-
1
-
-
84859149451
-
FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?
-
amp; ()
-
Alinari, L., Baiocchi, R.A. & Praetorius-Ibba, M. (2012) FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment? Autophagy, 8, 416-417.
-
(2012)
Autophagy
, vol.8
, pp. 416-417
-
-
Alinari, L.1
Baiocchi, R.A.2
Praetorius-Ibba, M.3
-
2
-
-
77952309720
-
S1P1 receptor directs the release of immature B cells from bone marrow into blood
-
Allende, M.L., Tuymetova, G., Lee, B.G., Bonifacino, E., Wu, Y.P. & Proia, R.L. (2010) S1P1 receptor directs the release of immature B cells from bone marrow into blood. Journal of Experimental Medicine, 207, 1113-1124.
-
(2010)
Journal of Experimental Medicine
, vol.207
, pp. 1113-1124
-
-
Allende, M.L.1
Tuymetova, G.2
Lee, B.G.3
Bonifacino, E.4
Wu, Y.P.5
Proia, R.L.6
-
3
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez, S.E., Harikumar, K.B., Hait, N.C., Allegood, J., Strub, G.M., Kim, E.Y., Maceyka, M., Jiang, H., Luo, C., Kordula, T., Milstien, S. & Spiegel, S. (2010) Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature, 465, 1084-1088.
-
(2010)
Nature
, vol.465
, pp. 1084-1088
-
-
Alvarez, S.E.1
Harikumar, K.B.2
Hait, N.C.3
Allegood, J.4
Strub, G.M.5
Kim, E.Y.6
Maceyka, M.7
Jiang, H.8
Luo, C.9
Kordula, T.10
Milstien, S.11
Spiegel, S.12
-
4
-
-
78049490720
-
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640
-
Antoon, J.W., White, M.D., Meacham, W.D., Slaughter, E.M., Muir, S.E., Elliott, S., Rhodes, L.V., Ashe, H.B., Wiese, T.E., Smith, C.D., Burow, M.E. & Beckman, B.S. (2010) Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology, 151, 5124-5135.
-
(2010)
Endocrinology
, vol.151
, pp. 5124-5135
-
-
Antoon, J.W.1
White, M.D.2
Meacham, W.D.3
Slaughter, E.M.4
Muir, S.E.5
Elliott, S.6
Rhodes, L.V.7
Ashe, H.B.8
Wiese, T.E.9
Smith, C.D.10
Burow, M.E.11
Beckman, B.S.12
-
5
-
-
79953314461
-
Targeting NFkB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2
-
Antoon, J.W., White, M.D., Slaughter, E.M., Driver, J.L., Khalili, H.S., Elliott, S., Smith, C.D., Burow, M.E. & Beckman, B.S. (2011a) Targeting NFkB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biology & Therapy, 11, 678-689.
-
(2011)
Cancer Biology & Therapy
, vol.11
, pp. 678-689
-
-
Antoon, J.W.1
White, M.D.2
Slaughter, E.M.3
Driver, J.L.4
Khalili, H.S.5
Elliott, S.6
Smith, C.D.7
Burow, M.E.8
Beckman, B.S.9
-
6
-
-
79959498910
-
Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer
-
Antoon, J.W., Meacham, W.D., Bratton, M.R., Slaughter, E.M., Rhodes, L.V., Ashe, H.B., Wiese, T.E., Burow, M.E. & Beckman, B.S. (2011b) Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer. Journal of Molecular Endocrinology, 46, 205-216.
-
(2011)
Journal of Molecular Endocrinology
, vol.46
, pp. 205-216
-
-
Antoon, J.W.1
Meacham, W.D.2
Bratton, M.R.3
Slaughter, E.M.4
Rhodes, L.V.5
Ashe, H.B.6
Wiese, T.E.7
Burow, M.E.8
Beckman, B.S.9
-
7
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma, H., Takahara, S., Ichimaru, N., Wang, J.D., Itoh, Y., Otsuki, Y., Morimoto, J., Fukui, R., Hoshiga, M., Ishihara, T., Nonomura, N., Suzuki, S., Okuyama, A. & Katsuoka, Y. (2002) Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Research, 62, 1410-1419.
-
(2002)
Cancer Research
, vol.62
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
Wang, J.D.4
Itoh, Y.5
Otsuki, Y.6
Morimoto, J.7
Fukui, R.8
Hoshiga, M.9
Ishihara, T.10
Nonomura, N.11
Suzuki, S.12
Okuyama, A.13
Katsuoka, Y.14
-
8
-
-
0038286415
-
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
-
Azuma, H., Takahara, S., Horie, S., Muto, S., Otsuki, Y. & Katsuoka, Y. (2003) Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. Journal of Urology, 169, 2372-2377.
-
(2003)
Journal of Urology
, vol.169
, pp. 2372-2377
-
-
Azuma, H.1
Takahara, S.2
Horie, S.3
Muto, S.4
Otsuki, Y.5
Katsuoka, Y.6
-
9
-
-
34247617182
-
Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
-
Bandhuvula, P. & Saba, J.D. (2007) Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends in Molecular Medicine, 13, 210-217.
-
(2007)
Trends in Molecular Medicine
, vol.13
, pp. 210-217
-
-
Bandhuvula, P.1
Saba, J.D.2
-
10
-
-
26644434393
-
The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity
-
Bandhuvula, P., Tam, Y.Y., Oskouian, B. & Saba, J.D. (2005) The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. Journal of Biological Chemistry, 280, 33697-33700.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 33697-33700
-
-
Bandhuvula, P.1
Tam, Y.Y.2
Oskouian, B.3
Saba, J.D.4
-
11
-
-
77954591796
-
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4
-
Bankovich, A.J., Shiow, L.R. & Cyster, J.G. (2010) CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. Journal of Biological Chemistry, 285, 22328-22337.
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 22328-22337
-
-
Bankovich, A.J.1
Shiow, L.R.2
Cyster, J.G.3
-
12
-
-
34249737950
-
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
-
Baran, Y., Salas, A., Senkal, C.E., Gunduz, U., Bielawski, J., Obeid, L.M. & Ogretmen, B. (2007) Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. Journal of Biological Chemistry, 282, 10922-10934.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 10922-10934
-
-
Baran, Y.1
Salas, A.2
Senkal, C.E.3
Gunduz, U.4
Bielawski, J.5
Obeid, L.M.6
Ogretmen, B.7
-
13
-
-
58049199390
-
Deactivation of sphingosine kinase 1 by protein phosphatase 2A
-
Barr, R.K., Lynn, H.E., Moretti, P.A., Khew-Goodall, Y. & Pitson, S.M. (2008) Deactivation of sphingosine kinase 1 by protein phosphatase 2A. Journal of Biological Chemistry, 283, 34994-35002.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 34994-35002
-
-
Barr, R.K.1
Lynn, H.E.2
Moretti, P.A.3
Khew-Goodall, Y.4
Pitson, S.M.5
-
14
-
-
1442265704
-
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
-
Baudhuin, L.M., Jiang, Y., Zaslavsky, A., Ishii, I., Chun, J. & Xu, Y. (2004) S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB Journal, 18, 341-343.
-
(2004)
FASEB Journal
, vol.18
, pp. 341-343
-
-
Baudhuin, L.M.1
Jiang, Y.2
Zaslavsky, A.3
Ishii, I.4
Chun, J.5
Xu, Y.6
-
15
-
-
46749153415
-
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions
-
Bayerl, M.G., Bruggeman, R.D., Conroy, E.J., Hengst, J.A., King, T.S., Jimenez, M., Claxton, D.F. & Yun, J.K. (2008) Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leukaemia & Lymphoma, 49, 948-954.
-
(2008)
Leukaemia & Lymphoma
, vol.49
, pp. 948-954
-
-
Bayerl, M.G.1
Bruggeman, R.D.2
Conroy, E.J.3
Hengst, J.A.4
King, T.S.5
Jimenez, M.6
Claxton, D.F.7
Yun, J.K.8
-
16
-
-
77951085269
-
A novel sphingosine kinase inhibitor induces autophagy in tumor cells
-
Beljanski, V., Knaak, C. & Smith, C.D. (2010) A novel sphingosine kinase inhibitor induces autophagy in tumor cells. Journal of Pharmacology and Experimental Therapeutics, 333, 454-464.
-
(2010)
Journal of Pharmacology and Experimental Therapeutics
, vol.333
, pp. 454-464
-
-
Beljanski, V.1
Knaak, C.2
Smith, C.D.3
-
17
-
-
79952343738
-
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
-
Beljanski, V., Lewis, C.S. & Smith, C.D. (2011) Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biology & Therapy, 11, 524-534.
-
(2011)
Cancer Biology & Therapy
, vol.11
, pp. 524-534
-
-
Beljanski, V.1
Lewis, C.S.2
Smith, C.D.3
-
18
-
-
26944440907
-
Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival
-
Bergom, C., Gao, C. & Newman, P.J. (2005) Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival. Leukaemia & Lymphoma, 46, 1409-1421.
-
(2005)
Leukaemia & Lymphoma
, vol.46
, pp. 1409-1421
-
-
Bergom, C.1
Gao, C.2
Newman, P.J.3
-
19
-
-
0347481389
-
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases
-
Billich, A., Bornancin, F., Devay, P., Mechtcheriakova, D., Urtz, N. & Baumruker, T. (2003) Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. Journal of Biological Chemistry, 278, 47408-47415.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 47408-47415
-
-
Billich, A.1
Bornancin, F.2
Devay, P.3
Mechtcheriakova, D.4
Urtz, N.5
Baumruker, T.6
-
20
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure, E., Pchejetski, D., Aouali, N., Morjani, H., Levade, T., Kohama, T. & Cuvillier, O. (2006) Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia, 20, 95-102.
-
(2006)
Leukemia
, vol.20
, pp. 95-102
-
-
Bonhoure, E.1
Pchejetski, D.2
Aouali, N.3
Morjani, H.4
Levade, T.5
Kohama, T.6
Cuvillier, O.7
-
21
-
-
43749123266
-
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells
-
Bonhoure, E., Lauret, A., Barnes, D.J., Martin, C., Malavaud, B., Kohama, T., Melo, J.V. & Cuvillier, O. (2008) Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. Leukemia, 22, 971-979.
-
(2008)
Leukemia
, vol.22
, pp. 971-979
-
-
Bonhoure, E.1
Lauret, A.2
Barnes, D.J.3
Martin, C.4
Malavaud, B.5
Kohama, T.6
Melo, J.V.7
Cuvillier, O.8
-
22
-
-
14844284989
-
Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer
-
Brindley, D.N. (2004) Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. Journal of Cellular Biochemistry, 92, 900-912.
-
(2004)
Journal of Cellular Biochemistry
, vol.92
, pp. 900-912
-
-
Brindley, D.N.1
-
23
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann, V., Davis, M.D., Heise, C.E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P., Foster, C.A., Zollinger, M. & Lynch, K.R. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry, 277, 21453-21457.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
24
-
-
0030592536
-
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity
-
Buehrer, B.M., Bardes, E.S. & Bell, R.M. (1996) Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity. Biochimica et Biophysica Acta, 1303, 233-242.
-
(1996)
Biochimica et Biophysica Acta
, vol.1303
, pp. 233-242
-
-
Buehrer, B.M.1
Bardes, E.S.2
Bell, R.M.3
-
25
-
-
84872468446
-
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins
-
Casson, L., Howell, L., Mathews, L.A., Ferrer, M., Southall, N., Guha, R., Keller, J.M., Thomas, C., Siskind, L.J. & Beverly, L.J. (2013) Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS ONE, 8, e54525.
-
(2013)
PLoS ONE
, vol.8
-
-
Casson, L.1
Howell, L.2
Mathews, L.A.3
Ferrer, M.4
Southall, N.5
Guha, R.6
Keller, J.M.7
Thomas, C.8
Siskind, L.J.9
Beverly, L.J.10
-
26
-
-
72249096210
-
Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
-
Cattoretti, G., Mandelbaum, J., Lee, N., Chaves, A.H., Mahler, A.M., Chadburn, A., Dalla-Favera, R., Pasqualucci, L. & MacLennan, A.J. (2009) Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Research, 69, 8686-8692.
