • 79960088916 scopus 로고    scopus 로고
    • Insulitis in human type 1 diabetes: the quest for an elusive lesion
    • In’t Veld P (2011) Insulitis in human type 1 diabetes: the quest for an elusive lesion. Islets 3:1–8
    • (2011) Islets , vol.3 , pp. 1-8
    • In’t Veld, P.1
  • 10
    • 11144347809 scopus 로고    scopus 로고
    • Animal models have little to teach us about type 1 diabetes: 2. In opposition of this proposal
    • PID: 15502929, COI: 1:STN:280:DC%2BD2crnvFWqtg%3D%3D
    • Leiter EH, von Herrath M (2004) Animal models have little to teach us about type 1 diabetes: 2. In opposition of this proposal. Diabetologia 47:1657–1660
    • (2004) Diabetologia , vol.47 , pp. 1657-1660
    • Leiter, E.H.1    von Herrath, M.2
  • 11
    • 10244226673 scopus 로고    scopus 로고
    • Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal
    • PID: 15490110, COI: 1:STN:280:DC%2BD2crnvFWrsw%3D%3D
    • Roep BO, Atkinson M (2004) Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal. Diabetologia 47:1650–1656
    • (2004) Diabetologia , vol.47 , pp. 1650-1656
    • Roep, B.O.1    Atkinson, M.2
  • 12
    • 10244255039 scopus 로고    scopus 로고
    • Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
    • COI: 1:CAS:528:DC%2BD2cXhtVarsb7L
    • Roep BO, Atkinson M, von Herrath M (2004) Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev 4:989–997
    • (2004) Nat Rev , vol.4 , pp. 989-997
    • Roep, B.O.1    Atkinson, M.2    von Herrath, M.3
  • 13
    • 84872018209 scopus 로고    scopus 로고
    • Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials
    • PID: 23258904, COI: 1:CAS:528:DC%2BC3sXlt1GntA%3D%3D
    • Staeva TP, Chatenoud L, Insel R, Atkinson MA (2013) Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 62:9–17
    • (2013) Diabetes , vol.62 , pp. 9-17
    • Staeva, T.P.1    Chatenoud, L.2    Insel, R.3    Atkinson, M.A.4
  • 14
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • PID: 8278351, COI: 1:CAS:528:DyaK2cXnsFehuw%3D%3D
    • Chatenoud L, Thervet E, Primo J, Bach JF (1994) Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A 91:123–127
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 17
    • 15844416698 scopus 로고
    • Ueber die beziehung der langenhans’schen inseln des pankreas zum diabetes mellitus
    • Schmidt MB (1902) Ueber die beziehung der langenhans’schen inseln des pankreas zum diabetes mellitus. Münch Med Wochenschr 49:51–54
    • (1902) Münch Med Wochenschr , vol.49 , pp. 51-54
    • Schmidt, M.B.1
  • 18
    • 0001126431 scopus 로고
    • Ueber “Insulitis” bei diabetes
    • Von Meyenburg M (1940) Ueber “Insulitis” bei diabetes. Schweiz Med Wochenschr 21:554–557
    • (1940) Schweiz Med Wochenschr , vol.21 , pp. 554-557
    • Von Meyenburg, M.1
  • 19
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • PID: 5318831, COI: 1:STN:280:DyaF28%2FgvF2isQ%3D%3D
    • Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 20
    • 70449204406 scopus 로고
    • Insulitis” in early juvenile diabetes
    • COI: 1:STN:280:DyaG1M%2FhtFOhug%3D%3D
    • LeCompte PM (1958) “Insulitis” in early juvenile diabetes. Arch Pathol Lab Med 66:450–457
    • (1958) Arch Pathol Lab Med , vol.66 , pp. 450-457
    • LeCompte, P.M.1
  • 22
    • 0035257102 scopus 로고    scopus 로고
    • The discovery of type 1 diabetes
    • PID: 11272129, COI: 1:CAS:528:DC%2BD3MXhtVOhu7g%3D
