High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Yusenko, Maria V ^a   Kuiper, Roland P ^b   Boethe, Tamas ^c   Ljungberg, Börje ^d   van Kessel, Geurts ^b   Geurts, Ad Geurts ^b   Kovacs, Gyula ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF PÉCS   (Hungary)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME 2; CHROMOSOME 21; CHROMOSOME 6; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DNA EXTRACTION; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE LOCUS; GENE MAPPING; GENE NUMBER; GENE OVEREXPRESSION; GENOME ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; KIDNEY ONCOCYTOMA; MONOSOMY; ONCOCYTOMA; TRANSCRIPTION REGULATION; GENE DOSAGE; GENETICS; HUMAN CHROMOSOME; KIDNEY TUMOR; PATHOLOGY; TUMOR CELL CULTURE;

ADENOMA, OXYPHILIC; CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN; GENE DOSAGE; GENE EXPRESSION PROFILING; HUMANS; KIDNEY NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR CELLS, CULTURED;

EID: 66749104378     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-152     Document Type: Article

References (37)

1. Akhtar M Kfoury H Kardar A Linjawi T Kovacs G Sarcomatoid chromophobe cell carcinoma of the kidney J Urol Pathol 1996, 4:155-166.
2. Badoual C Tissier F Lagorce-Pages C Delcourt A Vieillefond A Pulmonary metastases from a chromophobe renal cell carcinoma: 10 years' evolution Histopathology 2002, 40:300-302. 10.1046/j.1365-2559.2002.1363e.x 11895501
3. Crotty TB Farrow GM Lieber MM Chromophobe cell renal carcinoma: clinicopathological feature of 50 cases J Urol 1995, 154:964-967. 10.1016/S0022-5347(01)66944-1 7637102
4. Renshaw AA Henske EP Loughlin KR Shapiro C Weinberg DS Aggressive variants of chromophobe renal cell carcinoma Cancer 1996, 78:1756-1761. 10.1002/(SICI)1097-0142(19961015)78:8<1756::AID-CNCR16>3.0.CO;2-X 8859189
5. Davis CJ Sesterhenn IA Mostofi FK Ho CK Renal oncocytoma. Clinicopathological study of 166 patients J Urogenital Pathol 1991, 1:41-52.
6. Kovacs G Soudah B Hoene E Binucleated cells in a human renal cell carcinoma with 34 chromosomes Cancer Genet Cytogenet 1988, 31:211-215. 10.1016/0165-4608(88)90219-1 3349439
7. Kovacs A Kovacs G Low chromosome number in chromophobe renal cell carcinomas Genes Chromosomes Cancer 1992, 4:267-268. 10.1002/ gcc.2870040313 1382570
8. Speicher MR Schoell B du Manoir S Schröck E Ried T Cremer T Störkel S Kovacs A Kovacs G Specific loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridisation Am J Pathol 1994, 145:356-364. 1887405 7519827
9. Bugert P Gaul C Weber K Akhtar M Ljungberg B Kovacs G Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas Lab Invest 1997, 76:203-208. 9042156
10. Brunelli M Eble JN Zhang S Martignoni G Delahunt B Cheng L Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma Mod Pathol 2004, 18:161-169. 10.1038/modpathol.3800286
11. Füzesi L Gunawan B Braun S Boeckmann W Renal oncocytoma with a translocation t(9;11)(p23;q13) J Urol 2004, 152:471-472.
12. Presti JC Moch H Reuter VE Huynh D Waldman FM Comparative genomic hybridisation for genetic analysis of renal oncocytomas Genes Chromosomes Cancer 1996, 17:199-204. 10.1002/ (SICI)1098-2264(199612)17:4<199::AID-GCC1>3.0.CO;2-Z 8946201
13. Nagy A Buzogany I Kovacs G Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes Histopathology 2004, 44:542-546. 10.1111/ j.1365-2559.2004.01884.x 15186268
14. Herbers J Schullerus D Chudek J Bugert P Kanamaru H Zeisler J Ljungberg B Akhtar M Kovacs G Lack of genetic changes at specific genomic sites separates renal oncocytomas from renal cell carcinomas J Pathol 1998, 184:58-62. 10.1002/ (SICI)1096-9896(199801)184:1<58::AID-PATH987>3.0.CO;2-1 9582528
15. Kovacs G Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumours J Cancer Res Clin Oncol 1990, 116:318-323. 10.1007/BF01612912 2202729
16. Bugert P Kovacs G Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis Am J Pathol 1996, 149:2081-2088. 1865333 8952540
17. Wilhelm M Veltman JA Olshen A Jain AN Moore DH Presti JC Kovacs G Waldman FM Array based CGH for the differential diagnosis of renal cell cancer Cancer Res 2002, 62:957-960. 11861363
18. Furge KA Lucas KA Takahashi M Sugimura J Kort EJ Kanayama HO Kaqawa S Hoekstra P Curry J Yang XJ Teh BT Robust classification of renal cell carcinoma based on gene expression data and predicted cytogenetic profiles Cancer Res 2004, 64:4117-4121. 10.1158/0008-5472.CAN-04-0534 15205321
19. Takahashi M Yang XY Sugimura J Backdahl J Tretiakova M Qian CN Gray SG Knapp R Anema J Kahnoski R Nicol D Vogelzang NJ Furge KA Kanayama H Kagawa S The BT Molecular subclassification of kidney tumors and the discovery of new diagnostic markers Oncogene 2003, 22:6810-6818. 10.1038/ sj.onc.1206869 14555994
