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Volumn 15, Issue 4, 2015, Pages 300-314

Sphingosine kinases signalling in carcinogenesis

Author keywords

Cancer; Receptor tyrosine kinases (RTKs); Sphingolipids; Sphingosine 1 phosphate (S1P); Sphingosine kinase 1 (SphK1); Tyrosine kinase inibitors (TKIs)

Indexed keywords

3 (4 CHLOROPHENYL) N (4 PYRIDINYLMETHYL) ADAMANTANE 1 CARBOXAMIDE; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; CYCLIN D1; DOXORUBICIN; FINGOLIMOD; IMATINIB; IMMUNOMODULATING AGENT; INTERLEUKIN 3; N, N DIMETHYLSPHINGOSINE; NILOTINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SLP 120701; SLR 08081; SORAFENIB; SPHINGOLIPID; SPHINGOMAB; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 2; SPHINGOSINE KINASE INHIBITOR; THREODIHYDROSPHINGOSINE; UNCLASSIFIED DRUG; PHOSPHOTRANSFERASE;

EID: 84930974989     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557515666150227105415     Document Type: Article
Times cited : (27)

References (211)
  • 1
    • 0031662853 scopus 로고    scopus 로고
    • Sphingolipid functions in Saccharomyces cerevisiae: Comparision mammals
    • Dickson, R. C. Sphingolipid functions in Saccharomyces cerevisiae: comparision mammals. Ann. Rev. Biochem., 1998, 67, 27-48.
    • (1998) Ann. Rev. Biochem , vol.67 , pp. 27-48
    • Dickson, R.C.1
  • 2
    • 11244299268 scopus 로고    scopus 로고
    • Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer(flip-flop) lipid motion in membranes
    • Contreras, F. X.; Basanez, G.; Alonso, A.; Herrmann. A.; Goni, F. M. Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer(flip-flop) lipid motion in membranes. Biophy. J., 2005, 88(1), 348-359.
    • (2005) Biophy. J , vol.88 , Issue.1 , pp. 348-359
    • Contreras, F.X.1    Basanez, G.2    Alonso, A.3    Herrmann, A.4    Goni, F.M.5
  • 3
    • 0037135518 scopus 로고    scopus 로고
    • Sphingolipid transport: Rafts and translocators
    • van Meer, G.; Lisman, Q. Sphingolipid transport: rafts and translocators. J. Biol. Chem., 2002; 277(29), 25855-25858.
    • (2002) J. Biol. Chem , vol.277 , Issue.29 , pp. 25855-25858
    • van Meer, G.1    Lisman, Q.2
  • 4
    • 0029609895 scopus 로고
    • Functional role of glycosphingolipids in cell recognition and signaling
    • Hakomori, S.; Igarashi, Y. Functional role of glycosphingolipids in cell recognition and signaling. J. Biochem., 1995, 118(6), 1091-1103.
    • (1995) J. Biochem , vol.118 , Issue.6 , pp. 1091-1103
    • Hakomori, S.1    Igarashi, Y.2
  • 6
    • 21844477032 scopus 로고    scopus 로고
    • Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes
    • Lopez-Montero, I.; Rodriguez, N.; Cribier, S.; Pohl, A.; Velez, M.; Devaux, P. F. Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes. J. Biol. Chem., 2005, 280(27), 25811-25819.
    • (2005) J. Biol. Chem , vol.280 , Issue.27 , pp. 25811-25819
    • Lopez-Montero, I.1    Rodriguez, N.2    Cribier, S.3    Pohl, A.4    Velez, M.5    Devaux, P.F.6
  • 7
    • 2342570273 scopus 로고    scopus 로고
    • Acid and neutral sphingomyelinases: Roles and mechanisms of regulation
    • Marchesini, N.; Hannun, Y. A. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem. Cell Biol., 2004, 82(2), 27-44.
    • (2004) Biochem. Cell Biol , vol.82 , Issue.2 , pp. 27-44
    • Marchesini, N.1    Hannun, Y.A.2
  • 9
    • 0031866963 scopus 로고    scopus 로고
    • Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells
    • Furuya, S.; Mitoma, J.; Makino, A.; Hirabayashi, Y. Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells. J. Neurochem., 1998, 71(1), 366-377.
    • (1998) J. Neurochem , vol.71 , Issue.1 , pp. 366-377
    • Furuya, S.1    Mitoma, J.2    Makino, A.3    Hirabayashi, Y.4
  • 10
    • 0037203316 scopus 로고    scopus 로고
    • Sphingosine in apoptosis signaling
    • Cuvillier, O. Sphingosine in apoptosis signaling. Biochim. Biophys. Acta, 2002, 1585(2-3), 153-162.
    • (2002) Biochim. Biophys. Acta , vol.1585 , Issue.2-3 , pp. 153-162
    • Cuvillier, O.1
  • 11
    • 0035887215 scopus 로고    scopus 로고
    • Sphingosineinduced apoptosis is dependent on lysosomal proteases
    • Kagedal, K.; Zhao, M.; Svensson, I.; Brunk, UT. Sphingosineinduced apoptosis is dependent on lysosomal proteases. Biochem. J., 2001, 359, 335-343.
    • (2001) Biochem. J , vol.359 , pp. 335-343
    • Kagedal, K.1    Zhao, M.2    Svensson, I.3    Brunk, U.T.4
  • 12
    • 84868551757 scopus 로고    scopus 로고
    • Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress
    • Karliner, J. S. Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim. Biophys. Acta, 2013, 1831(1), 203-212.
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.1 , pp. 203-212
    • Karliner, J.S.1
  • 13
    • 79551614173 scopus 로고    scopus 로고
    • Regulation of sphingosine kinase and sphingolipid signaling
    • Pitson, S. M. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem. Sci., 2011, 36(2), 97-107.
    • (2011) Trends Biochem. Sci , vol.36 , Issue.2 , pp. 97-107
    • Pitson, S.M.1
  • 14
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: Biochemical and cellular regulation and role in disease
    • Taha, T. A.; Hannun, Y. A.; Obeid, L. M. Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol., 2006, 39(2), 113-131.
    • (2006) J. Biochem. Mol. Biol , vol.39 , Issue.2 , pp. 113-131
    • Taha, T.A.1    Hannun, Y.A.2    Obeid, L.M.3
  • 17
    • 0034661482 scopus 로고    scopus 로고
    • Sphingosine I-phosphate signalling in mammalian cells
    • Pyne, S.; Pyne, N. J. Sphingosine I-phosphate signalling in mammalian cells. Biochem. J., 2000, 349(Pt. 2), 385-402.
    • (2000) Biochem. J , vol.349 , pp. 385-402
    • Pyne, S.1    Pyne, N.J.2
  • 18
    • 0033588370 scopus 로고    scopus 로고
    • Comparison of intrinsic activities of the putative sphingosine I-phosphate receptor subtypes to regulate several signaling pathways in their cDNAtransfected Chinese hamster ovary cells
    • Kon, J.; Sato, K.; Watanabe, T.; Tomura, H.; Kuwabara, A.; Kimura, T.; Tamama, K.; Ishizuka, T.; Murata, N.; Kanda, T.; Kobayashi, I.; Ohta, H.; Ui, M.; Okajima, F. Comparison of intrinsic activities of the putative sphingosine I-phosphate receptor subtypes to regulate several signaling pathways in their cDNAtransfected Chinese hamster ovary cells. J. Biol. Chem., 1999, 274(34), 23940-23947.
    • (1999) J. Biol. Chem , vol.274 , Issue.34 , pp. 23940-23947
    • Kon, J.1    Sato, K.2    Watanabe, T.3    Tomura, H.4    Kuwabara, A.5    Kimura, T.6    Tamama, K.7    Ishizuka, T.8    Murata, N.9    Kanda, T.10    Kobayashi, I.11    Ohta, H.12    Ui, M.13    Okajima, F.14
  • 21
    • 18144420388 scopus 로고    scopus 로고
    • The G protein-coupled receptor SIP2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration
    • Lepley, D.; Paik, J. H.; Hla, T.; Ferrer, F. The G protein-coupled receptor SIP2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res., 2005, 65(9), 3788-3795.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3788-3795
    • Lepley, D.1    Paik, J.H.2    Hla, T.3    Ferrer, F.4
  • 22
    • 3142744111 scopus 로고    scopus 로고
    • The sphingosine-l-phosphate receptors SIPl, SIP2, and S1P3 function coordinately during embryonic angiogenesis
    • Kono, M.; Mi, Y.; Liu, Y.; Sasaki, T.; Allende, M. L.; Wu, Y. P.; Yamashita, T.; Proia, R. L. The sphingosine-l-phosphate receptors SIPl, SIP2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem., 2004, 279(28), 29367-29373.
    • (2004) J. Biol. Chem , vol.279 , Issue.28 , pp. 29367-29373
    • Kono, M.1    Mi, Y.2    Liu, Y.3    Sasaki, T.4    Allende, M.L.5    Wu, Y.P.6    Yamashita, T.7    Proia, R.L.8
  • 24
    • 0037684739 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor S 1 P4 regulates cell shape and motility via coupling to Gi and G 12/13
    • Graler, M. H.; Grosse, R.; Kusch, A.; Kremmer, E.; Gudermann, T.; Lipp, M. The sphingosine 1-phosphate receptor S 1 P4 regulates cell shape and motility via coupling to Gi and G 12/13. J. Cel. Biochem., 2003, 89(3), 507-519.