-
(2009)
Cancer Research
, vol.69
, pp. 8686-8692
-
-
Cattoretti, G.1
Mandelbaum, J.2
Lee, N.3
Chaves, A.H.4
Mahler, A.M.5
Chadburn, A.6
Dalla-Favera, R.7
Pasqualucci, L.8
MacLennan, A.J.9
-
27
-
-
68849112045
-
S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells
-
Chang, C.L., Ho, M.C., Lee, P.H., Hsu, C.Y., Huang, W.P. & Lee, H. (2009) S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. American Journal of Physiology. Cell Physiology, 297, C451-C458.
-
(2009)
American Journal of Physiology. Cell Physiology
, vol.297
-
-
Chang, C.L.1
Ho, M.C.2
Lee, P.H.3
Hsu, C.Y.4
Huang, W.P.5
Lee, H.6
-
28
-
-
33745124738
-
Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus
-
Chiba, K., Matsuyuki, H., Maeda, Y. & Sugahara, K. (2006) Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cellular & Molecular Immunology, 3, 11-19.
-
(2006)
Cellular & Molecular Immunology
, vol.3
, pp. 11-19
-
-
Chiba, K.1
Matsuyuki, H.2
Maeda, Y.3
Sugahara, K.4
-
29
-
-
28044460091
-
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
-
Chua, C.W., Lee, D.T., Ling, M.T., Zhou, C., Man, K., Ho, J., Chan, F.L., Wang, X. & Wong, Y.C. (2005) FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. International Journal of Cancer, 117, 1039-1048.
-
(2005)
International Journal of Cancer
, vol.117
, pp. 1039-1048
-
-
Chua, C.W.1
Lee, D.T.2
Ling, M.T.3
Zhou, C.4
Man, K.5
Ho, J.6
Chan, F.L.7
Wang, X.8
Wong, Y.C.9
-
30
-
-
37349013401
-
Follicular shuttling of marginal zone B cells facilitates antigen transport
-
Cinamon, G., Zachariah, M.A., Lam, O.M., Foss, F.W. Jr & Cyster, J.G. (2008) Follicular shuttling of marginal zone B cells facilitates antigen transport. Nature Immunology, 9, 54-62.
-
(2008)
Nature Immunology
, vol.9
, pp. 54-62
-
-
Cinamon, G.1
Zachariah, M.A.2
Lam, O.M.3
Foss Jr, F.W.4
Cyster, J.G.5
-
31
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen, J.A., Barkhof, F., Comi, G., Hartung, H.P., Khatri, B.O., Montalban, X., Pelletier, J., Capra, R., Gallo, P., Izquierdo, G., Tiel-Wilck, K., de Vera, A., Jin, J., Stites, T., Wu, S., Aradhye, S. & Kappos, L. (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. New England Journal of Medicine, 362, 402-415.
-
(2010)
New England Journal of Medicine
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
Hartung, H.P.4
Khatri, B.O.5
Montalban, X.6
Pelletier, J.7
Capra, R.8
Gallo, P.9
Izquierdo, G.10
Tiel-Wilck, K.11
de Vera, A.12
Jin, J.13
Stites, T.14
Wu, S.15
Aradhye, S.16
Kappos, L.17
-
32
-
-
33845692736
-
Sphingosine kinase-1-a potential therapeutic target in cancer
-
Cuvillier, O. (2007) Sphingosine kinase-1-a potential therapeutic target in cancer. Anti-Cancer Drugs, 18, 105-110.
-
(2007)
Anti-Cancer Drugs
, vol.18
, pp. 105-110
-
-
Cuvillier, O.1
-
33
-
-
0035525748
-
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier, O. & Levade, T. (2001) Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood, 98, 2828-2836.
-
(2001)
Blood
, vol.98
, pp. 2828-2836
-
-
Cuvillier, O.1
Levade, T.2
-
34
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P.G., Coso, O.A., Gutkind, S. & Spiegel, S. (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 381, 800-803.
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
35
-
-
77953507105
-
The future of CD20 monoclonal antibody therapy in B-cell malignancies
-
Czuczman, M.S. & Gregory, S.A. (2010) The future of CD20 monoclonal antibody therapy in B-cell malignancies. Leukaemia & Lymphoma, 51, 983-994.
-
(2010)
Leukaemia & Lymphoma
, vol.51
, pp. 983-994
-
-
Czuczman, M.S.1
Gregory, S.A.2
-
36
-
-
15444373345
-
Sphingosine 1-phosphate analogs as receptor antagonists
-
Davis, M.D., Clemens, J.J., Macdonald, T.L. & Lynch, K.R. (2005) Sphingosine 1-phosphate analogs as receptor antagonists. Journal of Biological Chemistry, 280, 9833-9841.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 9833-9841
-
-
Davis, M.D.1
Clemens, J.J.2
Macdonald, T.L.3
Lynch, K.R.4
-
37
-
-
34848867249
-
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2
-
Ding, G., Sonoda, H., Yu, H., Kajimoto, T., Goparaju, S.K., Jahangeer, S., Okada, T. & Nakamura, S. (2007) Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. Journal of Biological Chemistry, 282, 27493-27502.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 27493-27502
-
-
Ding, G.1
Sonoda, H.2
Yu, H.3
Kajimoto, T.4
Goparaju, S.K.5
Jahangeer, S.6
Okada, T.7
Nakamura, S.8
-
38
-
-
77749245824
-
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development
-
Donovan, E.E., Pelanda, R. & Torres, R.M. (2010) S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. European Journal of Immunology, 40, 688-698.
-
(2010)
European Journal of Immunology
, vol.40
, pp. 688-698
-
-
Donovan, E.E.1
Pelanda, R.2
Torres, R.M.3
-
39
-
-
53949121846
-
Systemic cancer therapy: evolution over the last 60 years
-
Dy, G.K. & Adjei, A.A. (2008) Systemic cancer therapy: evolution over the last 60 years. Cancer, 113, 1857-1887.
-
(2008)
Cancer
, vol.113
, pp. 1857-1887
-
-
Dy, G.K.1
Adjei, A.A.2
-
40
-
-
0034652159
-
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
-
Era, T. & Witte, O.N. (2000) Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate. Proceedings of the National Academy of Sciences of the United States of America, 97, 1737-1742.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 1737-1742
-
-
Era, T.1
Witte, O.N.2
-
41
-
-
77957957189
-
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation
-
Feng, H., Stachura, D.L., White, R.M., Gutierrez, A., Zhang, L., Sanda, T., Jette, C.A., Testa, J.R., Neuberg, D.S., Langenau, D.M., Kutok, J.L., Zon, L.I., Traver, D., Fleming, M.D., Kanki, J.P. & Look, A.T. (2010) T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell, 18, 353-366.
-
(2010)
Cancer Cell
, vol.18
, pp. 353-366
-
-
Feng, H.1
Stachura, D.L.2
White, R.M.3
Gutierrez, A.4
Zhang, L.5
Sanda, T.6
Jette, C.A.7
Testa, J.R.8
Neuberg, D.S.9
Langenau, D.M.10
Kutok, J.L.11
Zon, L.I.12
Traver, D.13
Fleming, M.D.14
Kanki, J.P.15
Look, A.T.16
-
42
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French, K.J., Schrecengost, R.S., Lee, B.D., Zhuang, Y., Smith, S.N., Eberly, J.L., Yun, J.K. & Smith, C.D. (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Research, 63, 5962-5969.
-
(2003)
Cancer Research
, vol.63
, pp. 5962-5969
-
-
French, K.J.1
Schrecengost, R.S.2
Lee, B.D.3
Zhuang, Y.4
Smith, S.N.5
Eberly, J.L.6
Yun, J.K.7
Smith, C.D.8
-
43
-
-
33745964562
-
Antitumor activity of sphingosine kinase inhibitors
-
French, K.J., Upson, J.J., Keller, S.N., Zhuang, Y., Yun, J.K. & Smith, C.D. (2006) Antitumor activity of sphingosine kinase inhibitors. Journal of Pharmacology and Experimental Therapeutics, 318, 596-603.
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.318
, pp. 596-603
-
-
French, K.J.1
Upson, J.J.2
Keller, S.N.3
Zhuang, Y.4
Yun, J.K.5
Smith, C.D.6
-
44
-
-
77949748845
-
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2
-
French, K.J., Zhuang, Y., Maines, L.W., Gao, P., Wang, W., Beljanski, V., Upson, J.J., Green, C.L., Keller, S.N. & Smith, C.D. (2010) Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. Journal of Pharmacology and Experimental Therapeutics, 333, 129-139.
-
(2010)
Journal of Pharmacology and Experimental Therapeutics
, vol.333
, pp. 129-139
-
-
French, K.J.1
Zhuang, Y.2
Maines, L.W.3
Gao, P.4
Wang, W.5
Beljanski, V.6
Upson, J.J.7
Green, C.L.8
Keller, S.N.9
Smith, C.D.10
-
45
-
-
84859727262
-
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
-
Fukuhara, S., Simmons, S., Kawamura, S., Inoue, A., Orba, Y., Tokudome, T., Sunden, Y., Arai, Y., Moriwaki, K., Ishida, J., Uemura, A., Kiyonari, H., Abe, T., Fukamizu, A., Hirashima, M., Sawa, H., Aoki, J., Ishii, M. & Mochizuki, N. (2012) The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. Journal of Clinical Investigation, 122, 1416-1426.
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 1416-1426
-
-
Fukuhara, S.1
Simmons, S.2
Kawamura, S.3
Inoue, A.4
Orba, Y.5
Tokudome, T.6
Sunden, Y.7
Arai, Y.8
Moriwaki, K.9
Ishida, J.10
Uemura, A.11
Kiyonari, H.12
Abe, T.13
Fukamizu, A.14
Hirashima, M.15
Sawa, H.16
Aoki, J.17
Ishii, M.18
Mochizuki, N.19
-
46
-
-
84874670502
-
Characterization of isoenzyme-selective inhibitors of human sphingosine kinases
-
Gao, P., Peterson, Y.K., Smith, R.A. & Smith, C.D. (2012) Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS ONE, 7, e44543.
-
(2012)
PLoS ONE
, vol.7
-
-
Gao, P.1
Peterson, Y.K.2
Smith, R.A.3
Smith, C.D.4
-
47
-
-
84866372484
-
Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner
-
Gault, C.R., Eblen, S.T., Neumann, C.A., Hannun, Y.A. & Obeid, L.M. (2012) Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. Journal of Biological Chemistry, 287, 31794-31803.
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 31794-31803
-
-
Gault, C.R.1
Eblen, S.T.2
Neumann, C.A.3
Hannun, Y.A.4
Obeid, L.M.5
-
48
-
-
84863338623
-
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release
-
Golan, K., Vagima, Y., Ludin, A., Itkin, T., Cohen-Gur, S., Kalinkovich, A., Kollet, O., Kim, C., Schajnovitz, A., Ovadya, Y., Lapid, K., Shivtiel, S., Morris, A.J., Ratajczak, M.Z. & Lapidot, T. (2012) S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood, 119, 2478-2488.
-
(2012)
Blood
, vol.119
, pp. 2478-2488
-
-
Golan, K.1
Vagima, Y.2
Ludin, A.3
Itkin, T.4
Cohen-Gur, S.5
Kalinkovich, A.6
Kollet, O.7
Kim, C.8
Schajnovitz, A.9
Ovadya, Y.10
Lapid, K.11
Shivtiel, S.12
Morris, A.J.13
Ratajczak, M.Z.14
Lapidot, T.15
-
49
-
-
78649740029
-
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4
-
Golfier, S., Kondo, S., Schulze, T., Takeuchi, T., Vassileva, G., Achtman, A.H., Graler, M.H., Abbondanzo, S.J., Wiekowski, M., Kremmer, E., Endo, Y., Lira, S.A., Bacon, K.B. & Lipp, M. (2010) Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4. FASEB Journal, 24, 4701-4710.
