메뉴 건너뛰기




Volumn , Issue , 2014, Pages 25-74

Neuropathology of parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84930320378     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-08046-8_2     Document Type: Chapter
Times cited : (15)

References (404)
  • 2
    • 80055097451 scopus 로고    scopus 로고
    • Projected numbers of people with movement disorders in the years 2030 and 2050
    • Bach JP, Ziegler U, Deuschl G, Dodel R, Doblhammer-Reiter G. Projected numbers of people with movement disorders in the years 2030 and 2050. Mov Disord. 2011;26:2286-90.
    • (2011) Mov Disord. , vol.26 , pp. 2286-2290
    • Bach, J.P.1    Ziegler, U.2    Deuschl, G.3    Dodel, R.4    Doblhammer-Reiter, G.5
  • 4
    • 47749133088 scopus 로고    scopus 로고
    • Lewy body disorders
    • Youdim MBH Riederer P Mandel SA Battistin L Lajtha A editors New York: Springer Science
    • Jellinger KA. Lewy body disorders. In: Youdim MBH, Riederer P, Mandel SA, Battistin L, Lajtha A, editors. Degenerative diseases of the nervous system. New York: Springer Science; 2007. p. 267-343.
    • (2007) Degenerative Diseases of the Nervous System , pp. 267-343
    • Jellinger, K.A.1
  • 5
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • Beach TG, Adler CH, Sue LI, Vedders L, Lue L, White Iii CL, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119:689-702.
    • (2010) Acta Neuropathol. , vol.119 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3    Vedders, L.4    Lue, L.5    White Iii, C.L.6
  • 6
    • 43649106356 scopus 로고    scopus 로고
    • Invited article: Nervous system pathology in sporadic Parkinson disease
    • Braak H, Del Tredici K. Invited article: nervous system pathology in sporadic Parkinson disease. Neurology. 2008;70:1916-25.
    • (2008) Neurology. , vol.70 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2
  • 7
    • 34247846268 scopus 로고    scopus 로고
    • Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease
    • Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, et al. Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol. 2007;66:354-62.
    • (2007) J Neuropathol Exp Neurol. , vol.66 , pp. 354-362
    • Fumimura, Y.1    Ikemura, M.2    Saito, Y.3    Sengoku, R.4    Kanemaru, K.5    Sawabe, M.6
  • 9
    • 84872863398 scopus 로고    scopus 로고
    • Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease
    • Mu L, Sobotka S, Chen J, Su H, Sanders I, Adler CH, et al. Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol. 2013;72:119-29.
    • (2013) J Neuropathol Exp Neurol. , vol.72 , pp. 119-129
    • Mu, L.1    Sobotka, S.2    Chen, J.3    Su, H.4    Sanders, I.5    Adler, C.H.6
  • 10
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain. 2008;131:642-50.
    • (2008) Brain. , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3    Mori, F.4    Kakita, A.5    Wakabayashi, K.6
  • 11
    • 77953033188 scopus 로고    scopus 로고
    • Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopa-thies of the brain
    • Wakabayashi K, Mori F, Tanji K, Orimo S, Takahashi H. Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopa-thies of the brain. Acta Neuropathol. 2010;120:1-12.
    • (2010) Acta Neuropathol. , vol.120 , pp. 1-12
    • Wakabayashi, K.1    Mori, F.2    Tanji, K.3    Orimo, S.4    Takahashi, H.5
  • 12
    • 84864130246 scopus 로고    scopus 로고
    • The role of alpha-synuclein in neurodegeneration-an update
    • Jellinger KA. The role of alpha-synuclein in neurodegeneration-an update. Transl Neurosci. 2012;3:75-122.
    • (2012) Transl Neurosci. , vol.3 , pp. 75-122
    • Jellinger, K.A.1
  • 13
    • 84855972240 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
    • Jellinger KA. Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov Disord. 2012;27:8-30.
    • (2012) Mov Disord. , vol.27 , pp. 8-30
    • Jellinger, K.A.1
  • 15
    • 84861739631 scopus 로고    scopus 로고
    • Evaluation of the Braak hypothesis: How far can it explain the pathogenesis of Parkinson's disease?
    • Halliday G, McCann H, Shepherd C. Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease? Expert Rev Neurother. 2012;12:673-86.
    • (2012) Expert Rev Neurother. , vol.12 , pp. 673-686
    • Halliday, G.1    McCann, H.2    Shepherd, C.3
  • 18
    • 33646082266 scopus 로고    scopus 로고
    • Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    • Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol. 2006;32:284-95.
    • (2006) Neuropathol Appl Neurobiol. , vol.32 , pp. 284-295
    • Bloch, A.1    Probst, A.2    Bissig, H.3    Adams, H.4    Tolnay, M.5
  • 19
    • 33947200337 scopus 로고    scopus 로고
    • Parkinson's disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons
    • Braak H, Sastre M, Bohl JR, de Vos RA, Del Tredici K. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre-and postganglionic neurons. Acta Neuropathol. 2007;113:421-9.
    • (2007) Acta Neuropathol. , vol.113 , pp. 421-429
    • Braak, H.1    Sastre, M.2    Bohl, J.R.3    De Vos, R.A.4    Del Tredici, K.5
  • 20
    • 84874210403 scopus 로고    scopus 로고
    • Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease
    • Gold A, Turkalp ZT, Munoz DG. Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease. Mov Disord. 2013;28:237-40.
    • (2013) Mov Disord. , vol.28 , pp. 237-240
    • Gold, A.1    Turkalp, Z.T.2    Munoz, D.G.3
  • 21
    • 41049097524 scopus 로고    scopus 로고
    • New insights into the pathology of Parkinson's disease: Does the peripheral autonomic system become central?
    • Probst A, Bloch A, Tolnay M. New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central? Eur J Neurol. 2008;15 Suppl 1:1-4.
    • (2008) Eur J Neurol. , vol.15 , pp. 1-4
    • Probst, A.1    Bloch, A.2    Tolnay, M.3
  • 23
    • 41149110768 scopus 로고    scopus 로고
    • Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
    • Phillips RJ, Walter GC, Wilder SL, Baronowsky EA, Powley TL. Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? Neuroscience. 2008;153:733-50.
    • (2008) Neuroscience. , vol.153 , pp. 733-750
    • Phillips, R.J.1    Walter, G.C.2    Wilder, S.L.3    Baronowsky, E.A.4    Powley, T.L.5
  • 26
    • 84871075728 scopus 로고    scopus 로고
    • New concepts in the early and preclinical detection of Parkinson's disease: Therapeutic implications
    • Akhtar RS, Stern MB. New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications. Expert Rev Neurother. 2012;12:1429-38.
    • (2012) Expert Rev Neurother. , vol.12 , pp. 1429-1438
    • Akhtar, R.S.1    Stern, M.B.2
  • 27
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment
    • Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol. 2009;8:464-74.
    • (2009) Lancet Neurol. , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 28
    • 79955112282 scopus 로고    scopus 로고
    • A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials
    • Lang AE. A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials. Mov Disord. 2011;26: 775-83.
    • (2011) Mov Disord. , vol.26 , pp. 775-783
    • Lang, A.E.1
  • 29
    • 84865997692 scopus 로고    scopus 로고
    • Clinical approach to Parkinson's disease: Features, diagnosis, and principles of management
    • Massano J, Bhatia KP. Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med. 2012;2:a008870.
    • (2012) Cold Spring Harb Perspect Med. , vol.2 , pp. a008870
    • Massano, J.1    Bhatia, K.P.2
  • 31
    • 84885982317 scopus 로고    scopus 로고
    • Nonmotor aspects of Parkinson's disease
    • Schapira AHV Lang AET Fahn S editors Philadelphia: Saunders-Elsevier
    • Tolosa E, Santamaria J, Gaig C, Compta Y. Nonmotor aspects of Parkinson's disease. In: Schapira AHV, Lang AET, Fahn S, editors. Movement disorders 4. Philadelphia: Saunders-Elsevier; 2010. p. 229-51.
    • (2010) Movement Disorders 4 , pp. 229-251
    • Tolosa, E.1    Santamaria, J.2    Gaig, C.3    Compta, Y.4
  • 32
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord. 2008; 23:837-44.
    • (2008) Mov Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 33
    • 0036169364 scopus 로고    scopus 로고
    • The heterogeneity of idiopathic Parkinson's disease
    • Foltynie T, Brayne C, Barker RA. The heterogeneity of idiopathic Parkinson's disease. J Neurol. 2002;249:138-45.
    • (2002) J Neurol. , vol.249 , pp. 138-145
    • Foltynie, T.1    Brayne, C.2    Barker, R.A.3
  • 34
    • 68949194368 scopus 로고    scopus 로고
    • Course in Parkinson disease subtypes: A 39-year clinicopathologic study
    • Rajput AH, Voll A, Rajput ML, Robinson CA, Rajput A. Course in Parkinson disease subtypes: A 39-year clinicopathologic study. Neurology. 2009;73:206-12.
    • (2009) Neurology. , vol.73 , pp. 206-212
    • Rajput, A.H.1    Voll, A.2    Rajput, M.L.3    Robinson, C.A.4    Rajput, A.5
  • 35
    • 84855925916 scopus 로고    scopus 로고
    • Toward a redefinition of Parkinson's disease
    • Stern MB, Lang A, Poewe W. Toward a redefinition of Parkinson's disease. Mov Disord. 2012;27:54-60.
    • (2012) Mov Disord. , vol.27 , pp. 54-60
    • Stern, M.B.1    Lang, A.2    Poewe, W.3
  • 36
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday GM, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol. 2011;122:187-204.
    • (2011) Acta Neuropathol. , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 38
    • 0036209085 scopus 로고    scopus 로고
    • The accuracy of diagnosis of Parkinsonian syndromes in a specialist movement disorder service
    • Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of Parkinsonian syndromes in a specialist movement disorder service. Brain. 2002;125:861-70.
    • (2002) Brain. , vol.125 , pp. 861-870
    • Hughes, A.J.1    Daniel, S.E.2    Ben-Shlomo, Y.3    Lees, A.J.4
  • 40
    • 0038147327 scopus 로고    scopus 로고
    • Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    • Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I, et al. Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord. 2003;18:467-86.
    • (2003) Mov Disord. , vol.18 , pp. 467-486
    • Litvan, I.1    Bhatia, K.P.2    Burn, D.J.3    Goetz, C.G.4    Lang, A.E.5    McKeith, I.6
  • 41
    • 71849092190 scopus 로고    scopus 로고
    • Diagnostic criteria for the neuropathological assessment of Parkinson disease: Report of the Neuropathology and Genetics Working Group of the Second International Brainstorming Conference on Parkinson disease
    • Dickson DW, Braak H, Duda JE, Duyckaerts C, Gasser T, Halliday GM, et al. Diagnostic criteria for the neuropathological assessment of Parkinson disease: Report of the Neuropathology and Genetics Working Group of the Second International Brainstorming Conference on Parkinson disease. Lancet Neurol. 2009;8:1150-7.
    • (2009) Lancet Neurol. , vol.8 , pp. 1150-1157
    • Dickson, D.W.1    Braak, H.2    Duda, J.E.3    Duyckaerts, C.4    Gasser, T.5    Halliday, G.M.6
  • 42
    • 84872729641 scopus 로고    scopus 로고
    • Parkinson's disease and Parkinsonism: Neuropathology
    • Dickson DW. Parkinson's disease and Parkinsonism: neuropathology. Cold Spring Harb Perspect Med. 2012;2:a009258.
    • (2012) Cold Spring Harb Perspect Med. , vol.2 , pp. a009258
    • Dickson, D.W.1
  • 43
    • 79957586330 scopus 로고    scopus 로고
    • Milestones in Parkinson's disease-clinical and pathologic features
    • Halliday G, Lees A, Stern M. Milestones in Parkinson's disease-clinical and pathologic features. Mov Disord. 2011;26:1015-21.
    • (2011) Mov Disord. , vol.26 , pp. 1015-1021
    • Halliday, G.1    Lees, A.2    Stern, M.3
  • 46
    • 84893028018 scopus 로고    scopus 로고
    • Synuclein and Parkinson's disease: An update
    • Martinez A, Gil C, editors London: The Royal Society of Chemistry
    • Jellinger KA. Synuclein and Parkinson's disease: an update. In: Martinez A, Gil C, editors. Emerging drugs and targets for Parkinson's disease. London: The Royal Society of Chemistry; 2013. p. 175-214.
    • (2013) Emerging Drugs and Targets for Parkinson's Disease , pp. 175-214
    • Jellinger, K.A.1
  • 47
    • 84930356373 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Pfeiffer RF, Wszolek ZK, Ebadi M, editors Boca Raton: CRC Press
    • Duda JE, Dickson DW. Neuropathology of Parkinson's disease. In: Pfeiffer RF, Wszolek ZK, Ebadi M, editors. Parkinson's disease. 2nd ed. Boca Raton: CRC Press; 2013. p. 492-506.
    • (2013) Parkinson's Disease. 2nd Ed , pp. 492-506
    • Duda, J.E.1    Dickson, D.W.2
  • 48
    • 84886045090 scopus 로고    scopus 로고
    • Pathology of Parkinson's disease-an overview
    • Schapira AHV Lang AET Fahn S editors Philadelphia: Saunders-Elsevier
    • Halliday G, Murphy K. Pathology of Parkinson's disease-an overview. In: Schapira AHV, Lang AET, Fahn S, editors. Movement disorders 4. Philadelphia: Saunders-Elsevier; 2010. p. 132-54.
    • (2010) Movement Disorders 4 , pp. 132-154
    • Halliday, G.1    Murphy, K.2
  • 50
    • 84865864065 scopus 로고    scopus 로고
    • The genetics and neuropathology of Parkinson's disease
    • Houlden H, Singleton AB. The genetics and neuropathology of Parkinson's disease. Acta Neuropathol. 2012;124:325-38.
    • (2012) Acta Neuropathol. , vol.124 , pp. 325-338
    • Houlden, H.1    Singleton, A.B.2
  • 51
    • 84862689309 scopus 로고    scopus 로고
    • The neuropathology of genetic Parkinson's disease
    • Poulopoulos M, Levy OA, Alcalay RN. The neuropathology of genetic Parkinson's disease. Mov Disord. 2012;27:831-42.
    • (2012) Mov Disord. , vol.27 , pp. 831-842
    • Poulopoulos, M.1    Levy, O.A.2    Alcalay, R.N.3
  • 52
    • 41549154550 scopus 로고    scopus 로고
    • Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies
    • Muntane G, Dalfo E, Martinez A, Ferrer I. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. 2008;152:913-23.
    • (2008) Neuroscience. , vol.152 , pp. 913-923
    • Muntane, G.1    Dalfo, E.2    Martinez, A.3    Ferrer, I.4
  • 53
    • 77957264418 scopus 로고    scopus 로고
    • The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies Parkinson's disease and Parkinson's disease dementia
    • Schulz-Schaeffer WJ. The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol. 2010;120:131-43.
    • (2010) Acta Neuropathol. , vol.120 , pp. 131-143
    • Schulz-Schaeffer, W.J.1
  • 54
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier P, Hirsch EC, Agid Y, Graybiel AM. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain. 1999;122 (Pt 8):1437-48.
    • (1999) Brain. , vol.122 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 55
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications
    • Kish SJ, Shannak K, Hornykiewicz O. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med. 1988;318:876-80.
    • (1988) N Engl J Med. , vol.318 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 56
    • 42049097441 scopus 로고    scopus 로고
    • Globus pallidus dopa-mine and Parkinson motor subtypes: Clinical and brain biochemical correlation
    • Rajput AH, Sitte HH, Rajput A, Fenton ME, PiflC, Hornykiewicz O. Globus pallidus dopa-mine and Parkinson motor subtypes: clinical and brain biochemical correlation. Neurology. 2008;70:1403-10.
    • (2008) Neurology. , vol.70 , pp. 1403-1410
    • Rajput, A.H.1    Sitte, H.H.2    Rajput, A.3    Fenton, M.E.4    Piflc5    Hornykiewicz, O.6
  • 57
    • 33747778859 scopus 로고    scopus 로고
    • Striatal dopaminergic neurons are lost with Parkinson's disease progression
    • Porritt MJ, Kingsbury AE, Hughes AJ, Howells DW. Striatal dopaminergic neurons are lost with Parkinson's disease progression. Mov Disord. 2006;21:2208-11.
