Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism

Experimental Cell Research

Volumn 314, Issue 19, 2008, Pages 3453-3465

  Berthold, Jessica ^a   Schenková, Kristína ^a,d   Ramos, Sonia ^a   Miura, Yoshie ^b   Furukawa, Manabu ^b   Aspenström, Pontus ^c   Rivero, Francisco ^a,d  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF HULL   (United Kingdom)

Author keywords

BTB domain; Cancer profiling array; Cullin; Rho guanosine triphosphatase; RhoBTB; Ubiquitin

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HETERODIMER; HOMODIMER; PROTEASOME; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOBTB PROTEIN; RHOBTB2 PROTEIN; RHOBTB3 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOREGULATION; BREAST TUMOR; GENE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY TUMOR; MOLECULAR INTERACTION; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; YEAST;

EID: 55149099596     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.09.005     Document Type: Article

References (42)

1. Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
2. Jaffe A.B., and Hall A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21 (2005) 247-269
3. Bustelo X., Sauzeau V., and Berenjeno I. GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays 29 (2007) 356-370
4. Sahai E., and Marshall C.J. RHO-GTPases and cancer. Nat. Rev. Cancer 2 (2002) 133-142
5. Gomez del Pulgar T., Benitah S.A., Valeron P.F., Espina C., and Lacal J.C. Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays 27 (2005) 602-613
6. Ellenbroek S., and Collard J. Rho GTPases: functions and association with cancer. Clin. Exp. Metastasis 24 (2007) 657-672
7. Clark E.A., Golub T.R., Lander E.S., and Hynes R.O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406 (2000) 532-535
8. Jordan P., Brazao R., Boavida M.G., Gespach C., and Chastre E. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene 18 (1999) 6835-6839
9. Fritz G., Brachetti C., Bahlmann F., Schmidt M., and Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br. J. Cancer 87 (2002) 635-644
10. Ramos S., Khademi F., Somesh B.P., and Rivero F. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Gene 298 (2002) 147-157
11. Berthold J., Schenková K., and Rivero F. Rho GTPases of the RhoBTB subfamily and tumorigenesis. Acta Pharmacol. Sin. 29 (2008) 285-295
12. Hamaguchi M., Meth J.L., von Klitzing C., Wei W., Esposito D., Rodgers L., Walsh T., Welcsh P., King M.C., and Wigler M.H. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 13647-13652
13. Knowles M.A., Aveyard J.S., Taylor C.F., Harnden P., and Bass S. Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer. Cancer Lett. 225 (2005) 121-130
14. Cho Y.G., Choi B.J., Song J.H., Zhang C., Nam S.W., Lee J.Y., and Park W.S. Genetic analysis of the DBC2 gene in gastric cancer. Acta Oncol. 47 (2008) 366-371
15. Ohadi M., Totonchi M., Maguire P., Lindblom A., Habibi R., Afshin Alavi B., Keyhani E., and Najmabadi H. Mutation analysis of the DBC2 gene in sporadic and familial breast cancer. Acta Oncol. 46 (2007) 770-772
16. Beder L.B., Gunduz M., Ouchida M., Gunduz E., Sakai A., Fukushima K., Nagatsuka H., Ito S., Honjo N., Nishizaki K., and Shimizu K. Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer. J. Cancer Res. Clin. Oncol. 132 (2006) 19-27
17. Rivero F., Dislich H., Glockner G., and Noegel A.A. The Dictyostelium discoideum family of Rho-related proteins. Nucleic Acids Res. 29 (2001) 1068-1079
18. Chang F.K., Sato N., Kobayashi-Simorowski N., Yoshihara T., Meth J.L., and Hamaguchi M. DBC2 is essential for transporting vesicular stomatitis virus glycoprotein. J. Mol. Biol. 364 (2006) 302-308
19. Furukawa M., He Y.J., Borchers C., and Xiong Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 5 (2003) 1001-1007
20. Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J., and Harper J.W. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425 (2003) 316-321
21. Geyer R., Wee S., Anderson S., Yates J., and Wolf D.A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 12 (2003) 783-790
22. Pintard L., Willis J.H., Willems A., Johnson J.L., Srayko M., Kurz T., Glaser S., Mains P.E., Tyers M., Bowerman B., and Peter M. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 425 (2003) 311-316
23. Petroski M.D., and Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev., Mol. Cell Biol. 6 (2005) 9-20
24. Stogios P.J., Downs G.S., Jauhal J.J., Nandra S.K., and Prive G.G. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6 (2005) R82
25. Wilkins A., Ping Q., and Carpenter C.L. RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex. Genes Dev. 18 (2004) 856-861
26. Aspenström P., Fransson A., and Saras J. Rho GTPases have diverse effects on the organization of the actin filament system. Biochem. J. 377 (2004) 327-337
27. Siripurapu V., Meth J., Kobayashi N., and Hamaguchi M. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. J. Mol. Biol. 346 (2005) 83-89
28. Yoshihara T., Collado D., and Hamaguchi M. Cyclin D1 downregulation is essential for DBC2fss tumor suppressor function. Biochem. Biophys. Res. Commun. 358 (2007) 1076-1079
29. S.N. Freeman, Y. Ma, W.D. Cress, Rhobtb2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis. J. Biol. Chem. in press (2007).
30. Noegel A.A., Blau-Wasser R., Sultana H., Muller R., Israel L., Schleicher M., Patel H., and Weijer C.J. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol. Biol. Cell 15 (2004) 934-945
31. Sambrook J., and Russell D.W. Molecular Cloning: a Laboratory Manual. 3rd ed. (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
32. Yu Y., Xiao Z., Ehrlich E.S., Yu X., and Yu X.-F. Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines. Genes Dev. 18 (2004) 2867-2872
33. McMahon M., Thomas N., Itoh K., Yamamoto M., and Hayes J.D. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitinylation of proteins by a "tethering" mechanism. J. Biol. Chem. 281 (2006) 24756-24768
34. St-Pierre B., Jiang Z., Egan S.E., and Zacksenhaus E. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. Gene Expr. Patterns 5 (2004) 245-251
35. Chew E.-H., Poobalasingam T., Hawkey C.J., and Hagen T. Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells - evidence for cullin dimerization. Cell. Signal. 19 (2007) 1071-1080
36. Wimuttisuk W., and Singer J.D. The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. Mol. Biol. Cell 18 (2007) 899-909
37. Zhang D.D., Lo S.C., Cross J.V., Templeton D.J., and Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24 (2004) 10941-10953
38. Shi Y., Chen J.-Y., Yang J., Li B., Chen Z.-H., and Xiao C.-G. DBC2 gene is silenced by promoter methylation in bladder cancer. Urol. Oncol. 26 (2008) 451-464
39. Du M., Sansores-Garcia L., Zu Z., and Wu K.K. Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family. J. Biol. Chem. 273 (1998) 24289-24292
40. Singer J.D., Gurian-West M., Clurman B., and Roberts J.M. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13 (1999) 2375-2387
41. Guardavaccaro D., and Pagano M. Oncogenic aberrations of cullin-dependent ubiquitin ligases. Oncogene 23 (2004) 2037-2049
42. Kondo K., Klco J., Nakamura E., Lechpammer M., and Kaelin Jr. W.G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1 (2002) 237-246