메뉴 건너뛰기




Volumn 42, Issue 1, 2012, Pages 92-101

The therapeutic potential of epigenetics in autoimmune diseases

Author keywords

DNA Methylation; Environment; Geoepidemiology; Histone modification; Tolerance breakdown

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DEOXYCYTIDINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DNA; DNA METHYLTRANSFERASE INHIBITOR; FOLIC ACID; HISTONE; HISTONE DEACETYLASE INHIBITOR; HYDRAZINE; MICRORNA; PROCAINAMIDE; PROCAINE; ZEBULARINE;

EID: 84857039147     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-011-8293-8     Document Type: Article
Times cited : (47)

References (173)
  • 2
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • 20479774 1:CAS:528:DC%2BC3cXmtFCjt78%3D
    • EE Eichler J Flint G Gibson A Kong SM Leal JH Moore JH Nadeau 2010 Missing heritability and strategies for finding the underlying causes of complex disease Nat Rev Genet 11 446 450 20479774 1:CAS:528:DC%2BC3cXmtFCjt78%3D
    • (2010) Nat Rev Genet , vol.11 , pp. 446-450
    • Eichler, E.E.1    Flint, J.2    Gibson, G.3    Kong, A.4    Leal, S.M.5    Moore, J.H.6    Nadeau, J.H.7
  • 3
    • 77953655362 scopus 로고    scopus 로고
    • Discovering gene-environment interactions in the post-genomic era
    • 20009481
    • N Naidoo KS Chia 2009 Discovering gene-environment interactions in the post-genomic era J Prev Med Public Health 42 356 359 20009481
    • (2009) J Prev Med Public Health , vol.42 , pp. 356-359
    • Naidoo, N.1    Chia, K.S.2
  • 4
    • 79958075452 scopus 로고    scopus 로고
    • To what extent are genetics clinically useful?
    • 21640929
    • S Vermeire 2011 To what extent are genetics clinically useful? Best Pract Res Clin Gastroenterol 25 Suppl 1 S8 14 21640929
    • (2011) Best Pract Res Clin Gastroenterol , vol.25 , Issue.SUPPL. 1 , pp. 8-14
    • Vermeire, S.1
  • 5
    • 84857039000 scopus 로고    scopus 로고
    • Testing for rare variant associations in complex diseases
    • 21542888
    • J Asimit E Zeggini 2011 Testing for rare variant associations in complex diseases Genome Med 3 24 21542888
    • (2011) Genome Med , vol.3 , pp. 24
    • Asimit, J.1    Zeggini, E.2
  • 6
    • 79955693133 scopus 로고    scopus 로고
    • Epigenetics and autoimmunity, with special emphasis on methylation
    • 21460598 1:CAS:528:DC%2BC3MXnvVensLs%3D
    • Y Renaudineau P Youinou 2011 Epigenetics and autoimmunity, with special emphasis on methylation Keio J Med 60 10 16 21460598 1:CAS:528: DC%2BC3MXnvVensLs%3D
    • (2011) Keio J Med , vol.60 , pp. 10-16
    • Renaudineau, Y.1    Youinou, P.2
  • 7
    • 79955675794 scopus 로고    scopus 로고
    • The epigenetics of autoimmunity
    • 21278766 1:CAS:528:DC%2BC3MXlsVCms7k%3D
    • F Meda M Folci A Baccarelli C Selmi 2011 The epigenetics of autoimmunity Cell Mol Immunol 8 226 236 21278766 1:CAS:528:DC%2BC3MXlsVCms7k%3D
    • (2011) Cell Mol Immunol , vol.8 , pp. 226-236
    • Meda, F.1    Folci, M.2    Baccarelli, A.3    Selmi, C.4
  • 9
    • 77954088653 scopus 로고    scopus 로고
    • Epigenetic histone code and autoimmunity
    • 19662539 1:CAS:528:DC%2BC3cXnvVeku7g%3D
    • J Dieker S Muller 2010 Epigenetic histone code and autoimmunity Clin Rev Allergy Immunol 39 78 84 19662539 1:CAS:528:DC%2BC3cXnvVeku7g%3D
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 78-84
    • Dieker, J.1    Muller, S.2
  • 10
    • 77952746458 scopus 로고    scopus 로고
    • Genome-wide analysis of histone h3 lysine 4 trimethylation by chip-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients
    • 20483040 1:STN:280:DC%2BC3czkslSisw%3D%3D
    • Y Dai L Zhang C Hu Y Zhang 2010 Genome-wide analysis of histone h3 lysine 4 trimethylation by chip-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients Clin Exp Rheumatol 28 158 168 20483040 1:STN:280:DC%2BC3czkslSisw%3D%3D
    • (2010) Clin Exp Rheumatol , vol.28 , pp. 158-168
    • Dai, Y.1    Zhang, L.2    Hu, C.3    Zhang, Y.4
  • 11
    • 79959507257 scopus 로고    scopus 로고
    • Expression signature of microrna-181-a reveals its crucial role in the pathogenesis of paediatric systemic lupus erythematosus
    • 21385555 1:STN:280:DC%2BC3MvkslOqsg%3D%3D
    • YA Lashine AM Seoudi S Salah AI Abdelaziz 2011 Expression signature of microrna-181-a reveals its crucial role in the pathogenesis of paediatric systemic lupus erythematosus Clin Exp Rheumatol 29 351 357 21385555 1:STN:280:DC%2BC3MvkslOqsg%3D%3D
    • (2011) Clin Exp Rheumatol , vol.29 , pp. 351-357
    • Lashine, Y.A.1    Seoudi, A.M.2    Salah, S.3    Abdelaziz, A.I.4
  • 12
    • 79960148707 scopus 로고    scopus 로고
    • Timing is everything: The when and how of environmentally induced changes in the epigenome of animals
    • 21636976
    • C Faulk DC Dolinoy 2011 Timing is everything: The when and how of environmentally induced changes in the epigenome of animals Epigenetics 6 791 797 21636976
    • (2011) Epigenetics , vol.6 , pp. 791-797
    • Faulk, C.1    Dolinoy, D.C.2
  • 13
    • 79959965712 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • 21681201 1:CAS:528:DC%2BC3MXnslSmtr4%3D
    • MK Skinner 2011 Environmental epigenomics and disease susceptibility EMBO Rep 12 620 622 21681201 1:CAS:528:DC%2BC3MXnslSmtr4%3D
    • (2011) EMBO Rep , vol.12 , pp. 620-622
    • Skinner, M.K.1
  • 14
    • 77954087192 scopus 로고    scopus 로고
    • Epigenetics lessons from twins: Prospects for autoimmune disease
    • 19653134 1:CAS:528:DC%2BC3cXnvVeku7Y%3D
    • E Ballestar 2010 Epigenetics lessons from twins: Prospects for autoimmune disease Clin Rev Allergy Immunol 39 30 41 19653134 1:CAS:528: DC%2BC3cXnvVeku7Y%3D
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 30-41
    • Ballestar, E.1
  • 17
    • 0345505676 scopus 로고    scopus 로고
    • Genetic liability of type 1 diabetes and the onset age among 22, 650 young Finnish twin pairs: A nationwide follow-up study
    • DOI 10.2337/diabetes.52.4.1052
    • V Hyttinen J Kaprio L Kinnunen M Koskenvuo J Tuomilehto 2003 Genetic liability of type 1 diabetes and the onset age among 22,650 young finnish twin pairs: A nationwide follow-up study Diabetes 52 1052 1055 12663480 1:CAS:528:DC%2BD3sXislOnsLo%3D (Pubitemid 36384278)
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 1052-1055
    • Hyttinen, V.1    Kaprio, J.2    Kinnunen, L.3    Koskenvuo, M.4    Tuomilehto, J.5
  • 18
    • 0029128706 scopus 로고
    • Concordance rates of insulin dependent diabetes mellitus: A population based study of young danish twins
    • 7580548 1:STN:280:DyaK28%2FhtFeisw%3D%3D
    • KO Kyvik A Green H Beck-Nielsen 1995 Concordance rates of insulin dependent diabetes mellitus: A population based study of young danish twins Bmj 311 913 917 7580548 1:STN:280:DyaK28%2FhtFeisw%3D%3D
    • (1995) Bmj , vol.311 , pp. 913-917
    • Kyvik, K.O.1    Green, A.2    Beck-Nielsen, H.3
  • 19
    • 0014822605 scopus 로고
    • Heberden oration, 1969. Rheumatoid arthritis - Nature or nurture?
