Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Guan, Hongyu ^a   Song, Libing ^b   Cai, Junchao ^c,d   Huang, Yongbo ^c,d   Wu, Jueheng ^c,d   Yuan, Jie ^c   Li, Jun ^c,d   Li, Mengfeng ^c,d  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; ANTINEOPLASTIC AGENT; BIM PROTEIN; EPIRUBICIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MCL 1; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; FOXO3 PROTEIN, MOUSE; LUCIFERASE; MEMBRANE PROTEIN; MESSENGER RNA; ONCOPROTEIN; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; BRAIN TUMOR; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; BRAIN NEOPLASMS; FORKHEAD TRANSCRIPTION FACTORS; GLIOMA; HUMANS; IMMUNOENZYME TECHNIQUES; LUCIFERASES; MEMBRANE PROTEINS; MICE; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 79956188245     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019946     Document Type: Article

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