-
(2010)
FASEB Journal
, vol.24
, pp. 4701-4710
-
-
Golfier, S.1
Kondo, S.2
Schulze, T.3
Takeuchi, T.4
Vassileva, G.5
Achtman, A.H.6
Graler, M.H.7
Abbondanzo, S.J.8
Wiekowski, M.9
Kremmer, E.10
Endo, Y.11
Lira, S.A.12
Bacon, K.B.13
Lipp, M.14
-
50
-
-
66449134500
-
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug
-
Guillermet-Guibert, J., Davenne, L., Pchejetski, D., Saint-Laurent, N., Brizuela, L., Guilbeau-Frugier, C., Delisle, M.B., Cuvillier, O., Susini, C. & Bousquet, C. (2009) Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug. Molecular Cancer Therapeutics, 8, 809-820.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, pp. 809-820
-
-
Guillermet-Guibert, J.1
Davenne, L.2
Pchejetski, D.3
Saint-Laurent, N.4
Brizuela, L.5
Guilbeau-Frugier, C.6
Delisle, M.B.7
Cuvillier, O.8
Susini, C.9
Bousquet, C.10
-
51
-
-
34249656324
-
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation
-
Hait, N.C., Bellamy, A., Milstien, S., Kordula, T. & Spiegel, S. (2007) Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. Journal of Biological Chemistry, 282, 12058-12065.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 12058-12065
-
-
Hait, N.C.1
Bellamy, A.2
Milstien, S.3
Kordula, T.4
Spiegel, S.5
-
52
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait, N.C., Allegood, J., Maceyka, M., Strub, G.M., Harikumar, K.B., Singh, S.K., Luo, C., Marmorstein, R., Kordula, T., Milstien, S. & Spiegel, S. (2009) Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science, 325, 1254-1257.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
53
-
-
33947634013
-
Erythrocytes store and release sphingosine 1-phosphate in blood
-
Hanel, P., Andreani, P. & Graler, M.H. (2007) Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB Journal, 21, 1202-1209.
-
(2007)
FASEB Journal
, vol.21
, pp. 1202-1209
-
-
Hanel, P.1
Andreani, P.2
Graler, M.H.3
-
54
-
-
38549152194
-
Principles of bioactive lipid signalling: lessons from sphingolipids
-
Hannun, Y.A. & Obeid, L.M. (2008) Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Reviews Molecular Cell Biology, 9, 139-150.
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
55
-
-
33644697587
-
Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
-
Ho, J.W., Man, K., Sun, C.K., Lee, T.K., Poon, R.T. & Fan, S.T. (2005) Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Molecular Cancer Therapeutics, 4, 1430-1438.
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, pp. 1430-1438
-
-
Ho, J.W.1
Man, K.2
Sun, C.K.3
Lee, T.K.4
Poon, R.T.5
Fan, S.T.6
-
56
-
-
56549085199
-
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner
-
Hofmann, L.P., Ren, S., Schwalm, S., Pfeilschifter, J. & Huwiler, A. (2008) Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biological Chemistry, 389, 1399-1407.
-
(2008)
Biological Chemistry
, vol.389
, pp. 1399-1407
-
-
Hofmann, L.P.1
Ren, S.2
Schwalm, S.3
Pfeilschifter, J.4
Huwiler, A.5
-
57
-
-
39449103924
-
FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling
-
Hung, J.H., Lu, Y.S., Wang, Y.C., Ma, Y.H., Wang, D.S., Kulp, S.K., Muthusamy, N., Byrd, J.C., Cheng, A.L. & Chen, C.S. (2008) FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research, 68, 1204-1212.
-
(2008)
Cancer Research
, vol.68
, pp. 1204-1212
-
-
Hung, J.H.1
Lu, Y.S.2
Wang, Y.C.3
Ma, Y.H.4
Wang, D.S.5
Kulp, S.K.6
Muthusamy, N.7
Byrd, J.C.8
Cheng, A.L.9
Chen, C.S.10
-
58
-
-
33751541195
-
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy
-
Huwiler, A. & Pfeilschifter, J. (2006) Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. Current Pharmaceutical Design, 12, 4625-4635.
-
(2006)
Current Pharmaceutical Design
, vol.12
, pp. 4625-4635
-
-
Huwiler, A.1
Pfeilschifter, J.2
-
59
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
Igarashi, N., Okada, T., Hayashi, S., Fujita, T., Jahangeer, S. & Nakamura, S. (2003) Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. Journal of Biological Chemistry, 278, 46832-46839.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 46832-46839
-
-
Igarashi, N.1
Okada, T.2
Hayashi, S.3
Fujita, T.4
Jahangeer, S.5
Nakamura, S.6
-
60
-
-
58149174085
-
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury
-
Jo, S.K., Bajwa, A., Ye, H., Vergis, A.L., Awad, A.S., Kharel, Y., Lynch, K.R. & Okusa, M.D. (2009) Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney International, 75, 167-175.
-
(2009)
Kidney International
, vol.75
, pp. 167-175
-
-
Jo, S.K.1
Bajwa, A.2
Ye, H.3
Vergis, A.L.4
Awad, A.S.5
Kharel, Y.6
Lynch, K.R.7
Okusa, M.D.8
-
61
-
-
24344501665
-
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue
-
Johnson, K.R., Johnson, K.Y., Crellin, H.G., Ogretmen, B., Boylan, A.M., Harley, R.A. & Obeid, L.M. (2005) Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. Journal of Histochemistry and Cytochemistry, 53, 1159-1166.
-
(2005)
Journal of Histochemistry and Cytochemistry
, vol.53
, pp. 1159-1166
-
-
Johnson, K.R.1
Johnson, K.Y.2
Crellin, H.G.3
Ogretmen, B.4
Boylan, A.M.5
Harley, R.A.6
Obeid, L.M.7
-
62
-
-
84856077778
-
Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice
-
Juarez, J.G., Harun, N., Thien, M., Welschinger, R., Baraz, R., Dela Pena, A., Pitson, S.M., Rettig, M., Dipersio, J.F., Bradstock, K.F. & Bendall, L.J. (2012) Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood, 119, 707-716.
-
(2012)
Blood
, vol.119
, pp. 707-716
-
-
Juarez, J.G.1
Harun, N.2
Thien, M.3
Welschinger, R.4
Baraz, R.5
Dela Pena, A.6
Pitson, S.M.7
Rettig, M.8
Dipersio, J.F.9
Bradstock, K.F.10
Bendall, L.J.11
-
63
-
-
33751530065
-
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
-
Kabashima, K., Haynes, N.M., Xu, Y., Nutt, S.L., Allende, M.L., Proia, R.L. & Cyster, J.G. (2006) Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. Journal of Experimental Medicine, 203, 2683-2690.
-
(2006)
Journal of Experimental Medicine
, vol.203
, pp. 2683-2690
-
-
Kabashima, K.1
Haynes, N.M.2
Xu, Y.3
Nutt, S.L.4
Allende, M.L.5
Proia, R.L.6
Cyster, J.G.7
-
64
-
-
70149120314
-
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts
-
Kapitonov, D., Allegood, J.C., Mitchell, C., Hait, N.C., Almenara, J.A., Adams, J.K., Zipkin, R.E., Dent, P., Kordula, T., Milstien, S. & Spiegel, S. (2009) Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Research, 69, 6915-6923.
-
(2009)
Cancer Research
, vol.69
, pp. 6915-6923
-
-
Kapitonov, D.1
Allegood, J.C.2
Mitchell, C.3
Hait, N.C.4
Almenara, J.A.5
Adams, J.K.6
Zipkin, R.E.7
Dent, P.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
65
-
-
58849083220
-
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
-
Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A. & Mochizuki, N. (2009) The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science, 323, 524-527.
-
(2009)
Science
, vol.323
, pp. 524-527
-
-
Kawahara, A.1
Nishi, T.2
Hisano, Y.3
Fukui, H.4
Yamaguchi, A.5
Mochizuki, N.6
-
66
-
-
59649086217
-
Role for sphingosine kinase 1 in colon carcinogenesis
-
Kawamori, T., Kaneshiro, T., Okumura, M., Maalouf, S., Uflacker, A., Bielawski, J., Hannun, Y.A. & Obeid, L.M. (2009) Role for sphingosine kinase 1 in colon carcinogenesis. FASEB Journal, 23, 405-414.
-
(2009)
FASEB Journal
, vol.23
, pp. 405-414
-
-
Kawamori, T.1
Kaneshiro, T.2
Okumura, M.3
Maalouf, S.4
Uflacker, A.5
Bielawski, J.6
Hannun, Y.A.7
Obeid, L.M.8
-
67
-
-
79957775905
-
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells
-
Kennedy, A.J., Mathews, T.P., Kharel, Y., Field, S.D., Moyer, M.L., East, J.E., Houck, J.D., Lynch, K.R. & Macdonald, T.L. (2011) Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry, 54, 3524-3548.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, pp. 3524-3548
-
-
Kennedy, A.J.1
Mathews, T.P.2
Kharel, Y.3
Field, S.D.4
Moyer, M.L.5
East, J.E.6
Houck, J.D.7
Lynch, K.R.8
Macdonald, T.L.9
-
68
-
-
79751527693
-
Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis
-
Keul, P., Lucke, S., von Wnuck Lipinski, K., Bode, C., Graler, M., Heusch, G. & Levkau, B. (2011) Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circulation Research, 108, 314-323.
-
(2011)
Circulation Research
, vol.108
, pp. 314-323
-
-
Keul, P.1
Lucke, S.2
von Wnuck Lipinski, K.3
Bode, C.4
Graler, M.5
Heusch, G.6
Levkau, B.7
-
69
-
-
84866379271
-
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate
-
Kharel, Y., Raje, M., Gao, M., Gellett, A.M., Tomsig, J.L., Lynch, K.R. & Santos, W.L. (2012) Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. Biochemical Journal, 447, 149-157.
-
(2012)
Biochemical Journal
, vol.447
, pp. 149-157
-
-
Kharel, Y.1
Raje, M.2
Gao, M.3
Gellett, A.M.4
Tomsig, J.L.5
Lynch, K.R.6
Santos, W.L.7
-
70
-
-
33645220593
-
Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization
-
Kihara, A., Anada, Y. & Igarashi, Y. (2006) Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization. Journal of Biological Chemistry, 281, 4532-4539.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 4532-4539
-
-
Kihara, A.1
Anada, Y.2
Igarashi, Y.3
-
71
-
-
77955016925
-
Runx regulation of sphingolipid metabolism and survival signaling
-
Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q., Wakelam, M.J., Cameron, E.R. & Neil, J.C. (2010) Runx regulation of sphingolipid metabolism and survival signaling. Cancer Research, 70, 5860-5869.
-
(2010)
Cancer Research
, vol.70
, pp. 5860-5869
-
-
Kilbey, A.1
Terry, A.2
Jenkins, A.3
Borland, G.4
Zhang, Q.5
Wakelam, M.J.6
Cameron, E.R.7
Neil, J.C.8
-
72
-
-
84867850672
-
Effect of alkyl chain length on sphingosine kinase 2 selectivity
-
Knott, K., Kharel, Y., Raje, M.R., Lynch, K.R. & Santos, W.L. (2012) Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & Medicinal Chemistry Letters, 22, 6817-6820.
-
(2012)
Bioorganic & Medicinal Chemistry Letters
, vol.22
, pp. 6817-6820
-
-
Knott, K.1
Kharel, Y.2
Raje, M.R.3
Lynch, K.R.4
Santos, W.L.5
-
73
-
-
33644772424
-
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner
-
Kobayashi, N., Nishi, T., Hirata, T., Kihara, A., Sano, T., Igarashi, Y. & Yamaguchi, A. (2006) Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. Journal of Lipid Research, 47, 614-621.
