-
1
-
-
84871253900
-
Molecular-based and alternative therapies for pancreatic cancer: Looking "out of the box"
-
Tholey, R.; Sawicki, J.A.; Brody, J.R. Molecular-based and alternative therapies for pancreatic cancer: Looking "out of the box". Cancer J. 2012, 18, 665-673.
-
(2012)
Cancer J.
, vol.18
, pp. 665-673
-
-
Tholey, R.1
Sawicki, J.A.2
Brody, J.R.3
-
2
-
-
84873988737
-
Tissue proteomics in pancreatic cancer study: Discovery, emerging technologies and challenges
-
Pan, S.; Brentnall, T.A.; Kelly, K.; Chen, R. Tissue proteomics in pancreatic cancer study: Discovery, emerging technologies and challenges. Proteomics 2013, 13, 710-721.
-
(2013)
Proteomics
, vol.13
, pp. 710-721
-
-
Pan, S.1
Brentnall, T.A.2
Kelly, K.3
Chen, R.4
-
4
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen, B.; Hannun, Y.A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 2004, 4, 604-616.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
5
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun, Y.A.; Obeid, L.M. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat. Rev. Mol. Cell. Biol. 2008, 9, 139-150.
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
6
-
-
78751518056
-
Dysregulation of sphingolipid metabolism in cancer
-
Ryland, L.K.; Fox, T.E.; Liu, X.; Loughran, T.P.; Kester, M. Dysregulation of sphingolipid metabolism in cancer. Cancer Biol. Ther. 2011, 11, 138-149.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 138-149
-
-
Ryland, L.K.1
Fox, T.E.2
Liu, X.3
Loughran, T.P.4
Kester, M.5
-
7
-
-
80054080467
-
Ceramide-based therapeutics for the treatment of cancer
-
Barth, B.M.; Cabot, M.C.; Kester, M. Ceramide-based therapeutics for the treatment of cancer. Anticancer Agents Med. Chem. 2011, 11, 911-919.
-
(2011)
Anticancer Agents Med. Chem.
, vol.11
, pp. 911-919
-
-
Barth, B.M.1
Cabot, M.C.2
Kester, M.3
-
8
-
-
83855164064
-
Sphingolipids in cancer
-
Furuya, H.; Shimizu, Y.; Kawamori, T. Sphingolipids in cancer. Cancer Metastasis Rev. 2011, 30, 567-576.
-
(2011)
Cancer Metastasis Rev.
, vol.30
, pp. 567-576
-
-
Furuya, H.1
Shimizu, Y.2
Kawamori, T.3
-
9
-
-
4444309565
-
The complex life of simple sphingolipids
-
Futerman, A.H.; Hannun, Y.A. The complex life of simple sphingolipids. EMBO Rep. 2004, 5, 777-782.
-
(2004)
EMBO Rep.
, vol.5
, pp. 777-782
-
-
Futerman, A.H.1
Hannun, Y.A.2
-
10
-
-
0029148660
-
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
-
Bose, R.; Verheij, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 1995, 82, 405-414.
-
(1995)
Cell
, vol.82
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
11
-
-
0034708594
-
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
-
Perry, D.K.; Carton, J.; Shah, A.K.; Meredith, F.; Uhlinger, D.J.; Hannun, Y.A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 2000, 275, 9078-9084.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9078-9084
-
-
Perry, D.K.1
Carton, J.2
Shah, A.K.3
Meredith, F.4
Uhlinger, D.J.5
Hannun, Y.A.6
-
12
-
-
0038626211
-
Tumor response to radiotherapy regulated by endothelial cell apoptosis
-
Garcia-Barros, M.; Paris, F.; Cordon-Cardo, C.; Lyden, D.; Rafii, S.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003, 300, 1155-1159.
-
(2003)
Science
, vol.300
, pp. 1155-1159
-
-
Garcia-Barros, M.1
Paris, F.2
Cordon-Cardo, C.3
Lyden, D.4
Rafii, S.5
Haimovitz-Friedman, A.6
Fuks, Z.7
Kolesnick, R.8
-
13
-
-
79953232027
-
Circulating sphingolipid biomarkers in models of type 1 diabetes
-
Fox, T.E.; Bewley, M.C.; Unrath, K.A.; Pedersen, M.M.; Anderson, R.E.; Jung, D.Y.; Jefferson, L.S.; Kim, J.K.; Bronson, S.K.; Flanagan, J.M.; et al. Circulating sphingolipid biomarkers in models of type 1 diabetes. J. Lipid Res. 2011, 52, 509-517.