    • 4916766 1:STN:280:DyaE3c3nvVyisw%3D%3D
    • JS Lawrence 1970 Heberden oration, 1969. Rheumatoid arthritis - nature or nurture? Ann Rheum Dis 29 357 379 4916766 1:STN:280:DyaE3c3nvVyisw%3D%3D
    • (1970) Ann Rheum Dis , vol.29 , pp. 357-379
    • Lawrence, J.S.1
  • 20
    • 0026550305 scopus 로고
    • Rheumatoid arthritis in twins: A study of aetiopathogenesis based on the australian twin registry
    • 1616321 1:STN:280:DyaK38zhtlSlsA%3D%3D
    • N Bellamy D Duffy N Martin J Mathews 1992 Rheumatoid arthritis in twins: A study of aetiopathogenesis based on the australian twin registry Ann Rheum Dis 51 588 593 1616321 1:STN:280:DyaK38zhtlSlsA%3D%3D
    • (1992) Ann Rheum Dis , vol.51 , pp. 588-593
    • Bellamy, N.1    Duffy, D.2    Martin, N.3    Mathews, J.4
  • 21
    • 0023024826 scopus 로고
    • Occurrence of rheumatoid arthritis in a nationwide series of twins
    • K Aho M Koskenvuo J Tuominen J Kaprio 1986 Occurrence of rheumatoid arthritis in a nationwide series of twins J Rheumatol 13 899 902 3820198 1:STN:280:DyaL2s7ktV2quw%3D%3D (Pubitemid 17203922)
    • (1986) Journal of Rheumatology , vol.13 , Issue.5 , pp. 899-902
    • Aho, K.1    Koskenvuo, M.2    Tuominen, J.3    Kaprio, J.4
  • 23
    • 0037006252 scopus 로고    scopus 로고
    • Relative importance of genetic effects in rheumatoid arthritis: Historical cohort study of Danish nationwide twin population
    • AJ Svendsen NV Holm K Kyvik PH Petersen P Junker 2002 Relative importance of genetic effects in rheumatoid arthritis: Historical cohort study of danish nationwide twin population Bmj 324 264 266 11823356 (Pubitemid 34121835)
    • (2002) British Medical Journal , vol.324 , Issue.7332 , pp. 264-266
    • Svendsen, A.J.1    Holm, N.V.2    Kyvik, K.3    Petersen, P.H.4    Junker, P.5
  • 24
    • 33644746325 scopus 로고    scopus 로고
    • A brief history of twins
    • DOI 10.1191/0961203306lu2263ed
    • SR Block 2006 A brief history of twins Lupus 15 61 64 16539274 1:STN:280:DC%2BD287ltVGgsw%3D%3D (Pubitemid 43345328)
    • (2006) Lupus , vol.15 , Issue.2 , pp. 61-64
    • Block, S.R.1
  • 25
    • 0016724949 scopus 로고
    • Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets
    • 1101680 1:STN:280:DyaE28%2FjslGksA%3D%3D
    • SR Block JB Winfield MD Lockshin WA D'Angelo CL Christian 1975 Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets Am J Med 59 533 552 1101680 1:STN:280:DyaE28%2FjslGksA%3D%3D
    • (1975) Am J Med , vol.59 , pp. 533-552
    • Block, S.R.1    Winfield, J.B.2    Lockshin, M.D.3    D'Angelo, W.A.4    Christian, C.L.5
  • 29
    • 25844442849 scopus 로고    scopus 로고
    • Concordance for multiple sclerosis in Danish twins: An update of a nationwide study
    • DOI 10.1191/1352458505ms1220oa
    • T Hansen A Skytthe E Stenager HC Petersen H Bronnum-Hansen KO Kyvik 2005 Concordance for multiple sclerosis in danish twins: An update of a nationwide study Mult Scler 11 504 510 16193885 1:STN:280:DC%2BD2MritVKmtg%3D%3D (Pubitemid 41387692)
    • (2005) Multiple Sclerosis , vol.11 , Issue.5 , pp. 504-510
    • Hansen, T.1    Skytthe, A.2    Stenager, E.3    Petersen, H.C.4    Bronnum-Hansen, H.5    Kyvik, K.6
  • 30
    • 0026497413 scopus 로고
    • Multiple sclerosis in 54 twinships: Concordance rate is independent of zygosity
    • French research group on multiple sclerosis
    • (1992) Multiple sclerosis in 54 twinships: Concordance rate is independent of zygosity. French research group on multiple sclerosis. Ann Neurol 32,724-727.
    • (1992) Ann Neurol , vol.32 , pp. 724-727
  • 31
    • 0038004795 scopus 로고    scopus 로고
    • Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies
    • DOI 10.1002/art.11173
    • C Feghali-Bostwick TA Medsger Jr TM Wright 2003 Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies Arthritis Rheum 48 1956 1963 12847690 (Pubitemid 36828691)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.7 , pp. 1956-1963
    • Feghali-Bostwick, C.1    Medsger Jr., T.A.2    Wright, T.M.3
  • 35
    • 77954089823 scopus 로고    scopus 로고
    • Epigenetic therapeutics in autoimmune disease
    • 19644776 1:CAS:528:DC%2BC3cXnvVersr4%3D
    • M Szyf 2010 Epigenetic therapeutics in autoimmune disease Clin Rev Allergy Immunol 39 62 77 19644776 1:CAS:528:DC%2BC3cXnvVersr4%3D
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 62-77
    • Szyf, M.1
  • 36
    • 0022617586 scopus 로고
    • + T cells
    • B Richardson L Kahn EJ Lovett J Hudson 1986 Effect of an inhibitor of DNA methylation on t cells. I. 5-azacytidine induces t4 expression on t8+ t cells J Immunol 137 35 39 2423610 1:CAS:528:DyaL28XksF2is7s%3D (Pubitemid 16100264)
    • (1986) Journal of Immunology , vol.137 , Issue.1 , pp. 35-39
    • Richardson, B.1    Kahn, L.2    Lovett, E.J.3    Hudson, J.4
  • 37
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • DOI 10.1002/art.10234
    • Q Lu M Kaplan D Ray S Zacharek D Gutsch B Richardson 2002 Demethylation of itgal (cd11a) regulatory sequences in systemic lupus erythematosus Arthritis Rheum 46 1282 1291 12115234 1:CAS:528:DC%2BD38XksVynsrs%3D (Pubitemid 34525836)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.5 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3    Ray, D.4    Zacharek, S.5    Gutsch, D.6    Richardson, B.7
  • 38
    • 77953288009 scopus 로고    scopus 로고
    • Epigenetics and sle: Rfx1 downregulation causes cd11a and cd70 overexpression by altering epigenetic modifications in lupus cd4+ t cells
    • 20223637
    • M Zhao Y Sun F Gao X Wu J Tang H Yin Y Luo B Richardson Q Lu 2010 Epigenetics and sle: Rfx1 downregulation causes cd11a and cd70 overexpression by altering epigenetic modifications in lupus cd4+ t cells J Autoimmun 35 58 69 20223637
    • (2010) J Autoimmun , vol.35 , pp. 58-69
    • Zhao, M.1    Sun, Y.2    Gao, F.3    Wu, X.4    Tang, J.5    Yin, H.6    Luo, Y.7    Richardson, B.8    Lu, Q.9
  • 39
    • 77954083521 scopus 로고    scopus 로고
    • Epigenetic perspectives in systemic lupus erythematosus: Pathogenesis, biomarkers, and therapeutic potentials
    • 19639427
    • S Zhao H Long Q Lu 2010 Epigenetic perspectives in systemic lupus erythematosus: Pathogenesis, biomarkers, and therapeutic potentials Clin Rev Allergy Immunol 39 3 9 19639427
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 3-9
    • Zhao, S.1    Long, H.2    Lu, Q.3
  • 40
    • 38449104652 scopus 로고    scopus 로고
    • Impaired t cell protein kinase c delta activation decreases erk pathway signaling in idiopathic and hydralazine-induced lupus
    • 17911642 1:CAS:528:DC%2BD2sXhtFWit77P
