The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription

Nucleic Acids Research

Volumn 37, Issue 8, 2009, Pages 2529-2538

  Yang, Yisheng ^a   Chang, Benny Hung Junn ^a   Samson, Susan L ^a   Li, Ming V ^a   Chan, Lawrence ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ST LUKE S EPISCOPAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; KRUPPEL LIKE FACTOR; MESSENGER RNA; NEUROGENIC DIFFERENTIATION FACTOR; PROTEIN GLIS3; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR NKX6-1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; INSULINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION;

ANIMALS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CONGENITAL HYPOTHYROIDISM; CRICETINAE; DIABETES MELLITUS; DNA; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RATS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

RATTUS;

EID: 65849094299     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp122     Document Type: Article

References (33)

1. Kim,Y.S., Lewandoski,M., Perantoni,A.O., Kurebayashi,S., Nakanishi,G. and Jetten,A.M. (2002) Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. J. Biol. Chem., 277, 30901-30913.
2. Zhang,F., Nakanishi,G., Kurebayashi,S., Yoshino,K., Perantoni,A., Kim,Y.S. and Jetten,A.M. (2002) Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions - roles in kidney development and neurogenesis. J. Biol. Chem., 277, 10139-10149.
3. Kim,Y.S., Nakanishi,G., Lewandoski,M. and Jetten,A.M. (2003) GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res., 31 5513-5525.
4. Attanasio,M., Uhlenhaut,N.H., Sousa,V.H., O'Toole,J.F., Otto,E., Anlag,K., Klugmann,C., Treier,A.C., Helou,J., Sayer,J.A. et al. (2007) Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat. Genet., 39, 1018-1024.
5. Kim,Y.S., Kang,H.S., Herbert,R., Beak,J.Y., Collins,J.B., Grissom,S.F. and Jetten,A.M. (2008) Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Mol. Cell Biol., 28, 2358-2367.
6. Beak,J.Y., Kang,H.S., Kim,Y.S. and Jetten,A.M. (2007) Kruppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. J. Bone Mineral Res., 22, 1234-1244.
7. Beak,J.Y., Kang,H.S., Kim,Y.S. and Jetten,A.M. (2008) Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic Acids Res., 36, 1690-1702.
8. Senee,V., Chelala,C., Duchatelet,S., Feng,D.R., Blanc,H., Cossec,J.C., Charon,C., Nicolino,M., Boileau,P., Cavener,D.R. et al. (2006) Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat. Genet., 38, 682-687.
9. Ohlsson,H., Karlsson,K. and Edlund,T. (1993) Ipf1, A homeodomain-containing transactivator of the insulin gene. EMBO J. 12, 4251-4259.
10. Peshavaria,M., Henderson,E., Sharma,A., Wright,C.V.E. and Stein,R. (1997) Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol. Cell Biol., 17, 3987-3996.
11. Ohneda,K., Mirmira,R.G., Wang,J.H., Johnson,J.D. and German,M.S. (2000) The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol. Cell Biol., 20, 900-911.
12. Zhao,L., Guo,M., Matsuoka,T.A., Hagman,D.K., Parazzoli,S.D., Poitout,V. and Stein,R. (2005) The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J. Biol. Chem., 280 11887-11894.
13. Aramata,S., Han,S., Yasuda,K. and Kataoka,K. (2005) Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1. Biochim. Biophys. Acta Gene Struct. Expression, 1730, 41-46.
14. Docherty,H.M., Hay,C.W., Ferguson,L.A., Barrow,J., Durward,E. and Docherty,K. (2005) Relative contribution of PDX-1, MafA and E47/beta 2 to the regulation of the human insulin promoter. Biochem. J., 389, 813-820.
15. Ritz-Laser,B., Estreicher,A., Klages,N., Saule,S. and Philippe,J. (1999) Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G(1) control element. J. Biol. Chem., 274, 4124-4132.
16. Sander,M., Neubuser,A., Kalamaras,J., Ee,H.C., Martin,G.R. and German,M.S. (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev., 11, 1662-1673.
17. Naya,F.J., Stellrecht,C.M.M. and Tsai,M.J. (1995) Tissue-specific regulation of the insulin gene by A novel basic helix-loop-helix transcription factor. Genes Dev., 9, 1009-1019.
18. Dumonteil,E., Laser,B., Constant,I. and Philippe,J. (1998) Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J. Biol. Chem. 273, 19945-19954.
19. Hay,C.W. and Docherty,K. (2006) Comparative analysis of insulin gene promoters - implications for diabetes research. Diabetes, 55 3201-3213.
20. Melloul,D., Marshak,S. and Cerasi,E. (2002) Regulation of insulin gene transcription. Diabetologia, 45, 309-326.
21. Barbetti,F. (2007) Diagnosis of neonatal and infancy-onset diabetes. Endocr. Dev., 11, 83-93.
22. Li,M.V., Chen,W., Poungvarin,N., Imamura,M. and Chan,L. (2008) Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from mondo conserved regions and essential trans-acting factor 14-3-3. Mol. Endocrinol., 22, 1658-1672.
23. Mizushima,S. and Nagata,S. (1990) pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res., 18, 5322.
24. Hohmeier,H.E., Mulder,H., Chen,G.X., Henkel-Rieger,R., Prentki,M. and Newgard,C.B. (2000) Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes, 49, 424-430.
25. Matsumura,K., Chang,B.H.J., Fujimiya,M., Chen,W., Kulkarni,R.N., Eguchi,Y., Kimura,H., Kojima,H. and Chan,L. (2007) Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol. Cell Biol., 27, 6026-6037.
26. Artner,I., Blanchi,B., Raum,J.C., Guo,M., Kaneko,T., Cordes,S., Sieweke,M. and Stein,R. (2007) MafB is required for islet beta cell maturation. Proc. Natl Acad. Sci. USA, 104, 3853-3858.
27. Artner,I., Le Lay,J., Hang,Y., Elghazi,L., Schisler,J.C., Henderson,E., Sosa-Pineda,B. and Stein,R. (2006) MafB: An activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes 55, 297-304.
28. Boam,D.S., Clark,A.R. and Docherty,K. (1990) Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J. Biol. Chem., 265, 8285-8296.
29. Clark,A.R., Wilson,M.E., Leibiger,I., Scott,V. and Docherty,K. (1995) A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter. Eur. J. Biochem., 232 627-632.
30. Pino,M.F., Ye,D.Z., Linning,K.D., Green,C.D., Wicksteed,B., Poitout,V. and Olson,L.K. (2005) Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Mol. Endocrinol., 19, 1343-1360.
31. Sander,M., Griffen,S.C., Huang,J. and German,M.S. (1998) A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets. Proc. Natl Acad. Sci. USA, 95, 11572-11577.
32. Sander,M., Sussel,L., Conners,J., Scheel,D., Kalamaras,J., Dela Cruz,F., Schwitzgebel,V., Hayes-Jordan,A. and German,M. (2000) Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development, 127, 5533-5540.
33. Mirmira,R.G., Watada,H. and German,M.S. (2000) Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. J. Biol. Chem., 275, 14743-14751.