    • (2006) Mov Disord. , vol.21 , pp. 2208-2211
    • Porritt, M.J.1    Kingsbury, A.E.2    Hughes, A.J.3    Howells, D.W.4
  • 58
    • 33646251393 scopus 로고    scopus 로고
    • New striatal dopa-mine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogen-esis
    • Tandé D, Hoglinger G, Debeir T, Freundlieb N, Hirsch EC, Francois C. New striatal dopa-mine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogen-esis. Brain. 2006;129:1194-200.
    • (2006) Brain. , vol.129 , pp. 1194-1200
    • Tandé, D.1    Hoglinger, G.2    Debeir, T.3    Freundlieb, N.4    Hirsch, E.C.5    Francois, C.6
  • 59
    • 79959588593 scopus 로고    scopus 로고
    • Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders
    • Mundinano IC, Caballero MC, Ordonez C, Hernandez M, DiCaudo C, Marcilla I, et al. Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders. Acta Neuropathol. 2011;122:61-74.
    • (2011) Acta Neuropathol. , vol.122 , pp. 61-74
    • Mundinano, I.C.1    Caballero, M.C.2    Ordonez, C.3    Hernandez, M.4    Dicaudo, C.5    Marcilla, I.6
  • 61
    • 79954479115 scopus 로고    scopus 로고
    • Regional volume analysis of the Parkinson disease brain in early disease stage: Gray matter, white matter, striatum, and thala-mus
    • Lee SH, Kim SS, Tae WS, Lee SY, Choi JW, Koh SB, et al. Regional volume analysis of the Parkinson disease brain in early disease stage: gray matter, white matter, striatum, and thala-mus. AJNR Am J Neuroradiol. 2011;32:682-7.
    • (2011) AJNR Am J Neuroradiol. , vol.32 , pp. 682-687
    • Lee, S.H.1    Kim, S.S.2    Tae, W.S.3    Lee, S.Y.4    Choi, J.W.5    Koh, S.B.6
  • 62
    • 34249096090 scopus 로고    scopus 로고
    • Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?-a [99mTc]-TRODAT-1 SPECT study
    • Shih MC, Franco de Andrade LA, Amaro Jr E, Felicio AC, Ferraz HB, Wagner J, et al. Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?-a [99mTc]-TRODAT-1 SPECT study. Mov Disord. 2007;22:863-6.
    • (2007) Mov Disord. , vol.22 , pp. 863-866
    • Shih, M.C.1    Franco De Andrade, L.A.2    Amaro, E.3    Felicio, A.C.4    Ferraz, H.B.5    Wagner, J.6
  • 63
    • 0342981758 scopus 로고    scopus 로고
    • Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
    • Ma SY, Roytta M, Rinne JO, Collan Y, Rinne UK. Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts. J Neurol Sci. 1997;151:83-7.
    • (1997) J Neurol Sci. , vol.151 , pp. 83-87
    • Ma, S.Y.1    Roytta, M.2    Rinne, J.O.3    Collan, Y.4    Rinne, U.K.5
  • 64
    • 79955484858 scopus 로고    scopus 로고
    • Progression of monoaminer-gic dysfunction in Parkinson's disease: A longitudinal (18)F-dopa PET study
    • Pavese N, Rivero-Bosch M, Lewis SJ, Whone AL, Brooks DJ. Progression of monoaminer-gic dysfunction in Parkinson's disease: a longitudinal (18)F-dopa PET study. Neuroimage. 2011;56:1463-8.
    • (2011) Neuroimage. , vol.56 , pp. 1463-1468
    • Pavese, N.1    Rivero-Bosch, M.2    Lewis, S.J.3    Whone, A.L.4    Brooks, D.J.5
  • 65
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemi-cal correlations
    • Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemi-cal correlations. J Neurol Sci. 1973;20:415-55.
    • (1973) J Neurol Sci. , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 68
    • 79952672042 scopus 로고    scopus 로고
    • Residual striatal dopaminergic nerve terminals in very long-standing Parkinson's disease: A single photon emission computed tomography imaging study
    • Djaldetti R, Lorberboym M, Karmon Y, Treves TA, Ziv I, Melamed E. Residual striatal dopaminergic nerve terminals in very long-standing Parkinson's disease: a single photon emission computed tomography imaging study. Mov Disord. 2011;26:327-30.
    • (2011) Mov Disord. , vol.26 , pp. 327-330
    • Djaldetti, R.1    Lorberboym, M.2    Karmon, Y.3    Treves, T.A.4    Ziv, I.5    Melamed, E.6
  • 69
    • 53149130592 scopus 로고    scopus 로고
    • Nigral burden of alpha-synuclein correlates with striatal dopamine deficit
    • Kovacs GG, Milenkovic IJ, Preusser M, Budka H. Nigral burden of alpha-synuclein correlates with striatal dopamine deficit. Mov Disord. 2008;23:1608-12.
    • (2008) Mov Disord. , vol.23 , pp. 1608-1612
    • Kovacs, G.G.1    Milenkovic, I.J.2    Preusser, M.3    Budka, H.4
  • 70
    • 84863188413 scopus 로고    scopus 로고
    • Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
    • Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain. 2012;135: 2058-73.
    • (2012) Brain. , vol.135 , pp. 2058-2073
    • Chu, Y.1    Morfini, G.A.2    Langhamer, L.B.3    He, Y.4    Brady, S.T.5    Kordower, J.H.6
  • 71
    • 0033591617 scopus 로고    scopus 로고
    • Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra
    • Ma SY, Ciliax BJ, Stebbins G, Jaffar S, Joyce JN, Cochran EJ, et al. Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. J Comp Neurol. 1999;409:25-37.
    • (1999) J Comp Neurol. , vol.409 , pp. 25-37
    • Ma, S.Y.1    Ciliax, B.J.2    Stebbins, G.3    Jaffar, S.4    Joyce, J.N.5    Cochran, E.J.6
  • 73
    • 0342445426 scopus 로고    scopus 로고
    • The vulnerability of nigral neurons to Parkinson's disease is unrelated to their intrinsic capacity for dopamine synthesis: An in situ hybridization study
    • Kingsbury AE, Marsden CD, Foster OJ. The vulnerability of nigral neurons to Parkinson's disease is unrelated to their intrinsic capacity for dopamine synthesis: an in situ hybridization study. Mov Disord. 1999;14:206-18.
    • (1999) Mov Disord. , vol.14 , pp. 206-218
    • Kingsbury, A.E.1    Marsden, C.D.2    Foster, O.J.3
  • 74
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Mov Disord. 2008;23: 474-83.
    • (2008) Mov Disord. , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 75
    • 84881427177 scopus 로고    scopus 로고
    • Parkinson disease: From pathology to molecular disease mechanisms
    • Dexter DT, Jenner P. Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med. 2013;62:132-44.
    • (2013) Free Radic Biol Med. , vol.62 , pp. 132-144
    • Dexter, D.T.1    Jenner, P.2
  • 76
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: A target for neuroprotec-tion?
    • Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotec-tion? Lancet Neurol. 2009;8:382-97.
    • (2009) Lancet Neurol. , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 77
    • 70350346842 scopus 로고    scopus 로고
    • The influence of microglia on the pathogenesis of Parkinson's disease
    • Long-Smith CM, Sullivan AM, Nolan YM. The influence of microglia on the pathogenesis of Parkinson's disease. Prog Neurobiol. 2009;89:277-87.
    • (2009) Prog Neurobiol. , vol.89 , pp. 277-287
    • Long-Smith, C.M.1    Sullivan, A.M.2    Nolan, Y.M.3
  • 78
    • 84872770499 scopus 로고    scopus 로고
    • Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease
    • Pradhan S, Andreasson K. Commentary: progressive inflammation as a contributing factor to early development of Parkinson's disease. Exp Neurol. 2013;241:148-55.
    • (2013) Exp Neurol. , vol.241 , pp. 148-155
    • Pradhan, S.1    Andreasson, K.2
  • 79
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
    • Tansey MG, Goldberg MS. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis. 2010;37:510-8.
    • (2010) Neurobiol Dis. , vol.37 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 81
    • 79951948479 scopus 로고    scopus 로고
    • Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
    • Alvarez-Erviti L, Couch Y, Richardson J, Cooper JM, Wood MJ. Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line. Neurosci Res. 2011; 69:337-42.
    • (2011) Neurosci Res. , vol.69 , pp. 337-342
    • Alvarez-Erviti, L.1    Couch, Y.2    Richardson, J.3    Cooper, J.M.4    Wood, M.J.5
  • 82
    • 33749046099 scopus 로고    scopus 로고
    • Progression patterns of neuronal loss and Lewy body pathology in the substantia nigra in Parkinson's disease
    • Wakabayashi K, Mori F, Takahashi H. Progression patterns of neuronal loss and Lewy body pathology in the substantia nigra in Parkinson's disease. Parkinsonism Relat Disord. 2006;12(suppl):S92-8.
    • (2006) Parkinsonism Relat Disord. , vol.12 , pp. S92-S98
    • Wakabayashi, K.1    Mori, F.2    Takahashi, H.3
  • 83
    • 70449532484 scopus 로고    scopus 로고
    • A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    • Greffard S, Verny M, Bonnet AM, Seilhean D, Hauw JJ, Duyckaerts C. A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol Aging. 2008;31:99-103.
    • (2008) Neurobiol Aging. , vol.31 , pp. 99-103
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Seilhean, D.4    Hauw, J.J.5    Duyckaerts, C.6
  • 84
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neuro-biology of axons
    • Cheng HC, Ulane CM, Burke RE. Clinical progression in Parkinson disease and the neuro-biology of axons. Ann Neurol. 2010;67:715-25.
    • (2010) Ann Neurol. , vol.67 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 85
    • 84880932230 scopus 로고    scopus 로고
    • Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
    • Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 2013;136: 2419-31.
    • (2013) Brain , vol.136 , pp. 2419-2431
    • Kordower, J.H.1    Olanow, C.W.2    Dodiya, H.B.3    Chu, Y.4    Beach, T.G.5    Adler, C.H.6
  • 86
    • 57049182374 scopus 로고    scopus 로고
    • Neuroanatomy and pathology of sporadic Parkinson's disease
    • Braak H, Del Tredici K. Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cell Biol. 2009;201:1-119.
    • (2009) Adv Anat Embryol Cell Biol. , vol.201 , pp. 1-119
    • Braak, H.1    Del Tredici, K.2
  • 87
    • 78650169532 scopus 로고    scopus 로고
    • Iron species-mediated dopamine oxidation, protea-some inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration
    • Zhou ZD, Lan YH, Tan EK, Lim TM. Iron species-mediated dopamine oxidation, protea-some inhibition, and dopaminergic cell demise: implications for iron-related dopaminergic neuron degeneration. Free Radic Biol Med. 2010;49:1856-71.
    • (2010) Free Radic Biol Med. , vol.49 , pp. 1856-1871
    • Zhou, Z.D.1    Lan, Y.H.2    Tan, E.K.3    Lim, T.M.4
  • 88
    • 0042433192 scopus 로고    scopus 로고
    • Neuromelanin-associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease
    • Faucheux BA, Martin ME, Beaumont C, Hauw JJ, Agid Y, Hirsch EC. Neuromelanin-associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. J Neurochem. 2003;86:1142-8.
    • (2003) J Neurochem. , vol.86 , pp. 1142-1148
    • Faucheux, B.A.1    Martin, M.E.2    Beaumont, C.3    Hauw, J.J.4    Agid, Y.5    Hirsch, E.C.6
  • 89
    • 80051632039 scopus 로고    scopus 로고
    • Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease
    • Lv Z, Jiang H, Xu H, Song N, Xie J. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. J Neural Transm. 2011;118: 361-9.
    • (2011) J Neural Transm. , vol.118 , pp. 361-369
    • Lv, Z.1    Jiang, H.2    Xu, H.3    Song, N.4    Xie, J.5
  • 90
    • 78649444888 scopus 로고    scopus 로고
    • Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples
    • Kell DB. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol. 2010;84:825-89.
    • (2010) Arch Toxicol. , vol.84 , pp. 825-889
    • Kell, D.B.1
  • 91
    • 80051801621 scopus 로고    scopus 로고
    • The relevance of iron in the pathogen-esis of Parkinson's disease
    • Sian-Hulsmann J, Mandel S, Youdim MB, Riederer P. The relevance of iron in the pathogen-esis of Parkinson's disease. J Neurochem. 2011;118:939-57.
    • (2011) J Neurochem. , vol.118 , pp. 939-957
    • Sian-Hulsmann, J.1    Mandel, S.2    Youdim, M.B.3    Riederer, P.4
  • 93
    • 27644548054 scopus 로고    scopus 로고
    • Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
    • Halliday GM, Ophof A, Broe M, Jensen PH, Kettle E, Fedorow H, et al. Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease. Brain. 2005;128:2654-64.
    • (2005) Brain. , vol.128 , pp. 2654-2664
    • Halliday, G.M.1    Ophof, A.2    Broe, M.3    Jensen, P.H.4    Kettle, E.5    Fedorow, H.6
  • 95
    • 80054849102 scopus 로고    scopus 로고
    • Generation of ferric iron links oxidative stress to alpha-synuclein oligomer formation
    • Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, et al. Generation of ferric iron links oxidative stress to alpha-synuclein oligomer formation. J Parkinsons Dis. 2011;1: 205-16.
    • (2011) J Parkinsons Dis. , vol.1 , pp. 205-216
    • Levin, J.1    Högen, T.2    Hillmer, A.S.3    Bader, B.4    Schmidt, F.5    Kamp, F.6
  • 96
    • 33645102892 scopus 로고    scopus 로고
    • Modifications of the iron-neuromelanin system in Parkinson's disease
    • Fasano M, Bergamasco B, Lopiano L. Modifications of the iron-neuromelanin system in Parkinson's disease. J Neurochem. 2006;96:909-16.
    • (2006) J Neurochem. , vol.96 , pp. 909-916
    • Fasano, M.1    Bergamasco, B.2    Lopiano, L.3
  • 97
    • 84885468645 scopus 로고    scopus 로고
    • Recent advances in alpha-synuclein functions, advanced glycation, and toxicity: Implications for Parkinson's disease
    • Guerrero E, Vasudevaraju P, Hegde ML, Britton GB, Rao KS. Recent advances in alpha-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease. Mol Neurobiol. 2013;47:525-36.
    • (2013) Mol Neurobiol. , vol.47 , pp. 525-536
    • Guerrero, E.1    Vasudevaraju, P.2    Hegde, M.L.3    Britton, G.B.4    Rao, K.S.5
  • 98
    • 77956393934 scopus 로고    scopus 로고
    • Alpha-synuclein, lipids and Parkinson's disease
    • Ruiperez V, Darios F, Davletov B. Alpha-synuclein, lipids and Parkinson's disease. Prog Lipid Res. 2010;49:420-8.
    • (2010) Prog Lipid Res. , vol.49 , pp. 420-428
    • Ruiperez, V.1    Darios, F.2    Davletov, B.3
  • 100
    • 0035896463 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor in the substantia nigra from control and Parkinsonian brains
    • Mogi M, Togari A, Kondo T, Mizuno Y, Kogure O, Kuno S, et al. Glial cell line-derived neurotrophic factor in the substantia nigra from control and Parkinsonian brains. Neurosci Lett. 2001;300:179-81.
    • (2001) Neurosci Lett. , vol.300 , pp. 179-181
    • Mogi, M.1    Togari, A.2    Kondo, T.3    Mizuno, Y.4    Kogure, O.5    Kuno, S.6
  • 101
    • 0034959811 scopus 로고    scopus 로고
    • Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain
    • Chauhan NB, Siegel GJ, Lee JM. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J Chem Neuroanat. 2001;21:277-88.
    • (2001) J Chem Neuroanat. , vol.21 , pp. 277-288
    • Chauhan, N.B.1    Siegel, G.J.2    Lee, J.M.3
  • 103
    • 0036298182 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions/rearrangements in Parkinson disease and related neurodegenerative disorders
    • Gu G, Reyes PE, Golden GT, Woltjer RL, Hulette C, Montine TJ, et al. Mitochondrial DNA deletions/rearrangements in Parkinson disease and related neurodegenerative disorders. J Neuropathol Exp Neurol. 2002;61:634-9.