    • (2003) J. Cel. Biochem , vol.89 , Issue.3 , pp. 507-519
    • Graler, M.H.1    Grosse, R.2    Kusch, A.3    Kremmer, E.4    Gudermann, T.5    Lipp, M.6
  • 25
    • 26444606350 scopus 로고    scopus 로고
    • Type 4 sphingosine Iphosphate G proteincoupled receptor (S1P4) transduces SIP effects on T cell proliferation and cytokine secretion without signaling migration
    • Wang, W.; Graeler, M. H.; Goetzl, E. J. Type 4 sphingosine Iphosphate G proteincoupled receptor (S1P4) transduces SIP effects on T cell proliferation and cytokine secretion without signaling migration. Faseb J., 2005, 19(12), 1731-1733.
    • (2005) Faseb J , vol.19 , Issue.12 , pp. 1731-1733
    • Wang, W.1    Graeler, M.H.2    Goetzl, E.J.3
  • 26
    • 0345578701 scopus 로고    scopus 로고
    • Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS
    • Terai, K.; Soga, T.; Takahashi, M.; Kamohara, M.; Ohno, K.; Yatsugi, S.; Okada, M.; Yamaguchi, T. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS. Neuroscience, 2003, 116(4), 1053-1062.
    • (2003) Neuroscience , vol.116 , Issue.4 , pp. 1053-1062
    • Terai, K.1    Soga, T.2    Takahashi, M.3    Kamohara, M.4    Ohno, K.5    Yatsugi, S.6    Okada, M.7    Yamaguchi, T.8
  • 27
    • 0032524291 scopus 로고    scopus 로고
    • Purification and characterization of rat kidney sphingosine kinase
    • Olivera, A.; Kohama, T.; Tu, Z.; Milstien, S.; Spiegel, S. Purification and characterization of rat kidney sphingosine kinase. J. Biol. Chem., 1998, 273(20), 12576-12583.
    • (1998) J. Biol. Chem , vol.273 , Issue.20 , pp. 12576-12583
    • Olivera, A.1    Kohama, T.2    Tu, Z.3    Milstien, S.4    Spiegel, S.5
  • 28
    • 0032508706 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of murine sphingosine kinase
    • Kohama, T.; Olivera, A.; Edsall, L.; Nagiec, M. M.; Dickson, R.; Spiegel, S. Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem., 1998, 273(37), 23722-23728.
    • (1998) J. Biol. Chem , vol.273 , Issue.37 , pp. 23722-23728
    • Kohama, T.1    Olivera, A.2    Edsall, L.3    Nagiec, M.M.4    Dickson, R.5    Spiegel, S.6
  • 30
    • 0034721844 scopus 로고    scopus 로고
    • Expression of a catalytically inactive sphingosine kinase mutant blocks agonistinduced sphingosine kinase activation. A dominant-negative sphingosine kinase
    • Pitson, S. M.; Moretti, P. A.; Zebol, J. R.; Xia, P.; Gamble, J. R.; Vadas. M. A.; D'Andrea, R. J.; Wattenberg, B. W. Expression of a catalytically inactive sphingosine kinase mutant blocks agonistinduced sphingosine kinase activation. A dominant-negative sphingosine kinase. J. Biol. Chem., 2000, 275(43), 33945-33950.
    • (2000) J. Biol. Chem , vol.275 , Issue.43 , pp. 33945-33950
    • Pitson, S.M.1    Moretti, P.A.2    Zebol, J.R.3    Xia, P.4    Gamble, J.R.5    Vadas, M.A.6    D'Andrea, R.J.7    Wattenberg, B.W.8
  • 32
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signalling lipid
    • Spiegel, S.; Milstien, S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol., 2003, 4(5), 397-407.
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , Issue.5 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 33
    • 0034643903 scopus 로고    scopus 로고
    • Human sphingosine kinase: Molecular cloning, functional characterization and tissue distribution
    • Melendez, A. J.; Carlos-Dias, E.; Gosink, M.; Allen, J. M.; Takacs, L. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. Gene., 2000, 251(1), 19-26.
    • (2000) Gene , vol.251 , Issue.1 , pp. 19-26
    • Melendez, A.J.1    Carlos-Dias, E.2    Gosink, M.3    Allen, J.M.4    Takacs, L.5
  • 34
    • 84868551757 scopus 로고    scopus 로고
    • Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress
    • Karliner, J. S. Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim. Biophys. Acta. 2013, 1831(1), 203-212.
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.1 , pp. 203-212
    • Karliner, J.S.1
  • 35
    • 79551614173 scopus 로고    scopus 로고
    • Regulation of sphingosine kinase and sphingolipid signaling
    • Pitson, S. M. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem. Sci., 2011, 36(2), 97-107.
    • (2011) Trends Biochem. Sci , vol.36 , Issue.2 , pp. 97-107
    • Pitson, S.M.1
  • 36
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: Biochemical and cellular regulation and role in disease
    • Taha, T. A.; Hannun, Y. A.; Obeid, L. M. Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol., 2006, 39(2), 113-131.
    • (2006) J. Biochem. Mol. Biol , vol.39 , Issue.2 , pp. 113-131
    • Taha, T.A.1    Hannun, Y.A.2    Obeid, L.M.3
  • 38
    • 0037144434 scopus 로고    scopus 로고
    • PKC dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-I-phosphate induced by phorbol 12-myristate 13-acetate(PMA)
    • Johnson, K. R.; Becker, K. P.; Facchinetti, M. M.; Hannun, Y. A.; Obeid, L. M. PKC dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-I-phosphate induced by phorbol 12-myristate 13-acetate(PMA). J. Biol. Chem., 2002, 277(38), 35257-35262.
    • (2002) J. Biol. Chem , vol.277 , Issue.38 , pp. 35257-35262
    • Johnson, K.R.1    Becker, K.P.2    Facchinetti, M.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 39
    • 84877802533 scopus 로고    scopus 로고
    • Oncogenic properties of sphingosine kinases in haematological malignancies
    • Wallington-Beddoe, C. T.; Bradstock, K. F.; Bendall, L. J. Oncogenic properties of sphingosine kinases in haematological malignancies. Br. J. Haematol., 2013, 161(5), 623-638.
    • (2013) Br. J. Haematol , vol.161 , Issue.5 , pp. 623-638
    • Wallington-Beddoe, C.T.1    Bradstock, K.F.2    Bendall, L.J.3
  • 40
    • 33744951972 scopus 로고    scopus 로고
    • The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane
    • Sutherland, C. M.; Moretti, P. A.; Hewitt, N. M.; Bagley, C. J.; Vadas, M. A.; Pitson, S. M. The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. J. Biol. Chem., 2006, 281(17), 11693-11701.
    • (2006) J. Biol. Chem , vol.281 , Issue.17 , pp. 11693-11701
    • Sutherland, C.M.1    Moretti, P.A.2    Hewitt, N.M.3    Bagley, C.J.4    Vadas, M.A.5    Pitson, S.M.6
  • 42
    • 0036841720 scopus 로고    scopus 로고
    • Sphingosine kinase mediates vascular endothelial growth factor-induced activation ofras and mitogen-activated protein kinases
    • Shu, X.; Wu, W.; Mosteller, R. D.; Broek, D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation ofras and mitogen-activated protein kinases. Mol. Cellular Biol., 2002, 22(22), 7758-7768.
    • (2002) Mol. Cellular Biol , vol.22 , Issue.22 , pp. 7758-7768
    • Shu, X.1    Wu, W.2    Mosteller, R.D.3    Broek, D.4
  • 43
    • 33845982224 scopus 로고    scopus 로고
    • Insulin like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by trans activating sphingosine 1-phosphate receptors
    • EI-Shewy, H. M.; Johnson, K. R.; Lee, M. H.; Jaffa, A. A.; Obeid, L. M.; Luttrell, L. M. Insulin like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by trans activating sphingosine 1-phosphate receptors. J. Biol. Chem., 2006, 281(42), 31399-31407.
    • (2006) J. Biol. Chem , vol.281 , Issue.42 , pp. 31399-31407
    • El-Shewy, H.M.1    Johnson, K.R.2    Lee, M.H.3    Jaffa, A.A.4    Obeid, L.M.5    Luttrell, L.M.6
  • 44
    • 56949095716 scopus 로고    scopus 로고
    • Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
    • Pyne, S.; Lee, S. C.; Long, J.; Pyne, N. J. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal, 2009, 21(1), 14-21.
    • (2009) Cell Signal , vol.21 , Issue.1 , pp. 14-21
    • Pyne, S.1    Lee, S.C.2    Long, J.3    Pyne, N.J.4
  • 45
    • 12344272084 scopus 로고    scopus 로고
    • Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
    • Pitson, S. M.; Xia, P; Leclercq, T. M.; Moretti, P. A.; Zebol, J. R.; Lynn, H. E.; Wattenberg, B. W.; Vadas, M. A. Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J. Exp. Med., 2005, 201(1), 49-54.