-
(2006)
Journal of Lipid Research
, vol.47
, pp. 614-621
-
-
Kobayashi, N.1
Nishi, T.2
Hirata, T.3
Kihara, A.4
Sano, T.5
Igarashi, Y.6
Yamaguchi, A.7
-
74
-
-
69249090929
-
Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes
-
Kobayashi, N., Yamaguchi, A. & Nishi, T. (2009) Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. Journal of Biological Chemistry, 284, 21192-21200.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 21192-21200
-
-
Kobayashi, N.1
Yamaguchi, A.2
Nishi, T.3
-
75
-
-
33749185077
-
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
-
Kohno, M., Momoi, M., Oo, M.L., Paik, J.H., Lee, Y.M., Venkataraman, K., Ai, Y., Ristimaki, A.P., Fyrst, H., Sano, H., Rosenberg, D., Saba, J.D., Proia, R.L. & Hla, T. (2006) Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Molecular and Cellular Biology, 26, 7211-7223.
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 7211-7223
-
-
Kohno, M.1
Momoi, M.2
Oo, M.L.3
Paik, J.H.4
Lee, Y.M.5
Venkataraman, K.6
Ai, Y.7
Ristimaki, A.P.8
Fyrst, H.9
Sano, H.10
Rosenberg, D.11
Saba, J.D.12
Proia, R.L.13
Hla, T.14
-
76
-
-
67650264305
-
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner
-
Lahiri, S., Park, H., Laviad, E.L., Lu, X., Bittman, R. & Futerman, A.H. (2009) Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. Journal of Biological Chemistry, 284, 16090-16098.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 16090-16098
-
-
Lahiri, S.1
Park, H.2
Laviad, E.L.3
Lu, X.4
Bittman, R.5
Futerman, A.H.6
-
77
-
-
68149124148
-
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis
-
Lai, W.Q., Irwan, A.W., Goh, H.H., Melendez, A.J., McInnes, I.B. & Leung, B.P. (2009) Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. Journal of Immunology, 183, 2097-2103.
-
(2009)
Journal of Immunology
, vol.183
, pp. 2097-2103
-
-
Lai, W.Q.1
Irwan, A.W.2
Goh, H.H.3
Melendez, A.J.4
McInnes, I.B.5
Leung, B.P.6
-
78
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
Lavieu, G., Scarlatti, F., Sala, G., Carpentier, S., Levade, T., Ghidoni, R., Botti, J. & Codogno, P. (2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. Journal of Biological Chemistry, 281, 8518-8527.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
79
-
-
23944509761
-
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
-
Le Scolan, E., Pchejetski, D., Banno, Y., Denis, N., Mayeux, P., Vainchenker, W., Levade, T. & Moreau-Gachelin, F. (2005) Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood, 106, 1808-1816.
-
(2005)
Blood
, vol.106
, pp. 1808-1816
-
-
Le Scolan, E.1
Pchejetski, D.2
Banno, Y.3
Denis, N.4
Mayeux, P.5
Vainchenker, W.6
Levade, T.7
Moreau-Gachelin, F.8
-
80
-
-
4544373119
-
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis
-
Le Stunff, H., Mikami, A., Giussani, P., Hobson, J.P., Jolly, P.S., Milstien, S. & Spiegel, S. (2004) Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. Journal of Biological Chemistry, 279, 34290-34297.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 34290-34297
-
-
Le Stunff, H.1
Mikami, A.2
Giussani, P.3
Hobson, J.P.4
Jolly, P.S.5
Milstien, S.6
Spiegel, S.7
-
81
-
-
33747588567
-
Cellular signalling by sphingosine kinase and sphingosine 1-phosphate
-
Leclercq, T.M. & Pitson, S.M. (2006) Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life, 58, 467-472.
-
(2006)
IUBMB Life
, vol.58
, pp. 467-472
-
-
Leclercq, T.M.1
Pitson, S.M.2
-
82
-
-
9344268261
-
Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
-
Lee, W.J., Yoo, H.S., Suh, P.G., Oh, S., Lim, J.S. & Lee, Y.M. (2004) Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells. Experimental & Molecular Medicine, 36, 420-427.
-
(2004)
Experimental & Molecular Medicine
, vol.36
, pp. 420-427
-
-
Lee, W.J.1
Yoo, H.S.2
Suh, P.G.3
Oh, S.4
Lim, J.S.5
Lee, Y.M.6
-
83
-
-
78651265495
-
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy
-
Lepine, S., Allegood, J.C., Park, M., Dent, P., Milstien, S. & Spiegel, S. (2011) Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death and Differentiation, 18, 350-361.
-
(2011)
Cell Death and Differentiation
, vol.18
, pp. 350-361
-
-
Lepine, S.1
Allegood, J.C.2
Park, M.3
Dent, P.4
Milstien, S.5
Spiegel, S.6
-
84
-
-
35648995431
-
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
-
Leroux, M.E., Auzenne, E., Evans, R., Hail, N. Jr, Spohn, W., Ghosh, S.C., Farquhar, D., McDonnell, T. & Klostergaard, J. (2007) Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate, 67, 1699-1717.
-
(2007)
Prostate
, vol.67
, pp. 1699-1717
-
-
Leroux, M.E.1
Auzenne, E.2
Evans, R.3
Hail Jr, N.4
Spohn, W.5
Ghosh, S.C.6
Farquhar, D.7
McDonnell, T.8
Klostergaard, J.9
-
85
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B. & Kroemer, G. (2008) Autophagy in the pathogenesis of disease. Cell, 132, 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
86
-
-
34547647448
-
Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis
-
Li, Q.F., Wu, C.T., Duan, H.F., Sun, H.Y., Wang, H., Lu, Z.Z., Zhang, Q.W., Liu, H.J. & Wang, L.S. (2007a) Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis. British Journal of Haematology, 138, 632-639.
-
(2007)
British Journal of Haematology
, vol.138
, pp. 632-639
-
-
Li, Q.F.1
Wu, C.T.2
Duan, H.F.3
Sun, H.Y.4
Wang, H.5
Lu, Z.Z.6
Zhang, Q.W.7
Liu, H.J.8
Wang, L.S.9
-
87
-
-
37149032222
-
Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells
-
Li, Q.F., Huang, W.R., Duan, H.F., Wang, H., Wu, C.T. & Wang, L.S. (2007b) Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene, 26, 7904-7908.
-
(2007)
Oncogene
, vol.26
, pp. 7904-7908
-
-
Li, Q.F.1
Huang, W.R.2
Duan, H.F.3
Wang, H.4
Wu, C.T.5
Wang, L.S.6
-
88
-
-
58149231552
-
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
-
Li, J., Guan, H.Y., Gong, L.Y., Song, L.B., Zhang, N., Wu, J., Yuan, J., Zheng, Y.J., Huang, Z.S. & Li, M. (2008a) Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. Clinical Cancer Research, 14, 6996-7003.
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 6996-7003
-
-
Li, J.1
Guan, H.Y.2
Gong, L.Y.3
Song, L.B.4
Zhang, N.5
Wu, J.6
Yuan, J.7
Zheng, Y.J.8
Huang, Z.S.9
Li, M.10
-
89
-
-
42749092078
-
Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis
-
Li, Q.F., Wu, C.T., Guo, Q., Wang, H. & Wang, L.S. (2008b) Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochemical and Biophysical Research Communications, 371, 159-162.
-
(2008)
Biochemical and Biophysical Research Communications
, vol.371
, pp. 159-162
-
-
Li, Q.F.1
Wu, C.T.2
Guo, Q.3
Wang, H.4
Wang, L.S.5
-
90
-
-
63149167365
-
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients
-
Li, W., Yu, C.P., Xia, J.T., Zhang, L., Weng, G.X., Zheng, H.Q., Kong, Q.L., Hu, L.J., Zeng, M.S., Zeng, Y.X., Li, M., Li, J. & Song, L.B. (2009) Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clinical Cancer Research, 15, 1393-1399.
-
(2009)
Clinical Cancer Research
, vol.15
, pp. 1393-1399
-
-
Li, W.1
Yu, C.P.2
Xia, J.T.3
Zhang, L.4
Weng, G.X.5
Zheng, H.Q.6
Kong, Q.L.7
Hu, L.J.8
Zeng, M.S.9
Zeng, Y.X.10
Li, M.11
Li, J.12
Song, L.B.13
-
91
-
-
79551468923
-
Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1
-
Li, Q.F., Yan, J., Zhang, K., Yang, Y.F., Xiao, F.J., Wu, C.T., Wang, H. & Wang, L.S. (2011) Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochemical and Biophysical Research Communications, 405, 31-36.
-
(2011)
Biochemical and Biophysical Research Communications
, vol.405
, pp. 31-36
-
-
Li, Q.F.1
Yan, J.2
Zhang, K.3
Yang, Y.F.4
Xiao, F.J.5
Wu, C.T.6
Wang, H.7
Wang, L.S.8
-
92
-
-
80052653011
-
Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
-
Liao, A., Broeg, K., Fox, T., Tan, S.F., Watters, R., Shah, M.V., Zhang, L.Q., Li, Y., Ryland, L., Yang, J., Aliaga, C., Dewey, A., Rogers, A., Loughran, K., Hirsch, L., Jarbadan, N.R., Baab, K.T., Liao, J., Wang, H.G., Kester, M., Desai, D., Amin, S., Loughran, T.P. Jr & Liu, X. (2011) Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood, 118, 2793-2800.
-
(2011)
Blood
, vol.118
, pp. 2793-2800
-
-
Liao, A.1
Broeg, K.2
Fox, T.3
Tan, S.F.4
Watters, R.5
Shah, M.V.6
Zhang, L.Q.7
Li, Y.8
Ryland, L.9
Yang, J.10
Aliaga, C.11
Dewey, A.12
Rogers, A.13
Loughran, K.14
Hirsch, L.15
Jarbadan, N.R.16
Baab, K.T.17
Liao, J.18
Wang, H.G.19
Kester, M.20
Desai, D.21
Amin, S.22
Loughran Jr, T.P.23
Liu, X.24
more..
-
93
-
-
79956301884
-
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells
-
Lim, K.G., Tonelli, F., Li, Z., Lu, X., Bittman, R., Pyne, S. & Pyne, N.J. (2011) FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. Journal of Biological Chemistry, 286, 18633-18640.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 18633-18640
-
-
Lim, K.G.1
Tonelli, F.2
Li, Z.3
Lu, X.4
Bittman, R.5
Pyne, S.6
Pyne, N.J.7
-
94
-
-
84862766241
-
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b
-
Lim, K.G., Tonelli, F., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S.M., Bittman, R., Pyne, S. & Pyne, N.J. (2012) Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. International Journal of Biochemistry & Cell Biology, 44, 1457-1464.
-
(2012)
International Journal of Biochemistry & Cell Biology
, vol.44
, pp. 1457-1464
-
-
Lim, K.G.1
Tonelli, F.2
Berdyshev, E.3
Gorshkova, I.4
Leclercq, T.5
Pitson, S.M.6
Bittman, R.7
Pyne, S.8
Pyne, N.J.9
-
95
-
-
0034733556
-
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
-
Liu, H., Sugiura, M., Nava, V.E., Edsall, L.C., Kono, K., Poulton, S., Milstien, S., Kohama, T. & Spiegel, S. (2000) Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. Journal of Biological Chemistry, 275, 19513-19520.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 19513-19520
-
-
Liu, H.1
Sugiura, M.2
Nava, V.E.3
Edsall, L.C.4
Kono, K.5
Poulton, S.6
Milstien, S.7
Kohama, T.8
Spiegel, S.9
-
96
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
-
Liu, H., Toman, R.E., Goparaju, S.K., Maceyka, M., Nava, V.E., Sankala, H., Payne, S.G., Bektas, M., Ishii, I., Chun, J., Milstien, S. & Spiegel, S. (2003) Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. Journal of Biological Chemistry, 278, 40330-40336.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.K.3
Maceyka, M.4
Nava, V.E.5
Sankala, H.6
Payne, S.G.7
Bektas, M.8
Ishii, I.9
Chun, J.10
Milstien, S.11
Spiegel, S.12
-
97
-
-
38049166147
-
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
-
Liu, Q., Zhao, X., Frissora, F., Ma, Y., Santhanam, R., Jarjoura, D., Lehman, A., Perrotti, D., Chen, C.S., Dalton, J.T., Muthusamy, N. & Byrd, J.C. (2008) FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood, 111, 275-284.
