Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease

Sleep Medicine

Volumn 8, Issue 1, 2007, Pages 60-64

  Boeve, B F ^a,b,d   Dickson, D W ^b,c,d   Olson, E J ^a,b   Shepard, J W ^a,b   Silber, M H ^a,b   Ferman, T J ^c,d   Ahlskog, J E ^a,b   Benarroch, E E ^a  

^a Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c MAYO CLINIC   (United States)

^d Mayo Alzheimer's Disease Research Center   (United States)

Author keywords

Lewy bodies; Lewy body disease; Parasomnia; REM sleep behavior disorder; Synuclein

Indexed keywords

CLONAZEPAM; FLUOXETINE;

AGED; ARTICLE; AUTOPSY; BRAIN STEM; CASE REPORT; CELL LOSS; DEATH; DIFFUSE LEWY BODY DISEASE; DISEASE ASSOCIATION; GLIOSIS; HUMAN; LOCUS CERULEUS; MALE; MONOAMINE NERVE CELL; NERVE CELL; NERVE CELL DEGENERATION; NERVE CELL NETWORK; ONSET AGE; PARASOMNIA; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

AGED; ALPHA-SYNUCLEIN; BRAIN STEM; DYSPNEA; ELECTROMYOGRAPHY; GLIOSIS; HUMANS; LEWY BODY DISEASE; MALE; MIDDLE AGED; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; POLYSOMNOGRAPHY; SEVERITY OF ILLNESS INDEX; SLEEP, REM;

EID: 33845968826     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2006.08.017     Document Type: Article

References (15)

1. Schenck C., and Mahowald M. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep 25 (2002) 120-138
2. Olson E., Boeve B., and Silber M. Rapid eye movement sleep behavior disorder: demographic, clinical, and laboratory findings in 93 cases. Brain 123 (2000) 331-339
3. Boeve B., Silber M., Parisi J., et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61 (2003) 40-45
4. Uchiyama M., Isse K., Tanaka K., et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 45 (1995) 709-712
5. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997;18:S1-S2.
6. Kosaka K., Yoshimura M., Ikeda K., and Budka H. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree - A new disease?. Clin Neuropathol 3 (1984) 185-192
7. McKeith I.G., Dickson D.W., Lowe J., Emre M., O'Brien J.T., Feldman H., et al. Dementia with Lewy bodies: diagnosis and management: third report of the DLB Consortium. Neurology 65 (2005) 1863-1872
8. Braak H., Del Tredici K., Rub U., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24 (2003) 197-211
9. Iranzo A., Graus F., Clover L., et al. Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis. Ann Neurol 59 (2006) 178-181
10. Kimura K., Tachibana N., Kohyama J., Otsuka Y., Fukazawa S., and Waki R. A discrete pontine ischemic lesion could cause REM sleep behavior disorder. Neurology 55 (2000) 894-895
11. Tippmann-Peikert M., Boeve B.F., and Keegan B.M. REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. Neurology 66 (2006) 1277-1279
12. Benarroch E., Schmeichel A., Low P., et al. Involvement of medullary regions controlling sympathetic output in Lewy body disease. Brain 128 (2005) 338-344
13. Schenck C.H., Garcia-Rill E., Skinner R.D., et al. A case of REM sleep behavior disorder with autopsy-confirmed Alzheimer's disease: postmortem brain stem histochemical analyses. Biol Psychiatry 40 (1996) 422-425
14. Rodrigo-Angulo M., Rodriguez-Veiga E., and Reinoso-Suarez F. A quantitative study of the brainstem cholinergic projections to the ventral part of the oral pontine reticular nucleus (REM sleep induction site) in the cat. Exp Brain Res 160 (2005) 334-343
15. Lu J., Sherman D., Devor M., and Saper C.B. A putative flip-flop switch for control of REM sleep. Nature (2006) May 10 [Epub ahead of print]