    • (2005) J. Exp. Med , vol.201 , Issue.1 , pp. 49-54
    • Pitson, S.M.1    Xia, P.2    Leclercq, T.M.3    Moretti, P.A.4    Zebol, J.R.5    Lynn, H.E.6    Wattenberg, B.W.7    Vadas, M.A.8
  • 46
    • 58049199390 scopus 로고    scopus 로고
    • Deactivation of sphingosine kinase 1 by protein phosphatase 2A
    • Barr, R. K.; Lynn, H. E.; Moretti, P. A.; Khew-Goodall, Y.; Pitson, S. M. Deactivation of sphingosine kinase 1 by protein phosphatase 2A. J. Biol. Chem., 2008, 283(50), 34994-5002.
    • (2008) J. Biol. Chem , vol.283 , Issue.50 , pp. 34994-35002
    • Barr, R.K.1    Lynn, H.E.2    Moretti, P.A.3    Khew-Goodall, Y.4    Pitson, S.M.5
  • 47
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner, E. M.; Kazanietz, M. G. Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer, 2007, 7(4), 281-294.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.4 , pp. 281-294
    • Griner, E.M.1    Kazanietz, M.G.2
  • 49
  • 51
    • 0142091073 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
    • Igarashi, N.; Okada, T.; Hayashi, S., Fujita, T.; Jahangeer, S.; Nakamura, S. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem., 2003, 278(43), 46832-46839.
    • (2003) J. Biol. Chem , vol.278 , Issue.43 , pp. 46832-46839
    • Igarashi, N.1    Okada, T.2    Hayashi, S.3    Fujita, T.4    Jahangeer, S.5    Nakamura, S.6
  • 52
  • 53
    • 34249656324 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 activation by ERK-mediated phosphorylation
    • Hait, N. C.; Bellamy, A.; Milstien, S.; Kordula, T., Spiegel, S. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J. Biol. Chem., 2007, 282(16), 12058-12065.
    • (2007) J. Biol. Chem , vol.282 , Issue.16 , pp. 12058-12065
    • Hait, N.C.1    Bellamy, A.2    Milstien, S.3    Kordula, T.4    Spiegel, S.5
  • 58
    • 0030963660 scopus 로고    scopus 로고
    • Jr. Characterization of ceramide synthesis A dihydroceramide desaturase introduces the 4, 5-trans-double bond of sphingosine at the level of dihydroceramide
    • Michel, C.; van Echten-Deckert, G.; Rother, J.; Sandhoff, K.; Wang, E.; Merrill, A. H. Jr. Characterization of ceramide synthesis A dihydroceramide desaturase introduces the 4, 5-trans-double bond of sphingosine at the level of dihydroceramide. J. Biol. Chem., 1997, 272(36), 22432-22437.
    • (1997) J. Biol. Chem , vol.272 , Issue.36 , pp. 22432-22437
    • Michel, C.1    van Echten-Deckert, G.2    Rother, J.3    Sandhoff, K.4    Wang, E.5    Merrill, A.H.6
  • 59
    • 84870252851 scopus 로고    scopus 로고
    • Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer
    • Ohotski, J.; Edwards, J.; Elsberger, B.; Watson, C.; Orange, C.; Mallon, E.; Pyne, S.; Pyne, N. J. Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. Int. J. Cancer, 2013, 132(3), 605-616.
    • (2013) Int. J. Cancer , vol.132 , Issue.3 , pp. 605-616
    • Ohotski, J.1    Edwards, J.2    Elsberger, B.3    Watson, C.4    Orange, C.5    Mallon, E.6    Pyne, S.7    Pyne, N.J.8
  • 60
    • 84859648774 scopus 로고    scopus 로고
    • Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer
    • Ohotski, J.; Long, J. S.; Orange, C.; Elsberger, B.; Mallon, E.; Doughty, J.; Pyne, S.; Pyne, N. J.; Edwards, J. Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. Br. J. Cancer, 2012, 106(8), 1453-1459.
    • (2012) Br. J. Cancer , vol.106 , Issue.8 , pp. 1453-1459
    • Ohotski, J.1    Long, J.S.2    Orange, C.3    Elsberger, B.4    Mallon, E.5    Doughty, J.6    Pyne, S.7    Pyne, N.J.8    Edwards, J.9
  • 61
    • 84887467273 scopus 로고    scopus 로고
    • ETS-1-mediated transcriptional upregulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis
    • Zhang, W.; Zhao, J.; Lee, J. F.; Gartung, A.; Jawadi, H.; Lambiv, W. L.; Honn, K. V.; Lee, M. J. ETS-1-mediated transcriptional upregulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. J. Biol. Chem., 2013, 288(45), 32126-3237.
    • (2013) J. Biol. Chem , vol.288 , Issue.45 , pp. 32126-33237
    • Zhang, W.1    Zhao, J.2    Lee, J.F.3    Gartung, A.4    Jawadi, H.5    Lambiv, W.L.6    Honn, K.V.7    Lee, M.J.8
  • 63
    • 84875843519 scopus 로고    scopus 로고
    • Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells
    • Kawahara, S.; Otsuji, Y.; Nakamura, M.; Murakami, M.; Murate, T.: Matsunaga, T.; Kanoh, H.; Seishima, M.; Banno, Y.; Hara, A. Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. Anticancer Drugs, 2013, 24(5), 473-483.
    • (2013) Anticancer Drugs , vol.24 , Issue.5 , pp. 473-483
    • Kawahara, S.1    Otsuji, Y.2    Nakamura, M.3    Murakami, M.4    Murate, T.5    Matsunaga, T.6    Kanoh, H.7    Seishima, M.8    Banno, Y.9    Hara, A.10
  • 64
    • 84891464403 scopus 로고    scopus 로고
    • Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells
    • Huang, Y. L.; Chang, C. L.; Tang, C. H.; Lin, Y. C.; Ju, T. K.; Huang, W. P.; Lee, H. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cell Signal., 2014, 26(3), 611-618.
    • (2014) Cell Signal , vol.26 , Issue.3 , pp. 611-618
    • Huang, Y.L.1    Chang, C.L.2    Tang, C.H.3    Lin, Y.C.4    Ju, T.K.5    Huang, W.P.6    Lee, H.7
  • 65
    • 84885029669 scopus 로고    scopus 로고
    • Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling
    • Beckham, T. H.; Cheng, J. C.; Lu, P.; Marrison, S. T.; Norris, J. S.; Liu, X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One, 2013, 8(10), e76593.
    • (2013) PLoS One , vol.8 , Issue.10
    • Beckham, T.H.1    Cheng, J.C.2    Lu, P.3    Marrison, S.T.4    Norris, J.S.5    Liu, X.6
  • 66
    • 84905858913 scopus 로고    scopus 로고
    • Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues
    • Wang, C.; Mao, J.; Redfield, S.; Mo, Y., Lage, J. M.; Zhou, X. Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues. Exp. Mol. Pathol., 2014, 97(2), 259-265.
    • (2014) Exp. Mol. Pathol , vol.97 , Issue.2 , pp. 259-265
    • Wang, C.1    Mao, J.2    Redfield, S.3    Mo, Y.4    Lage, J.M.5    Zhou, X.6
  • 67
    • 84916203333 scopus 로고    scopus 로고
    • Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
    • Don, A. S.; Lim, X. Y.; Couttas, T. A. Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation. Biomolecules, 2014, 4(1), 315-353.
    • (2014) Biomolecules , vol.4 , Issue.1 , pp. 315-353
    • Don, A.S.1    Lim, X.Y.2    Couttas, T.A.3
  • 68
    • 33644886904 scopus 로고    scopus 로고
    • High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced upregulation
    • Akao, Y.; Banno, Y.; Nakagawa, Y.; Hasegawa, N.; Kim, T. J.; Murate, T.; Igarashi, Y.; Nozawa, Y. High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced upregulation. Biochem. Biophys. Res. Commun., 2006, 342(4), 1284-1290.
    • (2006) Biochem. Biophys. Res. Commun , vol.342 , Issue.4 , pp. 1284-1290
    • Akao, Y.1    Banno, Y.2    Nakagawa, Y.3    Hasegawa, N.4    Kim, T.J.5    Murate, T.6    Igarashi, Y.7    Nozawa, Y.8
  • 71
    • 84866083158 scopus 로고    scopus 로고
    • First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: Implication for resistance to therapeutics in prostate cancer
    • Brizuela, L.; Ader, I.; Mazerolles, C.; Bocquet, M.; Malavaud, B.; Cuvillier, O. First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. Mol. Cancer Ther., 2012, 11(9), 1841-1851.
    • (2012) Mol. Cancer Ther , vol.11 , Issue.9 , pp. 1841-1851
    • Brizuela, L.1    Ader, I.2    Mazerolles, C.3    Bocquet, M.4    Malavaud, B.5    Cuvillier, O.6
  • 74
    • 84896385011 scopus 로고    scopus 로고
    • Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis
    • Zhang, Y.; Wang, Y.; Wan, Z.; Liu, S.; Cao, Y.; Zeng, Z. Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis. PLoS One, 2014, 9(82), e90362.
