메뉴 건너뛰기




Volumn 9, Issue 11, 2011, Pages 1509-1519

Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FOCAL ADHESION KINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P21; PROTEIN P53; SIGNAL PEPTIDE; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; VASCULAR CELL ADHESION MOLECULE 1;

EID: 81755162053     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0336     Document Type: Article
Times cited : (91)

References (54)
  • 3
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • DOI 10.1038/nrm2329, PII NRM2329
    • Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9:139-50. (Pubitemid 351158911)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.2 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 4
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999;147:545-58.
    • (1999) J Cell Biol , vol.147 , pp. 545-558
    • Olivera, A.1    Kohama, T.2    Edsall, L.3    Nava, V.4    Cuvillier, O.5    Poulton, S.6
  • 5
    • 0034661482 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate signalling in mammalian cells
    • DOI 10.1042/0264-6021:3490385
    • Pyne S, Pyne NJ. Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 2000;349:385-402. (Pubitemid 30465772)
    • (2000) Biochemical Journal , vol.349 , Issue.2 , pp. 385-402
    • Pyne, S.1    Pyne, N.J.2
  • 6
    • 0035196711 scopus 로고    scopus 로고
    • EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    • DOI 10.1096/fj.01-0523com
    • Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, et al. EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J 2001;15:2649-59. (Pubitemid 33131091)
    • (2001) FASEB Journal , vol.15 , Issue.14 , pp. 2649-2659
    • Rosenfeldt, H.M.1    Hobson, J.P.2    Maceyka, M.3    Olivera, A.4    Nava, V.E.5    Milstien, S.6    Spiegel, S.7
  • 7
    • 0037135572 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a key cell signaling molecule
    • DOI 10.1074/jbc.R200007200
    • Spiegel S, Milstien S. Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem 2002;277:25851-4. (Pubitemid 34967061)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 25851-25854
    • Spiegel, S.1    Milstien, S.2
  • 10
    • 0037144434 scopus 로고    scopus 로고
    • PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)
    • Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 2002;277:35257-62.
    • (2002) J Biol Chem , vol.277 , pp. 35257-35262
    • Johnson, K.R.1    Becker, K.P.2    Facchinetti, M.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 14
    • 25844457390 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
    • DOI 10.1016/j.febslet.2005.08.055, PII S0014579305010677
    • Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S, et al. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 2005;579:5313-7. (Pubitemid 41395149)
    • (2005) FEBS Letters , vol.579 , Issue.24 , pp. 5313-5317
    • Sarkar, S.1    Maceyka, M.2    Hait, N.C.3    Paugh, S.W.4    Sankala, H.5    Milstien, S.6    Spiegel, S.7
  • 15
    • 33645801577 scopus 로고    scopus 로고
    • Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: Modulation of sphingolipid levels and the induction of apoptosis
    • DOI 10.1096/fj.05-4412fje
    • Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J 2006;20:482-4. (Pubitemid 46671223)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 482-484
    • Taha, T.A.1    Kitatani, K.2    El-Alwani, M.3    Bielawski, J.4    Hannun, Y.A.5    Obeid, L.M.6
  • 20
    • 33748178875 scopus 로고    scopus 로고
    • Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate
    • DOI 10.1182/blood-2006-04-014852
    • Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B. Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 2006;108:1635-42. (Pubitemid 44316132)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1635-1642
    • Weigert, A.1    Johann, A.M.2    Von Knethen, A.3    Schmidt, H.4    Geisslinger, G.5    Brune, B.6
  • 21
    • 77951745553 scopus 로고    scopus 로고
    • Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
    • Weigert A, Cremer S, Schmidt MV, von Knethen A, Angioni C, Geisslinger G, et al. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. Blood 2010;115:3531-40.
    • (2010) Blood , vol.115 , pp. 3531-3540
    • Weigert, A.1    Cremer, S.2    Schmidt, M.V.3    Von Knethen, A.4    Angioni, C.5    Geisslinger, G.6
  • 22
    • 23844498431 scopus 로고    scopus 로고
    • Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
    • VanBrocklyn JR, Jackson CA, Pearl DK, Kotur MS, Snyder PJ, Prior TW. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J Neuropathol Exp Neurol 2005;64:695-705. (Pubitemid 41177111)
    • (2005) Journal of Neuropathology and Experimental Neurology , vol.64 , Issue.8 , pp. 695-705
    • Van Brooklyn, J.R.1    Jackson, C.A.2    Pearl, D.K.3    Kotur, M.S.4    Snyder, P.J.5    Prior, T.W.6
  • 23
    • 70249125866 scopus 로고    scopus 로고
    • Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
    • Weigert A, Schiffmann S, Sekar D, Ley S, Menrad H, Werno C, et al. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. Int J Cancer 2009;125:2114-21.