    • Gale EAM (2001) The discovery of type 1 diabetes. Diabetes 50:217–226
    • (2001) Diabetes , vol.50 , pp. 217-226
    • Gale, E.A.M.1
  • 23
    • 0018183984 scopus 로고
    • Islet cell survival determined by morphology: an immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus
    • PID: 75815
    • Gepts W, De Mey J (1978) Islet cell survival determined by morphology: an immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27(Suppl 1):251–261
    • (1978) Diabetes , vol.27 , pp. 251-261
    • Gepts, W.1    De Mey, J.2
  • 24
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
    • PID: 3522324, COI: 1:STN:280:DyaL283kvVCgtw%3D%3D
    • Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS (1986) The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:267–274
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3    Richmond, J.A.4    Weir, R.S.5
  • 25
    • 0019988450 scopus 로고
    • Pancreatic isleitis with coxsackie virus B5 infection
    • PID: 6282732, COI: 1:STN:280:DyaL383ht1Cjug%3D%3D
    • Ahmad N, Abraham AA (1982) Pancreatic isleitis with coxsackie virus B5 infection. Hum Pathol 13:661–662
    • (1982) Hum Pathol , vol.13 , pp. 661-662
    • Ahmad, N.1    Abraham, A.A.2
  • 26
    • 0021875480 scopus 로고
    • In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis
    • PID: 3159965, COI: 1:STN:280:DyaL2M3ktVCqsQ%3D%3D
    • Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. New Engl J Med 313:353–360
    • (1985) New Engl J Med , vol.313 , pp. 353-360
    • Bottazzo, G.F.1    Dean, B.M.2    McNally, J.M.3    MacKay, E.H.4    Swift, P.G.F.5    Gamble, D.R.6
  • 27
    • 34848851427 scopus 로고    scopus 로고
    • Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of ketoacidosis
    • PID: 17805509, COI: 1:CAS:528:DC%2BD2sXhtFSlsL%2FE
    • Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC (2007) Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of ketoacidosis. Diabetologia 50:2323–2331
    • (2007) Diabetologia , vol.50 , pp. 2323-2331
    • Butler, A.E.1    Galasso, R.2    Meier, J.J.3    Basu, R.4    Rizza, R.A.5    Butler, P.C.6
  • 28
    • 1542353353 scopus 로고
    • A study of the pathological anatomy of the pancreas in ninety cases of diabetes mellitus
    • PID: 19867248, COI: 1:CAS:528:DyaD1MXhtVOqsA%3D%3D
    • Cecil RL (1909) A study of the pathological anatomy of the pancreas in ninety cases of diabetes mellitus. J Exp Med 11:266–289
    • (1909) J Exp Med , vol.11 , pp. 266-289
    • Cecil, R.L.1
  • 30
    • 0014188207 scopus 로고
    • Fulminating diabetes with lymphocytic thyroiditis
    • PID: 5630415, COI: 1:STN:280:DyaF1c%2Fpt1ylsg%3D%3D
    • Crome L (1967) Fulminating diabetes with lymphocytic thyroiditis. Arch Dis Child 42:677–681
    • (1967) Arch Dis Child , vol.42 , pp. 677-681
    • Crome, L.1
  • 32
    • 0023181004 scopus 로고
    • Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus
    • PID: 3301484, COI: 1:STN:280:DyaL2s3nslSisg%3D%3D
    • Foulis AK, Farquharson MA, Hardman R (1987) Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:333–343
    • (1987) Diabetologia , vol.30 , pp. 333-343
    • Foulis, A.K.1    Farquharson, M.A.2    Hardman, R.3
  • 34
    • 0016640279 scopus 로고
    • Insulitis und perakuter diabetes mellitus
    • PID: 123675, COI: 1:STN:280:DyaE2M7kt1KmtA%3D%3D
    • Gladisch R, Bayer HP, Lipinski C, Stenzel M (1975) Insulitis und perakuter diabetes mellitus. Z Kinderheilk 119:5–14