    • (2014) PLoS One , vol.9 , Issue.82
    • Zhang, Y.1    Wang, Y.2    Wan, Z.3    Liu, S.4    Cao, Y.5    Zeng, Z.6
  • 79
    • 31044450344 scopus 로고    scopus 로고
    • The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7
    • Doll F.; Pfeilschifter J.; Huwiler A. The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7. Biochim. Biophys. Acta, 2005, 1738(1-3), 72-81.
    • (2005) Biochim. Biophys. Acta , vol.1738 , Issue.1-3 , pp. 72-81
    • Doll, F.1    Pfeilschifter, J.2    Huwiler, A.3
  • 80
    • 79958239245 scopus 로고    scopus 로고
    • The role of sphingosine kinase-1 in EGFRvIIIregulated growth and survival of glioblastoma cells
    • Estrada-Bernal A.; Lawler S. E.; Nowicki M. O.; Ray Chaudhury A.; van Brocklyn J. R. The role of sphingosine kinase-1 in EGFRvIIIregulated growth and survival of glioblastoma cells. J. Neurooncol., 2010 102(3), 353-366.
    • (2010) J. Neurooncol , vol.102 , Issue.3 , pp. 353-366
    • Estrada-Bernal, A.1    Lawler, S.E.2    Nowicki, M.O.3    Ray Chaudhury, A.4    van Brocklyn, J.R.5
  • 81
    • 8844239960 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor(EGFR) in human gastric cancer cells
    • Shida, D.; Kitayama, J.; Yamaguchi, H.; Yamashita, H.; Mori, K.; Watanabe, T.; Yatomi, Y.; Nagawa, H. Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor(EGFR) in human gastric cancer cells. FEBS Lett., 2004, 577(3), 333-338.
    • (2004) FEBS Lett , vol.577 , Issue.3 , pp. 333-338
    • Shida, D.1    Kitayama, J.2    Yamaguchi, H.3    Yamashita, H.4    Mori, K.5    Watanabe, T.6    Yatomi, Y.7    Nagawa, H.8
  • 82
    • 1442265704 scopus 로고    scopus 로고
    • S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    • Baudhuin, L. M.; Jiang, Y.; Zaslavsky, A.; Ishii, I.; Chun, J.; Xu, Y. S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB J., 2004, 18(2), 341-343.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 341-343
    • Baudhuin, L.M.1    Jiang, Y.2    Zaslavsky, A.3    Ishii, I.4    Chun, J.5    Xu, Y.6
  • 83
    • 0037189504 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII
    • Endo, A.; Nagashima, K.; Kurose, H.; Mochizuki, S.; Matsuda, M.; Mochizuki, N. Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. J. Biol. Chem., 2002, 277(26), 23747-23754.
    • (2002) J. Biol. Chem , vol.277 , Issue.26 , pp. 23747-23754
    • Endo, A.1    Nagashima, K.2    Kurose, H.3    Mochizuki, S.4    Matsuda, M.5    Mochizuki, N.6
  • 84
    • 0037044854 scopus 로고    scopus 로고
    • Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
    • Tanimoto, T.; Jin, Z. G.; Berk, B. C. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J. Biol. Chem., 2002, 277(45), 42997-43001.
    • (2002) J. Biol. Chem , vol.277 , Issue.45 , pp. 42997-43001
    • Tanimoto, T.1    Jin, Z.G.2    Berk, B.C.3
  • 86
    • 37149032222 scopus 로고    scopus 로고
    • Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells
    • Li Q. F.; Huang W. R.; Duan H. F.; Wang H.; Wu C. T.; Wang L. S. Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene, 2007, 26(57), 7904-7908.
    • (2007) Oncogene , vol.26 , Issue.57 , pp. 7904-7908
    • Li, Q.F.1    Huang, W.R.2    Duan, H.F.3    Wang, H.4    Wu, C.T.5    Wang, L.S.6
  • 87
    • 84903594166 scopus 로고    scopus 로고
    • Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells
    • Albinet V.; Bats M. L.; Huwiler A.; Rochaix P.; Chevreau C.; Segui B.; Levade T.; Andrieu-Abadie N. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene, 2014, 33(26), 3364-3373.
    • (2014) Oncogene , vol.33 , Issue.26 , pp. 3364-3373
    • Albinet, V.1    Bats, M.L.2    Huwiler, A.3    Rochaix, P.4    Chevreau, C.5    Segui, B.6    Levade, T.7    Andrieu-Abadie, N.8
  • 88
    • 84866372484 scopus 로고    scopus 로고
    • Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner
    • Gault, C. R.; Eblen, S. T.; Neumann, C. A.; Hannun, Y. A.; Obeid, L. M. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J. Biol. Chem., 2012, 287(38), 31794-31803.
    • (2012) J. Biol. Chem , vol.287 , Issue.38 , pp. 31794-31803
    • Gault, C.R.1    Eblen, S.T.2    Neumann, C.A.3    Hannun, Y.A.4    Obeid, L.M.5
  • 89
    • 84857788832 scopus 로고    scopus 로고
    • Defining a role for sphingosine kinase 1 in p53-dependent tumors
    • Helke, K. L.; Jenkins, R. W.; de Costa, A. M.; Hannun, Y. A., Obeid, L. M. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene, 2012, 31(9), 1166-1175.
    • (2012) Oncogene , vol.31 , Issue.9 , pp. 1166-1175
    • Helke, K.L.1    Jenkins, R.W.2    de Costa, A.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 90
    • 22144486976 scopus 로고    scopus 로고
    • Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1-beta and TNF-alpha induced production of inflammatory mediators
    • Billich A.; Bornancin F.; Mechtcheriakova D.; Natt F., Huesken D.; Baumruker T. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1-beta and TNF-alpha induced production of inflammatory mediators. Cell. Signal., 2005, 17(10), 1203-1217.
    • (2005) Cell. Signal , vol.17 , Issue.10 , pp. 1203-1217
    • Billich, A.1    Bornancin, F.2    Mechtcheriakova, D.3    Natt, F.4    Huesken, D.5    Baumruker, T.6
  • 93
    • 41249103991 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2
    • Anelli, V.; Gault, C. R.; Cheng, A. B.; Obeid, L. M. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J. Biol. Chem., 2008, 283(6), 3365-3375.
    • (2008) J. Biol. Chem , vol.283 , Issue.6 , pp. 3365-3375
    • Anelli, V.1    Gault, C.R.2    Cheng, A.B.3    Obeid, L.M.4
  • 94
    • 54249088951 scopus 로고    scopus 로고
    • Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells
    • Ader, I.; Brizuela, L.; Bouquerel, P.; Malavaud, B.; Cuvillier, O. Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. Cancer Res., 2008, 68(20), 8635-8642.
    • (2008) Cancer Res , vol.68 , Issue.20 , pp. 8635-8642
    • Ader, I.1    Brizuela, L.2    Bouquerel, P.3    Malavaud, B.4    Cuvillier, O.5
  • 95
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • Cuvillier O.; Pirianov G.; Kleuser B.; Vanek P. G.; Coso O. A.; Gutkind S.; Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 1996, 381(6585), 800-803.
    • (1996) Nature , vol.381 , Issue.6585 , pp. 800-803
    • Cuvillier, O.1    Pirianov, G.2    Kleuser, B.3    Vanek, P.G.4    Coso, O.A.5    Gutkind, S.6    Spiegel, S.7
  • 96
    • 0142241216 scopus 로고    scopus 로고
    • Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes
    • Sorensen, S. D.; Nicole, O.; Peavy, R. D.; Montoya, L. M.; Lee, C. J.; Murphy, T. J.; Traynelis, S. F.; Hepler, J. R. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol. Pharmacol., 2003, 64(5), 1199-1209.
    • (2003) Mol. Pharmacol , vol.64 , Issue.5 , pp. 1199-1209
    • Sorensen, S.D.1    Nicole, O.2    Peavy, R.D.3    Montoya, L.M.4    Lee, C.J.5    Murphy, T.J.6    Traynelis, S.F.7    Hepler, J.R.8
  • 97
    • 44949233776 scopus 로고    scopus 로고
    • Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells
    • Miller, A. V.; Alvarez, S. E.; Spiegel, S.; Lebman, D. A. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol. Cell. Biol., 2008, 28(12), 4142-4151.
    • (2008) Mol. Cell. Biol , vol.28 , Issue.12 , pp. 4142-4151
    • Miller, A.V.1    Alvarez, S.E.2    Spiegel, S.3    Lebman, D.A.4
  • 99
    • 79956188245 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells
    • Guan, H.; Song, L.; Cai, J.; Huang, Y.; Wu, J.; Yuan, J.; Li, J.; Li, M. Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. PLoS One, 2011, 6(5), e19946.
    • (2011) PLoS One , vol.6 , Issue.5
    • Guan, H.1    Song, L.2    Cai, J.3    Huang, Y.4    Wu, J.5    Yuan, J.6    Li, J.7    Li, M.8
  • 100
    • 84857546158 scopus 로고    scopus 로고
    • Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1-Jekyll Hidden behind Hyde
    • Takuwa, N.; Du, W.; Kaneko, E.; Okamoto, Y.; Yoshioka, K.; Takuwa, Y. Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1-Jekyll Hidden behind Hyde Am. J. Cancer Res., 2011, 1(14), 460-481.