    • (2002) J Neuropathol Exp Neurol. , vol.61 , pp. 634-639
    • Gu, G.1    Reyes, P.E.2    Golden, G.T.3    Woltjer, R.L.4    Hulette, C.5    Montine, T.J.6
  • 104
    • 79953653114 scopus 로고    scopus 로고
    • The Parkinson disease protein alpha-synuclein inhibits autophagy
    • Winslow AR, Rubinsztein DC. The Parkinson disease protein alpha-synuclein inhibits autophagy. Autophagy. 2011;7:429-31.
    • (2011) Autophagy. , vol.7 , pp. 429-431
    • Winslow, A.R.1    Rubinsztein, D.C.2
  • 105
    • 77956076600 scopus 로고    scopus 로고
    • Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?
    • Double KL, Reyes S, Werry EL, Halliday GM. Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Prog Neurobiol. 2010;92:316-29.
    • (2010) Prog Neurobiol. , vol.92 , pp. 316-329
    • Double, K.L.1    Reyes, S.2    Werry, E.L.3    Halliday, G.M.4
  • 106
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • Fearnley JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain. 1991;114(Pt 5):2283-301.
    • (1991) Brain. , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 107
    • 0031105375 scopus 로고    scopus 로고
    • Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease
    • McRitchie DA, Cartwright HR, Halliday GM. Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease. Exp Neurol. 1997;144:202-13.
    • (1997) Exp Neurol. , vol.144 , pp. 202-213
    • McRitchie, D.A.1    Cartwright, H.R.2    Halliday, G.M.3
  • 108
    • 0022203598 scopus 로고
    • Preservation of hypothalamic dopaminergic neurons in Parkinson's disease
    • Matzuk MM, Saper CB. Preservation of hypothalamic dopaminergic neurons in Parkinson's disease. Ann Neurol. 1985;18:552-5.
    • (1985) Ann Neurol. , vol.18 , pp. 552-555
    • Matzuk, M.M.1    Saper, C.B.2
  • 110
    • 34250897889 scopus 로고    scopus 로고
    • Hypocretin (orexin) cell loss in Parkinson's disease
    • Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease. Brain. 2007;130:1586-95.
    • (2007) Brain. , vol.130 , pp. 1586-1595
    • Thannickal, T.C.1    Lai, Y.Y.2    Siegel, J.M.3
  • 111
    • 79960167259 scopus 로고    scopus 로고
    • Selective neuronal vulnerability in neurodegenerative diseases: From stressor thresholds to degeneration
    • Saxena S, Caroni P. Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration. Neuron. 2011;71:35-48.
    • (2011) Neuron. , vol.71 , pp. 35-48
    • Saxena, S.1    Caroni, P.2
  • 112
    • 33747821466 scopus 로고    scopus 로고
    • Alzheimer disease with amygdala Lewy bodies: A distinct form of alpha-synucleinopathy
    • Uchikado H, Lin WL, DeLucia MW, Dickson DW. Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy. J Neuropathol Exp Neurol. 2006;65: 685-97.
    • (2006) J Neuropathol Exp Neurol. , vol.65 , pp. 685-697
    • Uchikado, H.1    Lin, W.L.2    Delucia, M.W.3    Dickson, D.W.4
  • 113
    • 0026348872 scopus 로고
    • Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway
    • Jellinger KA. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Mol Chem Neuropathol. 1991;14:153-97.
    • (1991) Mol Chem Neuropathol. , vol.14 , pp. 153-197
    • Jellinger, K.A.1
  • 115
    • 33846618232 scopus 로고    scopus 로고
    • Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy
    • Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy. Brain. 2007;130:469-75.
    • (2007) Brain. , vol.130 , pp. 469-475
    • Benarroch, E.E.1    Schmeichel, A.M.2    Low, P.A.3    Parisi, J.E.4
  • 119
    • 84855933800 scopus 로고    scopus 로고
    • Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease
    • Tamura T, Yoshida M, Hashizume Y, Sobue G. Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease. Neuropathology. 2012;32: 13-22.
    • (2012) Neuropathology. , vol.32 , pp. 13-22
    • Tamura, T.1    Yoshida, M.2    Hashizume, Y.3    Sobue, G.4
  • 120
    • 84871004211 scopus 로고    scopus 로고
    • Spinal cord lesions in sporadic Parkinson's disease
    • Del Tredici K, Braak H. Spinal cord lesions in sporadic Parkinson's disease. Acta Neuropathol. 2012;124:643-64.
    • (2012) Acta Neuropathol. , vol.124 , pp. 643-664
    • Del Tredici, K.1    Braak, H.2
  • 121
    • 67651149794 scopus 로고    scopus 로고
    • Lesions outside the CNS in Parkinson's disease
    • Djaldetti R, Lev N, Melamed E. Lesions outside the CNS in Parkinson's disease. Mov Disord. 2009;24:793-800.
    • (2009) Mov Disord. , vol.24 , pp. 793-800
    • Djaldetti, R.1    Lev, N.2    Melamed, E.3
  • 122
    • 74149090746 scopus 로고    scopus 로고
    • Olfactory system pathology as a model of Lewy neurodegenerative disease
    • Duda JE. Olfactory system pathology as a model of Lewy neurodegenerative disease. J Neurol Sci. 2010;289:49-54.
    • (2010) J Neurol Sci. , vol.289 , pp. 49-54
    • Duda, J.E.1
  • 123
    • 17644426053 scopus 로고    scopus 로고
    • Cognitive status correlates with neuropathologic stage in Parkinson disease
    • Braak H, Rub U, Jansen Steur EN, Del Tredici K, de Vos RA. Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology. 2005;64:1404-10.
    • (2005) Neurology. , vol.64 , pp. 1404-1410
    • Braak, H.1    Rub, U.2    Jansen Steur, E.N.3    Del Tredici, K.4    De Vos, R.A.5
  • 125
    • 71449128214 scopus 로고    scopus 로고
    • Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: An anatomical study
    • Ghebremedhin E, Del Tredici K, Langston JW, Braak H. Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol. 2009;118:777-84.
    • (2009) Acta Neuropathol. , vol.118 , pp. 777-784
    • Ghebremedhin, E.1    Del Tredici, K.2    Langston, J.W.3    Braak, H.4
  • 126
    • 33847205751 scopus 로고    scopus 로고
    • Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    • Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease. Brain Pathol. 2007;17:24-30.
    • (2007) Brain Pathol. , vol.17 , pp. 24-30
    • Orimo, S.1    Takahashi, A.2    Uchihara, T.3    Mori, F.4    Kakita, A.5    Wakabayashi, K.6
  • 129
    • 67349279396 scopus 로고    scopus 로고
    • Unified staging system for Lewy body disorders: Correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    • Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J, et al. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol. 2009;117:613-34.
    • (2009) Acta Neuropathol. , vol.117 , pp. 613-634
    • Beach, T.G.1    Adler, C.H.2    Lue, L.3    Sue, L.I.4    Bachalakuri, J.5    Henry-Watson, J.6
  • 132
  • 134
    • 84888394934 scopus 로고    scopus 로고
    • Inflammation and alpha-synuclein's prion-like behavior in Parkinson's disease-is there a link?
    • Lema Tomé CM, Tyson T, Rey NL, Grathwohl S, Britschgi M, Brundin P. Inflammation and alpha-synuclein's prion-like behavior in Parkinson's disease-is there a link? Mol Neurobiol. 2013;47:561-74.
    • (2013) Mol Neurobiol. , vol.47 , pp. 561-574
    • Tomé, L.1    Tyson T, C.M.2    Rey, N.L.3    Grathwohl, S.4    Britschgi, M.5    Brundin, P.6
  • 135
    • 84868148328 scopus 로고    scopus 로고
    • Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport
    • Freundt EC, Maynard N, Clancy EK, Roy S, Bousset L, Sourigues Y, et al. Neuron-to-neuron transmission of alpha-synuclein fibrils through axonal transport. Ann Neurol. 2012;72:517-24.
    • (2012) Ann Neurol. , vol.72 , pp. 517-524
    • Freundt, E.C.1    Maynard, N.2    Clancy, E.K.3    Roy, S.4    Bousset, L.5    Sourigues, Y.6
  • 136
    • 84867581207 scopus 로고    scopus 로고
    • Biochemical increase in phosphorylated a-synuclein precedes histopathology of Lewy-type synucleinopathies
    • Lue L-F, Walker DG, Adler CH, Shill H, Tran H, Akiyama H, et al. Biochemical increase in phosphorylated a-synuclein precedes histopathology of Lewy-type synucleinopathies. Brain Pathol. 2012;22:745-56.
    • (2012) Brain Pathol. , vol.22 , pp. 745-756
    • Lue, L.-F.1    Walker, D.G.2    Adler, C.H.3    Shill, H.4    Tran, H.5    Akiyama, H.6
  • 138
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson's disease
    • Burke RE, Dauer WT, Vonsattel JP. A critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol. 2008;64:485-91.
    • (2008) Ann Neurol. , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.3
  • 139
    • 83555166040 scopus 로고    scopus 로고
    • Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals
    • Kanazawa T, Adachi E, Orimo S, Nakamura A, Mizusawa H, Uchihara T. Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol. 2012;22:67-78.
    • (2012) Brain Pathol. , vol.22 , pp. 67-78
    • Kanazawa, T.1    Adachi, E.2    Orimo, S.3    Nakamura, A.4    Mizusawa, H.5    Uchihara, T.6
  • 141
    • 0038290644 scopus 로고    scopus 로고
    • Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies
    • Katsuse O, Iseki E, Marui W, Kosaka K. Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies. J Neurol Sci. 2003;211:29-35.
    • (2003) J Neurol Sci. , vol.211 , pp. 29-35
    • Katsuse, O.1    Iseki, E.2    Marui, W.3    Kosaka, K.4
  • 142
    • 84857716290 scopus 로고    scopus 로고
    • Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons
    • Lundblad M, Decressac M, Mattsson B, Bjorklund A. Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc Natl Acad Sci USA. 2012;109:3213-9.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , pp. 3213-3219
    • Lundblad, M.1    Decressac, M.2    Mattsson, B.3    Bjorklund, A.4
  • 143
    • 77954379317 scopus 로고    scopus 로고
    • SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
    • Garcia-Reitböck P, Anichtchik O, Bellucci A, Iovino M, Ballini C, Fineberg E, et al. SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain 2010;133:2032-44.
    • (2010) Brain , vol.133 , pp. 2032-2044
    • Garcia-Reitböck, P.1    Anichtchik, O.2    Bellucci, A.3    Iovino, M.4    Ballini, C.5    Fineberg, E.6
  • 144
    • 67649813448 scopus 로고    scopus 로고
    • Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    • Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, et al. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 2009;12:826-8.
    • (2009) Nat Neurosci. , vol.12 , pp. 826-828
    • Li, Y.1    Liu, W.2    Oo, T.F.3    Wang, L.4    Tang, Y.5    Jackson-Lewis, V.6
  • 145
    • 84864144621 scopus 로고    scopus 로고
    • Potential role of alpha-synuclein in neurodegeneration: Studies in a rat animal model
    • Stoica G, Lungu G, Bjorklund NL, Taglialatela G, Zhang X, Chiu V, et al. Potential role of alpha-synuclein in neurodegeneration: studies in a rat animal model. J Neurochem. 2012; 122:812-22.
    • (2012) J Neurochem. , vol.122 , pp. 812-822
    • Stoica, G.1    Lungu, G.2    Bjorklund, N.L.3    Taglialatela, G.4    Zhang, X.5    Chiu, V.6
  • 146
  • 147
    • 84871273435 scopus 로고    scopus 로고
    • Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
    • Milber JM, Noorigian J V, Morley JF, Petrovitch H, White L, Ross GW, et al. Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease. Neurology. 2012;79:2307-14.
    • (2012) Neurology. , vol.79 , pp. 2307-2314
    • Milber, J.M.1    Noorigian, J.V.2    Morley, J.F.3    Petrovitch, H.4    White, L.5    Ross, G.W.6
  • 148
    • 84866918574 scopus 로고    scopus 로고
    • From alpha-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease
    • Bellucci A, Zaltieri M, Navarria L, Grigoletto J, Missale C, Spano P. From alpha-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease. Brain Res. 2012;1476:183-202.
    • (2012) Brain Res. , vol.1476 , pp. 183-202
    • Bellucci, A.1    Zaltieri, M.2    Navarria, L.3    Grigoletto, J.4    Missale, C.5    Spano, P.6
  • 149
    • 33746893477 scopus 로고    scopus 로고
    • Relationship among alpha-synuclein accumulation, dopamine syn
    • thesis, and neurodegeneration in Parkinson disease substantia nigra
    • Mori F, Nishie M, Kakita A, Yoshimoto M, Takahashi H, Wakabayashi K. Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. J Neuropathol Exp Neurol. 2006;65:808-15.
    • (2006) J Neuropathol Exp Neurol. , vol.65 , pp. 808-815
    • Mori, F.1    Nishie, M.2    Kakita, A.3    Yoshimoto, M.4    Takahashi, H.5    Wakabayashi, K.6
  • 150
    • 1842454976 scopus 로고    scopus 로고
    • Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    • Sidhu A, Wersinger C, Vernier P. Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J. 2004;18:637-47.
    • (2004) FASEB J. , vol.18 , pp. 637-647
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 151
    • 74249111692 scopus 로고    scopus 로고
    • Brain alpha-synuclein accumulation in multiple system atrophy Parkinson's disease and progressive supranuclear palsy: A comparative investigation
    • Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, et al. Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation. Brain. 2010;133:172-88.
    • (2010) Brain. , vol.133 , pp. 172-188
    • Tong, J.1    Wong, H.2    Guttman, M.3    Ang, L.C.4    Forno, L.S.5    Shimadzu, M.6
  • 152
    • 77955664249 scopus 로고    scopus 로고
    • Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
    • Wills J, Jones J, Haggerty T, Duka V, Joyce JN, Sidhu A. Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol. 2010;225:210-8.
    • (2010) Exp Neurol. , vol.225 , pp. 210-218
    • Wills, J.1    Jones, J.2    Haggerty, T.3    Duka, V.4    Joyce, J.N.5    Sidhu, A.6
  • 153
    • 84861228335 scopus 로고    scopus 로고
    • Alpha-synuclein mRNA and soluble alpha-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
    • Quinn JG, Coulson DT, Brockbank S, Beyer N, Ravid R, Hellemans J, et al. Alpha-synuclein mRNA and soluble alpha-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. Brain Res. 2012;1459:71-80.
    • (2012) Brain Res. , vol.1459 , pp. 71-80
    • Quinn, J.G.1    Coulson, D.T.2    Brockbank, S.3    Beyer, N.4    Ravid, R.5    Hellemans, J.6
  • 155
    • 84878577036 scopus 로고    scopus 로고
    • Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    • Beyer K, Ariza A. Alpha-synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol. 2013;47:509-24.
    • (2013) Mol Neurobiol. , vol.47 , pp. 509-524
    • Beyer, K.1    Ariza, A.2
  • 156
    • 0344305371 scopus 로고    scopus 로고
    • Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
    • Kuusisto E, Parkkinen L, Alafuzoff I. Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol. 2003;62:1241-53.
    • (2003) J Neuropathol Exp Neurol. , vol.62 , pp. 1241-1253
    • Kuusisto, E.1    Parkkinen, L.2    Alafuzoff, I.3
  • 157
    • 84871489685 scopus 로고    scopus 로고
    • Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type his-topathology in human brains
    • Walker DG, Lue LF, Adler CH, Shill HA, Caviness JN, Sabbagh MN, et al. Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type his-topathology in human brains. Exp Neurol 2013;240:190-204.
    • (2013) Exp Neurol , vol.240 , pp. 190-204
    • Walker, D.G.1    Lue, L.F.2    Adler, C.H.3    Shill, H.A.4    Caviness, J.N.5    Sabbagh, M.N.6
  • 158
    • 79251589371 scopus 로고    scopus 로고
    • Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain
    • Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, et al. Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain. Brain Pathol. 2011;21:130-9.
    • (2011) Brain Pathol. , vol.21 , pp. 130-139
    • Wilhelmus, M.M.1    Verhaar, R.2    Andringa, G.3    Bol, J.G.4    Cras, P.5    Shan, L.6
  • 160
    • 78650680554 scopus 로고    scopus 로고
    • Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity
    • Izumi Y, Kume T, Akaike A. Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity. Yakugaku Zasshi. 2011;131:21-7.