    • (1975) Z Kinderheilk , vol.119 , pp. 5-14
    • Gladisch, R.1    Bayer, H.P.2    Lipinski, C.3    Stenzel, M.4
  • 35
    • 0026492896 scopus 로고
    • Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus
    • PID: 1385478
    • Hänninen A, Jalkanen S, Samli M, Toikkanen S, Nikolarakos G, Simell O (1992) Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 90:1901–1910
    • (1992) J Clin Invest , vol.90 , pp. 1901-1910
    • Hänninen, A.1    Jalkanen, S.2    Samli, M.3    Toikkanen, S.4    Nikolarakos, G.5    Simell, O.6
  • 36
    • 79960086329 scopus 로고
    • Ueber diabetes bei kindern
    • Heiberg KA (1911) Ueber diabetes bei kindern. Arch Kinderheilkunde 56:403–411
    • (1911) Arch Kinderheilkunde , vol.56 , pp. 403-411
    • Heiberg, K.A.1
  • 38
    • 0017698017 scopus 로고
    • An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus
    • COI: 1:STN:280:DyaE1c%2Fjs12hsA%3D%3D
    • Junker K, Egeberg J, Kromann H, Nerup J (1977) An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand Sect A 85:699–706
    • (1977) Acta Pathol Microbiol Scand Sect A , vol.85 , pp. 699-706
    • Junker, K.1    Egeberg, J.2    Kromann, H.3    Nerup, J.4
  • 39
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • PID: 15889096, COI: 1:CAS:528:DC%2BD2MXktVWhtb0%3D
    • Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA (2005) Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435:224–228
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6    Hering, B.J.7    Hafler, D.A.8
  • 40
    • 0021141234 scopus 로고
    • Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes
    • Klöppel G, Drenck CR, Oberholzer M (1984) Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. Virchows Arch 403:441–452
    • (1984) Virchows Arch , vol.403 , pp. 441-452
    • Klöppel, G.1    Drenck, C.R.2    Oberholzer, M.3
  • 41
    • 0015351064 scopus 로고
    • Insulitis (lymphocytic infiltration of pancreatic islets) in late-onset diabetes
    • PID: 4555102, COI: 1:STN:280:DyaE387ptFeguw%3D%3D
    • Lecompte PM, Legg MA (1972) Insulitis (lymphocytic infiltration of pancreatic islets) in late-onset diabetes. Diabetes 21:762–769
    • (1972) Diabetes , vol.21 , pp. 762-769
    • Lecompte, P.M.1    Legg, M.A.2
  • 43
    • 33745788583 scopus 로고    scopus 로고
    • Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes
    • PID: 16802132, COI: 1:STN:280:DC%2BD28vgslygtQ%3D%3D
    • Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838–1844
    • (2006) Diabetologia , vol.49 , pp. 1838-1844
    • Meier, J.J.1    Lin, J.C.2    Butler, A.E.3    Galasso, R.4    Martinez, D.S.5    Butler, P.C.6
  • 44
    • 73649170150 scopus 로고
    • Diabetic coma with acute inflammation of islets of Langerhans
    • COI: 1:STN:280:DyaF387ivVyntw%3D%3D
    • Nagler W (1963) Diabetic coma with acute inflammation of islets of Langerhans. J Am Med Assoc 184:723–724
    • (1963) J Am Med Assoc , vol.184 , pp. 723-724
    • Nagler, W.1
  • 45
    • 0027413552 scopus 로고
    • Relationship among residual beta cells, exocrine pancreas and islet cell antibodies in insulin-dependent diabetes mellitus
    • PID: 7682643, COI: 1:STN:280:DyaK3s3jtlCntw%3D%3D
    • Nakanishi KT, Miyashita H, Okubo M, Sugimoto T, Murase T, Kosaka K, Hara M (1993) Relationship among residual beta cells, exocrine pancreas and islet cell antibodies in insulin-dependent diabetes mellitus. Metabolism 42:196–203
