New insights into the pathology of Parkinson's disease: Does the peripheral autonomic system become central?

European Journal of Neurology

Volumn 15, Issue SUPPL. 1, 2008, Pages 1-4

  Probst, A ^a   Bloch, A ^a   Tolnay, M ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Alpha synuclein; Autonomic failure; Disease progression; Parkinson's disease; Peripheral autonomic structures

Indexed keywords

ALPHA SYNUCLEIN;

AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; BRAIN; BRAIN CORTEX; BRAIN STEM; GLOSSOPHARYNGEAL NERVE; HUMAN; IMMUNOHISTOCHEMISTRY; LEWY BODY; LIMBIC SYSTEM; NERVOUS SYSTEM; OLFACTORY NERVE; OLFACTORY NUCLEUS; PARKINSON DISEASE; PATHOLOGY; PRIORITY JOURNAL; REVIEW; SPINAL CORD; VAGUS NERVE;

ALPHA-SYNUCLEIN; AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NERVOUS SYSTEM DISEASES; CENTRAL NERVOUS SYSTEM; HUMANS; LEWY BODIES; PARKINSON DISEASE;

EID: 41049097524     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02057.x     Document Type: Review

References (20)

1. Damier P, Hirsch EC, Agid Y, Graybiel AM. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 1999 122 : 1437 1448.
2. Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN. Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathologica 1992 83 : 525 529.
3. Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997 276 : 2045 2047.
4. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997 388 : 839 840.
5. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proceedings National Academic Science of United states of America 1998 95 : 6469 6473.
6. Murphy DD, Rueter SM, Trojanowski JQ, Lee VM. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. Journal of Neuroscience 2000 20 : 3214 3220.
7. Jenco JM, Rawlingson A, Daniels B, Morris AJ. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 1998 37 : 4901 4909.
8. Tofaris GK, Spillantini MG. Alpha-synuclein dysfunction in Lewy body diseases. Movement Disorders 2005 20 (Suppl. 12 S37 S44.
9. Ostrerova N, Petrucelli L, Farrer M, et al. Alpha-synuclein shares physical and functional homology with 14-3-3 proteins. Journal of Neuroscience 1999 19 : 5782 5791.
10. Goldstein DS, Holmes C, Li ST, Bruce S, Metman LV, Cannon RO 3rd. Cardiac sympathetic denervation in Parkinson disease. Annals of Internal Medicine 2000 133 : 338 347.
11. Amino T, Orimo S, Itoh Y, Takahashi A, Uchihara T, Mizusawa H. Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Pathology 2005 15 : 29 34.
12. Orimo S, Amino T, Itoh Y, et al. Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathologica 2005 109 : 583 588.
13. Parkkinen L, Soininen H, Laakso M, Alafuzoff I. Alpha-synuclein pathology is highly dependent on the case selection. Neuropathology and Applied Neurobiology 2001 27 : 314 325.
14. Del Tredici K, Rub U, De Vos RA, Bohl JR, Braak H. Where does Parkinson disease pathology begin in the brain? Journal of Neuropathology and Experimental Neurology 2002 61 : 413 426.
15. Adler CH. Nonmotor complications in Parkinson's disease. Movement Disorders 2005 20 (Suppl. 11 S23 S29.
16. Magerkurth C, Schnitzer R, Braune S. Symptoms of autonomic failure in Parkinson's disease: prevalence and impact on daily life. Clinical Autonomic Research 2005 15 : 76 82.
17. Siddiqui MF, Rast S, Lynn MJ, Auchus AP, Pfeiffer RF. Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey. Parkinsonism Related Disorder 2002 8 : 277 284.
18. Kaufmann H, Nahm K, Purohit D, Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 2004 63 : 1093 1095.
19. Abbott RD, Petrovitch H, White LR, et al. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology 2001 57 : 456 462.
20. Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathology and Applied Neurobiology 2006 32 : 284 295.