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Volumn 108, Issue 37, 2011, Pages

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and β-cell apoptosis

Author keywords

Autoimmunity; Bioinformatics; Huntington's disease; Programmed cell death; Protein network

Indexed keywords

ADENYLATE KINASE DOMAIN CONTAINING 1; ARGININO SUCCINATE SYNTHETASE 1; GAMMA INTERFERON; GLUTAMINASE C; HLA DR ANTIGEN; HUNTINGTIN; HUNTINGTIN INTERACTING PROTEIN 14; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; PEPTIDES AND PROTEINS; PROTEIN KINASE C DELTA; STRESS ACTIVATED PROTEIN KINASE 1; SYNTAXIN 4; SYNTROPHIN BETA 2; UNCLASSIFIED DRUG;

EID: 80053074286     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104384108     Document Type: Article
Times cited : (55)

References (58)
  • 1
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
    • DOI 10.1007/s00109-003-0450-y
    • Donath MY, Størling J, Maedler K, Mandrup-Poulsen T (2003) Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes. J Mol Med 81:455-470. (Pubitemid 37070198)
    • (2003) Journal of Molecular Medicine , vol.81 , Issue.8 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 2
    • 0025094344 scopus 로고
    • Mapping genes in diabetes. Genetic epidemiological perspective
    • Rich SS (1990) Mapping genes in diabetes. Genetic epidemiological perspective. Diabetes 39:1315-1319.
    • (1990) Diabetes , vol.39 , pp. 1315-1319
    • Rich, S.S.1
  • 3
    • 25844441709 scopus 로고    scopus 로고
    • Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
    • DOI 10.2337/diabetes.54.10.2995
    • Concannon P, et al.; Type 1 Diabetes Genetics Consortium (2005) Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes 54:2995-3001. (Pubitemid 41401098)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2995-3001
    • Concannon, P.1    Erlich, H.A.2    Julier, C.3    Morahan, G.4    Nerup, J.5    Pociot, F.6    Todd, J.A.7    Rich, S.S.8
  • 4
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • Type 1 Diabetes Genetics Consortium
    • Barrett JC, et al.; Type 1 Diabetes Genetics Consortium (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41:703-707.
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1
  • 5
    • 64649096894 scopus 로고    scopus 로고
    • Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
    • Type 1 Diabetes Genetics Consortium
    • Concannon P, et al.; Type 1 Diabetes Genetics Consortium (2009) Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 58:1018-1022.
    • (2009) Diabetes , vol.58 , pp. 1018-1022
    • Concannon, P.1
  • 6
    • 0036181973 scopus 로고    scopus 로고
    • Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: The NOD model of type 1 diabetes
    • DOI 10.1101/gr.214102. Article published online before print in January 2002
    • Eaves IA, et al. (2002) Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: The NOD model of type 1 diabetes. Genome Res 12:232-243. (Pubitemid 34162990)
    • (2002) Genome Research , vol.12 , Issue.2 , pp. 232-243
    • Eaves, I.A.1    Wicker, L.S.2    Ghandour, G.3    Lyons, P.A.4    Peterson, L.B.5    Todd, J.A.6    Glynne, R.J.7
  • 9
    • 15044341082 scopus 로고    scopus 로고
    • Integration of text- and data-mining using ontologies successfully selects disease gene candidates
    • DOI 10.1093/nar/gki296
    • Tiffin N, et al. (2005) Integration of text- and data-mining using ontologies successfully selects disease gene candidates. Nucleic Acids Res 33:1544-1552. (Pubitemid 41418383)
    • (2005) Nucleic Acids Research , vol.33 , Issue.5 , pp. 1544-1552
    • Tiffin, N.1    Kelso, J.F.2    Powell, A.R.3    Pan, H.4    Bajic, V.B.5    Hide, W.A.6
  • 10
    • 33751017706 scopus 로고    scopus 로고
    • Discovering disease-genes by topological features in human protein-protein interaction network
    • DOI 10.1093/bioinformatics/btl467
    • Xu J, Li Y (2006) Discovering disease-genes by topological features in human proteinprotein interaction network. Bioinformatics 22:2800-2805. (Pubitemid 44742401)
    • (2006) Bioinformatics , vol.22 , Issue.22 , pp. 2800-2805
    • Xu, J.1    Li, Y.2
  • 11
    • 41549139527 scopus 로고    scopus 로고
    • Walking the interactome for prioritization of candidate disease genes
    • Köhler S, Bauer S, Horn D, Robinson PN (2008) Walking the interactome for prioritization of candidate disease genes. Am J Hum Genet 82:949-958.
