Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

Nature Neuroscience

Volumn 12, Issue 7, 2009, Pages 826-828

  Li, Yanping ^a   Liu, Wencheng ^a   Oo, Tinmarla F ^b   Wang, Lei ^a,c   Tang, Yi ^a,d   Jackson Lewis, Vernice ^b   Zhou, Chun ^b   Geghman, Kindiya ^a   Bogdanov, Mikhail ^a,c   Przedborski, Serge ^b   Beal, M Flint ^a   Burke, Robert E ^b   Li, Chenjian ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; BENSERAZIDE; DOPAMINE; LEUCINE RICH REPEAT KINASE 2; LEVODOPA; NOMIFENSINE; ANTIPARKINSON AGENT; DOPAMINE UPTAKE INHIBITOR; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DOPAMINE RELEASE; HYPOKINESIA; MOTOR DYSFUNCTION; MOUSE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSGENIC MOUSE; AGE; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECT; GENE TRANSFER; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGE FACTORS; ANIMALS; ANTIPARKINSON AGENTS; APOMORPHINE; BRAIN; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; GENE TRANSFER TECHNIQUES; HUMANS; LEVODOPA; MICE; MICE, TRANSGENIC; MOVEMENT DISORDERS; MUTATION, MISSENSE; NEURONS; NOMIFENSINE; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES;

EID: 67649813448     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2349     Document Type: Article

References (14)

1. Zimprich, A. et al. Neuron 44, 601-607 (2004).
2. Paisa'n-RuI'z, C. et al. Neuron 44, 595-600 (2004).
3. Di Fonzo, A. et al. Lancet 365, 412-415 (2005).
4. Gilks, W.P. et al. Lancet 365, 415-416 (2005).
5. Saunders-Pullman, R. et al. Neurosci. Lett. 402, 92-96 (2006).
6. Polymeropoulos, M.H. et al. Science 276, 2045-2047 (1997).
7. Ballatore, C., Lee, V.M. & Trojanowski, J.Q. Nat. Rev. Neurosci. 8, 663-672 (2007).
8. Tobin, J.E. et al. Neurology 71, 28-34 (2008).
9. Dauer, W. & Przedborski, S. Neuron 39, 889-909 (2003). 10.Melrose, H.L. et al. Neuroscience 147, 1047-1058 (2007).
10. El-Khodor, B.F. & Burke, R.E. J. Comp. Neurol. 452, 65-79 (2002).
11. Bü ki, A., Okonkwo, D.O., Wang, K.K. & Povlishock, J.T. J. Neurosci. 20, 2825-2834 (2000).
12. Kerschensteiner, M., Schwab, M.E., Lichtman, J.W. & Misgeld, T. Nat. Med. 11, 572-577 (2005).
13. Duda, J.E., Giasson, B.I., Mabon, M.E., Lee, V.M. & Trojanowski, J.Q. Ann. Neurol. 52, 205-210 (2002).
14. Biernat, J. et al. EMBO J. 11, 1593-1597 (1992).