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Volumn 23, Issue 23, 2004, Pages 4583-4594

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Author keywords

Apoptosis; Axin; HIPK2; p53; Phosphorylation

Indexed keywords

AXIN; PROTEIN KINASE; PROTEIN KINASE HIPK2; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 10644290911     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600475     Document Type: Article
Times cited : (144)

References (36)
  • 1
    • 0346727364 scopus 로고    scopus 로고
    • Conquering the complexity of p53
    • Attardi LD, DePinho RA (2004) Conquering the complexity of p53. Nat Genet 36: 7-8
    • (2004) Nat Genet , vol.36 , pp. 7-8
    • Attardi, L.D.1    DePinho, R.A.2
  • 2
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • Brooks CL, Gu W (2003) Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 15: 164-171
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 3
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R (1997) Wnt signaling: a common theme in animal development. Genes Dev 11: 3286-3305
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 4
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD (1999) Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96: 13777-13782
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 5
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads
    • Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, Piccolo S (2003) Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell 113: 301-314
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 7
    • 0033572746 scopus 로고    scopus 로고
    • Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
    • Dumaz N, Meek DW (1999) Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J 18: 7002-7010
    • (1999) EMBO J , vol.18 , pp. 7002-7010
    • Dumaz, N.1    Meek, D.W.2
  • 10
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb TM, Oren M (1996) p53 in growth control and neoplasia. Biochim Biophys Acta 1287: 77-102
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2
  • 11
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 12
    • 0141866703 scopus 로고    scopus 로고
    • Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation
    • Harada J, Kokura K, Kanei-Ishii C, Nomura T, Khan MM, Kim Y, Ishii S (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J Biol Chem 278: 38998-39005
    • (2003) J Biol Chem , vol.278 , pp. 38998-39005
    • Harada, J.1    Kokura, K.2    Kanei-Ishii, C.3    Nomura, T.4    Khan, M.M.5    Kim, Y.6    Ishii, S.7
  • 14
    • 0035842902 scopus 로고    scopus 로고
    • Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
    • Hsu W, Shakya R, Costantini F (2001) Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol 155: 1055-1064
    • (2001) J Cell Biol , vol.155 , pp. 1055-1064
    • Hsu, W.1    Shakya, R.2    Costantini, F.3
  • 15
    • 0032756584 scopus 로고    scopus 로고
    • Roles of Axin in the Wnt signalling pathway
    • Kikuchi A (1999) Roles of Axin in the Wnt signalling pathway. Cell Signal 11: 777-788
    • (1999) Cell Signal , vol.11 , pp. 777-788
    • Kikuchi, A.1
  • 16
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ, Prives C (1996) p53: puzzle and paradigm. Genes Dev 10: 1054-1072
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 17
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 18
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 19
    • 0141621205 scopus 로고    scopus 로고
    • Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation
    • Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC (2003) Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J Biol Chem 278: 37451-37458
    • (2003) J Biol Chem , vol.278 , pp. 37451-37458
    • Luo, W.1    Ng, W.W.2    Jin, L.H.3    Ye, Z.4    Han, J.5    Lin, S.C.6
  • 20
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13: 49-58
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 21
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 22
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 23
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
    • Peifer M, Polakis P (2000) Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287: 1606-1609
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 24
    • 0035966316 scopus 로고    scopus 로고
    • Why is p53 acetylated?
    • Prives C, Manley JL (2001) Why is p53 acetylated? Cell 107: 815-818
    • (2001) Cell , vol.107 , pp. 815-818
    • Prives, C.1    Manley, J.L.2
  • 25
    • 0037044836 scopus 로고    scopus 로고
    • SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling
    • Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC (2002) SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem 277: 42981-42986
    • (2002) J Biol Chem , vol.277 , pp. 42981-42986
    • Rui, H.L.1    Fan, E.2    Zhou, H.M.3    Xu, Z.4    Zhang, Y.5    Lin, S.C.6
  • 26
    • 0034808019 scopus 로고    scopus 로고
    • Down-regulation of beta-catenin by activated p53
    • Sadot E, Geiger B, Oren M, Ben-Ze'ev A (2001) Down-regulation of beta-catenin by activated p53. Mol Cell Biol 21: 6768-6781
    • (2001) Mol Cell Biol , vol.21 , pp. 6768-6781
    • Sadot, E.1    Geiger, B.2    Oren, M.3    Ben-Ze'ev, A.4
  • 28
    • 0037067656 scopus 로고    scopus 로고
    • p53: Good cop/bad cop
    • Sharpless NE, DePinho RA (2002) p53: good cop/bad cop. Cell 110: 9-12
    • (2002) Cell , vol.110 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 32
    • 0030776825 scopus 로고    scopus 로고
    • Two dominant mutations in the mouse fused gene are the result of transposon insertions
    • Vasicek TJ, Zeng L, Guan XJ, Zhang T, Costantini F, Tilghman SM (1997) Two dominant mutations in the mouse fused gene are the result of transposon insertions. Genetics 147: 777-786
    • (1997) Genetics , vol.147 , pp. 777-786
    • Vasicek, T.J.1    Zeng, L.2    Guan, X.J.3    Zhang, T.4    Costantini, F.5    Tilghman, S.M.6
  • 33
    • 0037737758 scopus 로고    scopus 로고
    • Regulation of p53 responses by post-translational modifications
    • Xu Y (2003) Regulation of p53 responses by post-translational modifications. Cell Death Differ 10: 400-403
    • (2003) Cell Death Differ , vol.10 , pp. 400-403
    • Xu, Y.1
  • 35
    • 0142258245 scopus 로고    scopus 로고
    • Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    • Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH (2003) Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115: 177-186
    • (2003) Cell , vol.115 , pp. 177-186
    • Zhang, Q.1    Yoshimatsu, Y.2    Hildebrand, J.3    Frisch, S.M.4    Goodman, R.H.5
  • 36
    • 0033521002 scopus 로고    scopus 로고
    • (2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling
    • (2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J Biol Chem 274: 35247-35254
    • (1999) J Biol Chem , vol.274 , pp. 35247-35254
    • Zhang, Y.1    Neo, S.Y.2    Wang, X.3    Han, J.4    Lin, S.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.