    • (1993) Metabolism , vol.42 , pp. 196-203
    • Nakanishi, K.T.1    Miyashita, H.2    Okubo, M.3    Sugimoto, T.4    Murase, T.5    Kosaka, K.6    Hara, M.7
  • 47
    • 0033035851 scopus 로고    scopus 로고
    • T-cell insulitis found in anti-GAD65+ diabetes with residual beta-cell function
    • PID: 10189541, COI: 1:STN:280:DyaK1M3gsFGguw%3D%3D
    • Shimada A, Imazu Y, Morinaga S, Funae O, Kasuga A, Atsumi Y, Matsuoka K (1999) T-cell insulitis found in anti-GAD65+ diabetes with residual beta-cell function. Diabetes Care 22:615–717
    • (1999) Diabetes Care , vol.22 , pp. 615-717
    • Shimada, A.1    Imazu, Y.2    Morinaga, S.3    Funae, O.4    Kasuga, A.5    Atsumi, Y.6    Matsuoka, K.7
  • 48
    • 0028278373 scopus 로고
    • Pancreas in recent-onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor Vbeta usage, and cytokine profile
    • PID: 7913115, COI: 1:CAS:528:DyaK2cXlsFGnur4%3D
    • Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernandez-Figuereas MT, Ariza A, Gomis R, Bragado R, Marti M, Jaraquemada D, Pujol-Borrell R (1994) Pancreas in recent-onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor Vbeta usage, and cytokine profile. J Immunol 153:1360–1377
    • (1994) J Immunol , vol.153 , pp. 1360-1377
    • Somoza, N.1    Vargas, F.2    Roura-Mir, C.3    Vives-Pi, M.4    Fernandez-Figuereas, M.T.5    Ariza, A.6    Gomis, R.7    Bragado, R.8    Marti, M.9    Jaraquemada, D.10    Pujol-Borrell, R.11
  • 49
    • 0006330037 scopus 로고
    • Inflammation involving the islands of Langerhans in diabetes; a report on pathological findings
    • Stansfield OH, Warren S (1928) Inflammation involving the islands of Langerhans in diabetes; a report on pathological findings. New Eng J Med 198:686–687
    • (1928) New Eng J Med , vol.198 , pp. 686-687
    • Stansfield, O.H.1    Warren, S.2
  • 50
    • 33846818313 scopus 로고    scopus 로고
    • Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor alpha in patients with recent-onset type 1 diabetes
    • PID: 17221211, COI: 1:CAS:528:DC%2BD2sXhtlKis7k%3D
    • Uno S, Imagawa A, Okita K, Sayama K, Moriwaki M, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I (2007) Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor alpha in patients with recent-onset type 1 diabetes. Diabetologia 50:596–601
    • (2007) Diabetologia , vol.50 , pp. 596-601
    • Uno, S.1    Imagawa, A.2    Okita, K.3    Sayama, K.4    Moriwaki, M.5    Iwahashi, H.6    Yamagata, K.7    Tamura, S.8    Matsuzawa, Y.9    Hanafusa, T.10    Miyagawa, J.11    Shimomura, I.12
  • 51
    • 0015750391 scopus 로고
    • Foetal cerebral oedema with insulitis in diabetic ketoacidosis
    • PID: 4203146, COI: 1:STN:280:DyaE2c%2Fmtlyrsg%3D%3D
    • Warne GL (1973) Foetal cerebral oedema with insulitis in diabetic ketoacidosis. Med J Aust 2:934–937
    • (1973) Med J Aust , vol.2 , pp. 934-937
    • Warne, G.L.1
  • 52
    • 0006280764 scopus 로고
    • The pathology of diabetes in children
    • Warren S (1927) The pathology of diabetes in children. J Am Med Assoc 88:99–101
    • (1927) J Am Med Assoc , vol.88 , pp. 99-101
    • Warren, S.1
  • 53
    • 0018799757 scopus 로고
    • Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis
    • PID: 219345, COI: 1:STN:280:DyaE1M7ls1Ogsg%3D%3D
    • Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173–1179
