(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells

Cellular Signalling

Volumn 23, Issue 10, 2011, Pages 1590-1595

  Lim, Keng Gat ^a   Sun, Chaode ^b   Bittman, Robert ^b   Pyne, Nigel J ^a   Pyne, Susan ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Apoptosis; Breast cancer; FTY720 analogues; Kinetics; Sphingosine kinase 2

Indexed keywords

ACTIN; FINGOLIMOD METHYL ETHER; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL SURVIVAL; DNA SYNTHESIS INHIBITION; DRUG EFFECT; DRUG SPECIFICITY; DRUG SYNTHESIS; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOSPECIFICITY;

ACTINS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MEMBRANE; ENZYME ASSAYS; FEMALE; HEK293 CELLS; HUMANS; LYSOPHOSPHOLIPIDS; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; PSEUDOPODIA; SPHINGOSINE;

EID: 79960730615     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.05.010     Document Type: Article

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