Alzheimer disease with amygdala lewy bodies: A distinct form of α-synucleinopathy

Journal of Neuropathology and Experimental Neurology

Volumn 65, Issue 7, 2006, Pages 685-697

  Uchikado, Hirotake ^a   Lin, Wen Lang ^a   Delucia, Michael W ^a   Dickson, Dennis W ^a  

^a MAYO CLINIC   (United States)

Author keywords

synuclein; Alzheimer disease; Amygdala; Immuno histochemistry; Lewy bodies

Indexed keywords

ALPHA SYNUCLEIN; APOLIPOPROTEIN E4;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN REGION; BRAIN STEM; BRAIN WEIGHT; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; DISEASE DURATION; FEMALE; GENE FREQUENCY; HUMAN; HUMAN TISSUE; LEWY BODY; MAJOR CLINICAL STUDY; MALE; NEOCORTEX; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; SCREENING; SENILE PLAQUE; SEX RATIO; TIME OF DEATH; DEMOGRAPHY; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; RETROSPECTIVE STUDY; STATISTICS; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYGDALA; DEMOGRAPHY; FEMALE; HUMANS; LEWY BODIES; LEWY BODY DISEASE; MALE; MIDDLE AGED; NEURONS; RETROSPECTIVE STUDIES; STATISTICS;

EID: 33747821466     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000225908.90052.07     Document Type: Article

References (55)

1. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996;47:1113-24
2. Dickson DW, Crystal HA, Mattiace LA, et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 1992;13:179-89
3. Hyman BT, Trojanowski JQ. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol 1997;56:1095-97
4. Hansen L, Salmon D, Galasko D, et al. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 1990;40:1-8
5. Mikolaenko I, Pletnikova O, Kawas CH, et al. Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol 2005;64:156-62
6. Parkkinen L, Soininen H, Alafuzoff I. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. J Neuropathol Exp Neurol 2003;62:363-67
7. Saito Y, Kawashima A, Ruberu NN, et al. Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 2003;62:644-54
8. Dickson DW. Alpha-synuclein and the Lewy body disorders. Curr Opin Neurol 2001;14:423-32
9. Arai Y, Yamazaki M, Mori O, et al. Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation. Brain Res 2001;888:287-96
10. Jellinger KA. Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution - a pilot study. Acta Neuropathol (Berl) 2003;106:191-201
11. Hamilton RL. Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 2000;10:378-84
12. Marui W, Iseki E, Ueda K, et al. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. J Neurol Sci 2000;174:81-84
13. Schmidt ML, Martin JA, Lee VM, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathol (Berl) 1996;91:475-81
14. Lippa CF, Fujiwara H, Mann DM, et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 1998;153:1365-70
15. Lippa CF, Schmidt ML, Lee VM, et al. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 1999;45:353-57
16. Rezaie P, Cairns NJ, Chadwick A, et al. Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease. Neurosci Lett 1996;212:111-14
17. Marui W, Iseki E, Nakai T, et al. Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. J Neurol Sci 2002;195:153-59
18. Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 2002;125:391-403
19. Hopper MW, Vogel FS. The limbic system in Alzheimer's disease. A neuropathologic investigation. Am J Pathol 1976;85:1-20
20. Mann DM, Yates PO, Marcyniuk B, et al. The topography of plaques and tangles in Down's syndrome patients of different ages. Neuropathol Appl Neurobiol 1986;12:447-57
21. Arnold SE, Hyman BT, Flory J, et al. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1991;1:103-16
22. Vereecken TH, Vogels OJ, Nieuwenhuys R. Neuron loss and shrinkage in the amygdala in Alzheimer's disease. Neurobiol Aging 1994;15:45-54
23. Tsuchiya K, Kosaka K. Neuropathological study of the amygdala in presenile Alzheimer's disease. J Neurol Sci 1990;100:165-73
24. Arriagada PV, Growdon JH, Hedley-Whyte ET, et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992;42:631-69
25. Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res Brain Res Rev 2003;41:88-123
26. Rolls E. Neurophysiology and functions of the primate amygdala. In: Aggleton JP, ed. The Amygdala. New York: Wiley-Liss, 1992:143-65
27. Barker WW, Luis CA, Kashuba A, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 2002;16:203-12
28. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 1985;42:1097-105
29. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991;82:239-59
30. Gloor P. The amygdala system. In: Gloor P, ed. The Temporal Lobe and Limbic System. New York: Oxford University Press, 1997:591-721
31. Gwinn-Hardy K, Mehta ND, Farrer M, et al. Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathol (Berl) 2000;99:663-72
32. Uchikado H, Delledonne A, Uitti R, Dickson DW. Coexistence of PSP and MSA: A case report and review of the literature. Acta Neuropathol (Berl) 2006;111:186-92
33. Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. Am J Pathol 2003;162:213-18
34. Crook R, Hardy J, Duff K. Single-day apolipoprotein E genotyping. J Neurosci Methods 1994;53:125-27
35. Baker M, Litvan I, Houlden H, et al. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Hum Mol Genet 1999;8:7111-15
36. Braak H, Del Tredici K, Rub U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211
37. Perry RH, Irving D, Blessed G, et al. Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci 1990;95:119-39
38. Kosaka K. Diffuse Lewy body diseases in Japan. J Neurol 1990;237:197-204
39. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-52
40. Uchikado H, DelleDonne A, Ahmed Z, Dickson DW. Lewy bodies in progressive supranuclear palsy represent an independent disease process. J Neuropathol Exp Neurol 2006;65:387-95
41. Marui W, Iseki E, Kato M, et al. Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease. Acta Neuropathol (Berl) 2004;108:121-28
42. Giasson BI, Forman MS, Higuchi M, et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003;300:636-40
43. Geddes JW. Alpha-synuclein: A potent inducer of tau pathology. Exp Neurol 2005;192:244-50
44. Iseki E, Marui W, Kosaka K, et al. Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease. Neurosci Lett 1999;265:9-12
45. Iseki E, Takayama N, Marui W, et al. Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains. J Neurol Sci 2002;195:85-91
46. Saito Y, Ruberu NN, Sawabe M, et al. Lewy body-related alpha-synucleinopathy in aging. J Neuropathol Exp Neurol 2004; 63:742-49
47. Pletnikova O, West N, Lee MK, et al. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging 2005;26:1183-92
48. Masliah E, Rockenstein E, Veinbergs I, et al. Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A 2001;98:12245-50
49. Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001;293:1487-91
50. Tsuang DW, Wilson RK, Lopez OL, et al. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology 2005;64:509-13
51. Lopez OL, Wisniewski S, Hamilton RL, et al. Predictors of progression in patients with AD and Lewy bodies. Neurology 2000;54:1774-79
52. Heyman A, Fillenbaum GG, Gearing M, et al. Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimer's disease: Consortium to establish a registry for Alzheimer's disease, part XIX. Neurology 1999;52:1839-44
53. Serby M, Brickman AM, Haroutunian V, et al. Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease. Am J Geriatr Psychiatry 2003;11:371-74
54. Merdes AR, Hansen LA, Jeste DV, et al. Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 2003;60:1586-90
55. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005;65:1863-72