    • (2011) Am. J. Cancer Res , vol.1 , Issue.14 , pp. 460-481
    • Takuwa, N.1    Du, W.2    Kaneko, E.3    Okamoto, Y.4    Yoshioka, K.5    Takuwa, Y.6
  • 102
    • 23844498431 scopus 로고    scopus 로고
    • Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
    • Van Brocklyn J. R.; Jackson C. A.; Pearl D. K.; Kotur M. S.; Snyder P. J.; Prior T. W. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J. Neuropathol. Exp. Neurol., 2005, 64(8), 695-705.
    • (2005) J. Neuropathol Exp. Neurol , vol.64 , Issue.8 , pp. 695-705
    • Van Brocklyn, J.R.1    Jackson, C.A.2    Pearl, D.K.3    Kotur, M.S.4    Snyder, P.J.5    Prior, T.W.6
  • 103
    • 77953610249 scopus 로고    scopus 로고
    • The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients
    • Yoshida, Y.; Nakada, M.; Harada, T.; Tanaka, S.; Furuta, T.; Hayashi, Y.; Kita, D.; Uchiyama, N.; Hayashi, Y.; Hamada, J. The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients. J. Neurooncol., 2010, 98(1), 41-47.
    • (2010) J. Neurooncol , vol.98 , Issue.1 , pp. 41-47
    • Yoshida, Y.1    Nakada, M.2    Harada, T.3    Tanaka, S.4    Furuta, T.5    Hayashi, Y.6    Kita, D.7    Uchiyama, N.8    Hayashi, Y.9    Hamada, J.10
  • 106
    • 0033230181 scopus 로고    scopus 로고
    • HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation
    • Bianchi, L.; Tacchini, L.; Cairo, G. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Acids Res., 1999, 27(21), 4223-4227.
    • (1999) Nucleic Acids Res , vol.27 , Issue.21 , pp. 4223-4227
    • Bianchi, L.1    Tacchini, L.2    Cairo, G.3
  • 107
    • 65949092331 scopus 로고    scopus 로고
    • When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: New targets for cancer therapy
    • Ader, I.; Malavaud, B.; Cuvillier, O. When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. Cancer Res., 2009, 69(9), 3723-3726.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 3723-3726
    • Ader, I.1    Malavaud, B.2    Cuvillier, O.3
  • 108
    • 66349091350 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: A novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells
    • Michaud, M. D.; Robitaille, G. A.; Gratton, J. P.; Richard, D. E. Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells. Arterioscler. Thromb. Vasc. Biol., 2009, 29(6), 902-908.
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , Issue.6 , pp. 902-908
    • Michaud, M.D.1    Robitaille, G.A.2    Gratton, J.P.3    Richard, D.E.4
  • 109
    • 79951942207 scopus 로고    scopus 로고
    • The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4 mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6
    • Pchejetski, D.; Nunes, J.; Coughlan, K.; Lall, H., Pitson, S. M.; Waxman, J.; Sumbayev, V. V. The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4 mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6. Immunol. Cell Biol., 2011, 89(2), 268-274.
    • (2011) Immunol. Cell Biol , vol.89 , Issue.2 , pp. 268-274
    • Pchejetski, D.1    Nunes, J.2    Coughlan, K.3    Lall, H.4    Pitson, S.M.5    Waxman, J.6    Sumbayev, V.V.7
  • 111
    • 0034733556 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
    • Liu, H.; Sugiura, M.; Nava, V. E.; Edsall, L. C.; Kono, K.; Poulton, S.; Milstien, S.; Kohama. T.; Spiegel, S. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem., 2000, 275(26), 19513-19520.
    • (2000) J. Biol. Chem , vol.275 , Issue.26 , pp. 19513-19520
    • Liu, H.1    Sugiura, M.2    Nava, V.E.3    Edsall, L.C.4    Kono, K.5    Poulton, S.6    Milstien, S.7    Kohama, T.8    Spiegel, S.9
  • 112
    • 35948936347 scopus 로고    scopus 로고
    • Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
    • Sankala, H. M.; Hait, N. C.; Paugh, S. W.; Shida, D.; Lepine, S.; Elmore. L. W.; Milstien, S.; Spiegel, S. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res., 2007, 67(21), 10466-10474.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10466-10474
    • Sankala, H.M.1    Hait, N.C.2    Paugh, S.W.3    Shida, D.4    Lepine, S.5    Elmore, L.W.6    Milstien, S.7    Spiegel, S.8
  • 113
    • 81755162053 scopus 로고    scopus 로고
    • Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration
    • Gao, P.; Smith, C. D. Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration. Mol. Cancer Res., 2011, 9(11), 1509-1519.
    • (2011) Mol. Cancer Res , vol.9 , Issue.11 , pp. 1509-1519
    • Gao, P.1    Smith, C.D.2
  • 115
    • 70249125866 scopus 로고    scopus 로고
    • Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
    • Weigert, A.; Schiffmann, S.; Sekar, D.; Ley, S.; Menrad, H.; Werno, C.; Grosch, S.; Geisslinger, G.; Brüne, B. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. Intl. J. Cancer, 2009, 125(9), 2114-2121.
    • (2009) Intl. J. Cancer , vol.125 , Issue.9 , pp. 2114-2121
    • Weigert, A.1    Schiffmann, S.2    Sekar, D.3    Ley, S.4    Menrad, H.5    Werno, C.6    Grosch, S.7    Geisslinger, G.8    Brüne, B.9
  • 116
    • 56549085199 scopus 로고    scopus 로고
    • Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner
    • Hofmann, L. P.; Ren, S.; Schwalm, S.; Pfeilschifter, J.; Huwiler, A. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biol. Chem., 2008, 389(11), 1399-1407.
    • (2008) Biol. Chem , vol.389 , Issue.11 , pp. 1399-1407
    • Hofmann, L.P.1    Ren, S.2    Schwalm, S.3    Pfeilschifter, J.4    Huwiler, A.5
  • 117
    • 68349093905 scopus 로고    scopus 로고
    • Regulation of macrophage function by sphingosine-1-phosphate
    • Weigert, A.; Weis, N.; Brune, B. Regulation of macrophage function by sphingosine-1-phosphate. Immunobiology, 2009, 214(9-10), 748-760.
    • (2009) Immunobiology , vol.214 , Issue.9-10 , pp. 748-760
    • Weigert, A.1    Weis, N.2    Brune, B.3
  • 119
  • 120
    • 12444323123 scopus 로고    scopus 로고
    • Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression
    • Bektas, M.; Jolly, P. S.; Muller, C.; Eberle, J.; Spiegel, S.; Geilen, CC. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene, 2005, 24(1), 178-187.
    • (2005) Oncogene , vol.24 , Issue.1 , pp. 178-187
    • Bektas, M.1    Jolly, P.S.2    Muller, C.3    Eberle, J.4    Spiegel, S.5    Geilen, C.C.6
  • 121
    • 15444373345 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate analogs as receptor antagonists
    • Davis, M. D.; Clemens, J. J.; Macdonald, T. L.; Lynch, K. R. Sphingosine-1-phosphate analogs as receptor antagonists. J. Biol. Chem., 2005, 280(11), 9833-9841.
    • (2005) J. Biol. Chem , vol.280 , Issue.11 , pp. 9833-9841
    • Davis, M.D.1    Clemens, J.J.2    Macdonald, T.L.3    Lynch, K.R.4
  • 125
    • 34249737950 scopus 로고    scopus 로고
    • Alterations of ceramide/sphingosine-1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
    • Baran, Y.; Salas, A.; Senkal, C. E.; Gunduz, U.; Bielawski, J.; Obeid, L. M.; Ogretmen, B. Alterations of ceramide/sphingosine-1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J. Biol. Chem., 2007, 282(15), 10922-10934.
    • (2007) J. Biol. Chem , vol.282 , Issue.15 , pp. 10922-10934
    • Baran, Y.1    Salas, A.2    Senkal, C.E.3    Gunduz, U.4    Bielawski, J.5    Obeid, L.M.6    Ogretmen, B.7
  • 128
    • 77954535502 scopus 로고    scopus 로고
    • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    • Tonelli, F.; Lim, K. G.; Loveridge, C.; Long, J.; Pitson, S. M.; Tigyi, G.; Bittman, R.; Pyne, S.; Pyne, N. J. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell. Signal., 2010, 22(10), 1536-1542.
    • (2010) Cell. Signal , vol.22 , Issue.10 , pp. 1536-1542
    • Tonelli, F.1    Lim, K.G.2    Loveridge, C.3    Long, J.4    Pitson, S.M.5    Tigyi, G.6    Bittman, R.7    Pyne, S.8    Pyne, N.J.9
  • 129
    • 70349333252 scopus 로고    scopus 로고
    • Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
    • Sukocheva, O.; Wang, L.; Verrier, E.; Vadas, M. A.; Xia, P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 2009, 150(10), 4484-449.
    • (2009) Endocrinology , vol.150 , Issue.10 , pp. 4484-4449
    • Sukocheva, O.1    Wang, L.2    Verrier, E.3    Vadas, M.A.4    Xia, P.5
  • 131
    • 84860724430 scopus 로고    scopus 로고
    • Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance
    • Antoon, J. W.; White, M. D.; Burow, M. E.; Beckman, B. S. Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance. Oncol. Rep., 2012, 27(6), 1779-1786.
