메뉴 건너뛰기




Volumn 28, Issue 1, 2013, Pages 61-70

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies

Author keywords

6 OHDA; Alpha synuclein; Dopamine; LRRK2; MPTP; Neurodegeneration; Viral vectors

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LEUCINE RICH REPEAT KINASE 2; NEUROTOXIN; OXIDOPAMINE; VIRUS VECTOR;

EID: 84873476695     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25108     Document Type: Review
Times cited : (152)

References (112)
  • 1
    • 0030300159 scopus 로고    scopus 로고
    • New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline
    • Gerlach M, Desser H, Youdim MBH, Riederer P. New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline. J Neural Transm 1996;48:7-21.
    • (1996) J Neural Transm , vol.48 , pp. 7-21
    • Gerlach, M.1    Desser, H.2    Youdim, M.B.H.3    Riederer, P.4
  • 2
    • 0025988085 scopus 로고
    • MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease
    • Gerlach M, Riederer P, Przuntek H, Youdim MBH. MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease. Eur J Pharmacol 1991;208:273-286.
    • (1991) Eur J Pharmacol , vol.208 , pp. 273-286
    • Gerlach, M.1    Riederer, P.2    Przuntek, H.3    Youdim, M.B.H.4
  • 3
    • 0026552602 scopus 로고
    • The MPTP-treated mouse as a model of parkinsonism: how good is it?
    • Heikkila RE, Sonsalla P. The MPTP-treated mouse as a model of parkinsonism: how good is it? Neurochem Int 1991;20:299-303.
    • (1991) Neurochem Int , vol.20 , pp. 299-303
    • Heikkila, R.E.1    Sonsalla, P.2
  • 4
    • 0024778987 scopus 로고
    • Animal models of parkinsonism using selective neurotoxins: clinical and basic implications
    • Zigmond MJ, Stricker EM. Animal models of parkinsonism using selective neurotoxins: clinical and basic implications. Int Rev Neurobiol 1989;31:1-79.
    • (1989) Int Rev Neurobiol , vol.31 , pp. 1-79
    • Zigmond, M.J.1    Stricker, E.M.2
  • 5
    • 79957608284 scopus 로고    scopus 로고
    • A tale on animal models of Parkinson's disease
    • Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Mov Disord 2011;26:993-1002.
    • (2011) Mov Disord , vol.26 , pp. 993-1002
    • Bezard, E.1    Przedborski, S.2
  • 6
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003;39:889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 7
    • 0037130450 scopus 로고    scopus 로고
    • Animal models of PD: pieces of the same puzzle?
    • Dawson T, Mandir A, Lee M. Animal models of PD: pieces of the same puzzle? Neuron 2002;35:219-222.
    • (2002) Neuron , vol.35 , pp. 219-222
    • Dawson, T.1    Mandir, A.2    Lee, M.3
  • 8
    • 0036829946 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative strategies for Parkinson's disease
    • Dawson TM, Dawson VL. Neuroprotective and neurorestorative strategies for Parkinson's disease. Nat Neurosci 2002; Suppl:1058-1061.
    • (2002) Nat Neurosci , Issue.SUPPL , pp. 1058-1061
    • Dawson, T.M.1    Dawson, V.L.2
  • 10
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance
    • Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 2008;1147:93-104.
    • (2008) Ann N Y Acad Sci , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3
  • 11
    • 26844505808 scopus 로고    scopus 로고
    • Toxin-induced models of Parkinson's disease
    • Bove J, Prou D, Perier C, Przedborski S. Toxin-induced models of Parkinson's disease. NeuroRx 2005;2:484-494.
    • (2005) NeuroRx , vol.2 , pp. 484-494
    • Bove, J.1    Prou, D.2    Perier, C.3    Przedborski, S.4
  • 12
    • 0031865569 scopus 로고    scopus 로고
    • Experimental models of Parkinson's disease: from the static to the dynamic
    • Bezard E, Imbert C, Gross CE. Experimental models of Parkinson's disease: from the static to the dynamic. Rev Neurosci 1998;9:71-90.
    • (1998) Rev Neurosci , vol.9 , pp. 71-90
    • Bezard, E.1    Imbert, C.2    Gross, C.E.3
  • 13
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications
    • Kish SJ, Shannak K, Hornykiewicz O. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med 1988;318:876-880.
    • (1988) N Engl J Med , vol.318 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 14
    • 0025065388 scopus 로고
    • Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
    • Brooks DJ, Ibanez V, Sawle GV, et al. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann Neurol 1990;28:547-555.
    • (1990) Ann Neurol , vol.28 , pp. 547-555
    • Brooks, D.J.1    Ibanez, V.2    Sawle, G.V.3
  • 15
    • 0032143368 scopus 로고    scopus 로고
    • Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    • Kirik D, Rosenblad C, Bjorklund A. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol 1998;152:259-277.
