Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

Journal of Clinical Investigation

Volumn 114, Issue 4, 2004, Pages 589-597

  Achenbach, Peter ^a   Koczwara, Kerstin ^a   Knopff, Annette ^a   Naserke, Heike ^a   Ziegler, Anette G ^a   Bonifacio, Ezio ^a,b  

^a INSTITUT FÜR DIABETESFORSCHUNG   (Germany)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; HLA DR4 ANTIGEN; HUMAN INSULIN; INSULIN ANTIBODY; PROINSULIN; EPITOPE; INSULIN;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; BIRTH; CARBOXY TERMINAL SEQUENCE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; EXPOSURE; HUMAN; IMMUNE RESPONSE; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MATURITY; PRIORITY JOURNAL; RADIOASSAY; AMINO ACID SEQUENCE; BINDING COMPETITION; BLOOD; CHEMISTRY; COMPARATIVE STUDY; HAPLOTYPE; IMMUNOLOGY; METABOLISM; PANCREAS ISLET; PRESCHOOL CHILD; PROSPECTIVE STUDY; RISK FACTOR;

AMINO ACID SEQUENCE; AUTOANTIBODIES; BINDING, COMPETITIVE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; EPITOPES; HAPLOTYPES; HLA-DR4 ANTIGEN; HUMANS; INFANT; INSULIN; INSULIN ANTIBODIES; ISLETS OF LANGERHANS; PROINSULIN; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 4344690190     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200421307     Document Type: Article

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