Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

Nature Communications

Volumn 6, Issue , 2015, Pages

  Izumi, Kenichi ^a,b   Mine, Keiichiro ^a   Inoue, Yoshitaka ^a   Teshima, Miho ^a   Ogawa, Shuichiro ^a   Kai, Yuji ^a   Kurafuji, Toshinobu ^a   Hirakawa, Kanako ^a   Miyakawa, Daiki ^a   Ikeda, Haruka ^a   Inada, Akari ^a   Hara, Manami ^c   Yamada, Hisakata ^d   Akashi, Koichi ^a   Niho, Yoshiyuki ^a   Ina, Keisuke ^e   Kobayashi, Takashi ^e   Yoshikai, Yasunobu ^d   Anzai, Keizo ^b   Yamashita, Teruo ^f   Minagawa, Hiroko ^f   Fujimoto, Shuji ^a   Kurisaki, Hironori ^a   Shimoda, Kazuya ^g   Katsuta, Hitoshi ^a   Nagafuchi, Seiho ^a   more..

^a KYUSHU UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c UNIVERSITY OF CHICAGO   (United States)

^d KYUSHU UNIVERSITY   (Japan)

^e OITA UNIVERSITY   (Japan)

^f AICHI PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^g UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; PROTEIN KINASE TYK2; MESSENGER RNA; TYK2 PROTEIN, MOUSE;

DIABETES; GENE EXPRESSION; MUTATION; PROTEIN; RODENT; VIRAL DISEASE; VIRUS;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL SPECIFICITY; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; ENCEPHALOMYOCARDITIS VIRUS; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUTANT; NONHUMAN; PANCREAS ISLET BETA CELL; PROMOTER REGION; VIRUS INDUCTION; VIRUS STRAIN; ANIMAL; C57BL MOUSE; CARDIOVIRUS INFECTION; EXPERIMENTAL DIABETES MELLITUS; GENETIC PREDISPOSITION; GENETICS; INBRED MOUSE STRAIN; KNOCKOUT MOUSE; METABOLISM; MUTATION; VIROLOGY;

MUS;

ANIMALS; CARDIOVIRUS INFECTIONS; DIABETES MELLITUS, EXPERIMENTAL; ENCEPHALOMYOCARDITIS VIRUS; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; INSULIN-SECRETING CELLS; INTERFERON TYPE I; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MUTATION; RNA, MESSENGER; TYK2 KINASE;

EID: 84926683121     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7748     Document Type: Article

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