    • G Gorelik JY Fang A Wu AH Sawalha B Richardson 2007 Impaired t cell protein kinase c delta activation decreases erk pathway signaling in idiopathic and hydralazine-induced lupus J Immunol 179 5553 5563 17911642 1:CAS:528:DC%2BD2sXhtFWit77P
    • (2007) J Immunol , vol.179 , pp. 5553-5563
    • Gorelik, G.1    Fang, J.Y.2    Wu, A.3    Sawalha, A.H.4    Richardson, B.5
  • 41
    • 18644376210 scopus 로고    scopus 로고
    • Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
    • Q Lu A Wu BC Richardson 2005 Demethylation of the same promoter sequence increases cd70 expression in lupus t cells and t cells treated with lupus-inducing drugs J Immunol 174 6212 6219 15879118 1:CAS:528: DC%2BD2MXjvV2mtLo%3D (Pubitemid 40663812)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 6212-6219
    • Lu, Q.1    Wu, A.2    Richardson, B.C.3
  • 42
    • 77649232595 scopus 로고    scopus 로고
    • The geoepidemiology of the antiphospholipid antibody syndrome
    • 19932199
    • M Biggioggero PL Meroni 2010 The geoepidemiology of the antiphospholipid antibody syndrome Autoimmun Rev 9 A299 304 19932199
    • (2010) Autoimmun Rev , vol.9 , pp. 299-304
    • Biggioggero, M.1    Meroni, P.L.2
  • 43
    • 77649235610 scopus 로고    scopus 로고
    • The geoepidemiology of systemic lupus erythematosus
    • 20036343 1:CAS:528:DC%2BC3cXhtVyltrjL
    • AT Borchers SM Naguwa Y Shoenfeld ME Gershwin 2010 The geoepidemiology of systemic lupus erythematosus Autoimmun Rev 9 A277 287 20036343 1:CAS:528:DC%2BC3cXhtVyltrjL
    • (2010) Autoimmun Rev , vol.9 , pp. 277-287
    • Borchers, A.T.1    Naguwa, S.M.2    Shoenfeld, Y.3    Gershwin, M.E.4
  • 44
    • 33947192488 scopus 로고    scopus 로고
    • Cluster of systemic lupus erythematosus (sle) associated with an oil field waste site: A cross sectional study
    • 17316448
    • J Dahlgren H Takhar P Anderson-Mahoney J Kotlerman J Tarr R Warshaw 2007 Cluster of systemic lupus erythematosus (sle) associated with an oil field waste site: A cross sectional study Environ Health 6 8 17316448
    • (2007) Environ Health , vol.6 , pp. 8
    • Dahlgren, J.1    Takhar, H.2    Anderson-Mahoney, P.3    Kotlerman, J.4    Tarr, J.5    Warshaw, R.6
  • 46
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • 19109892 1:CAS:528:DC%2BD1MXisFyjtw%3D%3D
    • K Rai IJ Huggins SR James AR Karpf DA Jones BR Cairns 2008 DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45 Cell 135 1201 1212 19109892 1:CAS:528:DC%2BD1MXisFyjtw%3D%3D
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3    Karpf, A.R.4    Jones, D.A.5    Cairns, B.R.6
  • 48
    • 77951745847 scopus 로고    scopus 로고
    • Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus t cells
    • 20131288 1:CAS:528:DC%2BC3cXhtFGnu7bI
    • Y Li M Zhao H Yin F Gao X Wu Y Luo S Zhao X Zhang Y Su N Hu H Long B Richardson Q Lu 2010 Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus t cells Arthritis Rheum 62 1438 1447 20131288 1:CAS:528:DC%2BC3cXhtFGnu7bI
    • (2010) Arthritis Rheum , vol.62 , pp. 1438-1447
    • Li, Y.1    Zhao, M.2    Yin, H.3    Gao, F.4    Wu, X.5    Luo, Y.6    Zhao, S.7    Zhang, X.8    Su, Y.9    Hu, N.10    Long, H.11    Richardson, B.12    Lu, Q.13
  • 50
    • 77954086999 scopus 로고    scopus 로고
    • The role of epigenetics in aging and autoimmunity
    • 19653133 1:CAS:528:DC%2BC3cXnvVeku70%3D
    • A Grolleau-Julius D Ray RL Yung 2010 The role of epigenetics in aging and autoimmunity Clin Rev Allergy Immunol 39 42 50 19653133 1:CAS:528: DC%2BC3cXnvVeku70%3D
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 42-50
    • Grolleau-Julius, A.1    Ray, D.2    Yung, R.L.3
  • 51
    • 0032774579 scopus 로고    scopus 로고
    • Abnormal DNA methylation and deoxycytosine-deoxyguanine content in nucleosomes from lymphocytes undergoing apoptosis
    • S Huck E Deveaud A Namane M Zouali 1999 Abnormal DNA methylation and deoxycytosine-deoxyguanine content in nucleosomes from lymphocytes undergoing apoptosis Faseb J 13 1415 1422 10428765 1:CAS:528:DyaK1MXltFaitrw%3D (Pubitemid 29382509)
    • (1999) FASEB Journal , vol.13 , Issue.11 , pp. 1415-1422
    • Huck, S.1    Deveaud, E.2    Namane, A.3    Zouali, M.4
  • 52
    • 0030199627 scopus 로고    scopus 로고
    • DNA methylation: A potential pathway to abnormal autoreactive lupus B cells
    • DOI 10.1006/clin.1996.0087
    • S Huck M Zouali 1996 DNA methylation: A potential pathway to abnormal autoreactive lupus b cells Clin Immunol Immunopathol 80 1 8 8674233 1:CAS:528:DyaK28Xkt1Khu7c%3D (Pubitemid 26227826)
    • (1996) Clinical Immunology and Immunopathology , vol.80 , Issue.1 , pp. 1-8
    • Huck, S.1    Zouali, M.2
  • 53
    • 44849127693 scopus 로고    scopus 로고
    • Genetic polymorphisms in ptpn22, padi-4, and ctla-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: Evidence of gene-environment interactions with heavy cigarette smoking
    • 18462498
    • KH Costenbader SC Chang I De Vivo R Plenge EW Karlson 2008 Genetic polymorphisms in ptpn22, padi-4, and ctla-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: Evidence of gene-environment interactions with heavy cigarette smoking Arthritis Res Ther 10 R52 18462498
    • (2008) Arthritis Res Ther , vol.10 , pp. 52
    • Costenbader, K.H.1    Chang, S.C.2    De Vivo, I.3    Plenge, R.4    Karlson, E.W.5
  • 55
    • 33846914679 scopus 로고    scopus 로고
    • The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis
    • DOI 10.1007/s11064-006-9144-5
    • MA Moscarello FG Mastronardi DD Wood 2007 The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis Neurochem Res 32 251 256 17031564 1:CAS:528:DC%2BD2sXhsVyqsLc%3D (Pubitemid 46238870)
    • (2007) Neurochemical Research , vol.32 , Issue.2 , pp. 251-256
    • Moscarello, M.A.1    Mastronardi, F.G.2    Wood, D.D.3
  • 56
    • 77951620945 scopus 로고    scopus 로고
    • Genetic associations in italian primary sclerosing cholangitis: Heterogeneity across europe defines a critical role for hla-c
    • 20347497 1:CAS:528:DC%2BC3cXlsFKksrg%3D
    • JR Hov A Lleo C Selmi B Woldseth L Fabris M Strazzabosco TH Karlsen P Invernizzi 2010 Genetic associations in italian primary sclerosing cholangitis: Heterogeneity across europe defines a critical role for hla-c J Hepatol 52 712 717 20347497 1:CAS:528:DC%2BC3cXlsFKksrg%3D
    • (2010) J Hepatol , vol.52 , pp. 712-717
    • Hov, J.R.1    Lleo, A.2    Selmi, C.3    Woldseth, B.4    Fabris, L.5    Strazzabosco, M.6    Karlsen, T.H.7    Invernizzi, P.8
  • 59
    • 79958036970 scopus 로고    scopus 로고
    • The recent rise in the frequency of type 1 diabetes: Who pulled the trigger?