-
(2011)
J. Lipid Res.
, vol.52
, pp. 509-517
-
-
Fox, T.E.1
Bewley, M.C.2
Unrath, K.A.3
Pedersen, M.M.4
Anderson, R.E.5
Jung, D.Y.6
Jefferson, L.S.7
Kim, J.K.8
Bronson, S.K.9
Flanagan, J.M.10
-
14
-
-
7244244035
-
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
-
Koybasi, S.; Senkal, C.E.; Sundararaj, K.; Spassieva, S.; Bielawski, J.; Osta, W.; Day, T.A.; Jiang, J.C.; Jazwinski, S.M.; Hannun, Y.A.; et al. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J. Biol. Chem. 2004, 279, 44311-44319.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44311-44319
-
-
Koybasi, S.1
Senkal, C.E.2
Sundararaj, K.3
Spassieva, S.4
Bielawski, J.5
Osta, W.6
Day, T.A.7
Jiang, J.C.8
Jazwinski, S.M.9
Hannun, Y.A.10
-
15
-
-
34548286300
-
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
-
Karahatay, S.; Thomas, K.; Koybasi, S.; Senkal, C.E.; Elojeimy, S.; Liu, X.; Bielawski, J.; Day, T.A.; Gillespie, M.B.; Sinha, D.; et al. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007, 256, 101-111.
-
(2007)
Cancer Lett.
, vol.256
, pp. 101-111
-
-
Karahatay, S.1
Thomas, K.2
Koybasi, S.3
Senkal, C.E.4
Elojeimy, S.5
Liu, X.6
Bielawski, J.7
Day, T.A.8
Gillespie, M.B.9
Sinha, D.10
-
16
-
-
65549143292
-
Ceramide synthases and ceramide levels are increased in breast cancer tissue
-
Schiffmann, S.; Sandner, J.; Birod, K.; Wobst, I.; Angioni, C.; Ruckhaberle, E.; Kaufmann, M.; Ackermann, H.; Lotsch, J.; Schmidt, H.; et al. Ceramide synthases and ceramide levels are increased in breast cancer tissue. Carcinogenesis 2009, 30, 745-752.
-
(2009)
Carcinogenesis
, vol.30
, pp. 745-752
-
-
Schiffmann, S.1
Sandner, J.2
Birod, K.3
Wobst, I.4
Angioni, C.5
Ruckhaberle, E.6
Kaufmann, M.7
Ackermann, H.8
Lotsch, J.9
Schmidt, H.10
-
17
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
Senkal, C.E.; Ponnusamy, S.; Bielawski, J.; Hannun, Y.A.; Ogretmen, B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010, 24, 296-308.
-
(2010)
FASEB J.
, vol.24
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
18
-
-
84857924002
-
Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth
-
Hartmann, D.; Lucks, J.; Fuchs, S.; Schiffmann, S.; Schreiber, Y.; Ferreiros, N.; Merkens, J.; Marschalek, R.; Geisslinger, G.; Grosch, S. Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth. Int. J. Biochem. Cell. Biol. 2012, 44, 620-628.
-
(2012)
Int. J. Biochem. Cell. Biol.
, vol.44
, pp. 620-628
-
-
Hartmann, D.1
Lucks, J.2
Fuchs, S.3
Schiffmann, S.4
Schreiber, Y.5
Ferreiros, N.6
Merkens, J.7
Marschalek, R.8
Geisslinger, G.9
Grosch, S.10
-
20
-
-
38349045075
-
Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
-
Gouaze-Andersson, V.; Yu, J.Y.; Kreitenberg, A.J.; Bielawska, A.; Giuliano, A.E.; Cabot, M.C. Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells. Biochim. Biophys. Acta 2007, 1771, 1407-1417.
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1407-1417
-
-
Gouaze-Andersson, V.1
Yu, J.Y.2
Kreitenberg, A.J.3
Bielawska, A.4
Giuliano, A.E.5
Cabot, M.C.6
-
21
-
-
33751245926
-
Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors
-
Couvelard, A.; Hu, J.; Steers, G.; O'Toole, D.; Sauvanet, A.; Belghiti, J.; Bedossa, P.; Gatter, K.; Ruszniewski, P.; Pezzella, F. Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors. Gastroenterology 2006, 131, 1597-1610.