20. Young AN Amin MB Moreno CS Lim SD Cohen C Petros JA Marshall FF Neish AS Expression profiling of renal epithelial neoplasms: A method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol 2001, 58:11639-11651.
21. Higgins JPT Shinghal R Gill H Reese JH Terris M Cohen RJ Fero M Pollack JR Rijn van de M Brooks JD Gene Expression Patterns in Renal Cell Carcinoma Assessed by Complementary DNA Microarray Am J Pathol 2003, 162:925-932. 1868114 12598325
22. Rohan S Tu JJ Kao J Mukherjee P Campagne F Zhou XK Hyjek E Alonso MA Chen YT Gene Expression Profiling Separates Chromophobe Renal Cell Carcinoma from Oncocytoma and Identifies Vesicular Transport and Cell Junction Proteins as Differentially Expressed Genes Clin Cancer Res 2006, 12:6937-6945. 10.1158/1078-0432.CCR-06-1268 17145811
23. Schuetz AN Yin-Goen Q Amin MB Moreno CS Cohen C Hornsby CD Yang WL Petros JA Issa MM Pattaras JG Oqan K Marshall FF Young AN Molecular classification of renal tumors by gene expression profiling J Mol Diagn 2005, 7:206-218. 1867531 15858144
24. Kovacs G Akhtar M Beckwith BJ Bugert P Cooper CS Delahunt B Eble JN Fleming S Ljungberg B Medeiros KJ Moch H Reuter VE Ritz E Roos G Schmidt D Srigley JR Störkel S Berg van den E Zbar B The Heidelberg classification of renal cell tumours J Pathol 1997, 183:131-133. 10.1002/ (SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G 9390023
25. Nannya Y Sanada M Nakazaki K Hosoya N Wang L Hangaishi A Kurokawa M Chiba S Bailey DK Kennedy GC Ogawa S A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays Cancer Res 2005, 65:6071-6079. 10.1158/ 0008-5472.CAN-05-0465 16024607
26. Tischfield YA Loss of heterozygsity or: How I learned to stop worrying and love mitotic recombination Am J Hum Genet 1997, 61:995-999. 1716040 9345110 10.1086/301617
27. Kovacs G Molecular differential pathology of renal cell tumours Histopathology 1993, 22:1-8. 10.1111/j.1365-2559.1993.tb00061.x 8436337
28. Contractor H Zariwala M Bugert P Zeisler J Kovacs G Mutation of the p53 tumour suppressor gene occurs preferentially in chromophobe type of renal cell tumours J Pathol 1997, 181:136-139. 10.1002/ (SICI)1096-9896(199702)181:2<136::AID-PATH766>3.0.CO;2-2 9120715
29. Sükösd F Digon B Fischer J Pietsch T Kovacs G Allelic loss at chromosome 10q23.3 but lack of mutation of the PTEN/MMAC1 in chromophobe renal cell carcinoma Cancer Genet Cytogenet 2001, 128:161-163. 10.1016/ S0165-4608(01)00413-7 11463457
30. Pavlovich CP Walther MM Eyler RA Hewitt SM Zbar B Linehan WM Merino MJ Renal tumours in Birt-Hogg-Dube syndrome Am J Surg Pathol 2002, 26:1542-1552. 10.1097/00000478-200212000-00002 12459621
31. Nagy A Zubakov D Stupar Z Kovacs G Lack of mutation of the folliculin gene in sporadic chromophobe RCC and renal oncocytoma Int J Cancer 2004, 109:472-475. 10.1002/ijc.11694 14961590
32. Koeman JM Russell RC Tan MH Petillo D Westphal M Koelzer K Metcalf JL Zhang Z Matsuda D Dykema KJ Houseman HL Kort EJ Furge LL Kahnoski RJ Richard S Vieillefond A Swiatek PJ The BP Ohh M Furge KA Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated ELGN2-mediated oxygen-sensing response PLoS Genet 2004, 4:e1000176. 10.1371/journal.pgen.1000176
33. Wu SL Kothari P Wheeler TM Reese T Connelly JH Cytokeratins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomas Mod Pathol 2002, 15:712-717. 10.1097/ 01.MP.0000017566.29755.8A 12118108
34. Abrahams NA MacLennan GT Khoury JD Ormsby AH Tamboli P Doglioni C Schumacher B Tickoo SK Chromophobe renal cell carcinoma: A comparative study of histological, immunhistochemical and ultrastructural features using high throughput tissue microarray Histopathology 2004, 45:593-602. 10.1111/j.1365-2559.2004.02003.x 15569050
35. Young AN de Oliveira Salles PG Lim SD Cohen C Petros JA Marshall FF Neish AS Amin MB Beta defensin-1, parvalbumin, and vimentin: A panel of diagnostic immunohistochemical markers for renal tumours derived from gene expression profiling studies using cDNA microarrays Am J Surg Pathol 2005, 27:199-205. 10.1097/00000478-200302000-00008
36. Mazal PR Exner M Haitel A Kreiger S Thomson RB Aronson PS Susani M Expression of kidney specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma Hum Pathol 2005, 36:22-28. 10.1016/ j.humpath.2004.09.011 15712178
37. Chen YT Tu JJ Kao J Zhou XK Mazumdar M Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma Clin Cancer Res 2005, 11:6558-6566. 10.1158/1078-0432.CCR-05-0647 16166433