    • 21641185
    • A Hasham Y Tomer 2011 The recent rise in the frequency of type 1 diabetes: Who pulled the trigger? J Autoimmun 37 1 2 21641185
    • (2011) J Autoimmun , vol.37 , pp. 1-2
    • Hasham, A.1    Tomer, Y.2
  • 61
    • 77952242738 scopus 로고    scopus 로고
    • Pre-existing autoimmunity determines type 1 diabetes outcome after flt3-ligand treatment
    • 20004555
    • TL Van Belle T Juntti J Liao MG von Herrath 2010 Pre-existing autoimmunity determines type 1 diabetes outcome after flt3-ligand treatment J Autoimmun 34 445 452 20004555
    • (2010) J Autoimmun , vol.34 , pp. 445-452
    • Van Belle, T.L.1    Juntti, T.2    Liao, J.3    Von Herrath, M.G.4
  • 62
    • 79958043752 scopus 로고    scopus 로고
    • Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
    • 21376535
    • AG Ziegler M Pflueger C Winkler P Achenbach B Akolkar JP Krischer E Bonifacio 2011 Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children J Autoimmun 37 3 7 21376535
    • (2011) J Autoimmun , vol.37 , pp. 3-7
    • Ziegler, A.G.1    Pflueger, M.2    Winkler, C.3    Achenbach, P.4    Akolkar, B.5    Krischer, J.P.6    Bonifacio, E.7
  • 63
    • 68249089241 scopus 로고    scopus 로고
    • Interplay between ptpn22 c1858t polymorphism and cow's milk formula exposure in type 1 diabetes
    • 19473815 1:CAS:528:DC%2BD1MXpvF2mt7g%3D
    • J Lempainen O Vaarala M Makela R Veijola O Simell M Knip R Hermann J Ilonen 2009 Interplay between ptpn22 c1858t polymorphism and cow's milk formula exposure in type 1 diabetes J Autoimmun 33 155 164 19473815 1:CAS:528: DC%2BD1MXpvF2mt7g%3D
    • (2009) J Autoimmun , vol.33 , pp. 155-164
    • Lempainen, J.1    Vaarala, O.2    Makela, M.3    Veijola, R.4    Simell, O.5    Knip, M.6    Hermann, R.7    Ilonen, J.8
  • 64
    • 67650718127 scopus 로고    scopus 로고
    • A low protein diet in early life delays the onset of diabetes in the non-obese diabetic mouse
    • 19228796 1:CAS:528:DC%2BD1MXmtlGmtro%3D
    • A Chamson-Reig EJ Arany K Summers DJ Hill 2009 A low protein diet in early life delays the onset of diabetes in the non-obese diabetic mouse J Endocrinol 201 231 239 19228796 1:CAS:528:DC%2BD1MXmtlGmtro%3D
    • (2009) J Endocrinol , vol.201 , pp. 231-239
    • Chamson-Reig, A.1    Arany, E.J.2    Summers, K.3    Hill, D.J.4
  • 65
    • 0042920727 scopus 로고    scopus 로고
    • Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas
    • S Boujendar E Arany D Hill C Remacle B Reusens 2003 Taurine supplementation of a low protein diet fed to rat dams normalizes the vascularization of the fetal endocrine pancreas J Nutr 133 2820 2825 12949371 1:CAS:528:DC%2BD3sXntlaksro%3D (Pubitemid 37099765)
    • (2003) Journal of Nutrition , vol.133 , Issue.9 , pp. 2820-2825
    • Boujendar, S.1    Arany, E.2    Hill, D.3    Remacle, C.4    Reusens, B.5
  • 66
    • 11144278293 scopus 로고    scopus 로고
    • Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice
    • DOI 10.1007/s00125-004-1535-z
    • E Arany B Strutt P Romanus C Remacle B Reusens DJ Hill 2004 Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice Diabetologia 47 1831 1837 15502919 1:CAS:528:DC%2BD2cXpsFKrt7c%3D (Pubitemid 40022420)
    • (2004) Diabetologia , vol.47 , Issue.10 , pp. 1831-1837
    • Arany, E.1    Strutt, B.2    Romanus, P.3    Remacle, C.4    Reusens, B.5    Hill, D.J.6
  • 67
    • 78651064276 scopus 로고    scopus 로고
    • Infectious agents and xenobiotics in the etiology of primary biliary cirrhosis
    • 21297248
    • C Selmi M De Santis F Cavaciocchi ME Gershwin 2010 Infectious agents and xenobiotics in the etiology of primary biliary cirrhosis Dis Markers 29 287 299 21297248
    • (2010) Dis Markers , vol.29 , pp. 287-299
    • Selmi, C.1    De Santis, M.2    Cavaciocchi, F.3    Gershwin, M.E.4
  • 68
    • 68149119166 scopus 로고    scopus 로고
    • The role of environmental factors in primary biliary cirrhosis
    • 19643668 1:CAS:528:DC%2BD1MXps1Wqu78%3D
    • C Selmi ME Gershwin 2009 The role of environmental factors in primary biliary cirrhosis Trends Immunol 30 415 420 19643668 1:CAS:528: DC%2BD1MXps1Wqu78%3D
    • (2009) Trends Immunol , vol.30 , pp. 415-420
    • Selmi, C.1    Gershwin, M.E.2
  • 69
    • 78149360234 scopus 로고    scopus 로고
    • Drug-induced lupus: An update
    • 20656071 1:CAS:528:DC%2BC3cXhtl2isLrP
    • U Katz G Zandman-Goddard 2010 Drug-induced lupus: An update Autoimmun Rev 10 46 50 20656071 1:CAS:528:DC%2BC3cXhtl2isLrP
    • (2010) Autoimmun Rev , vol.10 , pp. 46-50
    • Katz, U.1    Zandman-Goddard, G.2
  • 71
    • 77952240188 scopus 로고    scopus 로고
    • Peripheral b cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: Decreased memory b cells and membrane cd19 expression
    • 19963348 1:CAS:528:DC%2BC3cXltF2msbg%3D
    • AS Korganow AM Knapp H Nehme-Schuster P Soulas-Sprauel V Poindron JL Pasquali T Martin 2010 Peripheral b cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: Decreased memory b cells and membrane cd19 expression J Autoimmun 34 426 434 19963348 1:CAS:528:DC%2BC3cXltF2msbg%3D
    • (2010) J Autoimmun , vol.34 , pp. 426-434
    • Korganow, A.S.1    Knapp, A.M.2    Nehme-Schuster, H.3    Soulas-Sprauel, P.4    Poindron, V.5    Pasquali, J.L.6    Martin, T.7
  • 72
    • 77957801548 scopus 로고    scopus 로고
    • Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory t cells
    • 20638240 1:CAS:528:DC%2BC3cXht12ltLbL
    • C Scheinecker M Bonelli JS Smolen 2010 Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory t cells J Autoimmun 35 269 275 20638240 1:CAS:528:DC%2BC3cXht12ltLbL
    • (2010) J Autoimmun , vol.35 , pp. 269-275
    • Scheinecker, C.1    Bonelli, M.2    Smolen, J.S.3
  • 74
    • 77957765210 scopus 로고    scopus 로고
    • Innate immunity in systemic lupus erythematosus: Sensing endogenous nucleic acids
    • 20638241 1:CAS:528:DC%2BC3cXht12ltLnE
    • E Kontaki DT Boumpas 2010 Innate immunity in systemic lupus erythematosus: Sensing endogenous nucleic acids J Autoimmun 35 206 211 20638241 1:CAS:528:DC%2BC3cXht12ltLnE
    • (2010) J Autoimmun , vol.35 , pp. 206-211
    • Kontaki, E.1    Boumpas, D.T.2
  • 75
    • 0028576418 scopus 로고
    • Role of genetic factors in drug-related autoimmunity
    • 7703999 1:CAS:528:DyaK2MXjvFSktLo%3D
    • LE Adams AB Mongey 1994 Role of genetic factors in drug-related autoimmunity Lupus 3 443 447 7703999 1:CAS:528:DyaK2MXjvFSktLo%3D
    • (1994) Lupus , vol.3 , pp. 443-447
    • Adams, L.E.1    Mongey, A.B.2
  • 77
    • 80855143593 scopus 로고    scopus 로고
    • Dietary factors regulate cytokines in murine models of systemic lupus erythematosus
    • Hsieh CC, Lin BF (2011) Dietary factors regulate cytokines in murine models of systemic lupus erythematosus. Autoimmun Rev
    • (2011) Autoimmun Rev
    • Hsieh, C.C.1    Lin, B.F.2
  • 78
    • 80052677307 scopus 로고    scopus 로고
    • Pathogenesis of systemic lupus erythematosus revisited 2011: End organ resistance to damage, autoantibody initiation and diversification, and hla-dr
    • 21632208 1:CAS:528:DC%2BC3MXhtFGnsbbM
    • SM Fu US Deshmukh F Gaskin 2011 Pathogenesis of systemic lupus erythematosus revisited 2011: End organ resistance to damage, autoantibody initiation and diversification, and hla-dr J Autoimmun 37 104 112 21632208 1:CAS:528:DC%2BC3MXhtFGnsbbM
    • (2011) J Autoimmun , vol.37 , pp. 104-112
    • Fu, S.M.1    Deshmukh, U.S.2    Gaskin, F.3
  • 80
    • 79960459058 scopus 로고    scopus 로고
    • Environmental pathways to autoimmune diseases: The cases of primary biliary cirrhosis and multiple sclerosis
    • in press
    • Selmi C, Papini AM, Pugliese P, Arcaro MC, Gershwin ME (2011) Environmental pathways to autoimmune diseases: The cases of primary biliary cirrhosis and multiple sclerosis. Arch Med Sci in press
