GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

PLoS Genetics

Volumn 9, Issue 5, 2013, Pages

  Nogueira, Tatiane C ^a   Paula, Flavia M ^a   Villate, Olatz ^a   Colli, Maikel L ^a   Moura, Rodrigo F ^a   Cunha, Daniel A ^a   Marselli, Lorella ^b   Marchetti, Piero ^b   Cnop, Miriam ^a,c   Julier, Cécile ^d,e   Eizirik, Decio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

^c ERASME HOSPITAL   (Belgium)

^d INSERM   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 ONLY PROTEIN BIM; BIM PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; PALMITIC ACID; PROTEIN BAX; SRP55 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLIS3 GENE; GLUCOSE OXIDATION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LOSS OF FUNCTION MUTATION; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT;

AGED; ALTERNATIVE SPLICING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE PROTEINS; MICE; MIDDLE AGED; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; RATS; TRANSCRIPTION FACTORS;

RATTUS;

EID: 84878507398     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003532     Document Type: Article

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