    • (1979) N Engl J Med , vol.300 , pp. 1173-1179
    • Yoon, J.W.1    Austin, M.2    Onodera, T.3    Notkins, A.L.4
  • 54
    • 0021252607 scopus 로고
    • The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine tissue
    • PID: 6381192, COI: 1:STN:280:DyaL2c3os1CmtA%3D%3D
    • Foulis AK, Stewart JA (1984) The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine tissue. Diabetologia 26:456–461
    • (1984) Diabetologia , vol.26 , pp. 456-461
    • Foulis, A.K.1    Stewart, J.A.2
  • 55
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD and ICA512bcd/IA-2 autoantibodies
    • PID: 8666144, COI: 1:CAS:528:DyaK28Xkt1Wqs70%3D
    • Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD and ICA512bcd/IA-2 autoantibodies. Diabetes 45:926–933
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3    Yu, L.4    Pietropaolo, M.5    Jackson, R.A.6    Chase, H.P.7    Eisenbarth, G.S.8
  • 56
    • 84887859536 scopus 로고    scopus 로고
    • Predictors of progression to type 1 diabetes: preparing for immune interventions in the preclinical disease phase
    • PID: 24215407, COI: 1:CAS:528:DC%2BC3sXhslGgsbzE
    • Gorus FK, Keymeulen B, In’t Veld PA, Pipeleers DG (2013) Predictors of progression to type 1 diabetes: preparing for immune interventions in the preclinical disease phase. Expert Rev Clin Immunol 9:1173–1183
    • (2013) Expert Rev Clin Immunol , vol.9 , pp. 1173-1183
    • Gorus, F.K.1    Keymeulen, B.2    In’t Veld, P.A.3    Pipeleers, D.G.4
  • 59
    • 0028283078 scopus 로고
    • Lack of immunohistologic changes in the islets of nondiabetic, autoimmune, polyendocrine patients with beta-selective GAD-specific islet cell antibodies
    • PID: 7912208, COI: 1:STN:280:DyaK2c3otlOhsA%3D%3D
    • Wagner R, McNally JM, Bonifacio E, Genovese S, Foulis A, McGill M, Christie MR, Betterle C, Bosi E, Botazzo GF (1994) Lack of immunohistologic changes in the islets of nondiabetic, autoimmune, polyendocrine patients with beta-selective GAD-specific islet cell antibodies. Diabetes 43:851–56
    • (1994) Diabetes , vol.43 , pp. 851-856
    • Wagner, R.1    McNally, J.M.2    Bonifacio, E.3    Genovese, S.4    Foulis, A.5    McGill, M.6    Christie, M.R.7    Betterle, C.8    Bosi, E.9    Botazzo, G.F.10
  • 60
    • 0015863273 scopus 로고
    • Islets of Langerhans in juvenile diabetes mellitus
    • COI: 1:STN:280:DyaE2c%2FkvVyjuw%3D%3D
    • Doniach I, Morgan AG (1973) Islets of Langerhans in juvenile diabetes mellitus. Clin Endocrinol 2:233–248
    • (1973) Clin Endocrinol , vol.2 , pp. 233-248
    • Doniach, I.1    Morgan, A.G.2
  • 61
    • 0006373963 scopus 로고
    • The pathology of diabetes, with special reference to pancreatic regeneration
    • PID: 19969663, COI: 1:STN:280:DC%2BC3critFWqsw%3D%3D
    • Warren S, Root HF (1925) The pathology of diabetes, with special reference to pancreatic regeneration. Am J Pathol 1:415–429
    • (1925) Am J Pathol , vol.1 , pp. 415-429
    • Warren, S.1    Root, H.F.2
  • 62
    • 0027078251 scopus 로고
    • Pancreatic beta cells in insulin-dependent diabetes
    • PID: 1292912, COI: 1:CAS:528:DyaK3sXitlWhsb4%3D
    • Pipeleers D, Ling Z (1992) Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 8:209–227
    • (1992) Diabetes Metab Rev , vol.8 , pp. 209-227
    • Pipeleers, D.1    Ling, Z.2
  • 66
    • 0020623615 scopus 로고
    • Cellular composition of the human diabetic pancreas