    • (2011) Yakugaku Zasshi. , vol.131 , pp. 21-27
    • Izumi, Y.1    Kume, T.2    Akaike, A.3
  • 161
    • 41149177434 scopus 로고    scopus 로고
    • The progression of pathology in longitudinally followed patients with Parkinson's disease
    • Halliday G, Hely M, Reid W, Morris J. The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol. 2008;115:409-15.
    • (2008) Acta Neuropathol. , vol.115 , pp. 409-415
    • Halliday, G.1    Hely, M.2    Reid, W.3    Morris, J.4
  • 162
    • 53149133169 scopus 로고    scopus 로고
    • Serine 129 phos-phorylation of alpha-synuclein induces unfolded protein response-mediated cell death
    • Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, et al. Serine 129 phos-phorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J Biol Chem. 2008;283:23179-88.
    • (2008) J Biol Chem. , vol.283 , pp. 23179-23188
    • Sugeno, N.1    Takeda, A.2    Hasegawa, T.3    Kobayashi, M.4    Kikuchi, A.5    Mori, F.6
  • 163
    • 33645749795 scopus 로고    scopus 로고
    • Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra
    • Greffard S, Verny M, Bonnet AM, Beinis J Y, Gallinari C, Meaume S, et al. Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra. Arch Neurol. 2006;63:584-8.
    • (2006) Arch Neurol. , vol.63 , pp. 584-588
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Beinis, J.Y.4    Gallinari, C.5    Meaume, S.6
  • 164
    • 37349038248 scopus 로고    scopus 로고
    • Dopamine transporter relation to dopamine turnover in Parkinson's disease: A positron emission tomography study
    • Sossi V, de la Fuente-Fernandez R, Schulzer M, Troiano AR, Ruth TJ, Stoessl AJ. Dopamine transporter relation to dopamine turnover in Parkinson's disease: a positron emission tomography study. Ann Neurol. 2007;62:468-74.
    • (2007) Ann Neurol. , vol.62 , pp. 468-474
    • Sossi, V.1    De La Fuente-Fernandez, R.2    Schulzer, M.3    Troiano, A.R.4    Ruth, T.J.5    Stoessl, A.J.6
  • 165
    • 33845709899 scopus 로고    scopus 로고
    • Differences in neuro-pathologic characteristics across the Lewy body dementia spectrum
    • Ballard C, Ziabreva I, Perry R, Larsen JP, O'Brien J, McKeith I, et al. Differences in neuro-pathologic characteristics across the Lewy body dementia spectrum. Neurology. 2006;67: 1931-4.
    • (2006) Neurology. , vol.67 , pp. 1931-1934
    • Ballard, C.1    Ziabreva, I.2    Perry, R.3    Larsen, J.P.4    O'Brien, J.5    McKeith, I.6
  • 166
    • 77949897463 scopus 로고    scopus 로고
    • The progression of pathology in Parkinson's disease
    • Halliday GM, McCann H. The progression of pathology in Parkinson's disease. Ann N Y Acad Sci. 2010;1184:188-95.
    • (2010) Ann N y Acad Sci. , vol.1184 , pp. 188-195
    • Halliday, G.M.1    McCann, H.2
  • 167
    • 34547764857 scopus 로고    scopus 로고
    • Patterns of levodopa response in Parkinson's disease: A clinico-pathological study
    • Kempster PA, Williams DR, Selikhova M, Holton J, Revesz T, Lees AJ. Patterns of levodopa response in Parkinson's disease: a clinico-pathological study. Brain. 2007;130:2123-8.
    • (2007) Brain. , vol.130 , pp. 2123-2128
    • Kempster, P.A.1    Williams, D.R.2    Selikhova, M.3    Holton, J.4    Revesz, T.5    Lees, A.J.6
  • 168
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Chu Y, Kordower JH. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiol Dis. 2007;25:134-49.
    • (2007) Neurobiol Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 169
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol. 1996;55: 259-72.
    • (1996) J Neuropathol Exp Neurol. , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 171
    • 84871489685 scopus 로고    scopus 로고
    • Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type his-topathology in human brains
    • Walker DG, Lue LF, Adler CH, Shill HA, Caviness JN, Sabbagh MN, et al. Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type his-topathology in human brains. Exp Neurol. 2013;240:190-204.
    • (2013) Exp Neurol. , vol.240 , pp. 190-204
    • Walker, D.G.1    Lue, L.F.2    Adler, C.H.3    Shill, H.A.4    Caviness, J.N.5    Sabbagh, M.N.6
  • 172
    • 47749123020 scopus 로고    scopus 로고
    • Disorders of movement and system degeneration
    • Love S, Louis DN, Ellison DW, editors London: Hodder Arnold
    • Ince PG, Clark B, Holton JL, Revesz T, Wharton SB. Disorders of movement and system degeneration. In: Love S, Louis DN, Ellison DW, editors. Greenfield's neuropathology. 8th ed. London: Hodder Arnold; 2008. p. 889-1030.
    • (2008) Greenfield's Neuropathology. 8th Ed , pp. 889-1030
    • Ince, P.G.1    Clark, B.2    Holton, J.L.3    Revesz, T.4    Wharton, S.B.5
  • 173
    • 47749139266 scopus 로고    scopus 로고
    • Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions
    • Waxman EA, Duda JE, Giasson BI. Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathol. 2008;116:37-46.
    • (2008) Acta Neuropathol. , vol.116 , pp. 37-46
    • Waxman, E.A.1    Duda, J.E.2    Giasson, B.I.3
  • 174
    • 0035404388 scopus 로고    scopus 로고
    • A close association of torsinA and alpha-synuclein in Lewy bodies: A fluorescence resonance energy transfer study
    • Sharma N, Hewett J, Ozelius LJ, Ramesh V, McLean PJ, Breakefield XO, et al. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001;159:339-44.
    • (2001) Am J Pathol. , vol.159 , pp. 339-344
    • Sharma, N.1    Hewett, J.2    Ozelius, L.J.3    Ramesh, V.4    McLean, P.J.5    Breakefield, X.O.6
  • 175
    • 68649108355 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis
    • Banerjee R, Starkov AA, Beal MF, Thomas B. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta. 2009;1792:651-63.
    • (2009) Biochim Biophys Acta. , vol.1792 , pp. 651-663
    • Banerjee, R.1    Starkov, A.A.2    Beal, M.F.3    Thomas, B.4
  • 176
    • 78149365318 scopus 로고    scopus 로고
    • Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies
    • Dugger BN, Dickson DW. Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies. Acta Neuropathol. 2010;120:633-9.
    • (2010) Acta Neuropathol. , vol.120 , pp. 633-639
    • Dugger, B.N.1    Dickson, D.W.2
  • 177
    • 84857805677 scopus 로고    scopus 로고
    • Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder
    • Dugger BN, Murray ME, Boeve BF, Parisi JE, Benarroch EE, Ferman TJ, et al. Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder. Neuropathol Appl Neurobiol. 2012;38:142-52.
    • (2012) Neuropathol Appl Neurobiol. , vol.38 , pp. 142-152
    • Dugger, B.N.1    Murray, M.E.2    Boeve, B.F.3    Parisi, J.E.4    Benarroch, E.E.5    Ferman, T.J.6
  • 178
    • 84859370468 scopus 로고    scopus 로고
    • Presence of striatal amyloid plaques in Parkinson's disease dementia predicts concomitant Alzheimer's disease: Usefulness for amyloid imaging
    • Dugger BN, Serrano GE, Sue LI, Walker DG, Adler CH, Shill HA, et al. Presence of striatal amyloid plaques in Parkinson's disease dementia predicts concomitant Alzheimer's disease: usefulness for amyloid imaging. J Parkinsons Dis. 2012;2:57-65.
    • (2012) J Parkinsons Dis. , vol.2 , pp. 57-65
    • Dugger, B.N.1    Serrano, G.E.2    Sue, L.I.3    Walker, D.G.4    Adler, C.H.5    Shill, H.A.6
  • 179
    • 84865863969 scopus 로고    scopus 로고
    • Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy
    • Odagiri S, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K. Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy. Acta Neuropathol. 2012;124:173-86.
    • (2012) Acta Neuropathol. , vol.124 , pp. 173-186
    • Odagiri, S.1    Tanji, K.2    Mori, F.3    Kakita, A.4    Takahashi, H.5    Wakabayashi, K.6
  • 180
    • 0036095285 scopus 로고    scopus 로고
    • Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies
    • Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, et al. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002;160:1655-67.
    • (2002) Am J Pathol. , vol.160 , pp. 1655-1667
    • Schlossmacher, M.G.1    Frosch, M.P.2    Gai, W.P.3    Medina, M.4    Sharma, N.5    Forno, L.6
  • 181
    • 77953373923 scopus 로고    scopus 로고
    • Clues to how alpha-synuclein damages neurons in Parkinson's disease
    • Sulzer D. Clues to how alpha-synuclein damages neurons in Parkinson's disease. Mov Disord. 2010;25 Suppl 1:S27-31.
    • (2010) Mov Disord. , vol.25 , pp. S27-31
    • Sulzer, D.1
  • 183
    • 79952110154 scopus 로고    scopus 로고
    • Abstracts of the movement disorder society's thirteenth international congress of Parkinson's disease and movement disorders. June 8-10, 2009
    • Proteomic analysis of the substantia nigra in patients with Parkinson's disease. In: Abstracts of the movement disorder society's thirteenth international congress of Parkinson's disease and movement disorders. June 8-10, 2009. Mov Disord 2009; 24 Suppl 1: S39.
    • (2009) Mov Disord , vol.24 , pp. S39
  • 185
  • 186
    • 57049169723 scopus 로고    scopus 로고
    • Cellular glutathione peroxidase in human brain: Cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies
    • Power JH, Blumbergs PC. Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathol. 2009;117:63-73.
    • (2009) Acta Neuropathol. , vol.117 , pp. 63-73
    • Power, J.H.1    Blumbergs, P.C.2
  • 187
    • 44649167579 scopus 로고    scopus 로고
    • Three-layered structure shared between Lewy bodies and Lewy neurites-three-dimensional reconstruction of triple-labeled sections
    • Kanazawa T, Uchihara T, Takahashi A, Nakamura A, Orimo S, Mizusawa H. Three-layered structure shared between Lewy bodies and Lewy neurites-three-dimensional reconstruction of triple-labeled sections. Brain Pathol. 2008;18:415-22.
    • (2008) Brain Pathol. , vol.18 , pp. 415-422
    • Kanazawa, T.1    Uchihara, T.2    Takahashi, A.3    Nakamura, A.4    Orimo, S.5    Mizusawa, H.6
  • 188
    • 70350054626 scopus 로고    scopus 로고
    • Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance
    • Ugrumov M V. Non-dopaminergic neurons partly expressing dopaminergic phenotype: distribution in the brain, development and functional significance. J Chem Neuroanat. 2009;38: 241-56.
    • (2009) J Chem Neuroanat. , vol.38 , pp. 241-256
    • Ugrumov, M.V.1
  • 189
    • 79951499176 scopus 로고    scopus 로고
    • Glia: Initiators and progressors of pathology in Parkinson's disease
    • Halliday GM, Stevens CH. Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord. 2011;26:6-17.
    • (2011) Mov Disord. , vol.26 , pp. 6-17
    • Halliday, G.M.1    Stevens, C.H.2
  • 190
  • 191
    • 1842563060 scopus 로고    scopus 로고
    • Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers
    • Beach TG, Walker DG, Sue LI, Newell A, Adler CC, Joyce JN. Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers. J Neuropathol Exp Neurol. 2004;63:329-37.
    • (2004) J Neuropathol Exp Neurol. , vol.63 , pp. 329-337
    • Beach, T.G.1    Walker, D.G.2    Sue, L.I.3    Newell, A.4    Adler, C.C.5    Joyce, J.N.6
  • 192
    • 77953417539 scopus 로고    scopus 로고
    • Basic mechanisms of neurodegeneration: A critical update
    • Jellinger KA. Basic mechanisms of neurodegeneration: a critical update. J Cell Mol Med. 2010;14:457-87.
    • (2010) J Cell Mol Med. , vol.14 , pp. 457-487
    • Jellinger, K.A.1
  • 193
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alpha-synuclein impair complex i in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem. 2008;283: 9089-100.
    • (2008) J Biol Chem. , vol.283 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 194
    • 67349128592 scopus 로고    scopus 로고
    • Early involvement of the cerebral cortex in Parkinson's disease: Convergence of multiple metabolic defects
    • Ferrer I. Early involvement of the cerebral cortex in Parkinson's disease: convergence of multiple metabolic defects. Prog Neurobiol. 2009;88:89-103.
    • (2009) Prog Neurobiol. , vol.88 , pp. 89-103
    • Ferrer, I.1
  • 195
    • 84894291922 scopus 로고    scopus 로고
    • Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease
    • Mullin S, Schapira A. Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease. Mol Neurobiol. 2013;47:587-97.
    • (2013) Mol Neurobiol. , vol.47 , pp. 587-597
    • Mullin, S.1    Schapira, A.2
  • 196
    • 84862191747 scopus 로고
    • Alpha-synuclein misfolding and Parkinson's disease
    • Breydo L, Wu JW, Uversky VN. Alpha-synuclein misfolding and Parkinson's disease. Biochim Biophys Acta. 1822;2012:261-85.
    • (1822) Biochim Biophys Acta. , vol.2012 , pp. 261-285
    • Breydo, L.1    Wu, J.W.2    Uversky, V.N.3
  • 197
    • 84866702836 scopus 로고    scopus 로고
    • Alpha-synuclein in Parkinson's disease
    • Stefanis L. Alpha-synuclein in Parkinson's disease. Cold Spring Harb Perspect Med. 2012;2:a009399.
    • (2012) Cold Spring Harb Perspect Med. , vol.2 , pp. a009399
    • Stefanis, L.1
  • 198
    • 84862188904 scopus 로고    scopus 로고
    • The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease
    • Wan OW, Chung KK. The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease. PLoS One. 2012;7:e38545.
    • (2012) PLoS One. , vol.7 , pp. e38545
    • Wan, O.W.1    Chung, K.K.2
  • 199
    • 84863230467 scopus 로고    scopus 로고
    • Endoplasmic reticu-lum stress is important for the manifestations of alpha-synucleinopathy in vivo
    • Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, et al. Endoplasmic reticu-lum stress is important for the manifestations of alpha-synucleinopathy in vivo. J Neurosci. 2012;32:3306-20.
    • (2012) J Neurosci. , vol.32 , pp. 3306-3320
    • Colla, E.1    Coune, P.2    Liu, Y.3    Pletnikova, O.4    Troncoso, J.C.5    Iwatsubo, T.6
  • 201
    • 79955671043 scopus 로고    scopus 로고
    • Targeting oligomers in neurodegenerative disorders: Lessons from alpha-synuclein, tau, and amyloid-beta peptide
    • Gadad BS, Britton GB, Rao KS. Targeting oligomers in neurodegenerative disorders: lessons from alpha-synuclein, tau, and amyloid-beta peptide. J Alzheimers Dis. 2011;24 Suppl 2:223-32.
    • (2011) J Alzheimers Dis. , vol.24 , pp. 223-232
    • Gadad, B.S.1    Britton, G.B.2    Rao, K.S.3
  • 202
    • 84875415994 scopus 로고    scopus 로고
    • Alpha-synuclein oligomers and clinical implications for Parkinson disease
    • Kalia LV, Kalia SK, McLean PJ, Lozano AM, Lang AE. Alpha-synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol. 2013;73:155-69.
    • (2013) Ann Neurol. , vol.73 , pp. 155-169
    • Kalia, L.V.1    Kalia, S.K.2    McLean, P.J.3    Lozano, A.M.4    Lang, A.E.5
  • 205
  • 206
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy. 2011;7:279-96.
    • (2011) Autophagy. , vol.7 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 207
    • 84879606955 scopus 로고    scopus 로고
    • Alpha-synuclein and protein degradation systems: A reciprocal relationship
    • Xilouri M, Brekk OR, Stefanis L. Alpha-synuclein and protein degradation systems: a reciprocal relationship. Mol Neurobiol. 2013;47:537-51.