    • (2009) Int J Cancer , vol.125 , pp. 2114-2121
    • Weigert, A.1    Schiffmann, S.2    Sekar, D.3    Ley, S.4    Menrad, H.5    Werno, C.6
  • 28
    • 77949748845 scopus 로고    scopus 로고
    • Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2
    • French KJ, Zhuang Y, Maines LW, Gao P, Wang W, Beljanski V, et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther 2010;333:129-39.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 129-139
    • French, K.J.1    Zhuang, Y.2    Maines, L.W.3    Gao, P.4    Wang, W.5    Beljanski, V.6
  • 29
    • 84861642085 scopus 로고    scopus 로고
    • Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
    • May 18. [Epub ahead of print]
    • Beljanski V, Knaak C, Zhuang Y, Smith CD. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs 2010 May 18. [Epub ahead of print].
    • (2010) Invest New Drugs
    • Beljanski, V.1    Knaak, C.2    Zhuang, Y.3    Smith, C.D.4
  • 30
    • 79952343738 scopus 로고    scopus 로고
    • Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
    • Beljanski V, Lewis CS, Smith CD. Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol Ther 2011;11:524-34.
    • (2011) Cancer Biol Ther , vol.11 , pp. 524-534
    • Beljanski, V.1    Lewis, C.S.2    Smith, C.D.3
  • 32
    • 0037119991 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
    • Le Stunff H, Galve-Roperh I, Peterson C, Milstien S, Spiegel S. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol 2002;158:1039-49.
    • (2002) J Cell Biol , vol.158 , pp. 1039-1049
    • Le Stunff, H.1    Galve-Roperh, I.2    Peterson, C.3    Milstien, S.4    Spiegel, S.5
  • 33
    • 0036841720 scopus 로고    scopus 로고
    • Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
    • DOI 10.1128/MCB.22.22.7758-7768.2002
    • Shu X, Wu W, Mosteller RD, Broek D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol Cell Biol 2002;22:7758-68. (Pubitemid 35217287)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.22 , pp. 7758-7768
    • Shu, X.1    Wu, W.2    Mosteller, R.D.3    Broek, D.4
  • 35
    • 79955770841 scopus 로고    scopus 로고
    • BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
    • Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, et al. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. J Neurosci 2011;31:6850-7.
    • (2011) J Neurosci , vol.31 , pp. 6850-6857
    • Takasugi, N.1    Sasaki, T.2    Suzuki, K.3    Osawa, S.4    Isshiki, H.5    Hori, Y.6
  • 36
    • 0037853139 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm
    • DOI 10.1074/jbc.M211416200
    • Kihara A, Ikeda M, Kariya Y, Lee EY, Lee YM, Igarashi Y. Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. J Biol Chem 2003;278:14578-85. (Pubitemid 36800012)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 14578-14585
    • Kihara, A.1    Ikeda, M.2    Kariya, Y.3    Lee, E.-Y.4    Lee, Y.-M.5    Igarashi, Y.6
  • 37
    • 78650407629 scopus 로고    scopus 로고
    • Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
    • Huwiler A, Kotelevets N, Xin C, Pastukhov O, Pfeilschifter J, Zangemeister-Wittke U. Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Br J Pharmacol 2011;162:532-43.
    • (2011) Br J Pharmacol , vol.162 , pp. 532-543
    • Huwiler, A.1    Kotelevets, N.2    Xin, C.3    Pastukhov, O.4    Pfeilschifter, J.5    Zangemeister-Wittke, U.6
  • 38
    • 79551628419 scopus 로고    scopus 로고
    • Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: Role of sphingosine kinase 1 and S1P lyase
    • Berdyshev EV, Gorshkova I, Usatyuk P, Kalari S, Zhao Y, Pyne NJ, et al. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PloS One 2011;6:e16571.