-
(2006)
Gastroenterology
, vol.131
, pp. 1597-1610
-
-
Couvelard, A.1
Hu, J.2
Steers, G.3
O'Toole, D.4
Sauvanet, A.5
Belghiti, J.6
Bedossa, P.7
Gatter, K.8
Ruszniewski, P.9
Pezzella, F.10
-
22
-
-
0742322367
-
Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia
-
Park, H.U.; Kim, J.W.; Kim, G.E.; Bae, H.I.; Crawley, S.C.; Yang, S.C.; Gum, J.R., Jr.; Batra, S.K.; Rousseau, K.; Swallow, D.M.; et al. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Pancreas 2003, 26, e48-e54.
-
(2003)
Pancreas
, vol.26
-
-
Park, H.U.1
Kim, J.W.2
Kim, G.E.3
Bae, H.I.4
Crawley, S.C.5
Yang, S.C.6
Gum Jr., J.R.7
Batra, S.K.8
Rousseau, K.9
Swallow, D.M.10
-
23
-
-
13644255296
-
Expression of connexin26 in islets of Langerhans is associated with impaired glucose tolerance in patients with pancreatic adenocarcinoma
-
Pfeffer, F.; Koczan, D.; Adam, U.; Benz, S.; von Dobschuetz, E.; Prall, F.; Nizze, H.; Thiesen, H.J.; Hopt, U.T.; Lobler, M. Expression of connexin26 in islets of Langerhans is associated with impaired glucose tolerance in patients with pancreatic adenocarcinoma. Pancreas 2004, 29, 284-290.
-
(2004)
Pancreas
, vol.29
, pp. 284-290
-
-
Pfeffer, F.1
Koczan, D.2
Adam, U.3
Benz, S.4
von Dobschuetz, E.5
Prall, F.6
Nizze, H.7
Thiesen, H.J.8
Hopt, U.T.9
Lobler, M.10
-
24
-
-
1242316269
-
Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
-
Sato, N.; Fukushima, N.; Maitra, A.; Iacobuzio-Donahue, C.A.; van Heek, N.T.; Cameron, J.L.; Yeo, C.J.; Hruban, R.H.; Goggins, M. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am. J. Pathol. 2004, 164, 903-914.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 903-914
-
-
Sato, N.1
Fukushima, N.2
Maitra, A.3
Iacobuzio-Donahue, C.A.4
van Heek, N.T.5
Cameron, J.L.6
Yeo, C.J.7
Hruban, R.H.8
Goggins, M.9
-
25
-
-
0029815356
-
Sialyl Lewis(a) ganglioside in pancreatic cancer tissue correlates with the serum CA 19-9 level
-
Hamanaka, Y.; Hamanaka, S.; Suzuki, M. Sialyl Lewis(a) ganglioside in pancreatic cancer tissue correlates with the serum CA 19-9 level. Pancreas 1996, 13, 160-165.
-
(1996)
Pancreas
, vol.13
, pp. 160-165
-
-
Hamanaka, Y.1
Hamanaka, S.2
Suzuki, M.3
-
26
-
-
58149277751
-
Roles of bioactive sphingolipids in cancer biology and therapeutics
-
Saddoughi, S.A.; Song, P.; Ogretmen, B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem. 2008, 49, 413-440.
-
(2008)
Subcell Biochem.
, vol.49
, pp. 413-440
-
-
Saddoughi, S.A.1
Song, P.2
Ogretmen, B.3
-
27
-
-
0036436697
-
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
-
Nava, V.E.; Hobson, J.P.; Murthy, S.; Milstien, S.; Spiegel, S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell. Res. 2002, 281, 115-127.
-
(2002)
Exp. Cell. Res.
, vol.281
, pp. 115-127
-
-
Nava, V.E.1
Hobson, J.P.2
Murthy, S.3
Milstien, S.4
Spiegel, S.5
-
28
-
-
0037178555
-
Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and phosphatidylinositol 3-kinase beta
-
Van Brocklyn, J.; Letterle, C.; Snyder, P.; Prior, T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett. 2002, 181, 195-204.
-
(2002)
Cancer Lett.