    • (2011) Arch Med Sci
    • Selmi, C.1    Papini, A.M.2    Pugliese, P.3    Arcaro, M.C.4    Gershwin, M.E.5
  • 81
    • 58149475865 scopus 로고    scopus 로고
    • Aberrant t cell erk pathway signaling and chromatin structure in lupus
    • 18723128 1:CAS:528:DC%2BD1MXmtVylt7s%3D
    • G Gorelik B Richardson 2009 Aberrant t cell erk pathway signaling and chromatin structure in lupus Autoimmun Rev 8 196 198 18723128 1:CAS:528:DC%2BD1MXmtVylt7s%3D
    • (2009) Autoimmun Rev , vol.8 , pp. 196-198
    • Gorelik, G.1    Richardson, B.2
  • 82
    • 77649236513 scopus 로고    scopus 로고
    • The geoepidemiology of type 1 diabetes
    • 19969107
    • AT Borchers R Uibo ME Gershwin 2010 The geoepidemiology of type 1 diabetes Autoimmun Rev 9 A355 365 19969107
    • (2010) Autoimmun Rev , vol.9 , pp. 355-365
    • Borchers, A.T.1    Uibo, R.2    Gershwin, M.E.3
  • 83
    • 77649186719 scopus 로고    scopus 로고
    • Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis
    • 20034760 1:CAS:528:DC%2BC3cXjtVCksLk%3D
    • V Chandran SP Raychaudhuri 2010 Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis J Autoimmun 34 J314 321 20034760 1:CAS:528:DC%2BC3cXjtVCksLk%3D
    • (2010) J Autoimmun , vol.34 , pp. 314-321
    • Chandran, V.1    Raychaudhuri, S.P.2
  • 84
    • 77649239007 scopus 로고    scopus 로고
    • The environment, geoepidemiology and anca-associated vasculitides
    • 19892038 1:CAS:528:DC%2BC3cXhtVyltrjF
    • M Chen CG Kallenberg 2010 The environment, geoepidemiology and anca-associated vasculitides Autoimmun Rev 9 A293 298 19892038 1:CAS:528:DC%2BC3cXhtVyltrjF
    • (2010) Autoimmun Rev , vol.9 , pp. 293-298
    • Chen, M.1    Kallenberg, C.G.2
  • 85
    • 77649234262 scopus 로고    scopus 로고
    • The geoepidemiology of immune thrombocytopenic purpura
    • 19945546
    • S Deane SS Teuber ME Gershwin 2010 The geoepidemiology of immune thrombocytopenic purpura Autoimmun Rev 9 A342 349 19945546
    • (2010) Autoimmun Rev , vol.9 , pp. 342-349
    • Deane, S.1    Teuber, S.S.2    Gershwin, M.E.3
  • 86
    • 77649238967 scopus 로고    scopus 로고
    • Geoepidemiology: The environment and spondyloarthropathies
    • 20026258
    • M Ehrenfeld 2010 Geoepidemiology: The environment and spondyloarthropathies Autoimmun Rev 9 A325 329 20026258
    • (2010) Autoimmun Rev , vol.9 , pp. 325-329
    • Ehrenfeld, M.1
  • 87
    • 77649179578 scopus 로고    scopus 로고
    • Geoepidemiology of autoimmune liver diseases
    • 20036105 1:CAS:528:DC%2BC3cXjtVCksLs%3D
    • P Invernizzi 2010 Geoepidemiology of autoimmune liver diseases J Autoimmun 34 J300 306 20036105 1:CAS:528:DC%2BC3cXjtVCksLs%3D
    • (2010) J Autoimmun , vol.34 , pp. 300-306
    • Invernizzi, P.1
  • 88
    • 77649234307 scopus 로고    scopus 로고
    • Geoepidemiology of autoimmune hemolytic anemia
    • 19932202 1:CAS:528:DC%2BC3cXhtVyltrnM
    • JF Lambert UE Nydegger 2010 Geoepidemiology of autoimmune hemolytic anemia Autoimmun Rev 9 A350 354 19932202 1:CAS:528:DC%2BC3cXhtVyltrnM
    • (2010) Autoimmun Rev , vol.9 , pp. 350-354
    • Lambert, J.F.1    Nydegger, U.E.2
  • 89
    • 77649233106 scopus 로고    scopus 로고
    • The geoepidemiology of autoimmune intestinal diseases
    • 19903540
    • I Logan CL Bowlus 2010 The geoepidemiology of autoimmune intestinal diseases Autoimmun Rev 9 A372 378 19903540
    • (2010) Autoimmun Rev , vol.9 , pp. 372-378
    • Logan, I.1    Bowlus, C.L.2
  • 90
    • 77649231925 scopus 로고    scopus 로고
    • The geoepidemiology of sjogren's syndrome
    • 19903539
    • CP Mavragani HM Moutsopoulos 2010 The geoepidemiology of sjogren's syndrome Autoimmun Rev 9 A305 310 19903539
    • (2010) Autoimmun Rev , vol.9 , pp. 305-310
    • Mavragani, C.P.1    Moutsopoulos, H.M.2
  • 91
    • 77649237355 scopus 로고    scopus 로고
    • Chapter 33: Geoepidemiology of myasthenia gravis
    • 19922815
    • A Meyer Y Levy 2010 Chapter 33: Geoepidemiology of myasthenia gravis Autoimmun Rev 9 A383 386 19922815
    • (2010) Autoimmun Rev , vol.9 , pp. 383-386
    • Meyer, A.1    Levy, Y.2
  • 92
    • 77649237783 scopus 로고    scopus 로고
    • Multiple sclerosis: Geoepidemiology, genetics and the environment
    • 19932200 1:CAS:528:DC%2BC3cXhtVyltrnO
    • R Milo E Kahana 2010 Multiple sclerosis: Geoepidemiology, genetics and the environment Autoimmun Rev 9 A387 394 19932200 1:CAS:528:DC%2BC3cXhtVyltrnO
    • (2010) Autoimmun Rev , vol.9 , pp. 387-394
    • Milo, R.1    Kahana, E.2
  • 93
    • 77649239139 scopus 로고    scopus 로고
    • The geoepidemiology of autoimmune muscle disease
    • 19906360
    • S Prieto JM Grau 2010 The geoepidemiology of autoimmune muscle disease Autoimmun Rev 9 A330 334 19906360
    • (2010) Autoimmun Rev , vol.9 , pp. 330-334
    • Prieto, S.1    Grau, J.M.2
  • 94
    • 77949272156 scopus 로고    scopus 로고
    • Geoepidemiology of systemic sclerosis
    • 19906362
    • B Ranque L Mouthon 2010 Geoepidemiology of systemic sclerosis Autoimmun Rev 9 A311 318 19906362
    • (2010) Autoimmun Rev , vol.9 , pp. 311-318
    • Ranque, B.1    Mouthon, L.2
  • 95
    • 77649237304 scopus 로고    scopus 로고
    • Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders
    • 19914405
    • J Sands JM Tuscano 2010 Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders Autoimmun Rev 9 A335 341 19914405
    • (2010) Autoimmun Rev , vol.9 , pp. 335-341
    • Sands, J.1    Tuscano, J.M.2
  • 96
    • 77649233937 scopus 로고    scopus 로고
    • The worldwide gradient of autoimmune conditions
    • 20144744
    • C Selmi 2010 The worldwide gradient of autoimmune conditions Autoimmun Rev 9 A247 250 20144744
    • (2010) Autoimmun Rev , vol.9 , pp. 247-250
    • Selmi, C.1
  • 97
    • 77649238845 scopus 로고    scopus 로고
    • Nutrition, geoepidemiology, and autoimmunity
    • 19969106 1:CAS:528:DC%2BC3cXhtVyltrjJ
    • C Selmi K Tsuneyama 2010 Nutrition, geoepidemiology, and autoimmunity Autoimmun Rev 9 A267 270 19969106 1:CAS:528:DC%2BC3cXhtVyltrjJ
    • (2010) Autoimmun Rev , vol.9 , pp. 267-270
    • Selmi, C.1    Tsuneyama, K.2
  • 98
    • 77649185148 scopus 로고    scopus 로고
    • Defining and analyzing geoepidemiology and human autoimmunity
    • 20034761 1:CAS:528:DC%2BC3cXjtVCks70%3D
    • Y Shapira N Agmon-Levin Y Shoenfeld 2010 Defining and analyzing geoepidemiology and human autoimmunity J Autoimmun 34 J168 177 20034761 1:CAS:528:DC%2BC3cXjtVCks70%3D
    • (2010) J Autoimmun , vol.34 , pp. 168-177
    • Shapira, Y.1    Agmon-Levin, N.2    Shoenfeld, Y.3
  • 100
    • 77649184031 scopus 로고    scopus 로고
    • Geo-epidemiology and autoimmunity
    • 20056534 1:CAS:528:DC%2BC3cXjtVCks7w%3D
    • P Youinou JO Pers ME Gershwin Y Shoenfeld 2010 Geo-epidemiology and autoimmunity J Autoimmun 34 J163 167 20056534 1:CAS:528:DC%2BC3cXjtVCks7w%3D
    • (2010) J Autoimmun , vol.34 , pp. 163-167
    • Youinou, P.1    Pers, J.O.2    Gershwin, M.E.3    Shoenfeld, Y.4
  • 104
    • 67651232887 scopus 로고    scopus 로고
    • Genome-wide association studies in systemic lupus erythematosus: A perspective
    • 19664177
    • DS Cunninghame Graham 2009 Genome-wide association studies in systemic lupus erythematosus: A perspective Arthritis Res Ther 11 119 19664177
    • (2009) Arthritis Res Ther , vol.11 , pp. 119
    • Cunninghame Graham, D.S.1
  • 107
    • 80053896562 scopus 로고    scopus 로고
    • Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets
    • Hu X, Kim H, Stahl E, Plenge R, Daly M, Raychaudhuri S (2011) Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets. Am J Hum Genet
    • (2011) Am J Hum Genet
    • Hu, X.1    Kim, H.2    Stahl, E.3    Plenge, R.4    Daly, M.5    Raychaudhuri, S.6
  • 108
    • 71249130102 scopus 로고    scopus 로고
    • Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in genetic analysis workshop 16 rheumatoid arthritis data
