Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis

Chemistry and Biology

Volumn 19, Issue 6, 2012, Pages 669-673

  Chou, Danny Hung Chieh ^a,b   Holson, Edward B ^a   Wagner, Florence F ^a   Tang, Alicia J ^a   Maglathlin, Rebecca L ^a   Lewis, Timothy A ^a   Schreiber, Stuart L ^a,b   Wagner, Bridget K ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CYTOKINE; ENTINOSTAT; GLUCOSE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; INSULIN; NITRITE; TACEDINALINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; INHIBITION KINETICS; INSULIN RELEASE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; APOPTOSIS; BENZAMIDES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; INSULIN; INSULIN-SECRETING CELLS; PHENYLENEDIAMINES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84862726998     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.05.010     Document Type: Article

References (15)

1. J.E. Bradner, N. West, M.L. Grachan, E.F. Greenberg, S.J. Haggarty, T. Warnow, and R. Mazitschek Chemical phylogenetics of histone deacetylases Nat. Chem. Biol. 6 2010 238 243
2. D.H. Chou, N.E. Bodycombe, H.A. Carrinski, T.A. Lewis, P.A. Clemons, S.L. Schreiber, and B.K. Wagner Small-molecule suppressors of cytokine-induced beta-cell apoptosis ACS Chem. Biol. 5 2010 729 734
3. D.P. Christensen, M. Dahllöf, M. Lundh, D.N. Rasmussen, M.D. Nielsen, N. Billestrup, L.G. Grunnet, and T. Mandrup-Poulsen Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus Mol. Med. 17 2011 378 390
4. M. Cnop, N. Welsh, J.C. Jonas, A. Jörns, S. Lenzen, and D.L. Eizirik Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities Diabetes 54 Suppl 2 2005 S97 S107
5. M.I. Darville, and D.L. Eizirik Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells Diabetologia 41 1998 1101 1108
6. A. Fornoni, A. Pileggi, R.D. Molano, N.Y. Sanabria, T. Tejada, J. Gonzalez-Quintana, H. Ichii, L. Inverardi, C. Ricordi, and R.L. Pastori Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation Diabetologia 51 2008 298 308
7. L.G. Grunnet, R. Aikin, M.F. Tonnesen, S. Paraskevas, L. Blaabjerg, J. Storling, L. Rosenberg, N. Billestrup, D. Maysinger, and T. Mandrup-Poulsen Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells Diabetes 58 2009 1807 1815
8. L. Larsen, M. Tonnesen, S.G. Ronn, J. Storling, S. Jorgensen, P. Mascagni, C.A. Dinarello, N. Billestrup, and T. Mandrup-Poulsen Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells Diabetologia 50 2007 779 789
9. E.C. Lewis, L. Blaabjerg, J. Storling, S.G. Ronn, P. Mascagni, C.A. Dinarello, and T. Mandrup-Poulsen The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet beta-cells in vivo and in vitro Mol. Med. 17 2011 369 377 10.2119/molmed.2010.00152 Published online December 22, 2010
10. A. Merglen, S. Theander, B. Rubi, G. Chaffard, C.B. Wollheim, and P. Maechler Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Endocrinology 145 2004 667 678
11. J.L. Methot, P.K. Chakravarty, M. Chenard, J. Close, J.C. Cruz, W.K. Dahlberg, J. Fleming, C.L. Hamblett, J.E. Hamill, and P. Harrington Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) Bioorg. Med. Chem. Lett. 18 2008 973 978
12. S. Minucci, and P.G. Pelicci Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat. Rev. Cancer 6 2006 38 51
13. S. Miret, E.M. De Groene, and W. Klaffke Comparison of in vitro assays of cellular toxicity in the human hepatic cell line HepG2 J. Biomol. Screen. 11 2006 184 193
14. M. Reers, S.T. Smiley, C. Mottola-Hartshorn, A. Chen, M. Lin, and L.B. Chen Mitochondrial membrane potential monitored by JC-1 dye Methods Enzymol. 260 1995 406 417
15. G. Soldevila, M. Buscema, M. Doshi, R.F. James, G.F. Bottazzo, and R. Pujol-Borrell Cytotoxic effect of IFN-γ plus TNF-α on human islet cells J. Autoimmun. 4 1991 291 306