, vol.181
, pp. 195-204
-
-
Van Brocklyn, J.1
Letterle, C.2
Snyder, P.3
Prior, T.4
-
29
-
-
25844457390
-
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
-
Sarkar, S.; Maceyka, M.; Hait, N.C.; Paugh, S.W.; Sankala, H.; Milstien, S.; Spiegel, S. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett. 2005, 579, 5313-5317.
-
(2005)
FEBS Lett.
, vol.579
, pp. 5313-5317
-
-
Sarkar, S.1
Maceyka, M.2
Hait, N.C.3
Paugh, S.W.4
Sankala, H.5
Milstien, S.6
Spiegel, S.7
-
30
-
-
84864797320
-
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis
-
Ponnusamy, S.; Selvam, S.P.; Mehrotra, S.; Kawamori, T.; Snider, A.J.; Obeid, L.M.; Shao, Y.; Sabbadini, R.; Ogretmen, B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol. Med. 2012, 4, 761-775.
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 761-775
-
-
Ponnusamy, S.1
Selvam, S.P.2
Mehrotra, S.3
Kawamori, T.4
Snider, A.J.5
Obeid, L.M.6
Shao, Y.7
Sabbadini, R.8
Ogretmen, B.9
-
31
-
-
79953232027
-
Circulating sphingolipid biomarkers in models of type 1 diabetes
-
Fox, T.E.; Bewley, M.C.; Unrath, K.A.; Pedersen, M.M.; Anderson, R.E.; Jung, D.Y.; Jefferson, L.S.; Kim, J.K.; Bronson, S.K.; Flanagan, J.M.; et al. Circulating sphingolipid biomarkers in models of type 1 diabetes. J. Lipid Res. 2011, 52, 509-517.
-
(2011)
J. Lipid Res.
, vol.52
, pp. 509-517
-
-
Fox, T.E.1
Bewley, M.C.2
Unrath, K.A.3
Pedersen, M.M.4
Anderson, R.E.5
Jung, D.Y.6
Jefferson, L.S.7
Kim, J.K.8
Bronson, S.K.9
Flanagan, J.M.10
-
32
-
-
0037485571
-
Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate
-
Deutschman, D.H.; Carstens, J.S.; Klepper, R.L.; Smith, W.S.; Page, M.T.; Young, T.R.; Gleason, L.A.; Nakajima, N.; Sabbadini, R.A. Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. Am. Heart J. 2003, 146, 62-68.
-
(2003)
Am. Heart J.
, vol.146
, pp. 62-68
-
-
Deutschman, D.H.1
Carstens, J.S.2
Klepper, R.L.3
Smith, W.S.4
Page, M.T.5
Young, T.R.6
Gleason, L.A.7
Nakajima, N.8
Sabbadini, R.A.9
-
33
-
-
78149277336
-
Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells
-
Long, J.S.; Fujiwara, Y.; Edwards, J.; Tannahill, C.L.; Tigyi, G.; Pyne, S.; Pyne, N.J. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. J. Biol. Chem. 2010, 285, 35957-35966.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35957-35966
-
-
Long, J.S.1
Fujiwara, Y.2
Edwards, J.3
Tannahill, C.L.4
Tigyi, G.5
Pyne, S.6
Pyne, N.J.7
-
34
-
-
53049096639
-
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
-
Shida, D.; Fang, X.; Kordula, T.; Takabe, K.; Lepine, S.; Alvarez, S.E.; Milstien, S.; Spiegel, S. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 2008, 68, 6569-6577.
-
(2008)
Cancer Res.
, vol.68
, pp. 6569-6577
-
-
Shida, D.1
Fang, X.2
Kordula, T.3
Takabe, K.4
Lepine, S.5
Alvarez, S.E.6
Milstien, S.7
Spiegel, S.8
-
35
-
-
31044450344
-
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7
-
Doll, F.; Pfeilschifter, J.; Huwiler, A. The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7. Biochim. Biophys. Acta 2005, 1738, 72-81.
-
(2005)
Biochim. Biophys. Acta
, vol.1738
, pp. 72-81
-
-
Doll, F.1
Pfeilschifter, J.2
Huwiler, A.3
-
36
-
-
84866450512
-
The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
-
Evans, A.; Costello, E. The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. Front. Physiol. 2012, 3, 270.
-
(2012)
Front. Physiol.
, vol.3
, pp. 270
-
-
Evans, A.1
Costello, E.2
|