    • H Deshmukh X Kim-Howard SK Nath 2009 Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in genetic analysis workshop 16 rheumatoid arthritis data BMC Proc 7 3 S31
    • (2009) BMC Proc , vol.7 , Issue.3 , pp. 31
    • Deshmukh, H.1    Kim-Howard, X.2    Nath, S.K.3
  • 109
    • 70949087368 scopus 로고    scopus 로고
    • After the gwas rush: Nuggets of insight into the pathogenesis of autoimmune disease
    • 19926302
    • JS Danska P Poussier 2009 After the gwas rush: Nuggets of insight into the pathogenesis of autoimmune disease Semin Immunol 21 313 317 19926302
    • (2009) Semin Immunol , vol.21 , pp. 313-317
    • Danska, J.S.1    Poussier, P.2
  • 110
    • 58149333555 scopus 로고    scopus 로고
    • Autoimmune diseases: Insights from genome-wide association studies
    • 18852199 1:CAS:528:DC%2BD1cXhtlyjsrbF
    • G Lettre JD Rioux 2008 Autoimmune diseases: Insights from genome-wide association studies Hum Mol Genet 17 R116 121 18852199 1:CAS:528: DC%2BD1cXhtlyjsrbF
    • (2008) Hum Mol Genet , vol.17 , pp. 116-121
    • Lettre, G.1    Rioux, J.D.2
  • 111
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • DOI 10.1038/nrg2045, PII NRG2045
    • RL Jirtle MK Skinner 2007 Environmental epigenomics and disease susceptibility Nat Rev Genet 8 253 262 17363974 1:CAS:528:DC%2BD2sXivVGktbY%3D (Pubitemid 46439287)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 112
    • 33645796451 scopus 로고    scopus 로고
    • Inhibition of line-1 expression in the heart decreases ischemic damage by activation of akt/pkb signaling
    • 16418318 1:CAS:528:DC%2BD28XmsFers7w%3D
    • E Lucchinetti J Feng R Silva GV Tolstonog MC Schaub GG Schumann M Zaugg 2006 Inhibition of line-1 expression in the heart decreases ischemic damage by activation of akt/pkb signaling Physiol Genomics 25 314 324 16418318 1:CAS:528:DC%2BD28XmsFers7w%3D
    • (2006) Physiol Genomics , vol.25 , pp. 314-324
    • Lucchinetti, E.1    Feng, J.2    Silva, R.3    Tolstonog, G.V.4    Schaub, M.C.5    Schumann, G.G.6    Zaugg, M.7
  • 113
    • 0036119616 scopus 로고    scopus 로고
    • INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogens
    • SA Belinsky SS Snow KJ Nikula GL Finch CS Tellez WA Palmisano 2002 Aberrant cpg island methylation of the p16(ink4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens Carcinogenesis 23 335 339 11872642 1:CAS:528:DC%2BD38XitVGltbc%3D (Pubitemid 34224012)
    • (2002) Carcinogenesis , vol.23 , Issue.2 , pp. 335-339
    • Belinsky, S.A.1    Snow, S.S.2    Nikula, K.J.3    Finch, G.L.4    Tellez, C.S.5    Palmisano, W.A.6
  • 114
    • 37149003421 scopus 로고    scopus 로고
    • Metals and neurotoxicology
    • RO Wright A Baccarelli 2007 Metals and neurotoxicology J Nutr 137 2809 2813 18029504 1:CAS:528:DC%2BD2sXhtlOjsrvI (Pubitemid 350255318)
    • (2007) Journal of Nutrition , vol.137 , Issue.12 , pp. 2809-2813
    • Wright, R.O.1    Baccarelli, A.2
  • 115
  • 118
    • 82955187521 scopus 로고    scopus 로고
    • The antigen specificity of the rheumatoid arthritis-associated acpa directed to citrullinated fibrin is very closely restricted
    • Iobagiu C, Magyar A, Nogueira L, Cornillet M, Sebbag M, Arnaud J, Hudecz F, Serre G (2011) The antigen specificity of the rheumatoid arthritis-associated acpa directed to citrullinated fibrin is very closely restricted. J Autoimmun
    • (2011) J Autoimmun
    • Iobagiu, C.1    Magyar, A.2    Nogueira, L.3    Cornillet, M.4    Sebbag, M.5    Arnaud, J.6    Hudecz, F.7    Serre, G.8
  • 120
    • 78349244476 scopus 로고    scopus 로고
    • Epigenetics in rheumatoid arthritis
    • 19707891 1:CAS:528:DC%2BC3cXnvVersr8%3D
    • M Trenkmann M Brock C Ospelt S Gay 2010 Epigenetics in rheumatoid arthritis Clin Rev Allergy Immunol 39 10 19 19707891 1:CAS:528: DC%2BC3cXnvVersr8%3D
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 10-19
    • Trenkmann, M.1    Brock, M.2    Ospelt, C.3    Gay, S.4
  • 121
    • 79957927256 scopus 로고    scopus 로고
    • Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?
    • 21497675
    • C Ospelt KA Reedquist S Gay PP Tak 2011 Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis? Autoimmun Rev 10 519 524 21497675
    • (2011) Autoimmun Rev , vol.10 , pp. 519-524
    • Ospelt, C.1    Reedquist, K.A.2    Gay, S.3    Tak, P.P.4
  • 123
    • 70350049103 scopus 로고    scopus 로고
    • Abnormal DNA methylation in cd4+ t cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
    • 19444718 1:CAS:528:DC%2BD1MXht1CrsbnM
    • W Lei Y Luo K Yan S Zhao Y Li X Qiu Y Zhou H Long M Zhao Y Liang Y Su Q Lu 2009 Abnormal DNA methylation in cd4+ t cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis Scand J Rheumatol 38 369 374 19444718 1:CAS:528:DC%2BD1MXht1CrsbnM
    • (2009) Scand J Rheumatol , vol.38 , pp. 369-374
    • Lei, W.1    Luo, Y.2    Yan, K.3    Zhao, S.4    Li, Y.5    Qiu, X.6    Zhou, Y.7    Long, H.8    Zhao, M.9    Liang, Y.10    Su, Y.11    Lu, Q.12
  • 124
    • 73249146755 scopus 로고    scopus 로고
    • DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    • 19950268 1:CAS:528:DC%2BC3cXhtFKhtb7K
    • E Karouzakis RE Gay BA Michel S Gay M Neidhart 2009 DNA hypomethylation in rheumatoid arthritis synovial fibroblasts Arthritis Rheum 60 3613 3622 19950268 1:CAS:528:DC%2BC3cXhtFKhtb7K
    • (2009) Arthritis Rheum , vol.60 , pp. 3613-3622
    • Karouzakis, E.1    Gay, R.E.2    Michel, B.A.3    Gay, S.4    Neidhart, M.5
  • 126
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • DOI 10.1002/art.21948
    • Y Wang PS Fan B Kahaleh 2006 Association between enhanced type i collagen expression and epigenetic repression of the fli1 gene in scleroderma fibroblasts Arthritis Rheum 54 2271 2279 16802366 1:CAS:528:DC%2BD28XnslKhu7s%3D (Pubitemid 44051084)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.7 , pp. 2271-2279
    • Wang, Y.1    Fan, P.-S.2    Kahaleh, B.3
  • 128
    • 0025666735 scopus 로고
    • Evidence for impaired t cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • 2242063 1:CAS:528:DyaK38XjvFWjtg%3D%3D
    • B Richardson L Scheinbart J Strahler L Gross S Hanash M Johnson 1990 Evidence for impaired t cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis Arthritis Rheum 33 1665 1673 2242063 1:CAS:528: DyaK38XjvFWjtg%3D%3D
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 129
    • 33644841145 scopus 로고    scopus 로고
    • Type 1 diabetes
    • DOI 10.1016/S0140-6736(06)68341-4, PII S0140673606683414
    • D Daneman 2006 Type 1 diabetes Lancet 367 847 858 16530579 1:CAS:528:DC%2BD28Xit1ehtLw%3D (Pubitemid 43363372)
    • (2006) Lancet , vol.367 , Issue.9513 , pp. 847-858
    • Daneman, D.1
  • 131
    • 18144383173 scopus 로고    scopus 로고
    • From bases to basis: Linking genetics to causation in primary biliary cirrhosis
    • DOI 10.1016/S1542-3565(04)00678-0, PII S1542356504006780
    • P Invernizzi C Selmi IR Mackay M Podda ME Gershwin 2005 From bases to basis: Linking genetics to causation in primary biliary cirrhosis Clin Gastroenterol Hepatol 3 401 410 15880308 1:CAS:528:DC%2BD2MXltVWqtbo%3D (Pubitemid 40616904)
    • (2005) Clinical Gastroenterology and Hepatology , vol.3 , Issue.5 , pp. 401-410
    • Invernizzi, P.1    Selmi, C.2    Mackay, I.R.3    Podda, M.4    Gershwin, M.E.5
  • 132
    • 79955689227 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • 21529926 1:CAS:528:DC%2BC3MXlslKmsbs%3D
    • C Selmi CL Bowlus ME Gershwin RL Coppel 2011 Primary biliary cirrhosis Lancet 377 1600 1609 21529926 1:CAS:528:DC%2BC3MXlslKmsbs%3D
    • (2011) Lancet , vol.377 , pp. 1600-1609
    • Selmi, C.1    Bowlus, C.L.2    Gershwin, M.E.3    Coppel, R.L.4
  • 133
    • 8844239298 scopus 로고    scopus 로고
    • Primary biliary cirrhosis: Does X mark the spot?
