Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: Discovery of SphK1- and SphK2-selective inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 4, 2015, Pages 1879-1899

  Patwardhan, Neeraj N ^a   Morris, Emily A ^a   Kharel, Yugesh ^b   Raje, Mithun R ^a   Gao, Ming ^a   Tomsig, Jose L ^b   Lynch, Kevin R ^b   Santos, Webster L ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; GUANIDINE DERIVATIVE; SLP 120701; SLP 7111228; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG; GUANIDINE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR; SPHINGOSINE KINASE; SPHINGOSINE KINASE 2, HUMAN;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SYNTHESIS; HISTIOCYTIC LYMPHOMA; IN VIVO STUDY; MOUSE; NONHUMAN; RAT; RING OPENING; STRUCTURE ACTIVITY RELATION; U937 CELL LINE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; METABOLISM; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GUANIDINE; MOLECULAR STRUCTURE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923853766     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501760d     Document Type: Article

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