    • (2012) Oncol. Rep , vol.27 , Issue.6 , pp. 1779-1786
    • Antoon, J.W.1    White, M.D.2    Burow, M.E.3    Beckman, B.S.4
  • 132
    • 84856038067 scopus 로고    scopus 로고
    • Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
    • Beljanski, V.; Knaak, C.; Zhuang, Y.; Smith, C. D. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs, 2011, 29(6), 1132-1142.
    • (2011) Invest New Drugs , vol.29 , Issue.6 , pp. 1132-1142
    • Beljanski, V.1    Knaak, C.2    Zhuang, Y.3    Smith, C.D.4
  • 133
    • 41249103991 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2
    • Anelli, V.; Gault, C. R.; Cheng, A. B.; Obeid, L. M. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J. Biol Chem., 2008, 283(6), 3365-3375.
    • (2008) J. Biol Chem , vol.283 , Issue.6 , pp. 3365-3375
    • Anelli, V.1    Gault, C.R.2    Cheng, A.B.3    Obeid, L.M.4
  • 134
    • 79960344288 scopus 로고    scopus 로고
    • Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1alpha inactivation in hypoxic PC-3 prostate cancer cells
    • Cho, S. Y.; Lee, H. J.; Jeong, S. J.; Kim, H. S.; Chen, C. Y.; Lee, E. O.; Kim, S. H. Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1alpha inactivation in hypoxic PC-3 prostate cancer cells. J. Pineal Res., 2011, 51(1), 87-93.
    • (2011) J. Pineal Res , vol.51 , Issue.1 , pp. 87-93
    • Cho, S.Y.1    Lee, H.J.2    Jeong, S.J.3    Kim, H.S.4    Chen, C.Y.5    Lee, E.O.6    Kim, S.H.7
  • 135
    • 62549143484 scopus 로고    scopus 로고
    • Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells
    • Schnitzer, S. E.; Weigert, A.; Zhou, J.; Brune, B. Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol. Cancer Res., 2009, 7(3), 393-401.
    • (2009) Mol. Cancer Res , vol.7 , Issue.3 , pp. 393-401
    • Schnitzer, S.E.1    Weigert, A.2    Zhou, J.3    Brune, B.4
  • 136
    • 70349246856 scopus 로고    scopus 로고
    • The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta
    • Herr, B.; Zhou, J.; Werno, C.; Menrad, H.; Namgaladze, D.; Weigert, A.; Dehne, N.; Brüne, B. The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta. Blood, 2009, 114(10), 2140-2148.
    • (2009) Blood , vol.114 , Issue.10 , pp. 2140-2148
    • Herr, B.1    Zhou, J.2    Werno, C.3    Menrad, H.4    Namgaladze, D.5    Weigert, A.6    Dehne, N.7    Brüne, B.8
  • 138
    • 9644252866 scopus 로고    scopus 로고
    • Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
    • Chae, S. S.; Paik, J. H.; Furneaux, H.; Hla, T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J. Clin. Invest., 2005, 114(8), 1082-1089.
    • (2005) J. Clin. Invest , vol.114 , Issue.8 , pp. 1082-1089
    • Chae, S.S.1    Paik, J.H.2    Furneaux, H.3    Hla, T.4
  • 142
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab, S. R.; Pereira, J. P.; Matloubian, M.; Xu, Y.; Huang, Y.; Cyster, J. G. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science, 2005, 309(5741), 1735-1739.
    • (2005) Science , vol.309 , Issue.5741 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5    Cyster, J.G.6
  • 144
    • 84857787578 scopus 로고    scopus 로고
    • Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection
    • Nunes, J.; Naymark, M.; Sauer, L.; Muhammad, A.; Keun, H.; Sturge, J.; Stebbing, J.; Waxman, J.; Pchejetski, D. Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. Br. J. Cancer., 2012, 106(5), 909-915.
    • (2012) Br. J. Cancer , vol.106 , Issue.5 , pp. 909-915
    • Nunes, J.1    Naymark, M.2    Sauer, L.3    Muhammad, A.4    Keun, H.5    Sturge, J.6    Stebbing, J.7    Waxman, J.8    Pchejetski, D.9
  • 146
    • 0030054341 scopus 로고    scopus 로고
    • N, N dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets
    • Yatomi, Y.; Ruan, F.; Megidish, T.; Toyokuni, T.; Hakomori, S.; Igarashi, Y. N, N dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry, 1996, 35(2), 626-633.
    • (1996) Biochemistry , vol.35 , Issue.2 , pp. 626-633
    • Yatomi, Y.1    Ruan, F.2    Megidish, T.3    Toyokuni, T.4    Hakomori, S.5    Igarashi, Y.6
  • 147
    • 0032530864 scopus 로고    scopus 로고
    • N, N dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide
    • Edsall, L. C.; Van Brocklyn, J. R.; Cuvillier, O.; Kleuser, B.; Spiegel, S. N, N dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry, 1998, 37(37), 12892-12898.
    • (1998) Biochemistry , vol.37 , Issue.37 , pp. 12892-12898
    • Edsall, L.C.1    Van Brocklyn, J.R.2    Cuvillier, O.3    Kleuser, B.4    Spiegel, S.5
  • 148
    • 0034283195 scopus 로고    scopus 로고
    • Human sphingosine kinase: Purification, molecular cloning and characterization of the native and recombinant enzymes
    • Pitson, S. M.; D'Andrea, R. J.; Vandeleur, L.; Moretti, P. A.; Xia, P.; Gamble, J. R.; Vadas, M. A.; Wattenberg, B. W. Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochem. J., 2000, 350 Pt 2, 429-441.
    • (2000) Biochem. J , vol.350 , pp. 429-441
    • Pitson, S.M.1    D'Andrea, R.J.2    Vandeleur, L.3    Moretti, P.A.4    Xia, P.5    Gamble, J.R.6    Vadas, M.A.7    Wattenberg, B.W.8
  • 149
    • 0036173656 scopus 로고    scopus 로고
    • Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c
    • Kono, K.; Sugiura, M.; Kohama, T. Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c. J. Antibiot. (Tokyo), 2002, 55(1), 99-103.
    • (2002) J. Antibiot. (Tokyo) , vol.55 , Issue.1 , pp. 99-103
    • Kono, K.1    Sugiura, M.2    Kohama, T.3
  • 150
    • 84874425286 scopus 로고    scopus 로고
    • The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stressdependent mechanism
    • Tonelli, F.; Alossaimi, M.; Williamson, L.; Tate, R. J.; Watson, D. G.; Chan, E.; Bittman, R.; Pyne, N. J.; Pyne, S. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stressdependent mechanism. Br. J. Pharmacol., 2013, 168(6), 1497-1505.
    • (2013) Br. J. Pharmacol , vol.168 , Issue.6 , pp. 1497-1505
    • Tonelli, F.1    Alossaimi, M.2    Williamson, L.3    Tate, R.J.4    Watson, D.G.5    Chan, E.6    Bittman, R.7    Pyne, N.J.8    Pyne, S.9
  • 151
    • 0025756765 scopus 로고
    • Cell membrane signaling as target in cancer therapy: Inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice
    • Endo, K.; Igarashi, Y.; Nisar, M.; Zhou, Q. H.; Hakomori, S. Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res., 1991, 51(6), 1613-1618.
    • (1991) Cancer Res , vol.51 , Issue.6 , pp. 1613-1618
    • Endo, K.1    Igarashi, Y.2    Nisar, M.3    Zhou, Q.H.4    Hakomori, S.5
  • 152
    • 0030004270 scopus 로고    scopus 로고
    • Sphingosine and its methylated derivative N, N-dimethylsphingosine(DMS) induce apoptosis in a variety of human cancer cell lines
    • Sweeney, E. A.; Sakakura, C.; Shirahama, T.; Masamune, A.; Ohta, H.; Hakomori, S.; Igarashi, Y. Sphingosine and its methylated derivative N, N-dimethylsphingosine(DMS) induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer, 1996, 66(3), 358-366.
    • (1996) Int. J. Cancer , vol.66 , Issue.3 , pp. 358-366
    • Sweeney, E.A.1    Sakakura, C.2    Shirahama, T.3    Masamune, A.4    Ohta, H.5    Hakomori, S.6    Igarashi, Y.7
  • 153
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • Olivera, A.; Kohama, T.; Edsall, L.; Nava, V.; Cuvillier, O.; Poulton, S.; Spiegel, S. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Bio., 1999, 147(3), 545-558.
    • (1999) J. Cell Bio , vol.147 , Issue.3 , pp. 545-558
    • Olivera, A.1    Kohama, T.2    Edsall, L.3    Nava, V.4    Cuvillier, O.5    Poulton, S.6    Spiegel, S.7
  • 154
    • 48449100702 scopus 로고    scopus 로고
    • Downregulating sphingosine kinase-1 for cancer therapy
    • Cuvillier, O. Downregulating sphingosine kinase-1 for cancer therapy. Expert Opin. Ther. Targets, 2008, 12(8), 1009-1020.