    • (2008) Am J Hum Genet , vol.82 , pp. 949-958
    • Köhler, S.1    Bauer, S.2    Horn, D.3    Robinson, P.N.4
  • 13
    • 77950339092 scopus 로고    scopus 로고
    • Integrating pathway analysis and genetics of gene expression for genome-wide association studies
    • Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE (2010) Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet 86:581-591.
    • (2010) Am J Hum Genet , vol.86 , pp. 581-591
    • Zhong, H.1    Yang, X.2    Kaplan, L.M.3    Molony, C.4    Schadt, E.E.5
  • 14
    • 70149101114 scopus 로고    scopus 로고
    • Using genome-wide pathway analysis to unravel the etiology of complex diseases
    • Elbers CC, et al. (2009) Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genet Epidemiol 33:419-431.
    • (2009) Genet Epidemiol , vol.33 , pp. 419-431
    • Elbers, C.C.1
  • 15
    • 77349100428 scopus 로고    scopus 로고
    • Gene prioritization in Type 2 Diabetes using domain interactions and network analysis
    • Sharma A, Chavali S, Tabassum R, Tandon N, Bharadwaj D (2010) Gene prioritization in Type 2 Diabetes using domain interactions and network analysis. BMC Genomics 11:84.
    • (2010) BMC Genomics , vol.11 , pp. 84
    • Sharma, A.1    Chavali, S.2    Tabassum, R.3    Tandon, N.4    Bharadwaj, D.5
  • 16
    • 77649311266 scopus 로고    scopus 로고
    • Predicting type 1 diabetes candidate genes using human protein-protein interaction networks
    • Gao S, Wang X (2009) Predicting type 1 diabetes candidate genes using human protein-protein interaction networks. J Comput Sci Syst Biol 2:133.
    • (2009) J Comput Sci Syst Biol , vol.2 , pp. 133
    • Gao, S.1    Wang, X.2
  • 18
    • 1242292946 scopus 로고    scopus 로고
    • Mechanisms of genetic susceptibility to type I diabetes: Beyond HLA
    • DOI 10.1016/j.ymgme.2003.11.010
    • Anjos S, Polychronakos C (2004) Mechanisms of genetic susceptibility to type I diabetes: Beyond HLA. Mol Genet Metab 81:187-195. (Pubitemid 38221449)
    • (2004) Molecular Genetics and Metabolism , vol.81 , Issue.3 , pp. 187-195
    • Anjos, S.1    Polychronakos, C.2
  • 19
    • 77954288805 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes: What's next?
    • Pociot F, et al. (2010) Genetics of type 1 diabetes: What's next? Diabetes 59:1561-1571.
    • (2010) Diabetes , vol.59 , pp. 1561-1571
    • Pociot, F.1
  • 22
    • 11244337380 scopus 로고    scopus 로고
    • Huntingtin interacting protein 14 is an oncogenic human protein: Palmitoyl acyltransferase
    • DOI 10.1038/sj.onc.1208171
    • Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (2004) Huntingtin interacting protein 14 is an oncogenic human protein: Palmitoyl acyltransferase. Oncogene 23:9230-9237. (Pubitemid 40069693)
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9230-9237
    • Ducker, C.E.1    Stettler, E.M.2    French, K.J.3    Upson, J.J.4    Smith, C.D.5
  • 23
    • 33745627659 scopus 로고    scopus 로고
    • Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function
    • Yanai A, et al. (2006) Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci 9:824-831.
    • (2006) Nat Neurosci , vol.9 , pp. 824-831
    • Yanai, A.1
  • 24
    • 38049072215 scopus 로고    scopus 로고
    • Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles
    • Ohyama T, et al. (2007) Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol 179:1481-1496.
    • (2007) J Cell Biol , vol.179 , pp. 1481-1496
    • Ohyama, T.1
  • 25
    • 0842291578 scopus 로고    scopus 로고
    • Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells
    • DOI 10.1210/en.2003-1099
    • Merglen A, et al. (2004) Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 145:667-678. (Pubitemid 38183809)
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 667-678
    • Merglen, A.1    Theander, S.2    Rubi, B.3    Chaffard, G.4    Wollheim, C.B.5    Maechler, P.6
  • 26
    • 0027200206 scopus 로고
    • Transient transfection studies of secretion in bovine chromaffin cells and PC12 cells. Generation of kainate-sensitive chromaffin cells
    • Wick PF, Senter RA, Parsels LA, Uhler MD, Holz RW (1993) Transient transfection studies of secretion in bovine chromaffin cells and PC12 cells. Generation of kainatesensitive chromaffin cells. J Biol Chem 268:10983-10989. (Pubitemid 23162283)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.15 , pp. 10983-10989
