Neuropathologic alterations in mild cognitive impairment: A review

Journal of Alzheimer's Disease

Volumn 19, Issue 1, 2010, Pages 221-228

  Markesbery, William R ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Mild cognitive impairment; Neurofibrillary tangles; Preclinical Alzheimer's disease

Indexed keywords

AMYLOID BETA PROTEIN;

AGING; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARGYROPHILIA; AUTOPSY; CEREBROSPINAL FLUID; DISEASE COURSE; ENTORHINAL CORTEX; GENETIC MARKER; HIPPOCAMPUS; HUMAN; LEWY BODY; LONGITUDINAL STUDY; MEMORY DISORDER; MILD COGNITIVE IMPAIRMENT; NEOCORTEX; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW; STROKE; SYMPTOM;

EID: 75149192348     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1220     Document Type: Review

References (38)

1. Roth M, Tomlinson BE, BlessedG(1966) Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects. Nature 209, 109-110.
2. Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11, 205-242.
3. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
4. Markesbery WR (1998) Overview of dementing disorders in: Neuropathology of Dementing Disorders, Markesbery WR, ed., Arnold, London, pp. 1-24.
5. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82, 239-259.
6. Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58, 1791-1800.
7. Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42, 1097-1105.
8. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
9. (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 18, S1-S2.
10. Petersen RC (2003) Conceptual Overview in: Mild Cognitive Impairment, Petersen RC, ed., Oxford University Press, New York, NY, pp. 1-14.
11. Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, Tangalos EG, Boeve BF, Knopman DS, Braak H, Petersen RC (2006) Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol 63, 674-681.
12. Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 45, 358-368.
13. Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, Han LY, Bienias JL, Lee VM, Trojanowski JQ, Bennett DA, Arnold SE (2002) Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Ann Neurol 51, 182-189.
14. Riley KP, Snowdon DA, Markesbery WR (2002) Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 51, 567-577.
15. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR (2006) Neuropathologic substrate of mild cognitive impairment. Arch Neurol 63, 38-46.
16. Bennett DA, Schneider JA, Bienias JL, Evans DA, Wilson RS (2005) Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 64, 834-841.
17. Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, Berg L (2001) Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 58, 397-405. (Pubitemid 32217456)
18. Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, Jicha GA, Ivnik RJ, Smith GE, Tangalos EG, Braak H, Kokmen E (2006) Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol 63, 665-672.
19. Petersen RC, Morris JC (2003) Clinical Features in: Mild Cognitive Impairment, Petersen RC, ed., Oxford University Press, New York, NY, pp. 15-39.
20. Schmitt FA, Wetherby MM, Wekstein DR, Dearth CM, Markesbery WR (2001) Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project. Gerontologist 41, 716-722.
21. Mesulam M, Shaw P, Mash D,Weintraub S (2004) Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol 55, 815-828.
22. Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging 28, 327-335.
23. Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 27, 1372-1384.
24. Scheff SW, Price DA, Schmitt FA, DeKosky ST, Mufson EJ (2007) Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 68, 1501-1508.
25. SaitoY, Murayama S (2007) Neuropathology of mild cognitive impairment. Neuropathology 27, 578-584.
26. Morris JC (2006) Mild cognitive impairment is early-stage Alzheimer disease: time to revise diagnostic criteria. Arch Neurol 63, 15-16.
27. Schmitt FA, Davis DG, Wekstein DR, Smith CD, Ashford JW, Markesbery WR (2000) "Preclinical" AD revisited: neuropathology of cognitively normal older adults. Neurology 55, 370-376.
28. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS (2006) Neuropathology of older persons without cognitive impairment from two communitybased studies. Neurology 66, 1837-1844.
29. Erten-Lyons D, Woltjer RL, Dodge H, Nixon R, Vorobik R, Calvert JF, Leahy M, Montine T, Kaye J (2009) Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology 72, 354-360.
30. Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer's disease: a complex but coherent relationship. J Neuropathol Exp Neurol 1, 1-14.
31. Smith CD (2007) Mild cognitive impairment is too late: the case for presymptomatic detection and treatment of Alzheimer's disease. Cognitive Studies, 33-84.
32. Galvin JE, Powlishta KK, Wilkins K, McKeel DW, Jr., Xiong C, Grant E, Storandt M, Morris JC (2005) Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Arch Neurol 62, 758-765.
33. Jack CR, Jr., Petersen RC, Xu YC, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Waring SC, Tangalos EG, Kokmen E (1999) Prediction ofADwith MRI-based hippocampal volume in mild cognitive impairment. Neurology 52, 1397-1403.
34. Jack CR, Jr., Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC (2004) Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology 62, 591-600.
35. Jack CR, Jr., Shiung MM, Weigand SD, O'Brien PC, Gunter JL, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Tangalos EG, Petersen RC (2005) Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology 65, 1227-1231.
36. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR(2007) Brain structural alterations before mild cognitive impairment. Neurology 68, 1268-1273.
37. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334, 752-758.
38. Lockhart A (2006) Imaging Alzheimer's disease pathology: one target, many ligands. Drug Discov Today 11, 1093-1099.