Stimulatory effect of α -synuclein on the tau-phosphorylation by GSK-3 β

FEBS Journal

Volumn 278, Issue 24, 2011, Pages 4895-4904

  Kawakami, Fumitaka ^a   Suzuki, Minori ^a   Shimada, Naoki ^a   Kagiya, Go ^a   Ohta, Etsuro ^a   Tamura, Kei ^a   Maruyama, Hiroko ^a   Ichikawa, Takafumi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

synuclein; Alzheimer's disease; GSK 3 ; Hsp70; tau protein

Indexed keywords

ALPHA SYNUCLEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 70; TAU PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ALPHA-SYNUCLEIN; BETA-SYNUCLEIN; GAMMA-SYNUCLEIN; GLYCOGEN SYNTHASE KINASE 3; HSP70 HEAT-SHOCK PROTEINS; HUMANS; PHOSPHORYLATION; TAU PROTEINS;

MUS;

EID: 82755177802     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08389.x     Document Type: Article

References (27)

1. Goedert M, Spillantini MG, Jakes R, Rutherford D, &, Crowther RA, (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3, 519-526.
2. Iqbal K, Liu F, Gong CX, Alonso AC, &, Grundke-Iqbal I, (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118, 53-69.
3. Hanger DP, Anderton BH, &, Noble W, (2009) Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med 15, 112-119.
4. Lee VM, Goedert M, &, Trojanowski JQ, (2001) Neurodegenerative tauopathies. Annu Rev Neurosci 24, 1121-1159. (Pubitemid 32695256)
5. Dickson DW, (2009) Neuropathology of non-Alzheimer degenerative disorders. Int J Clin Exp Pathol 3, 1-23.
6. Hanger DP, Hughes K, Woodgett JR, Brion JP, &, Anderton BH, (1992) Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett 147, 58-62.
7. Mandelkow EM, Drewes G, Biernat J, Gustke J, Van Lint J, Vandenheede JR, &, Mandelkow E, (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett 314, 315-321. (Pubitemid 23005680)
8. Ishiguro K, Omori A, Takamatsu M, Sato K, Arioka M, Uchida T, &, Imahori K, (1992) Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments. Neurosci Lett 148, 202-206. (Pubitemid 23007739)
9. Arima K, Hirai S, Sunohara N, Aoto K, Izumiyama Y, Ueda K, Ikeda K, &, Kawai M, (1999) Cellular colocalization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Res 843, 53-61. (Pubitemid 29488694)
10. Ishizawa T, Mattila P, Davies P, Wang D, &, Dickson DW, (2003) Colocalization of tau and alphasynuclein epitopes in Lewy bodies. J Neuropathol Exp Neurol 62, 389-397. (Pubitemid 36403039)
11. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, &, Goedert M, (1997) Alpha-synuclein in Lewy bodies. Nature 388, 839-840.
12. Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, &, Iwatsubo T, (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152, 879-884. (Pubitemid 28173348)
13. Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, &, Jakes R, (1999) Alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem 274, 25481-25489. (Pubitemid 29418572)
14. Duka T, Duka V, Joyce JN, &, Sidhu A, (2009) Alpha-synuclein contributes to GSK-3beta catalyzed Tau phosphorylation in Parkinson's disease models. FASEB J 23, 2820-2830.
15. Hughes K, Nikolakaki E, Plyte SE, Totty NF, &, Woodgett JR, (1993) Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J 12, 803-808. (Pubitemid 23073729)
16. Wang QM, Fiol CJ, DePaoli-Roach AA, &, Roach PJ', (1994) Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. J Biol Chem 269, 14566-14574.
17. Kawakami F, Yamaguchi A, Suzuki K, Yamamoto T, &, Ohtsuki K, (2008) Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3β and the GSK-3β-mediated phosphorylation of myelin basic protein in vitro. J Biochem 143, 359-367. (Pubitemid 351363948)
18. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, &, Saitoh T, (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467-475.
19. Petersen K, Olesen OF, &, Mikkelsen JD, (1999) Developmental expression of alphasynuclein in rat hippocampus and cerebral cortex. Neuroscience 91, 651-659. (Pubitemid 29193274)
20. Segers-Nolten IM, Wilhelmus MM, Veldhuis G, van Rooijen BD, Drukarch B, &, Subramaniam V, (2008) Tissue transglutaminase modulates alpha-synuclein oligomerization. Protein Sci 17, 1395-1402.
21. Butner KA, &, Kirschner MW, (1991) Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol 115, 717-730. (Pubitemid 21909925)
22. Khatoon S, Grundke-Iqbal I, &, Iqbal K, (1992) Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59, 750-753.
23. Lavedan C, (1998) The synuclein family. Genome Res 8, 871-880. (Pubitemid 28495441)
24. Hernandez F, Borrell J, Guaza C, Avila J, &, Lucas JJ, (2002) Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. J Neurochem 83, 1529-1533. (Pubitemid 35477491)
25. Klucken J, Shin Y, Masliah E, Hyman BT, &, McLean PJ, (2004) Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem 279, 25497-25502. (Pubitemid 38756808)
26. Hartl FU, &, Hayer-Hartl M, (2002) Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295, 1852-1858. (Pubitemid 34214115)
27. Kawakami F, Suzuki K, &, Ohtsuki K, (2008) A novel consensus phosphorylation motif in sulfatide- and cholesterol-3-sulfate-binding protein substrates for CK1 in vitro. Biol Pharm Bull 31, 193-200. (Pubitemid 351198388)