    • (1998) Exp Neurol , vol.152 , pp. 259-277
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3
  • 16
    • 16244387184 scopus 로고    scopus 로고
    • A modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosets
    • Iravani MM, Syed E, Jackson MJ, Johnston LC, Smith LA, Jenner P. A modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosets. Eur J Neurosci 2005;21:841-854.
    • (2005) Eur J Neurosci , vol.21 , pp. 841-854
    • Iravani, M.M.1    Syed, E.2    Jackson, M.J.3    Johnston, L.C.4    Smith, L.A.5    Jenner, P.6
  • 17
    • 0242624508 scopus 로고    scopus 로고
    • Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys
    • Jan C, Pessiglione M, Tremblay L, Tande D, Hirsch EC, Francois C. Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys. Eur J Neurosci 2003;18:2082-2086.
    • (2003) Eur J Neurosci , vol.18 , pp. 2082-2086
    • Jan, C.1    Pessiglione, M.2    Tremblay, L.3    Tande, D.4    Hirsch, E.C.5    Francois, C.6
  • 18
    • 0035449393 scopus 로고    scopus 로고
    • Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease
    • Bezard E, Dovero S, Prunier C, et al. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson's disease. J Neurosci 2001;21:6853-6861.
    • (2001) J Neurosci , vol.21 , pp. 6853-6861
    • Bezard, E.1    Dovero, S.2    Prunier, C.3
  • 19
    • 23044483789 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning
    • Guigoni C, Dovero S, Aubert I, et al. Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning. Eur J Neurosci 2005;22:283-287.
    • (2005) Eur J Neurosci , vol.22 , pp. 283-287
    • Guigoni, C.1    Dovero, S.2    Aubert, I.3
  • 20
    • 0026587806 scopus 로고
    • Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW, Graybiel AM. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Proc Natl Acad Sci U S A 1992;89:3859-3863.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3859-3863
    • Moratalla, R.1    Quinn, B.2    DeLanney, L.E.3    Irwin, I.4    Langston, J.W.5    Graybiel, A.M.6
  • 21
    • 0025781009 scopus 로고
    • Effect of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey
    • Pifl C, Schingnitz G, Hornykiewicz O. Effect of 1-methyl-4- phenyl-1, 2, 3, 6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey. Neuroscience 1991;44:591-605.
    • (1991) Neuroscience , vol.44 , pp. 591-605
    • Pifl, C.1    Schingnitz, G.2    Hornykiewicz, O.3
  • 22
    • 77952549129 scopus 로고    scopus 로고
    • Genes regulated in MPTP-treated macaques and human Parkinson's disease suggest a common signature in prefrontal cortex
    • Storvik M, Arguel MJ, Schmieder S, et al. Genes regulated in MPTP-treated macaques and human Parkinson's disease suggest a common signature in prefrontal cortex. Neurobiol Dis 2010;38:386-394.
    • (2010) Neurobiol Dis , vol.38 , pp. 386-394
    • Storvik, M.1    Arguel, M.J.2    Schmieder, S.3
  • 23
    • 78149463043 scopus 로고    scopus 로고
    • Neuroanatomical study of the a11 diencephalospinal pathway in the non-human primate
    • Barraud Q, Obeid I, Aubert I, et al. Neuroanatomical study of the a11 diencephalospinal pathway in the non-human primate. PLoS One 2010;5(10):e13306.
    • (2010) PLoS One , vol.5 , Issue.10
    • Barraud, Q.1    Obeid, I.2    Aubert, I.3
  • 24
    • 58849098133 scopus 로고    scopus 로고
    • Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental parkinsonism
    • Chaumette T, Lebouvier T, Aubert P, et al. Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental parkinsonism. Neurogastroenterol Motil 2009;21:215-222.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 215-222
    • Chaumette, T.1    Lebouvier, T.2    Aubert, P.3
  • 25
    • 0034613450 scopus 로고    scopus 로고
    • Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain
    • Crowther RA, Daniel SE, Goedert M. Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci Lett 2000;292:128-130.
    • (2000) Neurosci Lett , vol.292 , pp. 128-130
    • Crowther, R.A.1    Daniel, S.E.2    Goedert, M.3
  • 26
    • 69849092676 scopus 로고    scopus 로고
    • No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
    • Halliday G, Herrero MT, Murphy K, et al. No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism. Mov Disord 2009;24:1519-1523.
    • (2009) Mov Disord , vol.24 , pp. 1519-1523
    • Halliday, G.1    Herrero, M.T.2    Murphy, K.3
  • 27
    • 20044385568 scopus 로고    scopus 로고
    • Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein
    • Fornai F, Schluter OM, Lenzi P, et al. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A 2005;102:3413-3418.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3413-3418