    • (2011) PloS One , vol.6
    • Berdyshev, E.V.1    Gorshkova, I.2    Usatyuk, P.3    Kalari, S.4    Zhao, Y.5    Pyne, N.J.6
  • 39
    • 0031961995 scopus 로고    scopus 로고
    • 2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • Niculescu AB III, Chen X, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629-43. Erratum in: Mol Cell Biol 1998;18:1763. (Pubitemid 28021073)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.1 , pp. 629-643
    • Niculescu III, A.B.1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 42
    • 4944225786 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: Role of reactive oxygen species
    • DOI 10.1182/blood-2004-02-0665
    • Deem TL, Cook-Mills JM. Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species. Blood 2004;104:2385-93. (Pubitemid 39331837)
    • (2004) Blood , vol.104 , Issue.8 , pp. 2385-2393
    • Deem, T.L.1    Cook-Mills, J.M.2
  • 43
    • 0029896940 scopus 로고    scopus 로고
    • Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro
    • Devine L, Lightman SL, Greenwood J. Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro. Immunology 1996;88:456-62. (Pubitemid 26225172)
    • (1996) Immunology , vol.88 , Issue.3 , pp. 456-462
    • Devine, L.1    Lightman, S.L.2    Greenwood, J.3
  • 45
    • 84861816291 scopus 로고    scopus 로고
    • Available from
    • Available from: http://dtp.nci.nih.gov/mtweb/hugosearch?genecard=SPHK1.
  • 47
    • 77952755702 scopus 로고    scopus 로고
    • Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia
    • Sensken SC, Bode C, Nagarajan M, Peest U, Pabst O, Graler MH. Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia. J Immunol 2010;184:4133-42.
    • (2010) J Immunol , vol.184 , pp. 4133-4142
    • Sensken, S.C.1    Bode, C.2    Nagarajan, M.3    Peest, U.4    Pabst, O.5    Graler, M.H.6
  • 49
    • 35948936347 scopus 로고    scopus 로고
    • Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
    • DOI 10.1158/0008-5472.CAN-07-2090
    • Sankala HM, Hait NC, Paugh SW, Shida D, Lepine S, Elmore LW, et al. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 2007;67:10466-74. (Pubitemid 350070822)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10466-10474
    • Sankala, H.M.1    Hait, N.C.2    Paugh, S.W.3    Shida, D.4    Lepine, S.5    Elmore, L.W.6    Dent, P.7    Milstien, S.8    Spiegel, S.9
  • 50
    • 1442265704 scopus 로고    scopus 로고
    • S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    • Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y. S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). FASEB J 2004;18:341-3.
    • (2004) FASEB J , vol.18 , pp. 341-343
    • Baudhuin, L.M.1    Jiang, Y.2    Zaslavsky, A.3    Ishii, I.4    Chun, J.5    Xu, Y.6
  • 51
    • 0344875587 scopus 로고    scopus 로고
    • 12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors
    • DOI 10.1074/jbc.M308749200
    • Olivera A, Rosenfeldt HM, Bektas M, Wang F, Ishii I, Chun J, et al. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem 2003;278:46452-60. (Pubitemid 37452217)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.47 , pp. 46452-46460
    • Olivera, A.1    Rosenfeldt, H.M.2    Bektas, M.3    Wang, F.4    Ishii, I.5    Chun, J.6    Milstien, S.7    Spiegel, S.8
  • 52
    • 51649125641 scopus 로고    scopus 로고
    • RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
    • Bessard A, Fremin C, Ezan F, Fautrel A, Gailhouste L, Baffet G. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene 2008;27:5315-25.
    • (2008) Oncogene , vol.27 , pp. 5315-5325
    • Bessard, A.1    Fremin, C.2    Ezan, F.3    Fautrel, A.4    Gailhouste, L.5    Baffet, G.6
  • 53
    • 34247358156 scopus 로고    scopus 로고
    • ERK2 but not ERK1 plays a key role in hepatocyte replication: An RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes
    • DOI 10.1002/hep.21551
    • Fremin C, Ezan F, Boisselier P, Bessard A, Pages G, Pouyssegur J, et al. ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes. Hepatology 2007;45:1035-45. (Pubitemid 46631572)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 1035-1045
    • Fremin, C.1    Ezan, F.2    Boisselier, P.3    Bessard, A.4    Pages, G.5    Pouyssegur, J.6    Baffet, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.