Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

Autophagy

Volumn 5, Issue 2, 2009, Pages 184-193

  Coward, Jesse ^a   Ambrosini, Grazia ^a   Musi, Elgilda ^a   Truman, Jean Philip ^a   Haimovitz Friedman, Adriana ^a   Allegood, Jeremy C ^b   Wang, Elaine ^b   Merrill Jr , Alfred H ^b   Schwartz, Gary K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Autophagy; L threo dihydrosphingosine; Phosphatidylinositol 3 kinase; PKC ; Safingol; Sphinganine

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; SAFINGOL;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; COLON CARCINOMA; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; SOLID TUMOR;

EID: 61649099040     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.2.7361     Document Type: Article

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