    • Fornai, F.1    Schluter, O.M.2    Lenzi, P.3
  • 29
    • 52249119906 scopus 로고    scopus 로고
    • Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys
    • McCormack AL, Mak SK, Shenasa M, Langston WJ, Forno LS, Di Monte DA. Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated squirrel monkeys. J Neuropathol Exp Neurol 2008;67:793-802.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 793-802
    • McCormack, A.L.1    Mak, S.K.2    Shenasa, M.3    Langston, W.J.4    Forno, L.S.5    Di Monte, D.A.6
  • 32
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially affected in Parkinson's disease
    • Hirsch EC, Graybiel AM, Agid Y. Melanized dopaminergic neurons are differentially affected in Parkinson's disease. Nature 1988;334:345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.C.1    Graybiel, A.M.2    Agid, Y.3
  • 33
    • 0027234249 scopus 로고
    • Does neuromelanin contribute to the vulnerability of cathecolaminergic neurons in monkeys intoxicated with MPTP?
    • Herrero MT, Hirsch EC, Kastner A, et al. Does neuromelanin contribute to the vulnerability of cathecolaminergic neurons in monkeys intoxicated with MPTP? Neuroscience 1993;56:499-511.
    • (1993) Neuroscience , vol.56 , pp. 499-511
    • Herrero, M.T.1    Hirsch, E.C.2    Kastner, A.3
  • 34
    • 78650527643 scopus 로고    scopus 로고
    • Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease
    • Zhang W, Phillips K, Wielgus AR, et al. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res 2011;19:63-72.
    • (2011) Neurotox Res , vol.19 , pp. 63-72
    • Zhang, W.1    Phillips, K.2    Wielgus, A.R.3
  • 35
    • 0032568534 scopus 로고    scopus 로고
    • alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 1998;95:6469-6473.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 37
    • 80054787664 scopus 로고    scopus 로고
    • What genetics tells us about the causes and mechanisms of Parkinson's disease
    • Corti O, Lesage S, Brice A. What genetics tells us about the causes and mechanisms of Parkinson's disease. Physiol Rev 2011;91:1161-1218.
    • (2011) Physiol Rev , vol.91 , pp. 1161-1218
    • Corti, O.1    Lesage, S.2    Brice, A.3
  • 38
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 39
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    • Masliah E, Rockenstein E, Veinbergs I, et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 2000;287:1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3
  • 40
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 2002;34:521-533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 41
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, Mallory M, Hashimoto M, et al. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002;68:568-578.
    • (2002) J Neurosci Res , vol.68 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3
  • 42
    • 69049119262 scopus 로고    scopus 로고
    • Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
    • Daher JP, Ying M, Banerjee R, et al. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Mol Neurodegener 2009;4:34.
    • (2009) Mol Neurodegener , vol.4 , pp. 34
    • Daher, J.P.1    Ying, M.2    Banerjee, R.3
  • 43
    • 0034663176 scopus 로고    scopus 로고
    • Neuropathology in mice expressing human alpha-synuclein
    • van der Putten H, Wiederhold KH, Probst A, et al. Neuropathology in mice expressing human alpha-synuclein. J Neurosci 2000;20:6021-6029.
    • (2000) J Neurosci , vol.20 , pp. 6021-6029
    • van der Putten, H.1    Wiederhold, K.H.2    Probst, A.3
  • 44
    • 36949031267 scopus 로고    scopus 로고
    • alpha-Synucleinopathy models and human neuropathology: similarities and differences
    • Kahle PJ. alpha-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 2008;115:87-95.
    • (2008) Acta Neuropathol , vol.115 , pp. 87-95
    • Kahle, P.J.1
  • 45
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet MF, Richter F. Modelling of Parkinson's disease in mice. Lancet Neurol 2011;10:1108-1118.
    • (2011) Lancet Neurol , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, F.2
  • 46
    • 0037173006 scopus 로고    scopus 로고
    • Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
    • Lee MK, Stirling W, Xu Y, et al. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A 2002;99:8968-8973.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3
  • 47
    • 0035191413 scopus 로고    scopus 로고
    • Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    • Kahle PJ, Neumann M, Ozmen L, et al. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 2001;159:2215-2225.