    • PID: 6347784, COI: 1:STN:280:DyaL3s3mt1ylsw%3D%3D
    • Rahier J, Goebbels RM, Henquin JC (1983) Cellular composition of the human diabetic pancreas. Diabetologia 24:366–371
    • (1983) Diabetologia , vol.24 , pp. 366-371
    • Rahier, J.1    Goebbels, R.M.2    Henquin, J.C.3
  • 67
    • 0019996086 scopus 로고
    • Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans
    • PID: 6131002, COI: 1:STN:280:DyaL3s7jt12jsA%3D%3D
    • Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH (1982) Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 31:694–700
    • (1982) Diabetes , vol.31 , pp. 694-700
    • Stefan, Y.1    Orci, L.2    Malaisse-Lagae, F.3    Perrelet, A.4    Patel, Y.5    Unger, R.H.6
  • 68
    • 0023618080 scopus 로고
    • Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy
    • PID: 3322901
    • Löhr M, Klöppel G (1987) Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia 30:757–762
    • (1987) Diabetologia , vol.30 , pp. 757-762
    • Löhr, M.1    Klöppel, G.2
  • 69
    • 78049320362 scopus 로고    scopus 로고
    • Residual insulin production and pancreatic beta cell turnover after 50 years of diabetes: Joslin Medalist study
    • PID: 20699420, COI: 1:CAS:528:DC%2BC3cXhsV2nsb%2FL
    • Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL (2010) Residual insulin production and pancreatic beta cell turnover after 50 years of diabetes: Joslin Medalist study. Diabetes 59:2846–2853
    • (2010) Diabetes , vol.59 , pp. 2846-2853
    • Keenan, H.A.1    Sun, J.K.2    Levine, J.3    Doria, A.4    Aiello, L.P.5    Eisenbarth, G.6    Bonner-Weir, S.7    King, G.L.8
  • 70
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration
    • PID: 16205882, COI: 1:CAS:528:DC%2BD2MXht1Skt7vJ
    • Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration. Diabetologia 48:2221–2228
    • (2005) Diabetologia , vol.48 , pp. 2221-2228
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3    Rizza, R.A.4    Butler, P.C.5
  • 71
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson MS and Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 447–485
    • (2005) Annu Rev Immunol , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 72
    • 2042419553 scopus 로고
    • The NOD mouse: a model for insulin-dependent diabetes mellitus
    • Wiley, New York:
    • Leiter EH (1977) The NOD mouse: a model for insulin-dependent diabetes mellitus. In: Current protocols in immunology, unit 15.9. Wiley, New York
    • (1977) Current protocols in immunology
    • Leiter, E.H.1
  • 73
    • 0002758516 scopus 로고
    • The NOD mouse: a model for analyzing the interplay between heredity and environment in development of autoimmune disease
    • Leiter EH (1993) The NOD mouse: a model for analyzing the interplay between heredity and environment in development of autoimmune disease. ILAR news 35:4–14
    • (1993) ILAR news , vol.35 , pp. 4-14
    • Leiter, E.H.1
  • 74
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
    • PID: 20424843, COI: 1:CAS:528:DC%2BC3MXntVGmuw%3D%3D
    • Driver JP, Serreze DV, Chen YG (2011) Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol 33:67–87
    • (2011) Semin Immunopathol , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.G.3
  • 75
    • 84875451200 scopus 로고    scopus 로고
    • Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse
    • PID: 23555752, COI: 1:CAS:528:DC%2BC3sXlslCgtrw%3D