    • Wick, P.F.1    Senter, R.A.2    Parsels, L.A.3    Uhler, M.D.4    Holz, R.W.5
  • 29
    • 77951158889 scopus 로고    scopus 로고
    • Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells
    • Roggli E, et al. (2010) Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes 59:978-986.
    • (2010) Diabetes , vol.59 , pp. 978-986
    • Roggli, E.1
  • 30
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of Cytokine-Induced NF-kappaB Activation by Adenovirus-Mediated Expression of a NF-kappaB Super-Repressor Prevents beta-Cell Apoptosis
    • Heimberg H, et al. (2001) Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes 50:2219-2224. (Pubitemid 33641904)
    • (2001) Diabetes , vol.50 , Issue.10 , pp. 2219-2224
    • Heimberg, H.1    Heremans, Y.2    Jobin, C.3    Leemans, R.4    Cardozo, A.K.5    Darville, M.6    Eizirik, D.L.7
  • 31
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor
    • DOI 10.1074/jbc.M005943200
    • Giannoukakis N, Rudert WA, Trucco M, Robbins PD (2000) Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor. J Biol Chem 275:36509-36513. (Pubitemid 32002047)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 33
    • 0031798539 scopus 로고    scopus 로고
    • Glutamate transport and storage in synaptic vesicles
    • DOI 10.1254/jjp.77.1
    • Ozkan ED, Ueda T (1998) Glutamate transport and storage in synaptic vesicles. Jpn J Pharmacol 77:1-10. (Pubitemid 28263985)
    • (1998) Japanese Journal of Pharmacology , vol.77 , Issue.1 , pp. 1-10
    • Ozkan, E.D.1    Ueda, T.2
  • 34
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689. (Pubitemid 129516341)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 35
    • 0033850451 scopus 로고    scopus 로고
    • The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells
    • Ammendrup A, et al. (2000) The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 49:1468-1476.
    • (2000) Diabetes , vol.49 , pp. 1468-1476
    • Ammendrup, A.1
  • 36
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK. Novel blockers of beta-cell death
    • Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50:77-82. (Pubitemid 32047984)
    • (2001) Diabetes , vol.50 , Issue.1 , pp. 77-82
    • Bonny, C.1    Oberson, A.2    Negri, S.3    Sauser, C.4    Schorderet, D.F.5
  • 37
    • 77449139439 scopus 로고    scopus 로고
    • Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction
    • Hennige AM, et al. (2010) Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59:119-127.
    • (2010) Diabetes , vol.59 , pp. 119-127
    • Hennige, A.M.1
  • 38
    • 29444444591 scopus 로고    scopus 로고
    • Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells
    • DOI 10.1210/me.2005-0157
    • Spurlin BA, Thurmond DC (2006) Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells. Mol Endocrinol 20:183-193. (Pubitemid 43011679)
    • (2006) Molecular Endocrinology , vol.20 , Issue.1 , pp. 183-193
    • Spurlin, B.A.1    Thurmond, D.C.2
  • 39
    • 0029086027 scopus 로고
    • Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: Induction of argininosuccinate synthetase by cytokines
    • Flodström M, Niemann A, Bedoya FJ, Morris SM, Jr., Eizirik DL (1995) Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: Induction of argininosuccinate synthetase by cytokines. Endocrinology 136:3200-3206.
    • (1995) Endocrinology , vol.136 , pp. 3200-3206
    • Flodström, M.1    Niemann, A.2    Bedoya, F.J.3    Morris Jr., S.M.4    Eizirik, D.L.5
  • 40
    • 77449145225 scopus 로고    scopus 로고
    • Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary betacells
    • Ortis F, et al. (2010) Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary betacells. Diabetes 59:358-374.
    • (2010) Diabetes , vol.59 , pp. 358-374
    • Ortis, F.1
  • 41
    • 36348948083 scopus 로고    scopus 로고
    • Drosophila Huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein
    • DOI 10.1523/JNEUROSCI.2464-07.2007
    • Stowers RS, Isacoff EY (2007) Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein. J Neurosci 27:12874-12883. (Pubitemid 350159572)
    • (2007) Journal of Neuroscience , vol.27 , Issue.47 , pp. 12874-12883
    • Stowers, R.S.1    Isacoff, E.Y.2
  • 42
    • 0028014432 scopus 로고