    • (2013) Mol Neurobiol. , vol.47 , pp. 537-551
    • Xilouri, M.1    Brekk, O.R.2    Stefanis, L.3
  • 208
    • 33747811791 scopus 로고    scopus 로고
    • Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease
    • Fujita Y, Ohama E, Takatama M, Al-Sarraj S, Okamoto K. Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Acta Neuropathol (Berl). 2006;112:261-5.
    • (2006) Acta Neuropathol (Berl). , vol.112 , pp. 261-265
    • Fujita, Y.1    Ohama, E.2    Takatama, M.3    Al-Sarraj, S.4    Okamoto, K.5
  • 209
    • 84878920856 scopus 로고    scopus 로고
    • Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease
    • Muller SK, Bender A, Laub C, Högen T, Schlaudraff F, Liss B, et al. Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease. Neurobiol Aging. 2013;34:2231-3.
    • (2013) Neurobiol Aging. , vol.34 , pp. 2231-2233
    • Muller, S.K.1    Bender, A.2    Laub, C.3    Högen, T.4    Schlaudraff, F.5    Liss, B.6
  • 210
    • 33846419768 scopus 로고    scopus 로고
    • Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
    • Braak H, Bohl JR, Muller CM, Rub U, de Vos RA, Del Tredici K. Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. Mov Disord. 2006;21:2042-51.
    • (2006) Mov Disord. , vol.21 , pp. 2042-2051
    • Braak, H.1    Bohl, J.R.2    Muller, C.M.3    Rub, U.4    De Vos, R.A.5    Del Tredici, K.6
  • 211
    • 33144489150 scopus 로고    scopus 로고
    • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
    • McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology. 2005;65:1863-72.
    • (2005) Neurology. , vol.65 , pp. 1863-1872
    • McKeith, I.G.1    Dickson, D.W.2    Lowe, J.3    Emre, M.4    O'Brien, J.T.5    Feldman, H.6
  • 212
    • 41349084608 scopus 로고    scopus 로고
    • Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort
    • Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG. Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology. 2008;70:1042-8.
    • (2008) Neurology. , vol.70 , pp. 1042-1048
    • Zaccai, J.1    Brayne, C.2    McKeith, I.3    Matthews, F.4    Ince, P.G.5
  • 214
    • 84862299730 scopus 로고    scopus 로고
    • Olfactory dysfunction in Parkinson disease
    • Doty RL. Olfactory dysfunction in Parkinson disease. Nat Rev Neurol. 2012;8:329-39.
    • (2012) Nat Rev Neurol. , vol.8 , pp. 329-339
    • Doty, R.L.1
  • 215
    • 79956196722 scopus 로고    scopus 로고
    • Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: Preclinical Parkinson disease
    • Ferrer I, Martinez A, Blanco R, Dalfo E, Carmona M. Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease. J Neural Transm. 2011;118:821-39.
    • (2011) J Neural Transm. , vol.118 , pp. 821-839
    • Ferrer, I.1    Martinez, A.2    Blanco, R.3    Dalfo, E.4    Carmona, M.5
  • 216
    • 0024210648 scopus 로고
    • Lewy body disease with and without dementia: A clinicopathological study of 35 cases
    • Kosaka K, Tsuchiya K, Yoshimura M. Lewy body disease with and without dementia: a clinicopathological study of 35 cases. Clin Neuropathol. 1988;7:299-305.
    • (1988) Clin Neuropathol. , vol.7 , pp. 299-305
    • Kosaka, K.1    Tsuchiya, K.2    Yoshimura, M.3
  • 217
    • 77953433969 scopus 로고    scopus 로고
    • Evidence in favor of Braak staging of Parkinson's disease
    • Dickson DW, Uchikado H, Fujishiro H, Tsuboi Y. Evidence in favor of Braak staging of Parkinson's disease. Mov Disord. 2010;25 Suppl 1:S78-82.
    • (2010) Mov Disord. , vol.25 , pp. S78-82
    • Dickson, D.W.1    Uchikado, H.2    Fujishiro, H.3    Tsuboi, Y.4
  • 218
    • 33750349255 scopus 로고    scopus 로고
    • Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease
    • Halliday GM, Del Tredici K, Braak H. Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease. J Neural Transm Suppl. 2006;70:99-103.
    • (2006) J Neural Transm Suppl. , vol.70 , pp. 99-103
    • Halliday, G.M.1    Del Tredici, K.2    Braak, H.3
  • 219
    • 77953011321 scopus 로고    scopus 로고
    • Relationships between age and late progression of Parkinson's disease: A clinico-pathological study
    • Kempster PA, O'Sullivan SS, Holton JL, Revesz T, Lees AJ. Relationships between age and late progression of Parkinson's disease: a clinico-pathological study. Brain. 2010;133: 1755-62.
    • (2010) Brain. , vol.133 , pp. 1755-1762
    • Kempster, P.A.1    O'Sullivan, S.S.2    Holton, J.L.3    Revesz, T.4    Lees, A.J.5
  • 220
    • 22244475735 scopus 로고    scopus 로고
    • Staging of sporadic Parkinson disease-related alpha-synuclein pathology: Inter-and intra-rater reliability
    • Muller CM, de Vos RA, Maurage CA, Thal DR, Tolnay M, Braak H. Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter-and intra-rater reliability. J Neuropathol Exp Neurol. 2005;64:623-8.
    • (2005) J Neuropathol Exp Neurol. , vol.64 , pp. 623-628
    • Muller, C.M.1    De Vos, R.A.2    Maurage, C.A.3    Thal, D.R.4    Tolnay, M.5    Braak, H.6
  • 221
    • 68749116710 scopus 로고    scopus 로고
    • A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
    • Jellinger KA. A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta. 2009;1792:730-40.
    • (2009) Biochim Biophys Acta. , vol.1792 , pp. 730-740
    • Jellinger, K.A.1
  • 222
    • 47749133029 scopus 로고    scopus 로고
    • Controversies over the staging of alpha-synuclein pathology in Parkinson's disease
    • author reply 129-31
    • Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RK. Controversies over the staging of alpha-synuclein pathology in Parkinson's disease. Acta Neuropathol. 2008;116:125-8. author reply 129-31.
    • (2008) Acta Neuropathol. , vol.116 , pp. 125-128
    • Kalaitzakis, M.E.1    Graeber, M.B.2    Gentleman, S.M.3    Pearce, R.K.4
  • 223
    • 42549125030 scopus 로고    scopus 로고
    • The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: A critical analysis of alpha-synuclein staging
    • Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RK. The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging. Neuropathol Appl Neurobiol. 2008;34:284-95.
    • (2008) Neuropathol Appl Neurobiol. , vol.34 , pp. 284-295
    • Kalaitzakis, M.E.1    Graeber, M.B.2    Gentleman, S.M.3    Pearce, R.K.4
  • 224
    • 41149141259 scopus 로고    scopus 로고
    • Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
    • Parkkinen L, Pirttila T, Alafuzoff I. Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol. 2008;115:399-407.
    • (2008) Acta Neuropathol. , vol.115 , pp. 399-407
    • Parkkinen, L.1    Pirttila, T.2    Alafuzoff, I.3
  • 225
    • 41149138514 scopus 로고    scopus 로고
    • Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
    • Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, et al. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol. 2008;18:220-4.
    • (2008) Brain Pathol. , vol.18 , pp. 220-224
    • Leverenz, J.B.1    Hamilton, R.2    Tsuang, D.W.3    Schantz, A.4    Vavrek, D.5    Larson, E.B.6
  • 226
    • 14844333173 scopus 로고    scopus 로고
    • Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: Evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    • Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, et al. Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol. 2005;64: 156-62.
    • (2005) J Neuropathol Exp Neurol. , vol.64 , pp. 156-162
    • Mikolaenko, I.1    Pletnikova, O.2    Kawas, C.H.3    O'Brien, R.4    Resnick, S.M.5    Crain, B.6
  • 227
    • 4344676234 scopus 로고    scopus 로고
    • Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease
    • Marui W, Iseki E, Kato M, Akatsu H, Kosaka K. Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. Acta Neuropathol. 2004;108:121-8.
    • (2004) Acta Neuropathol. , vol.108 , pp. 121-128
    • Marui, W.1    Iseki, E.2    Kato, M.3    Akatsu, H.4    Kosaka, K.5
  • 228
    • 33845968826 scopus 로고    scopus 로고
    • Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease
    • Boeve BF, Dickson DW, Olson EJ, Shepard JW, Silber MH, Ferman TJ, et al. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med. 2007;8:60-4.
    • (2007) Sleep Med. , vol.8 , pp. 60-64
    • Boeve, B.F.1    Dickson, D.W.2    Olson, E.J.3    Shepard, J.W.4    Silber, M.H.5    Ferman, T.J.6
  • 229
    • 79954602288 scopus 로고    scopus 로고
    • Incidental Lewy body disease: Do some cases represent a preclinical stage of dementia with Lewy bodies?
    • Frigerio R, Fujishiro H, Ahn TB, Josephs KA, Maraganore DM, Delledonne A, et al. Incidental Lewy body disease: Do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging 2011;32:857-63.
    • (2011) Neurobiol Aging , vol.32 , pp. 857-863
    • Frigerio, R.1    Fujishiro, H.2    Ahn, T.B.3    Josephs, K.A.4    Maraganore, D.M.5    Delledonne, A.6
  • 231
    • 79955485357 scopus 로고    scopus 로고
    • Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder
    • Postuma RB, Gagnon JF, Vendette M, Desjardins C, Montplaisir JY. Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Ann Neurol. 2011;69:811-8.
    • (2011) Ann Neurol. , vol.69 , pp. 811-818
    • Postuma, R.B.1    Gagnon, J.F.2    Vendette, M.3    Desjardins, C.4    Montplaisir, J.Y.5
  • 232
    • 7944238570 scopus 로고    scopus 로고
    • Lewy body-related alpha-synucleinopathy in the aged human brain
    • Jellinger KA. Lewy body-related alpha-synucleinopathy in the aged human brain. J Neural Transm. 2004;111:1219-35.
    • (2004) J Neural Transm. , vol.111 , pp. 1219-1235
    • Jellinger, K.A.1
  • 233
    • 43049126523 scopus 로고    scopus 로고
    • Systematic appraisal using immunohistochem-istry of brain pathology in aged and demented subjects
    • Aho L, Parkkinen L, Pirttila T, Alafuzoff I. Systematic appraisal using immunohistochem-istry of brain pathology in aged and demented subjects. Dement Geriatr Cogn Disord. 2008; 25:423-32.
    • (2008) Dement Geriatr Cogn Disord. , vol.25 , pp. 423-432
    • Aho, L.1    Parkkinen, L.2    Pirttila, T.3    Alafuzoff, I.4
  • 235
    • 0037383760 scopus 로고    scopus 로고
    • Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease
    • Parkkinen L, Soininen H, Alafuzoff I. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. J Neuropathol Exp Neurol. 2003;62:363-7.
    • (2003) J Neuropathol Exp Neurol. , vol.62 , pp. 363-367
    • Parkkinen, L.1    Soininen, H.2    Alafuzoff, I.3
  • 237
    • 0142030532 scopus 로고    scopus 로고
    • Age-associated prevalence and risk factors of Lewy body pathology in a general population: The Hisayama study
    • Wakisaka Y, Furuta A, Tanizaki Y, Kiyohara Y, Iida M, Iwaki T. Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol. 2003;106:374-82.
    • (2003) Acta Neuropathol. , vol.106 , pp. 374-382
    • Wakisaka, Y.1    Furuta, A.2    Tanizaki, Y.3    Kiyohara, Y.4    Iida, M.5    Iwaki, T.6
  • 239
    • 47749133805 scopus 로고    scopus 로고
    • Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies
    • Fujishiro H, Tsuboi Y, Lin WL, Uchikado H, Dickson DW. Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies. Acta Neuropathol. 2008;116:17-24.
    • (2008) Acta Neuropathol. , vol.116 , pp. 17-24
    • Fujishiro, H.1    Tsuboi, Y.2    Lin, W.L.3    Uchikado, H.4    Dickson, D.W.5
  • 240
    • 33644830518 scopus 로고    scopus 로고
    • Widespread and abundant alpha-synu-clein pathology in a neurologically unimpaired subject
    • Parkkinen L, Pirttila T, Tervahauta M, Alafuzoff I. Widespread and abundant alpha-synu-clein pathology in a neurologically unimpaired subject. Neuropathology. 2005;25:304-14.
    • (2005) Neuropathology. , vol.25 , pp. 304-314
    • Parkkinen, L.1    Pirttila, T.2    Tervahauta, M.3    Alafuzoff, I.4
  • 241
    • 78650934785 scopus 로고    scopus 로고
    • Interaction between alpha-synuclein and tau in Parkinson's disease comment on Wills et al.: Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218
    • Jellinger KA. Interaction between alpha-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Exp Neurol. 2011;227:13-8.
    • (2011) Exp Neurol. , vol.227 , pp. 13-18
    • Jellinger, K.A.1
  • 242
    • 77953023964 scopus 로고    scopus 로고
    • Protein coding of neurodegenerative dementias: The neu-ropathological basis of biomarker diagnostics
    • Kovacs GG, Botond G, Budka H. Protein coding of neurodegenerative dementias: the neu-ropathological basis of biomarker diagnostics. Acta Neuropathol. 2010;119:389-408.
    • (2010) Acta Neuropathol. , vol.119 , pp. 389-408
    • Kovacs, G.G.1    Botond, G.2    Budka, H.3
  • 243
    • 0035847186 scopus 로고    scopus 로고
    • Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation
    • Arai Y, Yamazaki M, Mori O, Muramatsu H, Asano G, Katayama Y. Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation. Brain Res. 2001;888:287-96.
    • (2001) Brain Res. , vol.888 , pp. 287-296
    • Arai, Y.1    Yamazaki, M.2    Mori, O.3    Muramatsu, H.4    Asano, G.5    Katayama, Y.6
  • 246
    • 0028879044 scopus 로고
    • Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: Implication of phosphoprotein phosphatase involvement
    • Baum L, Seger R, Woodgett JR, Kawabata S, Maruyama K, Koyama M, et al. Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement. Brain Res Mol Brain Res. 1995;34:1-17.
    • (1995) Brain Res Mol Brain Res. , vol.34 , pp. 1-17
    • Baum, L.1    Seger, R.2    Woodgett, J.R.3    Kawabata, S.4    Maruyama, K.5    Koyama, M.6
  • 247
    • 82755177802 scopus 로고    scopus 로고
    • Stimulatory effect of alpha-synuclein on the tau-phosphorylation by GSK-3beta
    • Kawakami F, Suzuki M, Shimada N, Kagiya G, Ohta E, Tamura K, et al. Stimulatory effect of alpha-synuclein on the tau-phosphorylation by GSK-3beta. FEBS J. 2011; 278:4895-904.
    • (2011) FEBS J. , vol.278 , pp. 4895-4904
    • Kawakami, F.1    Suzuki, M.2    Shimada, N.3    Kagiya, G.4    Ohta, E.5    Tamura, K.6
  • 248
    • 70349331692 scopus 로고    scopus 로고
    • Alpha-synuclein contributes to GSK-3beta-catalyzed tau phosphorylation in Parkinson's disease models
    • Duka T, Duka V, Joyce JN, Sidhu A. Alpha-synuclein contributes to GSK-3beta-catalyzed tau phosphorylation in Parkinson's disease models. FASEB J. 2009;23:2820-30.
    • (2009) FASEB J. , vol.23 , pp. 2820-2830
    • Duka, T.1    Duka, V.2    Joyce, J.N.3    Sidhu, A.4
  • 249
    • 33646483645 scopus 로고    scopus 로고
    • Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease
    • Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond S Y, et al. Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease. Chem Med Chem. 2006;1:256-66.
    • (2006) Chem Med Chem. , vol.1 , pp. 256-266
    • Kozikowski, A.P.1    Gaisina, I.N.2    Petukhov, P.A.3    Sridhar, J.4    King, L.T.5    Blond, S.Y.6
  • 250
    • 79960984489 scopus 로고    scopus 로고
    • Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
    • Kaul T, Credle J, Haggerty T, Oaks AW, Masliah E, Sidhu A. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci. 2011;12:79.