    • DOI 10.1016/j.autrev.2004.05.003, PII S1568997204000862
    • C Selmi P Invernizzi M Miozzo M Podda ME Gershwin 2004 Primary biliary cirrhosis: Does x mark the spot? Autoimmun Rev 3 493 499 15546796 1:CAS:528:DC%2BD2MXjs1yhtg%3D%3D (Pubitemid 39531240)
    • (2004) Autoimmunity Reviews , vol.3 , pp. 493-499
    • Selmi, C.1    Invernizzi, P.2    Miozzo, M.3    Podda, M.4    Gershwin, M.E.5
  • 136
    • 65549099910 scopus 로고    scopus 로고
    • Viral connection between drug rashes and autoimmune diseases: How autoimmune responses are generated after resolution of drug rashes
    • 19239928 1:CAS:528:DC%2BD1MXotVShsL0%3D
    • N Aota T Shiohara 2009 Viral connection between drug rashes and autoimmune diseases: How autoimmune responses are generated after resolution of drug rashes Autoimmun Rev 8 488 494 19239928 1:CAS:528:DC%2BD1MXotVShsL0%3D
    • (2009) Autoimmun Rev , vol.8 , pp. 488-494
    • Aota, N.1    Shiohara, T.2
  • 137
    • 60649120289 scopus 로고    scopus 로고
    • Aberrant epstein-barr viral infection in systemic lupus erythematosus
    • 19167523 1:CAS:528:DC%2BD1MXmtVyqs74%3D
    • BD Poole AK Templeton JM Guthridge EJ Brown JB Harley JA James 2009 Aberrant epstein-barr viral infection in systemic lupus erythematosus Autoimmun Rev 8 337 342 19167523 1:CAS:528:DC%2BD1MXmtVyqs74%3D
    • (2009) Autoimmun Rev , vol.8 , pp. 337-342
    • Poole, B.D.1    Templeton, A.K.2    Guthridge, J.M.3    Brown, E.J.4    Harley, J.B.5    James, J.A.6
  • 140
    • 67449168101 scopus 로고    scopus 로고
    • Costimulation modulation uncouples protection from immunopathology in memory t cell responses to influenza virus
    • 19454679 1:CAS:528:DC%2BD1MXmtVKru74%3D
    • JR Teijaro MN Njau D Verhoeven S Chandran SG Nadler J Hasday DL Farber 2009 Costimulation modulation uncouples protection from immunopathology in memory t cell responses to influenza virus J Immunol 182 6834 6843 19454679 1:CAS:528:DC%2BD1MXmtVKru74%3D
    • (2009) J Immunol , vol.182 , pp. 6834-6843
    • Teijaro, J.R.1    Njau, M.N.2    Verhoeven, D.3    Chandran, S.4    Nadler, S.G.5    Hasday, J.6    Farber, D.L.7
  • 141
    • 64849105620 scopus 로고    scopus 로고
    • Herpesvirus entry mediator-ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model
    • 19234211 1:CAS:528:DC%2BD1MXitFKgsrk%3D
    • M Pierer A Schulz M Rossol E Kendzia D Kyburz H Haentzschel C Baerwald U Wagner 2009 Herpesvirus entry mediator-ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model J Immunol 182 3139 3145 19234211 1:CAS:528:DC%2BD1MXitFKgsrk%3D
    • (2009) J Immunol , vol.182 , pp. 3139-3145
    • Pierer, M.1    Schulz, A.2    Rossol, M.3    Kendzia, E.4    Kyburz, D.5    Haentzschel, H.6    Baerwald, C.7    Wagner, U.8
  • 142
    • 71649091697 scopus 로고    scopus 로고
    • Alternatively activated macrophages in infection and autoimmunity
    • Fairweather D, Cihakova D (2009) Alternatively activated macrophages in infection and autoimmunity. J Autoimmun 33:222-230
    • (2009) J Autoimmun , vol.33 , pp. 222-230
    • Fairweather, D.1    Cihakova, D.2
  • 143
    • 56349118442 scopus 로고    scopus 로고
    • Autoimmunity and persistent viral infection: Two sides of the same coin?
    • Frazer IH (2008) Autoimmunity and persistent viral infection: Two sides of the same coin? J Autoimmun 31:131-135
    • (2008) J Autoimmun , vol.31 , pp. 131-135
    • Frazer, I.H.1
  • 144
    • 50549089597 scopus 로고    scopus 로고
    • Prevalence and significance of antibodies to citrullinated human papilloma virus-47 e2(345-362) in rheumatoid arthritis
    • Shi J, Sun X, Zhao Y, Zhao J, Li Z (2008) Prevalence and significance of antibodies to citrullinated human papilloma virus-47 e2(345-362) in rheumatoid arthritis. J Autoimmun
    • (2008) J Autoimmun
    • Shi, J.1    Sun, X.2    Zhao, Y.3    Zhao, J.4    Li, Z.5
  • 146
    • 79957951510 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer
    • 21556484 1:CAS:528:DC%2BC3MXnsl2ksrw%3D
    • CA Dinarello G Fossati P Mascagni 2011 Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer Mol Med 17 333 352 21556484 1:CAS:528:DC%2BC3MXnsl2ksrw%3D
    • (2011) Mol Med , vol.17 , pp. 333-352
    • Dinarello, C.A.1    Fossati, G.2    Mascagni, P.3
  • 147
    • 79251576774 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: The epigenetic therapeutics that repress hypoxia-inducible factors
    • 21151670
    • S Chen N Sang 2011 Histone deacetylase inhibitors: The epigenetic therapeutics that repress hypoxia-inducible factors J Biomed Biotechnol 2011 197946 21151670
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 197946
    • Chen, S.1    Sang, N.2
  • 150
    • 78651295381 scopus 로고    scopus 로고
    • Hdac inhibition by lbh589 affects the phenotype and function of human myeloid dendritic cells
    • 21102427 1:CAS:528:DC%2BC3MXksFKntw%3D%3D
    • W Song YT Tai Z Tian T Hideshima D Chauhan P Nanjappa MA Exley KC Anderson NC Munshi 2011 Hdac inhibition by lbh589 affects the phenotype and function of human myeloid dendritic cells Leukemia 25 161 168 21102427 1:CAS:528:DC%2BC3MXksFKntw%3D%3D
    • (2011) Leukemia , vol.25 , pp. 161-168
    • Song, W.1    Tai, Y.T.2    Tian, Z.3    Hideshima, T.4    Chauhan, D.5    Nanjappa, P.6    Exley, M.A.7    Anderson, K.C.8    Munshi, N.C.9
  • 152
    • 0036458731 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia
    • DOI 10.1046/j.1365-2141.2002.03955.x
    • R Crazzolara K Johrer RW Johnstone R Greil R Kofler B Meister D Bernhard 2002 Histone deacetylase inhibitors potently repress cxcr4 chemokine receptor expression and function in acute lymphoblastic leukaemia Br J Haematol 119 965 969 12472574 1:CAS:528:DC%2BD3sXnt12nuw%3D%3D (Pubitemid 35463820)
    • (2002) British Journal of Haematology , vol.119 , Issue.4 , pp. 965-969
    • Crazzolara, R.1    Johrer, K.2    Johnstone, R.W.3    Greil, R.4    Kofler, R.5    Meister, B.6    Bernhard, D.7
  • 153
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-κB action regulated by reversible acetylation
    • DOI 10.1126/science.1062374
    • L Chen W Fischle E Verdin WC Greene 2001 Duration of nuclear nf-kappab action regulated by reversible acetylation Science 293 1653 1657 1:CAS:528:DC%2BD3MXms1Chsb4%3D (Pubitemid 32807844)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1653-1657
    • Chen, L.-F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 154
    • 79957952191 scopus 로고    scopus 로고
    • Hdac inhibition and graft versus host disease
    • 21298214 1:CAS:528:DC%2BC3MXnsl2ksrc%3D