    • Carrero JA, Calderon B, Towfic F, Artyomov MN, Unanue ER (2013) Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS ONE 8:e59701
    • (2013) PLoS ONE , vol.8 , pp. e59701
    • Carrero, J.A.1    Calderon, B.2    Towfic, F.3    Artyomov, M.N.4    Unanue, E.R.5
  • 76
    • 0028223127 scopus 로고
    • Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta cell destruction in NOD mice
    • Janssen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA (1994) Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta cell destruction in NOD mice. Diabetes 43:667–675
    • (1994) Diabetes , vol.43 , pp. 667-675
    • Janssen, A.1    Homo-Delarche, F.2    Hooijkaas, H.3    Leenen, P.J.4    Dardenne, M.5    Drexhage, H.A.6
  • 77
    • 77954298756 scopus 로고    scopus 로고
    • Quantification and three-dimensional imaging of the insulitis-induced destruction of beta cells in murine type 1 diabetes
    • PID: 20393145
    • Alanentalo T, Hörnblad A, Mayans S, Nilsson AK, Sharpe J, Larefalk A, Ahlgren U, Holmberg D (2010) Quantification and three-dimensional imaging of the insulitis-induced destruction of beta cells in murine type 1 diabetes. Diabetes 59:1756–1764
    • (2010) Diabetes , vol.59 , pp. 1756-1764
    • Alanentalo, T.1    Hörnblad, A.2    Mayans, S.3    Nilsson, A.K.4    Sharpe, J.5    Larefalk, A.6    Ahlgren, U.7    Holmberg, D.8
  • 78
    • 84939928232 scopus 로고    scopus 로고
    • Quah HS, Miranda-Hernandez S, Khoo A, Harding A, Fynch S, Elkerbout L, Brodnicki TC, Baxter AG, Kay TWH, Thomas HE, Graham KL (2013) Deficiency in type I interferon signaling prevents the early inteferon-gene signature in pancreatic islets but not type 1 diabetes in non-obese diabetic mice. Diabetes (in press)
    • Quah HS, Miranda-Hernandez S, Khoo A, Harding A, Fynch S, Elkerbout L, Brodnicki TC, Baxter AG, Kay TWH, Thomas HE, Graham KL (2013) Deficiency in type I interferon signaling prevents the early inteferon-gene signature in pancreatic islets but not type 1 diabetes in non-obese diabetic mice. Diabetes (in press)
  • 79
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • PID: 16498451, COI: 1:CAS:528:DC%2BD28Xhsleltbw%3D
    • Aloisi F, Pujol-Borrell R (2006) Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 6:205–215
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-215
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 80
    • 0033843222 scopus 로고    scopus 로고
    • Lymphoid tissue homing chemokines are expressed in chronic inflammation
    • PID: 10751336, COI: 1:CAS:528:DC%2BD3cXjtV2isLs%3D
    • Hjelmstrom P, Fjell J, Nakagawa T, Sacca R, Cuff CA, Ruddle NH (2000) Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am J Pathol 156:1133–1138
    • (2000) Am J Pathol , vol.156 , pp. 1133-1138
    • Hjelmstrom, P.1    Fjell, J.2    Nakagawa, T.3    Sacca, R.4    Cuff, C.A.5    Ruddle, N.H.6
  • 81
    • 77953195621 scopus 로고    scopus 로고
    • Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs
    • Penaranda C, Tang Q, Ruddle NH, Bluestone JA (2010) Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes 50:1461–1468
    • (2010) Diabetes , vol.50 , pp. 1461-1468
    • Penaranda, C.1    Tang, Q.2    Ruddle, N.H.3    Bluestone, J.A.4
  • 82
    • 0032910989 scopus 로고    scopus 로고
    • Increased beta cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
    • PID: 10331402, COI: 1:CAS:528:DyaK1MXjtFSgsbs%3D
    • Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, Polonsky KS (1999) Increased beta cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48:989–996
    • (1999) Diabetes , vol.48 , pp. 989-996
    • Sreenan, S.1    Pick, A.J.2    Levisetti, M.3    Baldwin, A.C.4    Pugh, W.5    Polonsky, K.S.6
  • 83
    • 33845523340 scopus 로고    scopus 로고
    • Effects of autoimmunity and immune therapy on beta cell turnover in type 1 diabetes
    • PID: 17130466, COI: 1:CAS:528:DC%2BD28XhtlSmsLbK
    • Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AB, Herold KC (2006) Effects of autoimmunity and immune therapy on beta cell turnover in type 1 diabetes. Diabetes 55:3238–3244
    • (2006) Diabetes , vol.55 , pp. 3238-3244
    • Sherry, N.A.1    Kushner, J.A.2    Glandt, M.3    Kitamura, T.4    Brillantes, A.B.5    Herold, K.C.6
  • 85
    • 0020466235 scopus 로고
    • Lymphocytic insulitis in a ‘non-obese diabetic (NOD)’ strain of mice: an immunohistochemical and electron microscope investigation
    • Fujita T, Yui R, Kusumoto Y, Serizawa Y, Makini S, Tochino Y (1982) Lymphocytic insulitis in a ‘non-obese diabetic (NOD)’ strain of mice: an immunohistochemical and electron microscope investigation. Biomed Res 3:429–443
    • (1982) Biomed Res , vol.3 , pp. 429-443
    • Fujita, T.1    Yui, R.2    Kusumoto, Y.3    Serizawa, Y.4    Makini, S.5    Tochino, Y.6
  • 87
    • 77955559432 scopus 로고    scopus 로고
    • Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes
    • PID: 20532863, COI: 1:CAS:528:DC%2BC3cXpsV2ltb4%3D
    • Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010) Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia 53:2020–2028
    • (2010) Diabetologia , vol.53 , pp. 2020-2028
    • Willcox, A.1    Richardson, S.J.2    Bone, A.J.3    Foulis, A.K.4    Morgan, N.G.5
  • 88
    • 84874946657 scopus 로고    scopus 로고
    • Revisiting the notion of type 1 diabetes being a T-cell mediated autoimmune disease
    • COI: 1:CAS:528:DC%2BC3sXjtF2nt7w%3D
    • Skog O, Korsgren S, Melhus A, Korsgren O (2013) Revisiting the notion of type 1 diabetes being a T-cell mediated autoimmune disease. Curr Opin Endocrinol Diab Obes 20:118–123
    • (2013) Curr Opin Endocrinol Diab Obes , vol.20 , pp. 118-123
    • Skog, O.1    Korsgren, S.2    Melhus, A.3    Korsgren, O.4
  • 89
    • 84868130672 scopus 로고    scopus 로고
    • On the etiology of type 1 diabetes: a new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response
    • PID: 22944599, COI: 1:CAS:528:DC%2BC38XhslOltbbP
    • Korsgren O, Molin Y, Salmela K, Lundgren T, Melhus A, Korsgren O (2012) On the etiology of type 1 diabetes: a new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response. Am J Pathol 181:1735–1748
    • (2012) Am J Pathol , vol.181 , pp. 1735-1748
    • Korsgren, O.1    Molin, Y.2    Salmela, K.3    Lundgren, T.4    Melhus, A.5    Korsgren, O.6
  • 90
    • 80054711767 scopus 로고    scopus 로고
    • Insulitis in the human endocrine pancreas: does a viral infection lead to inflammation and beta cell replication?
    • PID: 21701817
    • In’t Veld P (2011) Insulitis in the human endocrine pancreas: does a viral infection lead to inflammation and beta cell replication? Diabetologia 54:2220–2222
    • (2011) Diabetologia , vol.54 , pp. 2220-2222
    • In’t Veld, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.