Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells

Molecular Cancer Research

Volumn 7, Issue 3, 2009, Pages 393-401

  Schnitzer, Steffen E ^a   Weigert, Andreas ^a   Zhou, Jie ^a   Brüne, Bernhard ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; ETOPOSIDE; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 2;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CANCER RESISTANCE; CELL DEATH; CELL HYPOXIA; CELL PROTECTION; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG CANCER; PARACRINE SIGNALING; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; SOLID TUMOR; TREATMENT FAILURE;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; CELL HYPOXIA; CELL LINE, TUMOR; CULTURE MEDIA; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; LUNG NEOPLASMS; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; RNA, SMALL INTERFERING; SPHINGOSINE; TRANSFECTION;

EID: 62549143484     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0156     Document Type: Article

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