    • (2008) Expert Opin. Ther. Targets , vol.12 , Issue.8 , pp. 1009-1020
    • Cuvillier, O.1
  • 156
    • 30744469407 scopus 로고    scopus 로고
    • Dihydrosphingosine Iphosphate stimulates MMP1 gene expression via activation of ERK1/2-Etsl pathway in human fibroblasts
    • Bu, S.; Yamanaka, M.; Pei, H.; Bielawska, A.; Bielawski, J.; Hannun, Y. A.; Obeid, L.; Trojanowska, M. Dihydrosphingosine Iphosphate stimulates MMP1 gene expression via activation of ERK1/2-Etsl pathway in human fibroblasts. Faseb J., 2006, 20(1), 184-186.
    • (2006) Faseb J , vol.20 , Issue.1 , pp. 184-186
    • Bu, S.1    Yamanaka, M.2    Pei, H.3    Bielawska, A.4    Bielawski, J.5    Hannun, Y.A.6    Obeid, L.7    Trojanowska, M.8
  • 157
    • 0028818393 scopus 로고
    • Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
    • Sachs, C. W.; Safa, A. R.; Harrison, S. D.; Fine, R. L. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J. Biol. Chem., 1995, 270(44), 26639-26648.
    • (1995) J. Biol. Chem , vol.270 , Issue.44 , pp. 26639-26648
    • Sachs, C.W.1    Safa, A.R.2    Harrison, S.D.3    Fine, R.L.4
  • 159
    • 79954625512 scopus 로고    scopus 로고
    • A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors
    • Dickson, M. A.; Carvajal, R. D.; Merrill, A. H. Jr.; Gonen, M.; Cane, L. M.; Schwartz, G. K. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin. Cancer Res., 2011, 17(8), 2484-2492.
    • (2011) Clin. Cancer Res , vol.17 , Issue.8 , pp. 2484-2492
    • Dickson, M.A.1    Carvajal, R.D.2    Merrill, A.H.3    Gonen, M.4    Cane, L.M.5    Schwartz, G.K.6
  • 160
    • 35648995431 scopus 로고    scopus 로고
    • Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
    • Leroux, M. E.; Auzenne, E.; Evans, R.; Hail, N., Jr.; Spohn, W.; Ghosh, S. C.; Farquhar, D.; McDonnell, T.; Klostergaard, J. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. The Prostate, 2007, 67(5), 1699-1717.
    • (2007) The Prostate , vol.67 , Issue.5 , pp. 1699-1717
    • Leroux, M.E.1    Auzenne, E.2    Evans, R.3    Hail, N.4    Spohn, W.5    Ghosh, S.C.6    Farquhar, D.7    McDonnell, T.8    Klostergaard, J.9
  • 161
    • 78649876185 scopus 로고    scopus 로고
    • The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
    • Loveridge, C.; Tonelli, F.; Leclercq, T.; Lim, K. G.; Long, J. S., Berdyshev, E.; Tate, R. J.; Natarajan, V.; Pitson, S. M.; Pyne, N. J.; Pyne, S. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J. Biol. Chem., 2010, 285(50), 38841-3852.
    • (2010) J. Biol. Chem , vol.285 , Issue.50 , pp. 33852-38841
    • Loveridge, C.1    Tonelli, F.2    Leclercq, T.3    Lim, K.G.4    Long, J.S.5    Berdyshev, E.6    Tate, R.J.7    Natarajan, V.8    Pitson, S.M.9    Pyne, N.J.10    Pyne, S.11
  • 163
    • 84921756222 scopus 로고    scopus 로고
    • A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells
    • Li, P. H.; Wu, J. X.; Zheng, J. N.; Pei, D. S. A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells. Asian Pac. J. Cancer Prev., 2014, 15(23), 10381-10385.
    • (2014) Asian Pac. J. Cancer Prev , vol.15 , Issue.23 , pp. 10381-10385
    • Li, P.H.1    Wu, J.X.2    Zheng, J.N.3    Pei, D.S.4
  • 164
    • 84876800693 scopus 로고    scopus 로고
    • The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells
    • Zhang, C.; He, H.; Zhang, H.; Yu, D.; Zhao, W.; Chen, Y.; Shao, R. The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells. Biochem. Biophys. Res. Commun., 2013, 434(1), 35-41.
    • (2013) Biochem. Biophys. Res. Commun , vol.434 , Issue.1 , pp. 35-41
    • Zhang, C.1    He, H.2    Zhang, H.3    Yu, D.4    Zhao, W.5    Chen, Y.6    Shao, R.7
  • 165
    • 2442679391 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 downregulates sphingosine 1-phosphate G-protein-coupled receptors
    • Graler, M. H.; Goetzl, E. J. The immunosuppressant FTY720 downregulates sphingosine 1-phosphate G-protein-coupled receptors. Faseb J., 2004, 18(3), 551-553.
    • (2004) Faseb J , vol.18 , Issue.3 , pp. 551-553
    • Graler, M.H.1    Goetzl, E.J.2
  • 167
    • 0037051102 scopus 로고    scopus 로고
    • Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
    • Permpongkosol, S.; Wang, J. D.; Takahara, S.; Matsumiya, K.; Nonomura, N.; Nishimura, K.; Tsujimura, A.; Kongkanand, A.; Okuyama, A. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Intl. J. Cancer, 2002, 98(2), 167-172.
    • (2002) Intl. J. Cancer , vol.98 , Issue.2 , pp. 167-172
    • Permpongkosol, S.1    Wang, J.D.2    Takahara, S.3    Matsumiya, K.4    Nonomura, N.5    Nishimura, K.6    Tsujimura, A.7    Kongkanand, A.8    Okuyama, A.9
  • 168
    • 0033564177 scopus 로고    scopus 로고
    • Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
    • Wang, J. D.; Takahara, S.; Nonomura, N.; Ichimaru, N.; Toki, K.; Azuma, H.; Matsumiya, K.; Okuyama, A.; Suzuki, S. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. The Prostate, 1999, 40(1), 50-55.
    • (1999) The Prostate , vol.40 , Issue.1 , pp. 50-55
    • Wang, J.D.1    Takahara, S.2    Nonomura, N.3    Ichimaru, N.4    Toki, K.5    Azuma, H.6    Matsumiya, K.7    Okuyama, A.8    Suzuki, S.9
  • 171
    • 79959948518 scopus 로고    scopus 로고
    • FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells
    • Wallington-Beddoe, C. T.; Hewson, J.; Bradstock, K. F.; Bendall, L. J. FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy, 2011, 7(7), 707-715.
    • (2011) Autophagy , vol.7 , Issue.7 , pp. 707-715
    • Wallington-Beddoe, C.T.1    Hewson, J.2    Bradstock, K.F.3    Bendall, L.J.4
  • 173
    • 84859149451 scopus 로고    scopus 로고
    • FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: Is FTY720 the next autophagy-blocking agent in lymphoma treatment?
    • Alinari, L.; Baiocchi, R. A.; Praetorius-Ibba, M. FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment? Autophagy, 2012, 8(3), 416-417.
    • (2012) Autophagy , vol.8 , Issue.3 , pp. 416-417
    • Alinari, L.1    Baiocchi, R.A.2    Praetorius-Ibba, M.3
  • 177
  • 179
    • 33846864904 scopus 로고    scopus 로고
    • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
    • Payne, S. G.; Oskeritzian, C. A.; Griffiths, R.; Subramanian, P.; Barbour, S. E.; Chalfant, C.; Milstien, S.; Spiegel, S. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood, 2007, 109(83), 1077-1085.
    • (2007) Blood , vol.109 , Issue.83 , pp. 1077-1085
    • Payne, S.G.1    Oskeritzian, C.A.2    Griffiths, R.3    Subramanian, P.4    Barbour, S.E.5    Chalfant, C.6    Milstien, S.7    Spiegel, S.8
  • 180
    • 33644697587 scopus 로고    scopus 로고
    • Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
    • Ho, J. W.; Man, K.; Sun, C. K.; Lee, T. K.; Poon, R. T.; Fan, S. T. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol. Cancer Ther., 2005, 4(9), 1430-1438.
    • (2005) Mol. Cancer Ther , vol.4 , Issue.9 , pp. 1430-1438
    • Ho, J.W.1    Man, K.2    Sun, C.K.3    Lee, T.K.4    Poon, R.T.5    Fan, S.T.6
  • 184
    • 79957775905 scopus 로고    scopus 로고
    • Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells
    • Kennedy, A. J.; Mathews, T. P.; Kharel, Y.; Field, S. D.; Moyer, M. L.; East, J. E.; Houck, J. D.; Lynch, K. R.; Macdonald, T. L. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J. Med. Chem., 2011, 54(10), 3524-3548.