-
(2008)
Blood
, vol.111
, pp. 275-284
-
-
Liu, Q.1
Zhao, X.2
Frissora, F.3
Ma, Y.4
Santhanam, R.5
Jarjoura, D.6
Lehman, A.7
Perrotti, D.8
Chen, C.S.9
Dalton, J.T.10
Muthusamy, N.11
Byrd, J.C.12
-
98
-
-
77953694847
-
FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma
-
Liu, Q., Alinari, L., Chen, C.S., Yan, F., Dalton, J.T., Lapalombella, R., Zhang, X., Mani, R., Lin, T., Byrd, J.C., Baiocchi, R.A. & Muthusamy, N. (2010) FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clinical Cancer Research, 16, 3182-3192.
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 3182-3192
-
-
Liu, Q.1
Alinari, L.2
Chen, C.S.3
Yan, F.4
Dalton, J.T.5
Lapalombella, R.6
Zhang, X.7
Mani, R.8
Lin, T.9
Byrd, J.C.10
Baiocchi, R.A.11
Muthusamy, N.12
-
99
-
-
84865159639
-
S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
-
Liu, Y., Deng, J., Wang, L., Lee, H., Armstrong, B., Scuto, A., Kowolik, C., Weiss, L.M., Forman, S. & Yu, H. (2012) S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood, 120, 1458-1465.
-
(2012)
Blood
, vol.120
, pp. 1458-1465
-
-
Liu, Y.1
Deng, J.2
Wang, L.3
Lee, H.4
Armstrong, B.5
Scuto, A.6
Kowolik, C.7
Weiss, L.M.8
Forman, S.9
Yu, H.10
-
100
-
-
13244270031
-
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
-
Lo, C.G., Xu, Y., Proia, R.L. & Cyster, J.G. (2005) Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. Journal of Experimental Medicine, 201, 291-301.
-
(2005)
Journal of Experimental Medicine
, vol.201
, pp. 291-301
-
-
Lo, C.G.1
Xu, Y.2
Proia, R.L.3
Cyster, J.G.4
-
101
-
-
27744547965
-
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
-
Maceyka, M., Sankala, H., Hait, N.C., Le Stunff, H., Liu, H., Toman, R., Collier, C., Zhang, M., Satin, L.S., Merrill, A.H. Jr, Milstien, S. & Spiegel, S. (2005) SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. Journal of Biological Chemistry, 280, 37118-37129.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 37118-37129
-
-
Maceyka, M.1
Sankala, H.2
Hait, N.C.3
Le Stunff, H.4
Liu, H.5
Toman, R.6
Collier, C.7
Zhang, M.8
Satin, L.S.9
Merrill Jr, A.H.10
Milstien, S.11
Spiegel, S.12
-
102
-
-
51349102583
-
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
-
Maceyka, M., Alvarez, S.E., Milstien, S. & Spiegel, S. (2008) Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Molecular and Cellular Biology, 28, 5687-5697.
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 5687-5697
-
-
Maceyka, M.1
Alvarez, S.E.2
Milstien, S.3
Spiegel, S.4
-
103
-
-
77954022674
-
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow
-
Maeda, Y., Seki, N., Sato, N., Sugahara, K. & Chiba, K. (2010) Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. International Immunology, 22, 515-525.
-
(2010)
International Immunology
, vol.22
, pp. 515-525
-
-
Maeda, Y.1
Seki, N.2
Sato, N.3
Sugahara, K.4
Chiba, K.5
-
104
-
-
79956274055
-
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
-
e656.
-
Marfe, G., Di Stefano, C., Gambacurta, A., Ottone, T., Martini, V., Abruzzese, E., Mologni, L., Sinibaldi-Salimei, P., de Fabritis, P., Gambacorti-Passerini, C., Amadori, S. & Birge, R.B. (2011) Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells. Experimental Hematology, 39, 653-665 e656.
-
(2011)
Experimental Hematology
, vol.39
, pp. 653-665
-
-
Marfe, G.1
Di Stefano, C.2
Gambacurta, A.3
Ottone, T.4
Martini, V.5
Abruzzese, E.6
Mologni, L.7
Sinibaldi-Salimei, P.8
de Fabritis, P.9
Gambacorti-Passerini, C.10
Amadori, S.11
Birge, R.B.12
-
105
-
-
36248957063
-
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
-
Massberg, S., Schaerli, P., Knezevic-Maramica, I., Köllnberger, M., Tubo, N., Moseman, E., Huff, I., Junt, T., Wagers, A., Mazo, I. & von Andrian, U. (2007) Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell, 131, 994-1008.
-
(2007)
Cell
, vol.131
, pp. 994-1008
-
-
Massberg, S.1
Schaerli, P.2
Knezevic-Maramica, I.3
Köllnberger, M.4
Tubo, N.5
Moseman, E.6
Huff, I.7
Junt, T.8
Wagers, A.9
Mazo, I.10
von Andrian, U.11
-
106
-
-
0037739755
-
A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells
-
Matsuoka, Y., Nagahara, Y., Ikekita, M. & Shinomiya, T. (2003) A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. British Journal of Pharmacology, 138, 1303-1312.
-
(2003)
British Journal of Pharmacology
, vol.138
, pp. 1303-1312
-
-
Matsuoka, Y.1
Nagahara, Y.2
Ikekita, M.3
Shinomiya, T.4
-
107
-
-
80855156707
-
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking
-
Mayol, K., Biajoux, V., Marvel, J., Balabanian, K. & Walzer, T. (2011) Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking. Blood, 118, 4863-4871.
-
(2011)
Blood
, vol.118
, pp. 4863-4871
-
-
Mayol, K.1
Biajoux, V.2
Marvel, J.3
Balabanian, K.4
Walzer, T.5
-
108
-
-
45049086146
-
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D
-
van Meeteren, L.A., Brinkmann, V., Saulnier-Blache, J.S., Lynch, K.R. & Moolenaar, W.H. (2008) Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters, 266, 203-208.
-
(2008)
Cancer Letters
, vol.266
, pp. 203-208
-
-
van Meeteren, L.A.1
Brinkmann, V.2
Saulnier-Blache, J.S.3
Lynch, K.R.4
Moolenaar, W.H.5
-
109
-
-
33750832270
-
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
-
Mitra, P., Oskeritzian, C.A., Payne, S.G., Beaven, M.A., Milstien, S. & Spiegel, S. (2006) Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proceedings of the National Academy of Sciences of the United States of America, 103, 16394-16399.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 16394-16399
-
-
Mitra, P.1
Oskeritzian, C.A.2
Payne, S.G.3
Beaven, M.A.4
Milstien, S.5
Spiegel, S.6
-
110
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi, K., Yamashita, T., Olivera, A., Miller, G.F., Spiegel, S. & Proia, R.L. (2005) Essential role for sphingosine kinases in neural and vascular development. Molecular and Cellular Biology, 25, 11113-11121.
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 11113-11121
-
-
Mizugishi, K.1
Yamashita, T.2
Olivera, A.3
Miller, G.F.4
Spiegel, S.5
Proia, R.L.6
-
111
-
-
45749139274
-
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
-
Nagaoka, Y., Otsuki, K., Fujita, T. & Uesato, S. (2008) Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biological &/and Pharmaceutical Bulletin, 31, 1177-1181.
-
(2008)
Biological &/and Pharmaceutical Bulletin
, vol.31
, pp. 1177-1181
-
-
Nagaoka, Y.1
Otsuki, K.2
Fujita, T.3
Uesato, S.4
-
112
-
-
67449098149
-
Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation
-
Nemoto, S., Nakamura, M., Osawa, Y., Kono, S., Itoh, Y., Okano, Y., Murate, T., Hara, A., Ueda, H., Nozawa, Y. & Banno, Y. (2009) Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. Journal of Biological Chemistry, 284, 10422-10432.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 10422-10432
-
-
Nemoto, S.1
Nakamura, M.2
Osawa, Y.3
Kono, S.4
Itoh, Y.5
Okano, Y.6
Murate, T.7
Hara, A.8
Ueda, H.9
Nozawa, Y.10
Banno, Y.11
-
113
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani, P., Santhanam, R., Oaks, J., Eiring, A., Notari, M., Blaser, B., Liu, S., Trotta, R., Muthusamy, N., Gambacorti-Passerini, C., Druker, B., Cortes, J., Marcucci, G., Chen, C., Verrills, N., Roy, D., Caligiuri, M., Bloomfield, C., Byrd, J. & Perrotti, D. (2007) FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. Journal of Clinical Investigation, 117, 2408-2421.
-
(2007)
Journal of Clinical Investigation
, vol.117
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.3
Eiring, A.4
Notari, M.5
Blaser, B.6
Liu, S.7
Trotta, R.8
Muthusamy, N.9
Gambacorti-Passerini, C.10
Druker, B.11
Cortes, J.12
Marcucci, G.13
Chen, C.14
Verrills, N.15
Roy, D.16
Caligiuri, M.17
Bloomfield, C.18
Byrd, J.19
Perrotti, D.20
more..
-
114
-
-
77649275845
-
Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma
-
Nishimura, H., Akiyama, T., Monobe, Y., Matsubara, K., Igarashi, Y., Abe, M., Sugihara, T. & Sadahira, Y. (2010) Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma. Modern Pathology, 23, 439-449.
-
(2010)
Modern Pathology
, vol.23
, pp. 439-449
-
-
Nishimura, H.1
Akiyama, T.2
Monobe, Y.3
Matsubara, K.4
Igarashi, Y.5
Abe, M.6
Sugihara, T.7
Sadahira, Y.8
-
115
-
-
27744479194
-
Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis
-
Okada, T., Ding, G., Sonoda, H., Kajimoto, T., Haga, Y., Khosrowbeygi, A., Gao, S., Miwa, N., Jahangeer, S. & Nakamura, S. (2005) Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. Journal of Biological Chemistry, 280, 36318-36325.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 36318-36325
-
-
Okada, T.1
Ding, G.2
Sonoda, H.3
Kajimoto, T.4
Haga, Y.5
Khosrowbeygi, A.6
Gao, S.7
Miwa, N.8
Jahangeer, S.9
Nakamura, S.10
-
116
-
-
0033230364
-
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
-
Olivera, A., Kohama, T., Edsall, L., Nava, V., Cuvillier, O., Poulton, S. & Spiegel, S. (1999) Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. Journal of Cell Biology, 147, 545-558.
-
(1999)
Journal of Cell Biology
, vol.147
, pp. 545-558
-
-
Olivera, A.1
Kohama, T.2
Edsall, L.3
Nava, V.4
Cuvillier, O.5
Poulton, S.6
Spiegel, S.7
-
117
-
-
57149134062
-
The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish
-
Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D. & Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current Biology, 18, 1882-1888.
-
(2008)
Current Biology
, vol.18
, pp. 1882-1888
-
-
Osborne, N.1
Brand-Arzamendi, K.2
Ober, E.A.3
Jin, S.W.4
Verkade, H.5
Holtzman, N.G.6
Yelon, D.7
Stainier, D.Y.8
-
118
-
-
43049171400
-
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions
-
Oskeritzian, C.A., Alvarez, S.E., Hait, N.C., Price, M.M., Milstien, S. & Spiegel, S. (2008) Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood, 111, 4193-4200.
-
(2008)
Blood
, vol.111
, pp. 4193-4200
-
-
Oskeritzian, C.A.1
Alvarez, S.E.2
Hait, N.C.3
Price, M.M.4
Milstien, S.5
Spiegel, S.6
-
119
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
Pappu, R., Schwab, S.R., Cornelissen, I., Pereira, J.P., Regard, J.B., Xu, Y., Camerer, E., Zheng, Y.W., Huang, Y., Cyster, J.G. & Coughlin, S.R. (2007) Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science, 316, 295-298.