    • S Choi P Reddy 2011 Hdac inhibition and graft versus host disease Mol Med 17 404 416 21298214 1:CAS:528:DC%2BC3MXnsl2ksrc%3D
    • (2011) Mol Med , vol.17 , pp. 404-416
    • Choi, S.1    Reddy, P.2
  • 156
    • 79957958931 scopus 로고    scopus 로고
    • Inhibition of hdac activity by itf2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis
    • 21327299 1:CAS:528:DC%2BC3MXnsl2ksrk%3D
    • LA Joosten F Leoni S Meghji P Mascagni 2011 Inhibition of hdac activity by itf2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis Mol Med 17 391 396 21327299 1:CAS:528:DC%2BC3MXnsl2ksrk%3D
    • (2011) Mol Med , vol.17 , pp. 391-396
    • Joosten, L.A.1    Leoni, F.2    Meghji, S.3    Mascagni, P.4
  • 157
    • 79957955613 scopus 로고    scopus 로고
    • Hdac inhibition in rheumatoid arthritis and juvenile idiopathic arthritis
    • 21308151 1:CAS:528:DC%2BC3MXnsl2ksrY%3D
    • J Vojinovic N Damjanov 2011 Hdac inhibition in rheumatoid arthritis and juvenile idiopathic arthritis Mol Med 17 397 403 21308151 1:CAS:528: DC%2BC3MXnsl2ksrY%3D
    • (2011) Mol Med , vol.17 , pp. 397-403
    • Vojinovic, J.1    Damjanov, N.2
  • 158
    • 79957932169 scopus 로고    scopus 로고
    • Hdac inhibition in lupus models
    • 21327298 1:CAS:528:DC%2BC3MXnsl2ks74%3D
    • CM Reilly N Regna N Mishra 2011 Hdac inhibition in lupus models Mol Med 17 417 425 21327298 1:CAS:528:DC%2BC3MXnsl2ks74%3D
    • (2011) Mol Med , vol.17 , pp. 417-425
    • Reilly, C.M.1    Regna, N.2    Mishra, N.3
  • 160
    • 79955552937 scopus 로고    scopus 로고
    • Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
    • 21538322 1:CAS:528:DC%2BC3MXltlGhtrw%3D
    • J Vojinovic N Damjanov C D'Urzo A Furlan G Susic S Pasic N Iagaru M Stefan CA Dinarello 2011 Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 63 1452 1458 21538322 1:CAS:528:DC%2BC3MXltlGhtrw%3D
    • (2011) Arthritis Rheum , vol.63 , pp. 1452-1458
    • Vojinovic, J.1    Damjanov, N.2    D'Urzo, C.3    Furlan, A.4    Susic, G.5    Pasic, S.6    Iagaru, N.7    Stefan, M.8    Dinarello, C.A.9
  • 163
    • 22144461094 scopus 로고    scopus 로고
    • Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy
    • H Gowher A Jeltsch 2004 Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy Cancer Biol Ther 3 1062 1068 15539938 1:CAS:528:DC%2BD2MXjvFOiu7c%3D (Pubitemid 41350986)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.11 , pp. 1062-1068
    • Gowher, H.1    Jeltsch, A.2
  • 164
    • 79955943143 scopus 로고    scopus 로고
    • Pharmocoepigenetics: A new approach to predicting individual drug responses and targeting new drugs
    • 21602587 1:CAS:528:DC%2BC3MXhs1Sns7fF
    • W Baer-Dubowska A Majchrzak-Celinska M Cichocki 2011 Pharmocoepigenetics: A new approach to predicting individual drug responses and targeting new drugs Pharmacol Rep 63 293 304 21602587 1:CAS:528:DC%2BC3MXhs1Sns7fF
    • (2011) Pharmacol Rep , vol.63 , pp. 293-304
    • Baer-Dubowska, W.1    Majchrzak-Celinska, A.2    Cichocki, M.3
  • 165
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • M Ingelman-Sundberg SC Sim A Gomez C Rodriguez-Antona 2007 Influence of cytochrome p450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects Pharmacol Ther 116 496 526 18001838 1:CAS:528:DC%2BD2sXhtlCrs7bE (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 166
    • 0033564370 scopus 로고    scopus 로고
    • Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance gene in human cancer cells
    • DOI 10.1046/j.1432-1327.1999.00469.x
    • H Kusaba M Nakayama T Harada M Nomoto K Kohno M Kuwano M Wada 1999 Association of 5' cpg demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells Eur J Biochem 262 924 932 10411657 1:CAS:528:DyaK1MXkt1yqsr8%3D (Pubitemid 29291053)
    • (1999) European Journal of Biochemistry , vol.262 , Issue.3 , pp. 924-932
    • Kusaba, H.1    Nakayama, M.2    Harada, T.3    Nomoto, M.4    Kohno, K.5    Kuwano, M.6    Wada, M.7
  • 167
    • 42549172744 scopus 로고    scopus 로고
    • Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (slc5a8) in human pancreatic cancer
    • 18437076 1:CAS:528:DC%2BD1cXltl2itr8%3D
    • JY Park JF Helm W Zheng QP Ly PJ Hodul BA Centeno MP Malafa 2008 Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (slc5a8) in human pancreatic cancer Pancreas 36 e32 39 18437076 1:CAS:528:DC%2BD1cXltl2itr8%3D
    • (2008) Pancreas , vol.36 , pp. 32-39
    • Park, J.Y.1    Helm, J.F.2    Zheng, W.3    Ly, Q.P.4    Hodul, P.J.5    Centeno, B.A.6    Malafa, M.P.7
  • 169
    • 0034917318 scopus 로고    scopus 로고
    • Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor α genes in breast carcinoma cells
    • DOI 10.1007/s002800100294
    • V Bovenzi RL Momparler 2001 Antineoplastic action of 5-aza-2'- deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells Cancer Chemother Pharmacol 48 71 76 11488527 1:CAS:528:DC%2BD3MXkvFGisb8%3D (Pubitemid 32662439)
    • (2001) Cancer Chemotherapy and Pharmacology , vol.48 , Issue.1 , pp. 71-76
    • Bovenzi, V.1    Momparler, R.L.2
  • 170
    • 80053462850 scopus 로고    scopus 로고
    • Metagenomics and personalized medicine
    • 21962506 1:CAS:528:DC%2BC3MXht1GrsLnL
    • HW Virgin JA Todd 2011 Metagenomics and personalized medicine Cell 147 44 56 21962506 1:CAS:528:DC%2BC3MXht1GrsLnL
    • (2011) Cell , vol.147 , pp. 44-56
    • Virgin, H.W.1    Todd, J.A.2
  • 171
    • 84934444787 scopus 로고    scopus 로고
    • Immunoinformatics and systems biology methods for personalized medicine
    • 20824473 1:CAS:528:DC%2BC3cXhtlKju7fP
    • Q Yan 2010 Immunoinformatics and systems biology methods for personalized medicine Methods Mol Biol 662 203 220 20824473 1:CAS:528:DC%2BC3cXhtlKju7fP
    • (2010) Methods Mol Biol , vol.662 , pp. 203-220
    • Yan, Q.1
  • 172
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • 18337604 1:CAS:528:DC%2BD1cXjt1ahs7Y%3D
    • M Esteller 2008 Epigenetics in cancer N Engl J Med 358 1148 1159 18337604 1:CAS:528:DC%2BD1cXjt1ahs7Y%3D
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 173
    • 79952950188 scopus 로고    scopus 로고
    • Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: Are we there yet?
    • 21421110 1:CAS:528:DC%2BC3MXjs1yqsbg%3D
    • O Odenike MJ Thirman AS Artz LA Godley RA Larson W Stock 2011 Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: Are we there yet? Semin Oncol 38 196 214 21421110 1:CAS:528:DC%2BC3MXjs1yqsbg%3D
    • (2011) Semin Oncol , vol.38 , pp. 196-214
    • Odenike, O.1    Thirman, M.J.2    Artz, A.S.3    Godley, L.A.4    Larson, R.A.5    Stock, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.