    • (2011) J. Med. Chem , vol.54 , Issue.10 , pp. 3524-3548
    • Kennedy, A.J.1    Mathews, T.P.2    Kharel, Y.3    Field, S.D.4    Moyer, M.L.5    East, J.E.6    Houck, J.D.7    Lynch, K.R.8    Macdonald, T.L.9
  • 185
    • 78449295649 scopus 로고    scopus 로고
    • Development of a Sphingosine Kinase 1 Specific Small-Molecule Inhibitor
    • Hengst, J.; Wang, X.; Sk, U.; Sharma, A.; Amin, S.; Yun, J. Development of a Sphingosine Kinase 1 Specific Small-Molecule Inhibitor. Bioorg. Med. Chem. Lett., 2010, 20(24), 7498-7502.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.24 , pp. 7498-7502
    • Hengst, J.1    Wang, X.2    Sk, U.3    Sharma, A.4    Amin, S.5    Yun, J.6
  • 186
    • 84907539523 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors
    • Vogt, D.; Weber, J.; Ihlefeld, K.; Brüggerhoff, A.; Proschak, E.; Stark, H. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg. Med. Chem., 2014, 22(19), 5354-5367.
    • (2014) Bioorg. Med. Chem , vol.22 , Issue.19 , pp. 5354-5367
    • Vogt, D.1    Weber, J.2    Ihlefeld, K.3    Brüggerhoff, A.4    Proschak, E.5    Stark, H.6
  • 187
    • 79955112221 scopus 로고    scopus 로고
    • Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247)
    • Sharma, A. K. Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247). Exp. Opin. Ther. Pat., 2011, 21(5), 807-812.
    • (2011) Exp. Opin. Ther. Pat , vol.21 , Issue.5 , pp. 807-812
    • Sharma, A.K.1
  • 189
    • 79960730615 scopus 로고    scopus 로고
    • (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
    • Lim, K. G.; Sun, C.; Bittman, R.; Pyne, N. J.; Pyne, S. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell. Signal., 2011, 23(10), 1590-1595.
    • (2011) Cell. Signal , vol.23 , Issue.10 , pp. 1590-1595
    • Lim, K.G.1    Sun, C.2    Bittman, R.3    Pyne, N.J.4    Pyne, S.5
  • 192
    • 77957770455 scopus 로고    scopus 로고
    • Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
    • Chumanevich, A. A.; Poudyal, D.; Cui, X.; Davis, T.; Wood, P. A.; Smith, C. D.; Hofseth, L. J. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis, 2010, 31(10), 1787-1793.
    • (2010) Carcinogenesis , vol.31 , Issue.10 , pp. 1787-1793
    • Chumanevich, A.A.1    Poudyal, D.2    Cui, X.3    Davis, T.4    Wood, P.A.5    Smith, C.D.6    Hofseth, L.J.7
  • 193
    • 84856038067 scopus 로고    scopus 로고
    • Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
    • Beljanski, V.; Knaak, C.; Zhuang, Y.; Smith, C. D. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest. New Drugs, 2011, 29(6), 1132-1142.
    • (2011) Invest. New Drugs , vol.29 , Issue.6 , pp. 1132-1142
    • Beljanski, V.1    Knaak, C.2    Zhuang, Y.3    Smith, C.D.4
  • 194
    • 79952343738 scopus 로고    scopus 로고
    • Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
    • Beljanski, V.; Lewis, C. S.; Smith, C. D. Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol. Ther. 2011, 11(5), 524-534.
    • (2011) Cancer Biol. Ther , vol.11 , Issue.5 , pp. 524-534
    • Beljanski, V.1    Lewis, C.S.2    Smith, C.D.3
  • 195
    • 84874670502 scopus 로고    scopus 로고
    • Characterization of isoenzyme-selective inhibitors of human sphingosine kinases
    • Gao, P.; Peterson, Y. K.; Smith, R. A.; Smith, C. D. Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One, 2012, 7(9), e44543.
    • (2012) PLoS One , vol.7 , Issue.9
    • Gao, P.1    Peterson, Y.K.2    Smith, R.A.3    Smith, C.D.4
  • 197
    • 84865331546 scopus 로고    scopus 로고
    • Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer
    • Antoon, J. W.; White, M. D.; Driver, J. L.; Burow, M. E.; Beckman, B. S. Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer. Exp. Biol. Med., 2012, 237(7), 832-844.
    • (2012) Exp. Biol. Med , vol.237 , Issue.7 , pp. 832-844
    • Antoon, J.W.1    White, M.D.2    Driver, J.L.3    Burow, M.E.4    Beckman, B.S.5
  • 198
    • 84899620852 scopus 로고    scopus 로고
    • Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival
    • Gestaut, M. M.; Antoon, J. W.; Burow, M. E.; Beckman, B. S. Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival. Pharmacol. Rep., 2014, 66(1), 174-178.
    • (2014) Pharmacol. Rep , vol.66 , Issue.1 , pp. 174-178
    • Gestaut, M.M.1    Antoon, J.W.2    Burow, M.E.3    Beckman, B.S.4
  • 199
    • 84866379271 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate
    • Kharel, Y.; Raje, M.; Gao, M.; Gellett, A. M.; Tomsig, J. L.; Lynch, K. R.; Santos, W. L. Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. Biochem. J., 2012, 447(1), 149-157.
    • (2012) Biochem. J , vol.447 , Issue.1 , pp. 149-157
    • Kharel, Y.1    Raje, M.2    Gao, M.3    Gellett, A.M.4    Tomsig, J.L.5    Lynch, K.R.6    Santos, W.L.7
  • 200
    • 33947147299 scopus 로고    scopus 로고
    • The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis
    • Olivera, A.; Mizugishi, K.; Tikhonova, A.; Ciaccia, L.; Odom, S.; Proia, R. L.; Rivera, J. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity, 2007, 26(3), 287-297.
    • (2007) Immunity , vol.26 , Issue.3 , pp. 287-297
    • Olivera, A.1    Mizugishi, K.2    Tikhonova, A.3    Ciaccia, L.4    Odom, S.5    Proia, R.L.6    Rivera, J.7
  • 202
    • 84855206931 scopus 로고    scopus 로고
    • Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors
    • Raje, M. R.; Knott, K.; Kharel.; Y, Bissel, P.; Lynch, K. R.; Santos, W. L. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorg. Med. Chem., 2012, 20(1), 183-194.
    • (2012) Bioorg. Med. Chem , vol.20 , Issue.1 , pp. 183-194
    • Raje, M.R.1    Knott, K.2    Kharel, Y.3    Bissel, P.4    Lynch, K.R.5    Santos, W.L.6
  • 203
    • 84874255475 scopus 로고    scopus 로고
    • Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2, 4-dione(K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent
    • Liu, K.; Guo, T. L.; Hait, N. C.; Allegood, J.; Parikh, H. I. Xu, W.; Kellogg, G. E.; Grant, S.; Spiegel, S.; Zhang, S. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2, 4-dione(K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One, 2013, 8(2), e56471.
    • (2013) PLoS One , vol.8 , Issue.2
    • Liu, K.1    Guo, T.L.2    Hait, N.C.3    Allegood, J.4    Parikh, H.I.5    Xu, W.6    Kellogg, G.E.7    Grant, S.8    Spiegel, S.9    Zhang, S.10
  • 206
    • 81355132801 scopus 로고    scopus 로고
    • Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation on of sphingosine kinase 2 and protein kinase D
    • Xiao, M.; Liu, Y. G.; Zou, F. Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation on of sphingosine kinase 2 and protein kinase D. Exp. Cell Res., 2012, 318(1), 43-52.
    • (2012) Exp. Cell Res , vol.318 , Issue.1 , pp. 43-52
    • Xiao, M.1    Liu, Y.G.2    Zou, F.3
  • 207
    • 84899415885 scopus 로고    scopus 로고
    • Sodium butyrate induces apoptosis of human colon cancer cells by modulating ERK and sphingosine kinase 2
    • Xiao, M.; Liu, Y. G.; Zou, M. C.; Zou, F. Sodium butyrate induces apoptosis of human colon cancer cells by modulating ERK and sphingosine kinase 2. Biomed. Environ. Sci., 2014, 27(3), 197-203.
    • (2014) Biomed. Environ. Sci , vol.27 , Issue.3 , pp. 197-203
    • Xiao, M.1    Liu, Y.G.2    Zou, M.C.3    Zou, F.4
  • 208
    • 84923853766 scopus 로고    scopus 로고
    • Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: Discovery of SphK 1 and 2 selective inhibitors
    • Feb 2
    • Patwardhan, N. N.; Morris, E.; Kharel, Y.; Raje, M.; Gao, M.; Tomsig, J.; Lynch, K. R.; Santos, W. L. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: Discovery of SphK 1 and 2 selective inhibitors. J. Med. Chem., 2015, Feb 2.
    • (2015) J. Med. Chem
    • Patwardhan, N.N.1    Morris, E.2    Kharel, Y.3    Raje, M.4    Gao, M.5    Tomsig, J.6    Lynch, K.R.7    Santos, W.L.8
  • 211
    • 84864797320 scopus 로고    scopus 로고
    • Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis
    • Ponnusamy, S.; Selvam, S. P.; Mehrotra, S.; Kawamori, T.; Snider, A. J.; Obeid, L. M.; Shao, Y.; Sabbadini, R.; Ogretmen, B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol. Med., 2012, 4(8), 761-775.
    • (2012) EMBO Mol. Med , vol.4 , Issue.8 , pp. 761-775
    • Ponnusamy, S.1    Selvam, S.P.2    Mehrotra, S.3    Kawamori, T.4    Snider, A.J.5    Obeid, L.M.6    Shao, Y.7    Sabbadini, R.8    Ogretmen, B.9


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