-
(2007)
Science
, vol.316
, pp. 295-298
-
-
Pappu, R.1
Schwab, S.R.2
Cornelissen, I.3
Pereira, J.P.4
Regard, J.B.5
Xu, Y.6
Camerer, E.7
Zheng, Y.W.8
Huang, Y.9
Cyster, J.G.10
Coughlin, S.R.11
-
120
-
-
0028329361
-
Liposomal N, N, N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III
-
Park, Y.S., Hakomori, S., Kawa, S., Ruan, F. & Igarashi, Y. (1994) Liposomal N, N, N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III. Cancer Research, 54, 2213-2217.
-
(1994)
Cancer Research
, vol.54
, pp. 2213-2217
-
-
Park, Y.S.1
Hakomori, S.2
Kawa, S.3
Ruan, F.4
Igarashi, Y.5
-
121
-
-
51649122574
-
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
-
Paugh, S.W., Paugh, B.S., Rahmani, M., Kapitonov, D., Almenara, J.A., Kordula, T., Milstien, S., Adams, J.K., Zipkin, R.E., Grant, S. & Spiegel, S. (2008) A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood, 112, 1382-1391.
-
(2008)
Blood
, vol.112
, pp. 1382-1391
-
-
Paugh, S.W.1
Paugh, B.S.2
Rahmani, M.3
Kapitonov, D.4
Almenara, J.A.5
Kordula, T.6
Milstien, S.7
Adams, J.K.8
Zipkin, R.E.9
Grant, S.10
Spiegel, S.11
-
122
-
-
33846864904
-
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
-
Payne, S.G., Oskeritzian, C.A., Griffiths, R., Subramanian, P., Barbour, S.E., Chalfant, C.E., Milstien, S. & Spiegel, S. (2007) The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood, 109, 1077-1085.
-
(2007)
Blood
, vol.109
, pp. 1077-1085
-
-
Payne, S.G.1
Oskeritzian, C.A.2
Griffiths, R.3
Subramanian, P.4
Barbour, S.E.5
Chalfant, C.E.6
Milstien, S.7
Spiegel, S.8
-
123
-
-
51049121847
-
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models
-
Pchejetski, D., Doumerc, N., Golzio, M., Naymark, M., Teissie, J., Kohama, T., Waxman, J., Malavaud, B. & Cuvillier, O. (2008) Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Molecular Cancer Therapeutics, 7, 1836-1845.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 1836-1845
-
-
Pchejetski, D.1
Doumerc, N.2
Golzio, M.3
Naymark, M.4
Teissie, J.5
Kohama, T.6
Waxman, J.7
Malavaud, B.8
Cuvillier, O.9
-
124
-
-
37849033437
-
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress
-
Pham, T.H., Okada, T., Matloubian, M., Lo, C.G. & Cyster, J.G. (2008) S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity, 28, 122-133.
-
(2008)
Immunity
, vol.28
, pp. 122-133
-
-
Pham, T.H.1
Okada, T.2
Matloubian, M.3
Lo, C.G.4
Cyster, J.G.5
-
125
-
-
79551614173
-
Regulation of sphingosine kinase and sphingolipid signaling
-
Pitson, S.M. (2011) Regulation of sphingosine kinase and sphingolipid signaling. Trends in Biochemical Sciences, 36, 97-107.
-
(2011)
Trends in Biochemical Sciences
, vol.36
, pp. 97-107
-
-
Pitson, S.M.1
-
126
-
-
0034721844
-
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase
-
Pitson, S.M., Moretti, P.A., Zebol, J.R., Xia, P., Gamble, J.R., Vadas, M.A., D'Andrea, R.J. & Wattenberg, B.W. (2000) Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. Journal of Biological Chemistry, 275, 33945-33950.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 33945-33950
-
-
Pitson, S.M.1
Moretti, P.A.2
Zebol, J.R.3
Xia, P.4
Gamble, J.R.5
Vadas, M.A.6
D'Andrea, R.J.7
Wattenberg, B.W.8
-
127
-
-
0142105397
-
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
-
Pitson, S.M., Moretti, P.A., Zebol, J.R., Lynn, H.E., Xia, P., Vadas, M.A. & Wattenberg, B.W. (2003) Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO Journal, 22, 5491-5500.
-
(2003)
EMBO Journal
, vol.22
, pp. 5491-5500
-
-
Pitson, S.M.1
Moretti, P.A.2
Zebol, J.R.3
Lynn, H.E.4
Xia, P.5
Vadas, M.A.6
Wattenberg, B.W.7
-
128
-
-
12344272084
-
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
-
Pitson, S.M., Xia, P., Leclercq, T.M., Moretti, P.A., Zebol, J.R., Lynn, H.E., Wattenberg, B.W. & Vadas, M.A. (2005) Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. Journal of Experimental Medicine, 201, 49-54.
-
(2005)
Journal of Experimental Medicine
, vol.201
, pp. 49-54
-
-
Pitson, S.M.1
Xia, P.2
Leclercq, T.M.3
Moretti, P.A.4
Zebol, J.R.5
Lynn, H.E.6
Wattenberg, B.W.7
Vadas, M.A.8
-
129
-
-
79961082952
-
Translational aspects of sphingosine 1-phosphate biology
-
Pyne, S. & Pyne, N.J. (2011) Translational aspects of sphingosine 1-phosphate biology. Trends in Molecular Medicine, 17, 463-472.
-
(2011)
Trends in Molecular Medicine
, vol.17
, pp. 463-472
-
-
Pyne, S.1
Pyne, N.J.2
-
130
-
-
84855206931
-
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors
-
Raje, M.R., Knott, K., Kharel, Y., Bissel, P., Lynch, K.R. & Santos, W.L. (2012) Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & Medicinal Chemistry, 20, 183-194.
-
(2012)
Bioorganic & Medicinal Chemistry
, vol.20
, pp. 183-194
-
-
Raje, M.R.1
Knott, K.2
Kharel, Y.3
Bissel, P.4
Lynch, K.R.5
Santos, W.L.6
-
131
-
-
84863738670
-
The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game
-
Ratajczak, M.Z., Kim, C., Janowska-Wieczorek, A. & Ratajczak, J. (2012a) The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game. Scientific World Journal, 2012, 758512.
-
(2012)
Scientific World Journal
, vol.2012
, pp. 758512
-
-
Ratajczak, M.Z.1
Kim, C.2
Janowska-Wieczorek, A.3
Ratajczak, J.4
-
132
-
-
80555154779
-
The role of innate immunity in trafficking of hematopoietic stem cells-an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids
-
Ratajczak, M.Z., Kim, C., Wu, W., Shin, D.M., Bryndza, E., Kucia, M. & Ratajczak, J. (2012b) The role of innate immunity in trafficking of hematopoietic stem cells-an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids. Advances in Experimental Medicine and Biology, 946, 37-54.
-
(2012)
Advances in Experimental Medicine and Biology
, vol.946
, pp. 37-54
-
-
Ratajczak, M.Z.1
Kim, C.2
Wu, W.3
Shin, D.M.4
Bryndza, E.5
Kucia, M.6
Ratajczak, J.7
-
133
-
-
58449109188
-
In vitro anti-leukaemia activity of sphingosine kinase inhibitor
-
Ricci, C., Onida, F., Servida, F., Radaelli, F., Saporiti, G., Todoerti, K., Deliliers, G.L. & Ghidoni, R. (2009) In vitro anti-leukaemia activity of sphingosine kinase inhibitor. British Journal of Haematology, 144, 350-357.
-
(2009)
British Journal of Haematology
, vol.144
, pp. 350-357
-
-
Ricci, C.1
Onida, F.2
Servida, F.3
Radaelli, F.4
Saporiti, G.5
Todoerti, K.6
Deliliers, G.L.7
Ghidoni, R.8
-
134
-
-
77954376747
-
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
-
Roberts, K.G., Smith, A.M., McDougall, F., Carpenter, H., Horan, M., Neviani, P., Powell, J.A., Thomas, D., Guthridge, M.A., Perrotti, D., Sim, A.T., Ashman, L.K. & Verrills, N.M. (2010) Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Research, 70, 5438-5447.
-
(2010)
Cancer Research
, vol.70
, pp. 5438-5447
-
-
Roberts, K.G.1
Smith, A.M.2
McDougall, F.3
Carpenter, H.4
Horan, M.5
Neviani, P.6
Powell, J.A.7
Thomas, D.8
Guthridge, M.A.9
Perrotti, D.10
Sim, A.T.11
Ashman, L.K.12
Verrills, N.M.13
-
135
-
-
0037145310
-
Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing
-
Rodriguez-Lafrasse, C., Alphonse, G., Aloy, M.T., Ardail, D., Gerard, J.P., Louisot, P. & Rousson, R. (2002) Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing. International Journal of Cancer, 101, 589-598.
-
(2002)
International Journal of Cancer
, vol.101
, pp. 589-598
-
-
Rodriguez-Lafrasse, C.1
Alphonse, G.2
Aloy, M.T.3
Ardail, D.4
Gerard, J.P.5
Louisot, P.6
Rousson, R.7
-
136
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
-
Rosen, H. & Goetzl, E.J. (2005) Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nature Reviews Immunology, 5, 560-570.
-
(2005)
Nature Reviews Immunology
, vol.5
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
137
-
-
52949143502
-
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
-
Ruckhaberle, E., Rody, A., Engels, K., Gaetje, R., von Minckwitz, G., Schiffmann, S., Grosch, S., Geisslinger, G., Holtrich, U., Karn, T. & Kaufmann, M. (2008) Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Research and Treatment, 112, 41-52.
-
(2008)
Breast Cancer Research and Treatment
, vol.112
, pp. 41-52
-
-
Ruckhaberle, E.1
Rody, A.2
Engels, K.3
Gaetje, R.4
von Minckwitz, G.5
Schiffmann, S.6
Grosch, S.7
Geisslinger, G.8
Holtrich, U.9
Karn, T.10
Kaufmann, M.11
-
138
-
-
52949135175
-
S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing
-
Ryser, M.F., Ugarte, F., Lehmann, R., Bornhauser, M. & Brenner, S. (2008) S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. Molecular Immunology, 46, 166-171.
-
(2008)
Molecular Immunology
, vol.46
, pp. 166-171
-
-
Ryser, M.F.1
Ugarte, F.2
Lehmann, R.3
Bornhauser, M.4
Brenner, S.5
-
139
-
-
79957980683
-
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A
-
Salas, A., Ponnusamy, S., Senkal, C.E., Meyers-Needham, M., Selvam, S.P., Saddoughi, S.A., Apohan, E., Sentelle, R.D., Smith, C., Gault, C.R., Obeid, L.M., El-Shewy, H.M., Oaks, J., Santhanam, R., Marcucci, G., Baran, Y., Mahajan, S., Fernandes, D., Stuart, R., Perrotti, D. & Ogretmen, B. (2011) Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood, 117, 5941-5952.
-
(2011)
Blood
, vol.117
, pp. 5941-5952
-
-
Salas, A.1
Ponnusamy, S.2
Senkal, C.E.3
Meyers-Needham, M.4
Selvam, S.P.5
Saddoughi, S.A.6
Apohan, E.7
Sentelle, R.D.8
Smith, C.9
Gault, C.R.10
Obeid, L.M.11
El-Shewy, H.M.12
Oaks, J.13
Santhanam, R.14
Marcucci, G.15
Baran, Y.16
Mahajan, S.17
Fernandes, D.18
Stuart, R.19
Perrotti, D.20
Ogretmen, B.21
more..
-
140
-
-
35948936347
-
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
-
Sankala, H.M., Hait, N.C., Paugh, S.W., Shida, D., Lepine, S., Elmore, L.W., Dent, P., Milstien, S. & Spiegel, S. (2007) Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research, 67, 10466-10474.