    • (2011) BMC Neurosci. , vol.12 , pp. 79
    • Kaul, T.1    Credle, J.2    Haggerty, T.3    Oaks, A.W.4    Masliah, E.5    Sidhu, A.6
  • 251
    • 79952860574 scopus 로고    scopus 로고
    • Tauopathic changes in the stria-tum of A53T alpha-synuclein mutant mouse model of Parkinson's disease
    • Wills J, Credle J, Haggerty T, Lee JH, Oaks AW, Sidhu A. Tauopathic changes in the stria-tum of A53T alpha-synuclein mutant mouse model of Parkinson's disease. PLoS One. 2011; 6:e17953.
    • (2011) PLoS One. , vol.6 , pp. e17953
    • Wills, J.1    Credle, J.2    Haggerty, T.3    Lee, J.H.4    Oaks, A.W.5    Sidhu, A.6
  • 252
    • 79953150761 scopus 로고    scopus 로고
    • Parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote tau protein phosphory-lation at ser262 and destabilize microtubule cytoskeleton in vitro
    • Qureshi HY, Paudel HK. Parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote tau protein phosphory-lation at ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011;286: 5055-68.
    • (2011) J Biol Chem. , vol.286 , pp. 5055-5068
    • Qureshi, H.Y.1    Paudel, H.K.2
  • 253
    • 79957636327 scopus 로고    scopus 로고
    • Induction of intracellular tau aggregation is promoted by alpha-synuclein seeds and provides novel insights into the hyperphosphorylation of tau
    • Waxman EA, Giasson BI. Induction of intracellular tau aggregation is promoted by alpha-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci. 2011;31:7604-18.
    • (2011) J Neurosci. , vol.31 , pp. 7604-7618
    • Waxman, E.A.1    Giasson, B.I.2
  • 254
    • 80055079219 scopus 로고    scopus 로고
    • Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy
    • Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, et al. Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy. PLoS One. 2011;6:e26609. doi: 10.1371/journal.pone.0026609.
    • (2011) PLoS One. , vol.6 , pp. e26609
    • Badiola, N.1    De Oliveira, R.M.2    Herrera, F.3    Guardia-Laguarta, C.4    Gonçalves, S.A.5    Pera, M.6
  • 257
    • 2342556414 scopus 로고    scopus 로고
    • Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation
    • Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, et al. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Exp Neurol. 2004;187:279-88.
    • (2004) Exp Neurol. , vol.187 , pp. 279-288
    • Kotzbauer, P.T.1    Giasson, B.I.2    Kravitz, A.V.3    Golbe, L.I.4    Mark, M.H.5    Trojanowski, J.Q.6
  • 258
    • 80053421282 scopus 로고    scopus 로고
    • E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent detrimental motor impairments
    • Emmer KL, Waxman EA, Covy JP, Giasson BI. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent detrimental motor impairments. J Biol Chem. 2011;286:35104-18.
    • (2011) J Biol Chem. , vol.286 , pp. 35104-35118
    • Emmer, K.L.1    Waxman, E.A.2    Covy, J.P.3    Giasson, B.I.4
  • 259
    • 84888202286 scopus 로고    scopus 로고
    • Alpha-Synuclein improves diagnostic and prognostic performance of tau and A-beta in Alzheimer's disease
    • Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J. Alpha-Synuclein improves diagnostic and prognostic performance of tau and A-beta in Alzheimer's disease. Acta Neuropathol. 2013. doi:10.1007/s00401-013-1148-z.
    • (2013) Acta Neuropathol.
    • Toledo, J.B.1    Korff, A.2    Shaw, L.M.3    Trojanowski, J.Q.4    Zhang, J.5
  • 260
    • 19444363661 scopus 로고    scopus 로고
    • Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases
    • Pletnikova O, West N, Lee MK, Rudow GL, Skolasky RL, Dawson TM, et al. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging. 2005;26:1183-92.
    • (2005) Neurobiol Aging. , vol.26 , pp. 1183-1192
    • Pletnikova, O.1    West, N.2    Lee, M.K.3    Rudow, G.L.4    Skolasky, R.L.5    Dawson, T.M.6
  • 261
    • 58849143335 scopus 로고    scopus 로고
    • Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: Relationship and links in Alzheimer's disease
    • Huang HC, Jiang ZF. Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease. J Alzheimers Dis. 2009;16:15-27.
    • (2009) J Alzheimers Dis. , vol.16 , pp. 15-27
    • Huang, H.C.1    Jiang, Z.F.2
  • 262
    • 41149152243 scopus 로고    scopus 로고
    • Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients
    • Lashley T, Holton JL, Gray E, Kirkham K, O'Sullivan SS, Hilbig A, et al. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol. 2008;115:417-25.
    • (2008) Acta Neuropathol. , vol.115 , pp. 417-425
    • Lashley, T.1    Holton, J.L.2    Gray, E.3    Kirkham, K.4    O'Sullivan, S.S.5    Hilbig, A.6
  • 263
    • 78649740289 scopus 로고    scopus 로고
    • Alpha-synuclein induced synapse damage is enhanced by amyloid-beta1-42
    • Bate C, Gentleman S, Williams A. Alpha-synuclein induced synapse damage is enhanced by amyloid-beta1-42. Mol Neurodegener. 2010;5:55.
    • (2010) Mol Neurodegener. , vol.5 , pp. 55
    • Bate, C.1    Gentleman, S.2    Williams, A.3
  • 264
    • 41149084580 scopus 로고    scopus 로고
    • Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies
    • Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, et al. Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol. 2008;210:409-20.
    • (2008) Exp Neurol. , vol.210 , pp. 409-420
    • Obi, K.1    Akiyama, H.2    Kondo, H.3    Shimomura, Y.4    Hasegawa, M.5    Iwatsubo, T.6
  • 265
    • 33748584602 scopus 로고    scopus 로고
    • Interaction between Abeta peptide and alpha synuclein: Molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease
    • Mandal PK, Pettegrew JW, Masliah E, Hamilton RL, Mandal R. Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res. 2006;31:1153-62.
    • (2006) Neurochem Res. , vol.31 , pp. 1153-1162
    • Mandal, P.K.1    Pettegrew, J.W.2    Masliah, E.3    Hamilton, R.L.4    Mandal, R.5
  • 267
    • 73949142307 scopus 로고    scopus 로고
    • Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
    • Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, et al. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci USA. 2009;106:20057-62.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , pp. 20057-20062
    • Rhein, V.1    Song, X.2    Wiesner, A.3    Ittner, L.M.4    Baysang, G.5    Meier, F.6
  • 268
    • 84862310662 scopus 로고    scopus 로고
    • Past, present, and future of the pathophysiological model of the Basal Ganglia
    • Obeso JA, Lanciego JL. Past, present, and future of the pathophysiological model of the Basal Ganglia. Front Neuroanat 2011;5:39.
    • (2011) Front Neuroanat , vol.5 , pp. 39
    • Obeso, J.A.1    Lanciego, J.L.2
  • 269
    • 60149088953 scopus 로고    scopus 로고
    • Synaptic plasticity, dopamine and Parkinson's disease: One step ahead
    • Calabresi P, Mercuri NB, Di Filippo M. Synaptic plasticity, dopamine and Parkinson's disease: one step ahead. Brain. 2009;132:285-7.
    • (2009) Brain. , vol.132 , pp. 285-287
    • Calabresi, P.1    Mercuri, N.B.2    Di Filippo, M.3
  • 271
    • 84874861183 scopus 로고    scopus 로고
    • The cerebellum in Parkinson's disease
    • Wu T, Hallett M. The cerebellum in Parkinson's disease. Brain. 2013;136:696-709.
    • (2013) Brain. , vol.136 , pp. 696-709
    • Wu, T.1    Hallett, M.2
  • 272
    • 0032588334 scopus 로고    scopus 로고
    • Post mortem studies in Parkinson's disease-is it possible to detect brain areas for specific symptoms?
    • Jellinger KA. Post mortem studies in Parkinson's disease-is it possible to detect brain areas for specific symptoms? J Neural Transm Suppl. 1999;56:1-29.
    • (1999) J Neural Transm Suppl. , vol.56 , pp. 1-29
    • Jellinger, K.A.1
  • 274
    • 25844469660 scopus 로고    scopus 로고
    • Direct receptor cross-talk can mediate the modulation of excitatory and inhibitory neurotransmission by dopamine
    • Lee FJ, Wang YT, Liu F. Direct receptor cross-talk can mediate the modulation of excitatory and inhibitory neurotransmission by dopamine. J Mol Neurosci. 2005;26:245-52.
    • (2005) J Mol Neurosci. , vol.26 , pp. 245-252
    • Lee, F.J.1    Wang, Y.T.2    Liu, F.3
  • 275
    • 0036140132 scopus 로고    scopus 로고
    • Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: Studies combining in vivo intracellular recordings and reverse microdialysis
    • West AR, Grace AA. Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis. J Neurosci. 2002;22: 294-304.
    • (2002) J Neurosci. , vol.22 , pp. 294-304
    • West, A.R.1    Grace, A.A.2
  • 276
    • 61449253124 scopus 로고    scopus 로고
    • Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease
    • Reetz K, Gaser C, Klein C, Hagenah J, Büchel C, Gottschalk S, et al. Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease. Mov Disord. 2009;24:99-103.
    • (2009) Mov Disord. , vol.24 , pp. 99-103
    • Reetz, K.1    Gaser, C.2    Klein, C.3    Hagenah, J.4    Büchel, C.5    Gottschalk, S.6
  • 278
    • 79957606507 scopus 로고    scopus 로고
    • Milestones in research on the pathophysiol-ogy of Parkinson's disease
    • Wichmann T, DeLong MR, Guridi J, Obeso JA. Milestones in research on the pathophysiol-ogy of Parkinson's disease. Mov Disord. 2011;26:1032-41.
    • (2011) Mov Disord. , vol.26 , pp. 1032-1041
    • Wichmann, T.1    Delong, M.R.2    Guridi, J.3    Obeso, J.A.4
  • 279
    • 0036322266 scopus 로고    scopus 로고
    • Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
    • Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol. 2002;52:205-10.
    • (2002) Ann Neurol. , vol.52 , pp. 205-210
    • Duda, J.E.1    Giasson, B.I.2    Mabon, M.E.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 280
    • 38949177433 scopus 로고    scopus 로고
    • Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
    • Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat Disord. 2007;13 Suppl 3:S251-8.
    • (2007) Parkinsonism Relat Disord. , vol.13 , pp. S251-S258
    • Deutch, A.Y.1    Colbran, R.J.2    Winder, D.J.3
  • 281
    • 0029956583 scopus 로고    scopus 로고
    • Striatal efferent involvement and its correlation to levodopa efficacy in patients with multiple system atrophy
    • Ito H, Kusaka H, Matsumoto S, Imai T. Striatal efferent involvement and its correlation to levodopa efficacy in patients with multiple system atrophy. Neurology. 1996;47:1291-9.
    • (1996) Neurology. , vol.47 , pp. 1291-1299
    • Ito, H.1    Kusaka, H.2    Matsumoto, S.3    Imai, T.4
  • 282
  • 283
  • 284
    • 79551662648 scopus 로고    scopus 로고
    • Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in Parkinsonian mice
    • Ding Y, Won L, Britt JP, Lim SA, McGehee DS, Kang UJ. Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in Parkinsonian mice. Proc Natl Acad Sci USA. 2011;108:840-5.
    • (2011) Proc Natl Acad Sci USA. , vol.108 , pp. 840-845
    • Ding, Y.1    Won, L.2    Britt, J.P.3    Lim, S.A.4    McGehee, D.S.5    Kang, U.J.6
  • 285
    • 44949236082 scopus 로고    scopus 로고
    • Sprouting of dopa-mine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia
    • Lee J, Zhu WM, Stanic D, Finkelstein DI, Horne MH, Henderson J, et al. Sprouting of dopa-mine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia. Brain. 2008;131:1574-87.
    • (2008) Brain. , vol.131 , pp. 1574-1587
    • Lee, J.1    Zhu, W.M.2    Stanic, D.3    Finkelstein, D.I.4    Horne, M.H.5    Henderson, J.6
  • 286
  • 287
    • 77957966489 scopus 로고    scopus 로고
    • Levodopa-induced dyskine-sias in patients with Parkinson's disease: Filling the bench-to-bedside gap
    • Calabresi P, Di Filippo M, Ghiglieri V, Tambasco N, Picconi B. Levodopa-induced dyskine-sias in patients with Parkinson's disease: filling the bench-to-bedside gap. Lancet Neurol. 2010;9:1106-17.
    • (2010) Lancet Neurol. , vol.9 , pp. 1106-1117
    • Calabresi, P.1    Di Filippo, M.2    Ghiglieri, V.3    Tambasco, N.4    Picconi, B.5
  • 288
    • 0026076047 scopus 로고
    • The neuropathologic basis of different clinical subgroups of Parkinson's disease
    • Paulus W, Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol. 1991;50:743-55.
    • (1991) J Neuropathol Exp Neurol. , vol.50 , pp. 743-755
    • Paulus, W.1    Jellinger, K.2
  • 290
  • 291
    • 78650890392 scopus 로고    scopus 로고
    • Involvement of the cerebellothalamocortical pathway in Parkinson disease
    • Ni Z, Pinto AD, Lang AE, Chen R. Involvement of the cerebellothalamocortical pathway in Parkinson disease. Ann Neurol. 2010;68:816-24.
    • (2010) Ann Neurol. , vol.68 , pp. 816-824
    • Ni, Z.1    Pinto, A.D.2    Lang, A.E.3    Chen, R.4
  • 292
    • 79952500499 scopus 로고    scopus 로고
    • Pallidal dysfunction drives a cere-bellothalamic circuit into Parkinson tremor
    • Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Toni I. Pallidal dysfunction drives a cere-bellothalamic circuit into Parkinson tremor. Ann Neurol. 2011;69:269-81.
    • (2011) Ann Neurol. , vol.69 , pp. 269-281
    • Helmich, R.C.1    Janssen, M.J.2    Oyen, W.J.3    Bloem, B.R.4    Toni, I.5
  • 293
    • 84870199264 scopus 로고    scopus 로고
    • Cerebral causes and consequences of Parkinsonian resting tremor: A tale of two circuits?
    • Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR. Cerebral causes and consequences of Parkinsonian resting tremor: a tale of two circuits? Brain. 2012;135:3206-26.
    • (2012) Brain. , vol.135 , pp. 3206-3226
    • Helmich, R.C.1    Hallett, M.2    Deuschl, G.3    Toni, I.4    Bloem, B.R.5
  • 294
    • 78649687189 scopus 로고    scopus 로고
    • Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects
    • Mure H, Hirano S, Tang CC, Isaias IU, Antonini A, Ma Y, et al. Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effects. Neuroimage. 2011;54:1244-53.
    • (2011) Neuroimage. , vol.54 , pp. 1244-1253
    • Mure, H.1    Hirano, S.2    Tang, C.C.3    Isaias, I.U.4    Antonini, A.5    Ma, Y.6
  • 296
    • 84878322665 scopus 로고    scopus 로고
    • Timing of deep brain stimulation in Parkinson disease: A need for reappraisal?
    • Desouza RM, Moro E, Lang AE, Schapira AH. Timing of deep brain stimulation in Parkinson disease: a need for reappraisal? Ann Neurol. 2013;73:565-75.
    • (2013) Ann Neurol. , vol.73 , pp. 565-575
    • Desouza, R.M.1    Moro, E.2    Lang, A.E.3    Schapira, A.H.4
  • 297
    • 78650886621 scopus 로고    scopus 로고
    • Are we making progress in the understanding of tremor in Parkinson's disease?
    • Hallett M, Deuschl G. Are we making progress in the understanding of tremor in Parkinson's disease? Ann Neurol. 2010;68:780-1.
    • (2010) Ann Neurol. , vol.68 , pp. 780-781
    • Hallett, M.1    Deuschl, G.2
  • 298
    • 84855935795 scopus 로고    scopus 로고
    • Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT SPECT
    • Eggers C, Kahraman D, Fink GR, Schmidt M, Timmermann L. Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT SPECT. Basal Ganglia. 2011;1:34.
    • (2011) Basal Ganglia. , vol.1 , pp. 34
    • Eggers, C.1    Kahraman, D.2    Fink, G.R.3    Schmidt, M.4    Timmermann, L.5
  • 299
    • 78349310514 scopus 로고    scopus 로고
    • Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
    • Kehagia AA, Barker RA, Robbins TW. Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol. 2010;9:1200-13.