    • A role for synaptic vesicles in non-neuronal cells: Clues from pancreatic beta cells and from chromaffin cells
    • Thomas-Reetz AC, De Camilli P (1994) A role for synaptic vesicles in non-neuronal cells: Clues from pancreatic beta cells and from chromaffin cells. FASEB J 8:209-216.
    • (1994) FASEB J , vol.8 , pp. 209-216
    • Thomas-Reetz, A.C.1    De Camilli, P.2
  • 43
    • 4744375389 scopus 로고    scopus 로고
    • The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis
    • DOI 10.1074/jbc.C400360200
    • Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S (2004) The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis. J Biol Chem 279:41271-41274. (Pubitemid 39313564)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41271-41274
    • Ohara-Imaizumi, M.1    Cardozo, A.K.2    Kikuta, T.3    Eizirik, D.L.4    Nagamatsu, S.5
  • 44
    • 0033009587 scopus 로고    scopus 로고
    • Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
    • Hurlbert MS, et al. (1999) Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes 48:649-651. (Pubitemid 29106885)
    • (1999) Diabetes , vol.48 , Issue.3 , pp. 649-651
    • Hurlbert, M.S.1    Zhou, W.2    Wasmeier, C.3    Kaddis, F.G.4    Hutton, J.C.5    Freed, C.R.6
  • 46
    • 0015521813 scopus 로고
    • Increased frequency of diabetes mellitus in patients with Huntington's chorea
    • Podolsky S, Leopold NA, Sax DS (1972) Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet 1:1356-1358.
    • (1972) Lancet , vol.1 , pp. 1356-1358
    • Podolsky, S.1    Leopold, N.A.2    Sax, D.S.3
  • 48
    • 63449090757 scopus 로고    scopus 로고
    • Huntingtin as an essential integrator of intracellular vesicular trafficking
    • Caviston JP, Holzbaur EL (2009) Huntingtin as an essential integrator of intracellular vesicular trafficking. Trends Cell Biol 19:147-155.
    • (2009) Trends Cell Biol , vol.19 , pp. 147-155
    • Caviston, J.P.1    Holzbaur, E.L.2
  • 49
    • 70349569018 scopus 로고    scopus 로고
    • Mutant huntingtin interacts with beta-tubulin and disrupts vesicular transport and insulin secretion
    • Smith R, et al. (2009) Mutant huntingtin interacts with beta-tubulin and disrupts vesicular transport and insulin secretion. Hum Mol Genet 18:3942-3954.
    • (2009) Hum Mol Genet , vol.18 , pp. 3942-3954
    • Smith, R.1
  • 50
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis
    • DOI 10.1007/s001250100021
    • Eizirik DL, Mandrup-Poulsen T (2001) A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133. (Pubitemid 34015464)
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 51
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • DOI 10.2337/diabetes.54.suppl-2.S97
    • Cnop M, et al. (2005) Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities. Diabetes 54(Suppl 2):S97-S107. (Pubitemid 43343337)
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.-C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 52
    • 77956276832 scopus 로고    scopus 로고
    • High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression
    • Fred RG, Bang-Berthelsen CH, Mandrup-Poulsen T, Grunnet LG, Welsh N (2010) High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS ONE 5:e10843.
    • (2010) PLoS ONE , vol.5
    • Fred, R.G.1    Bang-Berthelsen, C.H.2    Mandrup-Poulsen, T.3    Grunnet, L.G.4    Welsh, N.5
  • 54
    • 66649132790 scopus 로고    scopus 로고
    • PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis
    • Moore F, et al. (2009) PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes 58:1283-1291.
    • (2009) Diabetes , vol.58 , pp. 1283-1291
    • Moore, F.1
  • 56
    • 0035710746 scopus 로고    scopus 로고
    • -Delta DeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 57
    • 77956586071 scopus 로고    scopus 로고
    • LocusZoom: Regional visualization of genome-wide association scan results
    • Pruim RJ, et al. (2010) LocusZoom: Regional visualization of genome-wide association scan results. Bioinformatics 26:2336-2337.
    • (2010) Bioinformatics , vol.26 , pp. 2336-2337
    • Pruim, R.J.1
  • 58
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • DOI 10.1093/bioinformatics/bth457
    • Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265. (Pubitemid 40202029)
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4


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