-
(2007)
Cancer Research
, vol.67
, pp. 10466-10474
-
-
Sankala, H.M.1
Hait, N.C.2
Paugh, S.W.3
Shida, D.4
Lepine, S.5
Elmore, L.W.6
Dent, P.7
Milstien, S.8
Spiegel, S.9
-
141
-
-
33746365908
-
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
-
Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., Don, A., Marsolais, D., Matheu, M.P., Wei, S.H., Parker, I., Jo, E., Cheng, W.C., Cahalan, M.D., Wong, C.H. & Rosen, H. (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nature Chemical Biology, 2, 434-441.
-
(2006)
Nature Chemical Biology
, vol.2
, pp. 434-441
-
-
Sanna, M.G.1
Wang, S.K.2
Gonzalez-Cabrera, P.J.3
Don, A.4
Marsolais, D.5
Matheu, M.P.6
Wei, S.H.7
Parker, I.8
Jo, E.9
Cheng, W.C.10
Cahalan, M.D.11
Wong, C.H.12
Rosen, H.13
-
142
-
-
46949094718
-
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes
-
Sato, K., Malchinkhuu, E., Horiuchi, Y., Mogi, C., Tomura, H., Tosaka, M., Yoshimoto, Y., Kuwabara, A. & Okajima, F. (2007) Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes. Journal of Neurochemistry, 103, 2610-2619.
-
(2007)
Journal of Neurochemistry
, vol.103
, pp. 2610-2619
-
-
Sato, K.1
Malchinkhuu, E.2
Horiuchi, Y.3
Mogi, C.4
Tomura, H.5
Tosaka, M.6
Yoshimoto, Y.7
Kuwabara, A.8
Okajima, F.9
-
143
-
-
70350707758
-
Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel
-
Sauer, L., Nunes, J., Salunkhe, V., Skalska, L., Kohama, T., Cuvillier, O., Waxman, J. & Pchejetski, D. (2009) Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel. International Journal of Cancer, 125, 2728-2736.
-
(2009)
International Journal of Cancer
, vol.125
, pp. 2728-2736
-
-
Sauer, L.1
Nunes, J.2
Salunkhe, V.3
Skalska, L.4
Kohama, T.5
Cuvillier, O.6
Waxman, J.7
Pchejetski, D.8
-
144
-
-
62549143484
-
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells
-
Schnitzer, S.E., Weigert, A., Zhou, J. & Brune, B. (2009) Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Molecular Cancer Research, 7, 393-401.
-
(2009)
Molecular Cancer Research
, vol.7
, pp. 393-401
-
-
Schnitzer, S.E.1
Weigert, A.2
Zhou, J.3
Brune, B.4
-
145
-
-
84860812174
-
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
-
Schnute, M.E., McReynolds, M.D., Kasten, T., Yates, M., Jerome, G., Rains, J.W., Hall, T., Chrencik, J., Kraus, M., Cronin, C.N., Saabye, M., Highkin, M.K., Broadus, R., Ogawa, S., Cukyne, K., Zawadzke, L.E., Peterkin, V., Iyanar, K., Scholten, J.A., Wendling, J., Fujiwara, H., Nemirovskiy, O., Wittwer, A.J. & Nagiec, M.M. (2012) Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochemical Journal, 444, 79-88.
-
(2012)
Biochemical Journal
, vol.444
, pp. 79-88
-
-
Schnute, M.E.1
McReynolds, M.D.2
Kasten, T.3
Yates, M.4
Jerome, G.5
Rains, J.W.6
Hall, T.7
Chrencik, J.8
Kraus, M.9
Cronin, C.N.10
Saabye, M.11
Highkin, M.K.12
Broadus, R.13
Ogawa, S.14
Cukyne, K.15
Zawadzke, L.E.16
Peterkin, V.17
Iyanar, K.18
Scholten, J.A.19
Wendling, J.20
Fujiwara, H.21
Nemirovskiy, O.22
Wittwer, A.J.23
Nagiec, M.M.24
more..
-
146
-
-
24644469502
-
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
-
Schwab, S., Pereira, J., Matloubian, M., Xu, Y., Huang, Y. & Cyster, J. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science, 309, 1735-1739.
-
(2005)
Science
, vol.309
, pp. 1735-1739
-
-
Schwab, S.1
Pereira, J.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.6
-
147
-
-
84868538868
-
B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides
-
Schwamb, J., Feldhaus, V., Baumann, M., Patz, M., Brodesser, S., Brinker, R., Claasen, J., Pallasch, C.P., Hallek, M., Wendtner, C.M. & Frenzel, L.P. (2012) B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides. Blood, 120, 3978-3985.
-
(2012)
Blood
, vol.120
, pp. 3978-3985
-
-
Schwamb, J.1
Feldhaus, V.2
Baumann, M.3
Patz, M.4
Brodesser, S.5
Brinker, R.6
Claasen, J.7
Pallasch, C.P.8
Hallek, M.9
Wendtner, C.M.10
Frenzel, L.P.11
-
148
-
-
0030943828
-
Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells
-
Shatrov, V.A., Lehmann, V. & Chouaib, S. (1997) Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. Biochemical and Biophysical Research Communications, 234, 121-124.
-
(1997)
Biochemical and Biophysical Research Communications
, vol.234
, pp. 121-124
-
-
Shatrov, V.A.1
Lehmann, V.2
Chouaib, S.3
-
149
-
-
53049096639
-
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
-
Shida, D., Fang, X., Kordula, T., Takabe, K., Lepine, S., Alvarez, S.E., Milstien, S. & Spiegel, S. (2008) Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Research, 68, 6569-6577.
-
(2008)
Cancer Research
, vol.68
, pp. 6569-6577
-
-
Shida, D.1
Fang, X.2
Kordula, T.3
Takabe, K.4
Lepine, S.5
Alvarez, S.E.6
Milstien, S.7
Spiegel, S.8
-
150
-
-
46149100507
-
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells
-
Sobue, S., Nemoto, S., Murakami, M., Ito, H., Kimura, A., Gao, S., Furuhata, A., Takagi, A., Kojima, T., Nakamura, M., Ito, Y., Suzuki, M., Banno, Y., Nozawa, Y. & Murate, T. (2008) Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. International Journal of Hematology, 87, 266-275.
-
(2008)
International Journal of Hematology
, vol.87
, pp. 266-275
-
-
Sobue, S.1
Nemoto, S.2
Murakami, M.3
Ito, H.4
Kimura, A.5
Gao, S.6
Furuhata, A.7
Takagi, A.8
Kojima, T.9
Nakamura, M.10
Ito, Y.11
Suzuki, M.12
Banno, Y.13
Nozawa, Y.14
Murate, T.15
-
151
-
-
79953324725
-
Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-kappaB pathway in human non-small cell lung cancer
-
Song, L., Xiong, H., Li, J., Liao, W., Wang, L., Wu, J. & Li, M. (2011) Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-kappaB pathway in human non-small cell lung cancer. Clinical Cancer Research, 17, 1839-1849.
-
(2011)
Clinical Cancer Research
, vol.17
, pp. 1839-1849
-
-
Song, L.1
Xiong, H.2
Li, J.3
Liao, W.4
Wang, L.5
Wu, J.6
Li, M.7
-
152
-
-
79957610938
-
The outs and the ins of sphingosine-1-phosphate in immunity
-
Spiegel, S. & Milstien, S. (2011) The outs and the ins of sphingosine-1-phosphate in immunity. Nature Reviews Immunology, 11, 403-415.
-
(2011)
Nature Reviews Immunology
, vol.11
, pp. 403-415
-
-
Spiegel, S.1
Milstien, S.2
-
153
-
-
0032527809
-
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling
-
Stam, J.C., Michiels, F., van der Kammen, R.A., Moolenaar, W.H. & Collard, J.G. (1998) Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO Journal, 17, 4066-4074.
-
(1998)
EMBO Journal
, vol.17
, pp. 4066-4074
-
-
Stam, J.C.1
Michiels, F.2
van der Kammen, R.A.3
Moolenaar, W.H.4
Collard, J.G.5
-
154
-
-
78049502852
-
Extracellular and intracellular actions of sphingosine-1-phosphate
-
Strub, G.M., Maceyka, M., Hait, N.C., Milstien, S. & Spiegel, S. (2010) Extracellular and intracellular actions of sphingosine-1-phosphate. Advances in Experimental Medicine and Biology, 688, 141-155.
-
(2010)
Advances in Experimental Medicine and Biology
, vol.688
, pp. 141-155
-
-
Strub, G.M.1
Maceyka, M.2
Hait, N.C.3
Milstien, S.4
Spiegel, S.5
-
155
-
-
70349333252
-
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
-
Sukocheva, O., Wang, L., Verrier, E., Vadas, M.A. & Xia, P. (2009) Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 150, 4484-4492.
-
(2009)
Endocrinology
, vol.150
, pp. 4484-4492
-
-
Sukocheva, O.1
Wang, L.2
Verrier, E.3
Vadas, M.A.4
Xia, P.5
-
156
-
-
3142660497
-
Lysophospholipids are potential biomarkers of ovarian cancer
-
Sutphen, R., Xu, Y., Wilbanks, G.D., Fiorica, J., Grendys, E.C. Jr, LaPolla, J.P., Arango, H., Hoffman, M.S., Martino, M., Wakeley, K., Griffin, D., Blanco, R.W., Cantor, A.B., Xiao, Y.J. & Krischer, J.P. (2004) Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiology, Biomarkers & Prevention, 13, 1185-1191.
-
(2004)
Cancer Epidemiology, Biomarkers & Prevention
, vol.13
, pp. 1185-1191
-
-
Sutphen, R.1
Xu, Y.2
Wilbanks, G.D.3
Fiorica, J.4
Grendys Jr, E.C.5
LaPolla, J.P.6
Arango, H.7
Hoffman, M.S.8
Martino, M.9
Wakeley, K.10
Griffin, D.11
Blanco, R.W.12
Cantor, A.B.13
Xiao, Y.J.14
Krischer, J.P.15
-
157
-
-
46949104885
-
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
-
Takabe, K., Paugh, S.W., Milstien, S. & Spiegel, S. (2008) "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacological Reviews, 60, 181-195.
-
(2008)
Pharmacological Reviews
, vol.60
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
158
-
-
77951214876
-
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
-
Takabe, K., Kim, R.H., Allegood, J.C., Mitra, P., Ramachandran, S., Nagahashi, M., Harikumar, K.B., Hait, N.C., Milstien, S. & Spiegel, S. (2010) Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. Journal of Biological Chemistry, 285, 10477-10486.
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 10477-10486
-
-
Takabe, K.1
Kim, R.H.2
Allegood, J.C.3
Mitra, P.4
Ramachandran, S.5
Nagahashi, M.6
Harikumar, K.B.7
Hait, N.C.8
Milstien, S.9
Spiegel, S.10
-
159
-
-
84863373152
-
Treatment options for chronic myeloid leukemia
-
Tanaka, M.F., Kantarjian, H., Cortes, J., Ohanian, M. & Jabbour, E. (2012) Treatment options for chronic myeloid leukemia. Expert Opinion on Pharmacotherapy, 13, 815-828.
-
(2012)
Expert Opinion on Pharmacotherapy
, vol.13
, pp. 815-828
-
-
Tanaka, M.F.1
Kantarjian, H.2
Cortes, J.3
Ohanian, M.4
Jabbour, E.5
-
160
-
-
0027165675
-
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins
-
Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T. & Honjo, T. (1993) Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science, 261, 600-603.
-
(1993)
Science
, vol.261
, pp. 600-603
-
-
Tashiro, K.1
Tada, H.2
Heilker, R.3
Shirozu, M.4
Nakano, T.5
Honjo, T.6
-
161
-
-
77954535502
-
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
-
Tonelli, F., Lim, K.G., Loveridge, C., Long, J., Pitson, S.M., Tigyi, G., Bittman, R., Pyne, S. & Pyne, N.J. (2010) FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling, 22, 1536-1542.