    • (2010) Lancet Neurol. , vol.9 , pp. 1200-1213
    • Kehagia, A.A.1    Barker, R.A.2    Robbins, T.W.3
  • 300
    • 65249115240 scopus 로고    scopus 로고
    • Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest study
    • Aarsland D, Bronnick K, Larsen JP, Tysnes OB, Alves G. Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study. Neurology. 2009;72:1121-6.
    • (2009) Neurology. , vol.72 , pp. 1121-1126
    • Aarsland, D.1    Bronnick, K.2    Larsen, J.P.3    Tysnes, O.B.4    Alves, G.5
  • 302
    • 77950813474 scopus 로고    scopus 로고
    • The epidemiology of dementia associated with Parkinson's disease
    • Aarsland D, Kurz MW. The epidemiology of dementia associated with Parkinson's disease. Brain Pathol. 2010;20:633-9.
    • (2010) Brain Pathol. , vol.20 , pp. 633-639
    • Aarsland, D.1    Kurz, M.W.2
  • 303
    • 14944354884 scopus 로고    scopus 로고
    • Sydney Multicenter Study of Parkinson's disease: Non-L-dopa-responsive problems dominate at 15 years
    • Hely MA, Morris JG, Reid WG, Trafficante R. Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord. 2005;20: 190-9.
    • (2005) Mov Disord. , vol.20 , pp. 190-199
    • Hely, M.A.1    Morris, J.G.2    Reid, W.G.3    Trafficante, R.4
  • 304
    • 70449523595 scopus 로고    scopus 로고
    • The morbid anatomy of dementia in Parkinson's disease
    • Kalaitzakis ME, Pearce RK. The morbid anatomy of dementia in Parkinson's disease. Acta Neuropathol. 2009;118:587-98.
    • (2009) Acta Neuropathol. , vol.118 , pp. 587-598
    • Kalaitzakis, M.E.1    Pearce, R.K.2
  • 305
    • 79957453213 scopus 로고    scopus 로고
    • Lewy-and Alzheimer-type pathologies in Parkinson's disease dementia: Which is more important?
    • Compta Y, Parkkinen L, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, et al. Lewy-and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? Brain. 2011;134:1493-505.
    • (2011) Brain. , vol.134 , pp. 1493-1505
    • Compta, Y.1    Parkkinen, L.2    O'Sullivan, S.S.3    Vandrovcova, J.4    Holton, J.L.5    Collins, C.6
  • 306
    • 84855957245 scopus 로고    scopus 로고
    • Hierarchical cluster analysis of cortical pathology suggests pathologic heterogeneity of dementia in Parkinson's disease (abs)
    • Dickson D, Orr C, Murray M, Pahwa R, Lyons K, Goldman S, et al. Hierarchical cluster analysis of cortical pathology suggests pathologic heterogeneity of dementia in Parkinson's disease (abs). J Neuropathol Exp Neurol. 2011;70:505.
    • (2011) J Neuropathol Exp Neurol. , vol.70 , pp. 505
    • Dickson, D.1    Orr, C.2    Murray, M.3    Pahwa, R.4    Lyons, K.5    Goldman, S.6
  • 309
  • 311
    • 78651069320 scopus 로고    scopus 로고
    • Heterogeneous neuropathological findings in Parkinson's disease with mild cognitive impairment
    • Adler CH, Caviness JN, Sabbagh MN, Shill HA, Connor DJ, Sue L, et al. Heterogeneous neuropathological findings in Parkinson's disease with mild cognitive impairment. Acta Neuropathol. 2010;120:827-8.
    • (2010) Acta Neuropathol. , vol.120 , pp. 827-828
    • Adler, C.H.1    Caviness, J.N.2    Sabbagh, M.N.3    Shill, H.A.4    Connor, D.J.5    Sue, L.6
  • 312
    • 78651067661 scopus 로고    scopus 로고
    • Neuropathology in Parkinson's disease with mild cognitive impairment
    • Jellinger KA. Neuropathology in Parkinson's disease with mild cognitive impairment. Acta Neuropathol. 2010;120:829-30.
    • (2010) Acta Neuropathol. , vol.120 , pp. 829-830
    • Jellinger, K.A.1
  • 313
  • 315
    • 75149192348 scopus 로고    scopus 로고
    • Neuropathologic alterations in mild cognitive impairment: A review
    • Markesbery WR. Neuropathologic alterations in mild cognitive impairment: a review. J Alzheimers Dis. 2010;19:221-8.
    • (2010) J Alzheimers Dis. , vol.19 , pp. 221-228
    • Markesbery, W.R.1
  • 316
    • 77950839159 scopus 로고    scopus 로고
    • Neuroimaging and cognition in Parkinson's disease dementia
    • Silbert LC, Kaye J. Neuroimaging and cognition in Parkinson's disease dementia. Brain Pathol. 2010;20:646-53.
    • (2010) Brain Pathol. , vol.20 , pp. 646-653
    • Silbert, L.C.1    Kaye, J.2
  • 318
    • 84855916495 scopus 로고    scopus 로고
    • Lesions associated with cognitive impairment and dementia
    • Halliday G, Barker RA, Rowe DB, editors Oxford: Oxford University Press
    • Evans JR, Revesz T, Barker RA. Lesions associated with cognitive impairment and dementia. In: Halliday G, Barker RA, Rowe DB, editors. Non-dopamine lesions in Parkinson's disease. Oxford: Oxford University Press; 2011. p. 261-87.
    • (2011) Non-dopamine Lesions in Parkinson's Disease , pp. 261-287
    • Evans, J.R.1    Revesz, T.2    Barker, R.A.3
  • 319
    • 43849090633 scopus 로고    scopus 로고
    • Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease
    • Bouchard TP, Malykhin N, Martin WR, Hanstock CC, Emery DJ, Fisher NJ, et al. Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease. Neurobiol Aging. 2008;29:1027-39.
    • (2008) Neurobiol Aging. , vol.29 , pp. 1027-1039
    • Bouchard, T.P.1    Malykhin, N.2    Martin, W.R.3    Hanstock, C.C.4    Emery, D.J.5    Fisher, N.J.6
  • 320
    • 29944443921 scopus 로고    scopus 로고
    • Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
    • Fujita M, Ichise M, Zoghbi SS, Liow JS, Ghose S, Vines DC, et al. Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease. Ann Neurol. 2006;59:174-7.
    • (2006) Ann Neurol. , vol.59 , pp. 174-177
    • Fujita, M.1    Ichise, M.2    Zoghbi, S.S.3    Liow, J.S.4    Ghose, S.5    Vines, D.C.6
  • 321
    • 42049122792 scopus 로고    scopus 로고
    • Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease
    • Huang C, Mattis P, Perrine K, Brown N, Dhawan V, Eidelberg D. Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease. Neurology. 2008;70: 1470-7.
    • (2008) Neurology. , vol.70 , pp. 1470-1477
    • Huang, C.1    Mattis, P.2    Perrine, K.3    Brown, N.4    Dhawan, V.5    Eidelberg, D.6
  • 322
    • 0031283218 scopus 로고    scopus 로고
    • Morphological substrates of dementia in parkinsonism. A critical update
    • Jellinger KA. Morphological substrates of dementia in parkinsonism. A critical update. J Neural Transm Suppl. 1997;51:57-82.
    • (1997) J Neural Transm Suppl. , vol.51 , pp. 57-82
    • Jellinger, K.A.1
  • 323
    • 84878761244 scopus 로고    scopus 로고
    • Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia
    • Del Tredici K, Braak H. Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia. J Neurol Neurosurg Psychiatry. 2013;84:774-83.
    • (2013) J Neurol Neurosurg Psychiatry. , vol.84 , pp. 774-783
    • Del Tredici, K.1    Braak, H.2
  • 325
    • 79151475168 scopus 로고    scopus 로고
    • Differential response of the central noradrenergic nervous system to the loss of locus coeru-leus neurons in Parkinson's disease and Alzheimer's disease
    • McMillan PJ, White SS, Franklin A, Greenup JL, Leverenz JB, Raskind MA, et al. Differential response of the central noradrenergic nervous system to the loss of locus coeru-leus neurons in Parkinson's disease and Alzheimer's disease. Brain Res. 2011;1373:240-52.
    • (2011) Brain Res. , vol.1373 , pp. 240-252
    • McMillan, P.J.1    White, S.S.2    Franklin, A.3    Greenup, J.L.4    Leverenz, J.B.5    Raskind, M.A.6
  • 326
    • 65649084493 scopus 로고    scopus 로고
    • Parkinson's disease dementia and dementia with Lewy bodies: Different aspects of one entity
    • Aarsland D, Londos E, Ballard C. Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity. Int Psychogeriatr. 2009;21:216-9.
    • (2009) Int Psychogeriatr. , vol.21 , pp. 216-219
    • Aarsland, D.1    Londos, E.2    Ballard, C.3
  • 327
    • 21144441564 scopus 로고    scopus 로고
    • Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both
    • Kraybill ML, Larson EB, Tsuang DW, Teri L, McCormick WC, Bowen JD, et al. Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology. 2005;64:2069-73.
    • (2005) Neurology. , vol.64 , pp. 2069-2073
    • Kraybill, M.L.1    Larson, E.B.2    Tsuang, D.W.3    Teri, L.4    McCormick, W.C.5    Bowen, J.D.6
  • 329
    • 67349131839 scopus 로고    scopus 로고
    • Staging/typing of Lewy body related alpha-synuclein pathology: A study of the BrainNet Europe Consortium
    • Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, et al. Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol. 2009;117:635-52.
    • (2009) Acta Neuropathol. , vol.117 , pp. 635-652
    • Alafuzoff, I.1    Ince, P.G.2    Arzberger, T.3    Al-Sarraj, S.4    Bell, J.5    Bodi, I.6
  • 332
    • 77957924992 scopus 로고    scopus 로고
    • Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia
    • Fujishiro H, Iseki E, Higashi S, Kasanuki K, Murayama N, Togo T, et al. Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia. Neurosci Lett. 2010;486:19-23.
    • (2010) Neurosci Lett. , vol.486 , pp. 19-23
    • Fujishiro, H.1    Iseki, E.2    Higashi, S.3    Kasanuki, K.4    Murayama, N.5    Togo, T.6
  • 333
    • 79956224885 scopus 로고    scopus 로고
    • Striatal beta-amyloid in dementia with Lewy bodies but not Parkinson's disease
    • Halliday GM, Song YJ, Harding AJ. Striatal beta-amyloid in dementia with Lewy bodies but not Parkinson's disease. J Neural Transm. 2011;118:713.
    • (2011) J Neural Transm. , vol.118 , pp. 713
    • Halliday, G.M.1    Song, Y.J.2    Harding, A.J.3
  • 334
    • 0032532714 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: Comparisons with Parkinson's disease
    • Piggott MA, Perry EK, Marshall EF, McKeith IG, Johnson M, Melrose HL, et al. Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson's disease. Biol Psychiatry. 1998;44:765-74.
    • (1998) Biol Psychiatry. , vol.44 , pp. 765-774
    • Piggott, M.A.1    Perry, E.K.2    Marshall, E.F.3    McKeith, I.G.4    Johnson, M.5    Melrose, H.L.6
  • 335
    • 36249014794 scopus 로고    scopus 로고
    • Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies
    • Francis PT, Perry EK. Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. Mov Disord. 2007;22 Suppl 17:S351-7.
    • (2007) Mov Disord. , vol.22 , pp. S351-S357
    • Francis, P.T.1    Perry, E.K.2
  • 337
    • 0036142959 scopus 로고    scopus 로고
    • Parkinson disease neuropathol-ogy: Later-developing dementia and loss of the levodopa response
    • Apaydin H, Ahlskog JE, Parisi JE, Boeve BF, Dickson DW. Parkinson disease neuropathol-ogy: later-developing dementia and loss of the levodopa response. Arch Neurol. 2002; 59:102-12.
    • (2002) Arch Neurol. , vol.59 , pp. 102-112
    • Apaydin, H.1    Ahlskog, J.E.2    Parisi, J.E.3    Boeve, B.F.4    Dickson, D.W.5
  • 338
    • 0037744714 scopus 로고    scopus 로고
    • Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    • Kovari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, et al. Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathol (Berl). 2003;106:83-8.
    • (2003) Acta Neuropathol (Berl). , vol.106 , pp. 83-88
    • Kovari, E.1    Gold, G.2    Herrmann, F.R.3    Canuto, A.4    Hof, P.R.5    Bouras, C.6
  • 339
    • 0033923545 scopus 로고    scopus 로고
    • Alpha-Synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease
    • Mattila PM, Rinne JO, Helenius H, Dickson DW, Roytta M. Alpha-Synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol. 2000;100:285-90.
    • (2000) Acta Neuropathol. , vol.100 , pp. 285-290
    • Mattila, P.M.1    Rinne, J.O.2    Helenius, H.3    Dickson, D.W.4    Roytta, M.5
  • 340
    • 0032818428 scopus 로고    scopus 로고
    • Neuritic degeneration in the hippocampus and amygdala in Parkinson's disease in relation to Alzheimer pathology
    • Mattila PM, Rinne JO, Helenius H, Roytta M. Neuritic degeneration in the hippocampus and amygdala in Parkinson's disease in relation to Alzheimer pathology. Acta Neuropathol (Berl). 1999;98:157-64.
    • (1999) Acta Neuropathol (Berl). , vol.98 , pp. 157-164
    • Mattila, P.M.1    Rinne, J.O.2    Helenius, H.3    Roytta, M.4
  • 341
    • 0031874688 scopus 로고    scopus 로고
    • Simplified neuropathological diagnosis of dementia with Lewy bodies
    • Harding AJ, Halliday GM. Simplified neuropathological diagnosis of dementia with Lewy bodies. Neuropathol Appl Neurobiol. 1998;24:195-201.
    • (1998) Neuropathol Appl Neurobiol. , vol.24 , pp. 195-201
    • Harding, A.J.1    Halliday, G.M.2
  • 342
    • 33750440495 scopus 로고    scopus 로고
    • Hippocampal neuron and glial cell numbers in Parkinson's disease-a stereological study
    • Joelving FC, Billeskov R, Christensen JR, West M, Pakkenberg B. Hippocampal neuron and glial cell numbers in Parkinson's disease-a stereological study. Hippocampus. 2006; 16:826-33.
    • (2006) Hippocampus. , vol.16 , pp. 826-833
    • Joelving, F.C.1    Billeskov, R.2    Christensen, J.R.3    West, M.4    Pakkenberg, B.5
  • 343
    • 0037928426 scopus 로고    scopus 로고
    • Lewy body cortical involvement may not always predict dementia in Parkinson's disease
    • Colosimo C, Hughes AJ, Kilford L, Lees AJ. Lewy body cortical involvement may not always predict dementia in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2003;74: 852-6.
    • (2003) J Neurol Neurosurg Psychiatry. , vol.74 , pp. 852-856
    • Colosimo, C.1    Hughes, A.J.2    Kilford, L.3    Lees, A.J.4
  • 345
    • 34547626782 scopus 로고    scopus 로고
    • In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
    • Weisman D, Cho M, Taylor C, Adame A, Thal LJ, Hansen LA. In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology. 2007;69: 356-9.
    • (2007) Neurology. , vol.69 , pp. 356-359
    • Weisman, D.1    Cho, M.2    Taylor, C.3    Adame, A.4    Thal, L.J.5    Hansen, L.A.6
  • 346
    • 41149152169 scopus 로고    scopus 로고
    • Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
    • Jellinger KA, Attems J. Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease. Acta Neuropathol. 2008;115:127-36.
    • (2008) Acta Neuropathol. , vol.115 , pp. 127-136
    • Jellinger, K.A.1    Attems, J.2
  • 347
    • 0029800578 scopus 로고    scopus 로고
    • Amyloid beta-peptide and the dementia of Parkinson's disease
    • Jendroska K, Lees AJ, Poewe W, Daniel SE. Amyloid beta-peptide and the dementia of Parkinson's disease. Mov Disord. 1996;11:647-53.
    • (1996) Mov Disord. , vol.11 , pp. 647-653
    • Jendroska, K.1    Lees, A.J.2    Poewe, W.3    Daniel, S.E.4
  • 348
    • 0037250282 scopus 로고    scopus 로고
    • Prevalence of amyloid-beta deposition in the cerebral cortex in Parkinson's disease
    • Mastaglia FL, Johnsen RD, Byrnes ML, Kakulas BA. Prevalence of amyloid-beta deposition in the cerebral cortex in Parkinson's disease. Mov Disord. 2003;18:81-6.
