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Volumn 135, Issue 7, 2012, Pages 2058-2073

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease

Author keywords

Axonal neuropathies; Conventional kinesin; Cytoplasmic dynein; Parkinson's disease; synuclein

Indexed keywords

ALPHA SYNUCLEIN; CYTOPLASMIC DYNEIN; DOPAMINE; DYNEIN LIGHT CHAIN TCTEX TYPE 3; KINESIN; KINESIN LIGHT CHAIN 1; MOLECULAR MOTOR; MUTANT PROTEIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 84863188413     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/aws133     Document Type: Article
Times cited : (236)

References (37)
  • 1
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • DOI 10.1016/j.nbd.2006.08.021, PII S0969996106002191
    • Chu Y, Kordower JH. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease? Neurobiol Dis 2007; 25: 134-49. (Pubitemid 44765223)
    • (2007) Neurobiology of Disease , vol.25 , Issue.1 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 2
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
    • Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 2009; 35: 385-98.
    • (2009) Neurobiol Dis , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya, H.2    Aebischer, P.3    Olanow, C.W.4    Kordower, J.H.5
  • 4
    • 78349309689 scopus 로고    scopus 로고
    • α-Synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease
    • Chu Y, Mickiewicz AL, Kordower JH. α-Synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease. Neurobiol Dis 2011; 41: 71-82.
    • (2011) Neurobiol Dis , vol.41 , pp. 71-82
    • Chu, Y.1    Mickiewicz, A.L.2    Kordower, J.H.3
  • 5
    • 63849332293 scopus 로고    scopus 로고
    • Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy
    • Chung CY, Koprich JB, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci 2009; 29: 3365-73.
    • (2009) J Neurosci , vol.29 , pp. 3365-3373
    • Chung, C.Y.1    Koprich, J.B.2    Siddiqi, H.3    Isacson, O.4
  • 7
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • DOI 10.1016/S0896-6273(03)00568-3
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. [Review]. Neuron 2003; 39: 889-909. (Pubitemid 37130207)
    • (2003) Neuron , vol.39 , Issue.6 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 9
    • 57649211993 scopus 로고    scopus 로고
    • Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    • Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, et al. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron 2008; 60: 1022-38.
    • (2008) Neuron , vol.60 , pp. 1022-1038
    • Flavell, S.W.1    Kim, T.K.2    Gray, J.M.3    Harmin, D.A.4    Hemberg, M.5    Hong, E.J.6
  • 11
    • 0034045587 scopus 로고    scopus 로고
    • An isoform of kinesin light chain specific for the Golgi complex
    • Gyoeva FK, Bybikova EM, Minin AA. An isoform of kinesin light chain specific for the Golgi complex. J Cell Sci 2000; 113: 2047-54. (Pubitemid 30386508)
    • (2000) Journal of Cell Science , vol.113 , Issue.11 , pp. 2047-2054
    • Gyoeva, F.K.1    Bybikova, E.M.2    Minin, A.A.3
  • 12
    • 0035310420 scopus 로고    scopus 로고
    • A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies
    • DOI 10.1016/S0022-510X(01)00481-6, PII S0022510X01004816
    • Iseki E, Kato M, Marui W, Uéda K, Kosaka K. A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies. J Neurol Sci 2001; 185: 129-34. (Pubitemid 32318518)
    • (2001) Journal of the Neurological Sciences , vol.185 , Issue.2 , pp. 129-134
    • Iseki, E.1    Kato, M.2    Marui, W.3    Ueda, K.4    Kosaka, K.5
  • 13
    • 0028985267 scopus 로고
    • The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995; 14: 467-75.
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.6
  • 14
    • 0033516587 scopus 로고    scopus 로고
    • Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein
    • DOI 10.1016/S0304-3940(99)00411-5, PII S0304394099004115
    • Jakes R, Crowther RA, Lee VM, Trojanowski JQ, Iwatsubo T, Goedert M. Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein. Neurosci Lett 1999; 269: 13-6. (Pubitemid 29305690)
    • (1999) Neuroscience Letters , vol.269 , Issue.1 , pp. 13-16
    • Jakes, R.1    Crowther, R.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4    Iwatsubo, T.5    Goedert, M.6
  • 15
    • 0032824809 scopus 로고    scopus 로고
    • Axonal transport of synucleins is mediated by all rate components
    • DOI 10.1046/j.1460-9568.1999.00754.x
    • Jensen PH, Li JY, Dahlström A, Dotti CG. Axonal transport of synucleins is mediated by all rate components. Eur J Neurosci 1999; 11: 3369-76. (Pubitemid 29484233)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.10 , pp. 3369-3376
    • Dotti, C.G.1
  • 16
    • 34248383674 scopus 로고    scopus 로고
    • Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: Relevance to selective neuronal vulnerability
    • DOI 10.1002/cne.21333
    • Kanaan NM, Kordower JH, Collier TJ. Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability. J Comp Neurol 2007; 502: 683-700. (Pubitemid 46732491)
    • (2007) Journal of Comparative Neurology , vol.502 , Issue.5 , pp. 683-700
    • Kanaan, N.M.1    Kordower, J.H.2    Collier, T.J.3
  • 18
    • 0347717732 scopus 로고    scopus 로고
    • Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations
    • Li W, Hoffman PN, Stirling W, Price DL, Lee MK. Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. J Neurochem 2004; 88: 401-10. (Pubitemid 38084556)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.2 , pp. 401-410
    • Li, W.1    Hoffman, P.N.2    Stirling, W.3    Price, D.L.4    Lee, M.K.5
  • 19
    • 34249716301 scopus 로고    scopus 로고
    • The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3
    • DOI 10.1074/jbc.M611279200
    • Lo KW, Kogoy JM, Pfister KK. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. J Biol Chem 2007; 282: 11205-12. (Pubitemid 47100802)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 11205-11212
    • Lo, K.W.-H.1    Kogoy, J.M.2    Pfister, K.K.3
  • 20
    • 0042477558 scopus 로고    scopus 로고
    • Alpha-synuclein and presynaptic function: Implications for Parkinson's disease
    • DOI 10.1385/NMM:2:2:115
    • Lykkebo S, Jensen PH. Alpha-synuclein and presynaptic function: implications for Parkinson's disease.[Review]. Neuromol Med 2002; 2: 115-29. (Pubitemid 37012500)
    • (2002) NeuroMolecular Medicine , vol.2 , Issue.2 , pp. 115-129
    • Lykkebo, S.1    Jensen, P.H.2
  • 21
    • 33646492153 scopus 로고    scopus 로고
    • A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers
    • Madine J, Doig AJ, Middleton DA. A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers. Biochemistry 2006; 45: 5783-92.
    • (2006) Biochemistry , vol.45 , pp. 5783-5792
    • Madine, J.1    Doig, A.J.2    Middleton, D.A.3
  • 26
    • 0031194454 scopus 로고    scopus 로고
    • Reduction in p140-trkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease
    • DOI 10.1006/exnr.1997.6504
    • Mufson EJ, Lavine N, Jaffar S, Kordower JH, Quirion R, Saragovi HU. Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp Neurol 1997; 146: 91-103. (Pubitemid 27319723)
    • (1997) Experimental Neurology , vol.146 , Issue.1 , pp. 91-103
    • Mufson, E.J.1    Lavine, N.2    Jaffar, S.3    Kordower, J.H.4    Quirion, R.5    Saragovi, H.U.6
  • 29
    • 0037012844 scopus 로고    scopus 로고
    • Axonal self-destruction and neurodegeneration
    • Review
    • Raff MC, Whitmore AV, Finn JT. Axonal self-destruction and neurodegeneration. [Review]. Science 2002; 296: 868-71.
    • (2002) Science , vol.296 , pp. 868-871
    • Raff, M.C.1    Whitmore, A.V.2    Finn, J.T.3
  • 30
    • 14244261725 scopus 로고    scopus 로고
    • Axonal transport defects: A common theme in neurodegenerative diseases
    • DOI 10.1007/s00401-004-0952-x
    • Roy S, Zhang B, Lee VM, Trojanowski JQ. Axonal transport defects: a common theme in neurodegenerative diseases. [Review]. Acta Neuropathol 2005; 109: 5-13. (Pubitemid 40287785)
    • (2005) Acta Neuropathologica , vol.109 , Issue.1 , pp. 5-13
    • Roy, S.1    Zhang, B.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 31
    • 77953796839 scopus 로고    scopus 로고
    • A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    • Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci 2010; 30: 8083-95.
    • (2010) J Neurosci , vol.30 , pp. 8083-8095
    • Scott, D.A.1    Tabarean, I.2    Tang, Y.3    Cartier, A.4    Masliah, E.5    Roy, S.6
  • 33
    • 77954732464 scopus 로고    scopus 로고
    • Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain
    • 2010
    • Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, et al. 2010) Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain. J Neurochem 2010; 114: 1007-18.
    • (2010) J Neurochem , vol.114 , pp. 1007-1018
    • Siebert, H.1    Kahle, P.J.2    Kramer, M.L.3    Isik, T.4    Schlüter, O.M.5    Schulz-Schaeffer, W.J.6
  • 34
    • 33749515974 scopus 로고    scopus 로고
    • Single-molecule observations of neck linker conformational changes in the kinesin motor protein
    • DOI 10.1038/nsmb1151, PII NSMB1151
    • Tomishige M, Stuurman N, Vale RD. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol 2006; 13: 887-94. (Pubitemid 44527370)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.10 , pp. 887-894
    • Tomishige, M.1    Stuurman, N.2    Vale, R.D.3
  • 35
    • 44349169012 scopus 로고    scopus 로고
    • Systemic AAV6 delivery mediating RNA interference against SOD1: Neuromuscular transduction does not alter disease progression in fALS mice
    • DOI 10.1038/mt.2008.73, PII MT200873
    • Towne C, Raoul C, Schneider BL, Aebischer P. Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice. Mol Ther 2008; 16: 1018-25. (Pubitemid 351737065)
    • (2008) Molecular Therapy , vol.16 , Issue.6 , pp. 1018-1025
    • Towne, C.1    Raoul, C.2    Schneider, B.L.3    Aebischer, P.4
  • 36
    • 77957224859 scopus 로고    scopus 로고
    • Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
    • Review
    • Ulusoy A, Decressac M, Kirik D, Björklund A. Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease. [Review]. Prog Brain Res 2010; 184: 89-111.
    • (2010) Prog Brain Res , vol.184 , pp. 89-111
    • Ulusoy, A.1    Decressac, M.2    Kirik, D.3    Björklund, A.4
  • 37
    • 27844470590 scopus 로고    scopus 로고
    • Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    • DOI 10.1242/jcs.02558
    • Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci 2005; 118: 4645-54. (Pubitemid 41646375)
    • (2005) Journal of Cell Science , vol.118 , Issue.20 , pp. 4645-4654
    • Utton, M.A.1    Noble, W.J.2    Hill, J.E.3    Anderton, B.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.