The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19932-19937

  Sharp, Tyson V ^a   Al Attar, Ahmad ^b   Foxler, Daniel E ^a   Ding, Li ^c   Vallim, Thomas Q De A ^a   Zhang, Yining ^a   Nijmeh, Hala S ^a   Webb, Thomas M ^a   Nicholson, Andrew G ^d   Zhang, Qunyuan ^c   Kraja, Aldi ^c   Spendlove, Ian ^b   Osborne, John ^c   Mardis, Elaine ^c   Longmore, Gregory D ^e  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

^e WASHINGTON UNIVERSITY   (United States)

Author keywords

Epigenetic silencing; K Ras G12D; LIM proteins; Retinoblastoma; Tumor suppressor genes

Indexed keywords

LIM PROTEIN; RETINOBLASTOMA PROTEIN; UVOMORULIN; LIMD1 PROTEIN, HUMAN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CELL ADHESION; CELL COMMUNICATION; CELL JUNCTION; CHROMOSOME 3P; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE LOSS; GENE MUTATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HETEROZYGOSITY LOSS; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIMD1 GENE; LUNG ADENOCARCINOMA; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; ONCOGENE K RAS; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR PROMOTION; TUMOR SUPPRESSOR GENE; ADENOCARCINOMA; ANIMAL; CHEMICALLY INDUCED DISORDER; CHROMOSOME 3; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LUNG ALVEOLUS; LUNG TUMOR; METABOLISM; MOUSE MUTANT; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; TUMOR CELL LINE;

MUS;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, RAS; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MICE; MICE, MUTANT STRAINS; PROMOTER REGIONS, GENETIC; PULMONARY ALVEOLI;

EID: 58149376465     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805003105     Document Type: Article

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