    • (2003) Mov Disord. , vol.18 , pp. 81-86
    • Mastaglia, F.L.1    Johnsen, R.D.2    Byrnes, M.L.3    Kakulas, B.A.4
  • 349
    • 56749185181 scopus 로고    scopus 로고
    • Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography
    • Edison P, Rowe CC, Rinne JO, Ng S, Ahmed I, Kemppainen N, et al. Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 2008;79:1331-8.
    • (2008) J Neurol Neurosurg Psychiatry. , vol.79 , pp. 1331-1338
    • Edison, P.1    Rowe, C.C.2    Rinne, J.O.3    Ng, S.4    Ahmed, I.5    Kemppainen, N.6
  • 352
    • 77951879145 scopus 로고    scopus 로고
    • Inverse relationship between cerebrovascular lesions and severity of Lewy body pathology in patients with Lewy body diseases
    • Ghebremedhin E, Rosenberger A, Rub U, Vuksic M, Berhe T, Bickeböller H, et al. Inverse relationship between cerebrovascular lesions and severity of Lewy body pathology in patients with Lewy body diseases. J Neuropathol Exp Neurol. 2010;69:442-8.
    • (2010) J Neuropathol Exp Neurol. , vol.69 , pp. 442-448
    • Ghebremedhin, E.1    Rosenberger, A.2    Rub, U.3    Vuksic, M.4    Berhe, T.5    Bickeböller, H.6
  • 353
    • 80055082804 scopus 로고    scopus 로고
    • Parkinson's disease and alpha-synuclein expression
    • Devine MJ, Gwinn K, Singleton A, Hardy J. Parkinson's disease and alpha-synuclein expression. Mov Disord. 2011;26:2160-8.
    • (2011) Mov Disord. , vol.26 , pp. 2160-2168
    • Devine, M.J.1    Gwinn, K.2    Singleton, A.3    Hardy, J.4
  • 354
    • 84857031377 scopus 로고    scopus 로고
    • Parkin PINK1 and mitochondrial integrity: Emerging concepts of mitochondrial dysfunction in Parkinson's disease
    • Pilsl A, Winklhofer KF. Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease. Acta Neuropathol. 2012;123:173-88.
    • (2012) Acta Neuropathol. , vol.123 , pp. 173-188
    • Pilsl, A.1    Winklhofer, K.F.2
  • 355
    • 84879601218 scopus 로고    scopus 로고
    • Neuronal vulnerability, pathogenesis, and Parkinson's disease
    • Sulzer D, Surmeier DJ. Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord. 2013;28:41-50.
    • (2013) Mov Disord. , vol.28 , pp. 41-50
    • Sulzer, D.1    Surmeier, D.J.2
  • 356
    • 79959242100 scopus 로고    scopus 로고
    • Mitochondrial contribution to Parkinson's disease pathogenesis
    • Schapira AH, Gegg M. Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis. 2011;2011:159160.
    • (2011) Parkinsons Dis. , vol.2011 , pp. 159160
    • Schapira, A.H.1    Gegg, M.2
  • 358
    • 79951534656 scopus 로고    scopus 로고
    • LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
    • Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, et al. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci. 2011; 31:2225-37.
    • (2011) J Neurosci. , vol.31 , pp. 2225-2237
    • Piccoli, G.1    Condliffe, S.B.2    Bauer, M.3    Giesert, F.4    Boldt, K.5    De Astis, S.6
  • 359
    • 81055140895 scopus 로고    scopus 로고
    • PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
    • Wang X, Winter D, AshrafiG, Schlehe J, Wong YL, Selkoe D, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 2011;147:893-906.
    • (2011) Cell. , vol.147 , pp. 893-906
    • Wang, X.1    Winter, D.2    Ashrafig3    Schlehe, J.4    Wong, Y.L.5    Selkoe, D.6
  • 361
    • 84880937493 scopus 로고    scopus 로고
    • Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations
    • Tzoulis C, Tran GT, Schwarzlmuller T, Specht K, Haugarvoll K, Balafkan N et al. Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations. Brain 2013;136:2393-404.
    • (2013) Brain , vol.136 , pp. 2393-2404
    • Tzoulis, C.1    Tran, G.T.2    Schwarzlmuller, T.3    Specht, K.4    Haugarvoll, K.5    Balafkan, N.6
  • 362
    • 84879971693 scopus 로고    scopus 로고
    • Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins
    • Hurley MJ, Brandon B, Gentleman SM, Dexter DT. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain. 2013;136: 2077-97.
    • (2013) Brain. , vol.136 , pp. 2077-2097
    • Hurley, M.J.1    Brandon, B.2    Gentleman, S.M.3    Dexter, D.T.4
  • 363
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy-lysosome pathway in neurodegen-eration associated with Parkinson's disease
    • Pan T, Kondo S, Le W, Jankovic J. The role of autophagy-lysosome pathway in neurodegen-eration associated with Parkinson's disease. Brain. 2008;131:1969-78.
    • (2008) Brain. , vol.131 , pp. 1969-1978
    • Pan, T.1    Kondo, S.2    Le Jankovic W, J.3
  • 364
    • 84880756245 scopus 로고    scopus 로고
    • Defective autophagy in Parkinson's disease: Role of oxidative stress
    • Janda E, Isidoro C, Carresi C, Mollace V. Defective autophagy in Parkinson's disease: role of oxidative stress. Mol Neurobiol. 2012;46:639-61.
    • (2012) Mol Neurobiol. , vol.46 , pp. 639-661
    • Janda, E.1    Isidoro, C.2    Carresi, C.3    Mollace, V.4
  • 365
    • 84864150600 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease: Molecular mechanisms and pathophysiological consequences
    • Exner N, Lutz AK, Haass C, Winklhofer KF. Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J. 2012;31: 3038-62.
    • (2012) EMBO J. , vol.31 , pp. 3038-3062
    • Exner, N.1    Lutz, A.K.2    Haass, C.3    Winklhofer, K.F.4
  • 366
    • 78650017514 scopus 로고    scopus 로고
    • Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease
    • Bueler H. Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease. Apoptosis. 2010;15:1336-53.
    • (2010) Apoptosis. , vol.15 , pp. 1336-1353
    • Bueler, H.1
  • 367
    • 79959305691 scopus 로고    scopus 로고
    • Mitochondria: The next (neurode)generation
    • Schon EA, Przedborski S. Mitochondria: the next (neurode)generation. Neuron. 2011;70: 1033-53.
    • (2011) Neuron. , vol.70 , pp. 1033-1053
    • Schon, E.A.1    Przedborski, S.2
  • 369
    • 84857030799 scopus 로고    scopus 로고
    • Neurodegeneration as a consequence of failed mitochondrial maintenance
    • Karbowski M, Neutzner A. Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol. 2012;123:157-71.
    • (2012) Acta Neuropathol. , vol.123 , pp. 157-171
    • Karbowski, M.1    Neutzner, A.2
  • 370
    • 84857977793 scopus 로고    scopus 로고
    • Mitochondrial quality control and dynamics in Parkinson's disease
    • McCoy MK, Cookson MR. Mitochondrial quality control and dynamics in Parkinson's disease. Antioxid Redox Signal. 2012;16:869-82.
    • (2012) Antioxid Redox Signal. , vol.16 , pp. 869-882
    • McCoy, M.K.1    Cookson, M.R.2
  • 371
    • 79957606041 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Schapira AH, Jenner P. Etiology and pathogenesis of Parkinson's disease. Mov Disord. 2011;26:1049-55.
    • (2011) Mov Disord. , vol.26 , pp. 1049-1055
    • Schapira, A.H.1    Jenner, P.2
  • 372
    • 67649739079 scopus 로고    scopus 로고
    • Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis
    • Altamura S, Muckenthaler MU. Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis. 2009;16:879-95.
    • (2009) J Alzheimers Dis. , vol.16 , pp. 879-895
    • Altamura, S.1    Muckenthaler, M.U.2
  • 374
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegen-erative diseases
    • Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegen-erative diseases. Nat Rev Mol Cell Biol. 2010;11:301-7.
    • (2010) Nat Rev Mol Cell Biol. , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 376
    • 68649112842 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress in Parkinson's disease
    • Tsang AH, Chung KK. Oxidative and nitrosative stress in Parkinson's disease. Biochim Biophys Acta. 2009;1792:643-50.
    • (2009) Biochim Biophys Acta. , vol.1792 , pp. 643-650
    • Tsang, A.H.1    Chung, K.K.2
  • 377
    • 84862807906 scopus 로고    scopus 로고
    • Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T a-synuclein mutation
    • Huang Y, Chegini F, Chua G, Murphy K, Gai W, Halliday GM. Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T a-synuclein mutation. Translat Neurodeg. 2012;1:2. doi: 10.1186/2047-9158-1-2.
    • (2012) Translat Neurodeg. , vol.1 , pp. 2
    • Huang, Y.1    Chegini, F.2    Chua, G.3    Murphy, K.4    Gai, W.5    Halliday, G.M.6
  • 379
    • 79957620836 scopus 로고    scopus 로고
    • Parkinson's disease, proteins, and prions: Milestones
    • Olanow CW, McNaught K. Parkinson's disease, proteins, and prions: milestones. Mov Disord. 2011;26:1056-71.
    • (2011) Mov Disord. , vol.26 , pp. 1056-1071
    • Olanow, C.W.1    McNaught, K.2
  • 381
    • 84864870837 scopus 로고    scopus 로고
    • Alpha-synuclein: From secretion to dysfunction and death
    • Marques O, Outeiro TF. Alpha-synuclein: from secretion to dysfunction and death. Cell Death Dis. 2012;3:e350.
    • (2012) Cell Death Dis. , vol.3 , pp. e350
    • Marques, O.1    Outeiro, T.F.2
  • 382
    • 79958091447 scopus 로고    scopus 로고
    • Glial dysfunction in the pathogenesis of alpha-synucleinopathies: Emerging concepts
    • Fellner L, Jellinger KA, Wenning GK, Stefanova N. Glial dysfunction in the pathogenesis of alpha-synucleinopathies: emerging concepts. Acta Neuropathol. 2011;121:675-93.
    • (2011) Acta Neuropathol. , vol.121 , pp. 675-693
    • Fellner, L.1    Jellinger, K.A.2    Wenning, G.K.3    Stefanova, N.4
  • 383
    • 84862908978 scopus 로고    scopus 로고
    • Alpha-synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases
    • Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, et al. Alpha-synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem. 2012;120:440-52.
    • (2012) J Neurochem. , vol.120 , pp. 440-452
    • Martin, Z.S.1    Neugebauer, V.2    Dineley, K.T.3    Kayed, R.4    Zhang, W.5    Reese, L.C.6
  • 385
    • 84860615324 scopus 로고    scopus 로고
    • Neurotoxin-based models of Parkinson's disease
    • Bove J, Perier C. Neurotoxin-based models of Parkinson's disease. Neuroscience. 2012; 211:51-76.
    • (2012) Neuroscience. , vol.211 , pp. 51-76
    • Bove, J.1    Perier, C.2
  • 386
    • 77957239234 scopus 로고    scopus 로고
    • Neurotoxic in vivo models of Parkinson's disease recent advances
    • Cannon JR, Greenamyre JT. Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res. 2010;184:17-33.
    • (2010) Prog Brain Res. , vol.184 , pp. 17-33
    • Cannon, J.R.1    Greenamyre, J.T.2
  • 389
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron. 2010;66:646-61.
    • (2010) Neuron. , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 391
    • 84859107964 scopus 로고    scopus 로고
    • Cellular models to investigate biochemical pathways in Parkinson's disease
    • Alberio T, Lopiano L, Fasano M. Cellular models to investigate biochemical pathways in Parkinson's disease. FEBS J. 2012;279:1146-55.
    • (2012) FEBS J. , vol.279 , pp. 1146-1155
    • Alberio, T.1    Lopiano, L.2    Fasano, M.3
  • 392
    • 79251551356 scopus 로고    scopus 로고
    • Alpha-synuclein transgenic drosophila as a model of Parkinson's disease and related synucleinopathies
    • Mizuno H, Fujikake N, Wada K, Nagai Y. Alpha-synuclein transgenic drosophila as a model of Parkinson's disease and related synucleinopathies. Parkinsons Dis. 2010;2011:212706.
    • (2010) Parkinsons Dis. , vol.2011 , pp. 212706
    • Mizuno, H.1    Fujikake, N.2    Wada, K.3    Nagai, Y.4
  • 393
    • 79551648939 scopus 로고    scopus 로고
    • Drosophila models of Parkinson's disease
    • Whitworth AJ. Drosophila models of Parkinson's disease. Adv Genet. 2011;73:1-50.
    • (2011) Adv Genet. , vol.73 , pp. 1-50
    • Whitworth, A.J.1
  • 394
    • 77955842871 scopus 로고    scopus 로고
    • LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
    • Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, et al. LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiol Dis. 2010;40:73-81.
    • (2010) Neurobiol Dis. , vol.40 , pp. 73-81
    • Yao, C.1    El Khoury, R.2    Wang, W.3    Byrd, T.A.4    Pehek, E.A.5    Thacker, C.6
  • 395
    • 80051549269 scopus 로고    scopus 로고
    • Parkinson's disease mouse models in translational research
    • Antony PM, Diederich NJ, Balling R. Parkinson's disease mouse models in translational research. Mamm Genome. 2011;22:401-19.
    • (2011) Mamm Genome. , vol.22 , pp. 401-419
    • Antony, P.M.1    Diederich, N.J.2    Balling, R.3
  • 396
    • 79957608284 scopus 로고    scopus 로고
    • A tale on animal models of Parkinson's disease
    • Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Mov Disord. 2011;26:993-1002.
    • (2011) Mov Disord. , vol.26 , pp. 993-1002
    • Bezard, E.1    Przedborski, S.2
  • 397
    • 84873476695 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies
    • Bezard E, Yue Z, Kirik D, Spillantini MG. Animal models of Parkinson's disease: limits and relevance to neuroprotection studies. Mov Disord. 2013;28:61-70. doi: 10.1002/mds.25108.
    • (2013) Mov Disord. , vol.28 , pp. 61-70
    • Bezard, E.1    Yue, Z.2    Kirik, D.3    Spillantini, M.G.4
  • 399
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet MF, Richter F. Modelling of Parkinson's disease in mice. Lancet Neurol. 2011;10:1108-18.
    • (2011) Lancet Neurol. , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, F.2
  • 400
    • 79960069979 scopus 로고    scopus 로고
    • Alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    • Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, et al. alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J Neurosci. 2011;31:10076-87.
    • (2011) J Neurosci. , vol.31 , pp. 10076-10087
    • Lim, Y.1    Kehm, V.M.2    Lee, E.B.3    Soper, J.H.4    Li, C.5    Trojanowski, J.Q.6
  • 401
    • 84865535547 scopus 로고    scopus 로고
    • Use of viral vectors to create animal models for Parkinson's disease
    • Low K, Aebischer P. Use of viral vectors to create animal models for Parkinson's disease. Neurobiol Dis. 2012;48:189-201.
    • (2012) Neurobiol Dis. , vol.48 , pp. 189-201
    • Low, K.1    Aebischer, P.2
  • 402
    • 84862303338 scopus 로고    scopus 로고
    • Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
    • Ulusoy A, Bjorklund T, Buck K, Kirik D. Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons. Neurobiol Dis. 2012;47:367-77.
    • (2012) Neurobiol Dis. , vol.47 , pp. 367-377
    • Ulusoy, A.1    Bjorklund, T.2    Buck, K.3    Kirik, D.4
  • 403
    • 84903560349 scopus 로고    scopus 로고
    • α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models
    • Eschbach J, Danzer KM. α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models. Neurodegener Dis 2014;14:1-17.
    • (2014) Neurodegener Dis , vol.14 , pp. 1-17
    • Eschbach, J.1    Danzer, K.M.2
  • 404
    • 84859108554 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease
    • Blandini F, Armentero MT. Animal models of Parkinson's disease. FEBS J. 2012;279: 1156-66.
    • (2012) FEBS J. , vol.279 , pp. 1156-1166
    • Blandini, F.1    Armentero, M.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.