-
(2010)
Cellular Signalling
, vol.22
, pp. 1536-1542
-
-
Tonelli, F.1
Lim, K.G.2
Loveridge, C.3
Long, J.4
Pitson, S.M.5
Tigyi, G.6
Bittman, R.7
Pyne, S.8
Pyne, N.J.9
-
162
-
-
33847644587
-
FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft
-
Ubai, T., Azuma, H., Kotake, Y., Inamoto, T., Takahara, K., Ito, Y., Kiyama, S., Sakamoto, T., Horie, S., Muto, S., Takahara, S., Otsuki, Y. & Katsuoka, Y. (2007) FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Research, 27, 75-88.
-
(2007)
Anticancer Research
, vol.27
, pp. 75-88
-
-
Ubai, T.1
Azuma, H.2
Kotake, Y.3
Inamoto, T.4
Takahara, K.5
Ito, Y.6
Kiyama, S.7
Sakamoto, T.8
Horie, S.9
Muto, S.10
Takahara, S.11
Otsuki, Y.12
Katsuoka, Y.13
-
163
-
-
51749100808
-
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?
-
amp; ()
-
Vadas, M., Xia, P., McCaughan, G. & Gamble, J. (2008) The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction? Biochimica et Biophysica Acta, 1781, 442-447.
-
(2008)
Biochimica et Biophysica Acta
, vol.1781
, pp. 442-447
-
-
Vadas, M.1
Xia, P.2
McCaughan, G.3
Gamble, J.4
-
164
-
-
23844498431
-
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
-
Van Brocklyn, J.R., Jackson, C.A., Pearl, D.K., Kotur, M.S., Snyder, P.J. & Prior, T.W. (2005) Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. Journal of Neuropathology and Experimental Neurology, 64, 695-705.
-
(2005)
Journal of Neuropathology and Experimental Neurology
, vol.64
, pp. 695-705
-
-
Van Brocklyn, J.R.1
Jackson, C.A.2
Pearl, D.K.3
Kotur, M.S.4
Snyder, P.J.5
Prior, T.W.6
-
165
-
-
33746897677
-
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
-
Venkataraman, K., Thangada, S., Michaud, J., Oo, M.L., Ai, Y., Lee, Y.M., Wu, M., Parikh, N.S., Khan, F., Proia, R.L. & Hla, T. (2006) Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochemical Journal, 397, 461-471.
-
(2006)
Biochemical Journal
, vol.397
, pp. 461-471
-
-
Venkataraman, K.1
Thangada, S.2
Michaud, J.3
Oo, M.L.4
Ai, Y.5
Lee, Y.M.6
Wu, M.7
Parikh, N.S.8
Khan, F.9
Proia, R.L.10
Hla, T.11
-
166
-
-
35548994468
-
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
-
Vessey, D.A., Kelley, M., Zhang, J., Li, L., Tao, R. & Karliner, J.S. (2007) Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. Journal of Biochemical and Molecular Toxicology, 21, 273-279.
-
(2007)
Journal of Biochemical and Molecular Toxicology
, vol.21
, pp. 273-279
-
-
Vessey, D.A.1
Kelley, M.2
Zhang, J.3
Li, L.4
Tao, R.5
Karliner, J.S.6
-
167
-
-
65549167989
-
Differential regulation of sphingosine kinases 1 and 2 in lung injury
-
Wadgaonkar, R., Patel, V., Grinkina, N., Romano, C., Liu, J., Zhao, Y., Sammani, S., Garcia, J.G. & Natarajan, V. (2009) Differential regulation of sphingosine kinases 1 and 2 in lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology, 296, L603-L613.
-
(2009)
American Journal of Physiology. Lung Cellular and Molecular Physiology
, vol.296
-
-
Wadgaonkar, R.1
Patel, V.2
Grinkina, N.3
Romano, C.4
Liu, J.5
Zhao, Y.6
Sammani, S.7
Garcia, J.G.8
Natarajan, V.9
-
168
-
-
79959948518
-
FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells
-
Wallington-Beddoe, C.T., Hewson, J., Bradstock, K.F. & Bendall, L.J. (2011a) FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy, 7, 707-715.
-
(2011)
Autophagy
, vol.7
, pp. 707-715
-
-
Wallington-Beddoe, C.T.1
Hewson, J.2
Bradstock, K.F.3
Bendall, L.J.4
-
169
-
-
84877832334
-
Sphingosine Kinase inhibition has pre-clinical activity in acute lymphoblastic leukemia
-
Wallington-Beddoe, C., Ho, D., Bradstock, K. & Bendall, L. (2011b) Sphingosine Kinase inhibition has pre-clinical activity in acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts), 118, 3573.
-
(2011)
Blood (ASH Annual Meeting Abstracts)
, vol.118
, pp. 3573
-
-
Wallington-Beddoe, C.1
Ho, D.2
Bradstock, K.3
Bendall, L.4
-
170
-
-
84877808117
-
Identification of sphingosine kinases as therapeutic targets in B-lineage acute lymphoblastic leukemia
-
Wallington-Beddoe, C., Bradstock, K. & Bendall, L. (2012a) Identification of sphingosine kinases as therapeutic targets in B-lineage acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts), 120, 1499.
-
(2012)
Blood (ASH Annual Meeting Abstracts)
, vol.120
, pp. 1499
-
-
Wallington-Beddoe, C.1
Bradstock, K.2
Bendall, L.3
-
171
-
-
84860503855
-
Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia
-
Wallington-Beddoe, C.T., Don, A.S., Hewson, J., Qiao, Q., Papa, R.A., Lock, R.B., Bradstock, K.F. & Bendall, L.J. (2012b) Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia. PLoS ONE, 7, e36429.
-
(2012)
PLoS ONE
, vol.7
-
-
Wallington-Beddoe, C.T.1
Don, A.S.2
Hewson, J.3
Qiao, Q.4
Papa, R.A.5
Lock, R.B.6
Bradstock, K.F.7
Bendall, L.J.8
-
172
-
-
0033564177
-
Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
-
Wang, J.D., Takahara, S., Nonomura, N., Ichimaru, N., Toki, K., Azuma, H., Matsumiya, K., Okuyama, A. & Suzuki, S. (1999) Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate, 40, 50-55.
-
(1999)
Prostate
, vol.40
, pp. 50-55
-
-
Wang, J.D.1
Takahara, S.2
Nonomura, N.3
Ichimaru, N.4
Toki, K.5
Azuma, H.6
Matsumiya, K.7
Okuyama, A.8
Suzuki, S.9
-
173
-
-
33744807983
-
The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function
-
Wattenberg, B.W., Pitson, S.M. & Raben, D.M. (2006) The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. Journal of Lipid Research, 47, 1128-1139.
-
(2006)
Journal of Lipid Research
, vol.47
, pp. 1128-1139
-
-
Wattenberg, B.W.1
Pitson, S.M.2
Raben, D.M.3
-
174
-
-
70249125866
-
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
-
Weigert, A., Schiffmann, S., Sekar, D., Ley, S., Menrad, H., Werno, C., Grosch, S., Geisslinger, G. & Brune, B. (2009) Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. International Journal of Cancer, 125, 2114-2121.
-
(2009)
International Journal of Cancer
, vol.125
, pp. 2114-2121
-
-
Weigert, A.1
Schiffmann, S.2
Sekar, D.3
Ley, S.4
Menrad, H.5
Werno, C.6
Grosch, S.7
Geisslinger, G.8
Brune, B.9
-
175
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
Xia, P., Gamble, J.R., Wang, L., Pitson, S.M., Moretti, P.A., Wattenberg, B.W., D'Andrea, R.J. & Vadas, M.A. (2000) An oncogenic role of sphingosine kinase. Current Biology, 10, 1527-1530.
-
(2000)
Current Biology
, vol.10
, pp. 1527-1530
-
-
Xia, P.1
Gamble, J.R.2
Wang, L.3
Pitson, S.M.4
Moretti, P.A.5
Wattenberg, B.W.6
D'Andrea, R.J.7
Vadas, M.A.8
-
176
-
-
71749100899
-
Discovery of novel sphingosine kinase 1 inhibitors
-
Xiang, Y., Asmussen, G., Booker, M., Hirth, B., Kane, J.L. Jr, Liao, J., Noson, K.D. & Yee, C. (2009) Discovery of novel sphingosine kinase 1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19, 6119-6121.
-
(2009)
Bioorganic & Medicinal Chemistry Letters
, vol.19
, pp. 6119-6121
-
-
Xiang, Y.1
Asmussen, G.2
Booker, M.3
Hirth, B.4
Kane Jr, J.L.5
Liao, J.6
Noson, K.D.7
Yee, C.8
-
177
-
-
0035793032
-
The role and clinical applications of bioactive lysolipids in ovarian cancer
-
Xu, Y., Xiao, Y.J., Baudhuin, L.M. & Schwartz, B.M. (2001) The role and clinical applications of bioactive lysolipids in ovarian cancer. Journal of the Society for Gynecologic Investigation, 8, 1-13.
-
(2001)
Journal of the Society for Gynecologic Investigation
, vol.8
, pp. 1-13
-
-
Xu, Y.1
Xiao, Y.J.2
Baudhuin, L.M.3
Schwartz, B.M.4
-
178
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
Yasui, H., Hideshima, T., Raje, N., Roccaro, A.M., Shiraishi, N., Kumar, S., Hamasaki, M., Ishitsuka, K., Tai, Y.T., Podar, K., Catley, L., Mitsiades, C.S., Richardson, P.G., Albert, R., Brinkmann, V., Chauhan, D. & Anderson, K.C. (2005) FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Research, 65, 7478-7484.
-
(2005)
Cancer Research
, vol.65
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Hamasaki, M.7
Ishitsuka, K.8
Tai, Y.T.9
Podar, K.10
Catley, L.11
Mitsiades, C.S.12
Richardson, P.G.13
Albert, R.14
Brinkmann, V.15
Chauhan, D.16
Anderson, K.C.17
-
179
-
-
0035005887
-
Sphingosine 1-phosphate: synthesis and release
-
Yatomi, Y., Ozaki, Y., Ohmori, T. & Igarashi, Y. (2001) Sphingosine 1-phosphate: synthesis and release. Prostaglandins & Other Lipid Mediators, 64, 107-122.
-
(2001)
Prostaglandins & Other Lipid Mediators
, vol.64
, pp. 107-122
-
-
Yatomi, Y.1
Ozaki, Y.2
Ohmori, T.3
Igarashi, Y.4
-
180
-
-
55849100058
-
Network model of survival signaling in large granular lymphocyte leukemia
-
Zhang, R., Shah, M.V., Yang, J., Nyland, S.B., Liu, X., Yun, J.K., Albert, R. & Loughran, T.P. Jr (2008) Network model of survival signaling in large granular lymphocyte leukemia. Proceedings of the National Academy of Sciences of the United States of America, 105, 16308-16313.
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 16308-16313
-
-
Zhang, R.1
Shah, M.V.2
Yang, J.3
Nyland, S.B.4
Liu, X.5
Yun, J.K.6
Albert, R.7
Loughran Jr, T.P.8
-
181
-
-
84871890104
-
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
-
Zhang, L., Orban, M., Lorenz, M., Barocke, V., Braun, D., Urtz, N., Schulz, C., von Bruhl, M.L., Tirniceriu, A., Gaertner, F., Proia, R.L., Graf, T., Bolz, S.S., Montanez, E., Prinz, M., Muller, A., von Baumgarten, L., Billich, A., Sixt, M., Fassler, R., von Andrian, U.H., Junt, T. & Massberg, S. (2012) A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. Journal of Experimental Medicine, 209, 2165-2181.
-
(2012)
Journal of Experimental Medicine
, vol.209
, pp. 2165-2181
-
-
Zhang, L.1
Orban, M.2
Lorenz, M.3
Barocke, V.4
Braun, D.5
Urtz, N.6
Schulz, C.7
von Bruhl, M.L.8
Tirniceriu, A.9
Gaertner, F.10
Proia, R.L.11
Graf, T.12
Bolz, S.S.13
Montanez, E.14
Prinz, M.15
Muller, A.16
von Baumgarten, L.17
Billich, A.18
Sixt, M.19
Fassler, R.20
von Andrian, U.H.21
Junt, T.22
Massberg, S.23
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