    • (2001) Am J Pathol , vol.159 , pp. 2215-2225
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 48
    • 33646097224 scopus 로고    scopus 로고
    • Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders
    • Tofaris GK, Garcia Reitbock P, Humby T, et al. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. J Neurosci 2006;26:3942-3950.
    • (2006) J Neurosci , vol.26 , pp. 3942-3950
    • Tofaris, G.K.1    Garcia Reitbock, P.2    Humby, T.3
  • 49
    • 0036245056 scopus 로고    scopus 로고
    • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    • Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, et al. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol 2002;175:35-48.
    • (2002) Exp Neurol , vol.175 , pp. 35-48
    • Richfield, E.K.1    Thiruchelvam, M.J.2    Cory-Slechta, D.A.3
  • 50
    • 80053151301 scopus 로고    scopus 로고
    • Neuropathology in mice expressing mouse alpha-synuclein
    • Rieker C, Dev KK, Lehnhoff K, et al. Neuropathology in mice expressing mouse alpha-synuclein. PLoS One 2011;6(9):e24834.
    • (2011) PLoS One , vol.6 , Issue.9
    • Rieker, C.1    Dev, K.K.2    Lehnhoff, K.3
  • 51
    • 0034979314 scopus 로고    scopus 로고
    • Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
    • Matsuoka Y, Vila M, Lincoln S, et al. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol Dis 2001;8:535-539.
    • (2001) Neurobiol Dis , vol.8 , pp. 535-539
    • Matsuoka, Y.1    Vila, M.2    Lincoln, S.3
  • 52
    • 39749196233 scopus 로고    scopus 로고
    • Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice
    • Wakamatsu M, Ishii A, Iwata S, et al. Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Neurobiol Aging 2008;29:574-585.
    • (2008) Neurobiol Aging , vol.29 , pp. 574-585
    • Wakamatsu, M.1    Ishii, A.2    Iwata, S.3
  • 53
    • 0031728689 scopus 로고    scopus 로고
    • Synthetic filaments assembled from C-terminally truncated alpha-synuclein
    • Crowther RA, Jakes R, Spillantini MG, Goedert M. Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Lett 1998;436:309-312.
    • (1998) FEBS Lett , vol.436 , pp. 309-312
    • Crowther, R.A.1    Jakes, R.2    Spillantini, M.G.3    Goedert, M.4
  • 54
    • 0038116620 scopus 로고    scopus 로고
    • Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
    • Murray IV, Giasson BI, Quinn SM, et al. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 2003;42:8530-8540.
    • (2003) Biochemistry , vol.42 , pp. 8530-8540
    • Murray, I.V.1    Giasson, B.I.2    Quinn, S.M.3
  • 55
    • 84867571567 scopus 로고    scopus 로고
    • Critical role for truncated alpha-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease
    • March 27. doi: 10.1111/j.1750-3639.2012.00597.x.
    • Prasad K, Beach TG, Hedreen J, Richfield EK. Critical role for truncated alpha-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease. Brain Pathol 2012 March 27. doi: 10.1111/j.1750-3639.2012.00597.x.
    • (2012) Brain Pathol
    • Prasad, K.1    Beach, T.G.2    Hedreen, J.3    Richfield, E.K.4
  • 56
    • 84855188545 scopus 로고    scopus 로고
    • alpha-synuclein phosphorylation and truncation are normal events in the adult human brain
    • Muntane G, Ferrer I, Martinez-Vicente M. alpha-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience 2012;200:106-119.
    • (2012) Neuroscience , vol.200 , pp. 106-119
    • Muntane, G.1    Ferrer, I.2    Martinez-Vicente, M.3
  • 57
    • 20744442130 scopus 로고    scopus 로고
    • A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease
    • Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 2005;280:22670-22678.
    • (2005) J Biol Chem , vol.280 , pp. 22670-22678
    • Liu, C.W.1    Giasson, B.I.2    Lewis, K.A.3    Lee, V.M.4    Demartino, G.N.5    Thomas, P.J.6
  • 58
    • 13844320376 scopus 로고    scopus 로고
    • Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
    • Li W, West N, Colla E, et al. Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A 2005;102:2162-2167.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2162-2167
    • Li, W.1    West, N.2    Colla, E.3
  • 59
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M, Nakajo S, Tu PH, et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998;152:879-884.
    • (1998) Am J Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3
  • 60
    • 0034609561 scopus 로고    scopus 로고
    • Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein
    • Rochet JC, Conway KA, Lansbury PT, Jr. Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 2000;39:10619-10626.
    • (2000) Biochemistry , vol.39 , pp. 10619-10626
    • Rochet, J.C.1    Conway, K.A.2    Lansbury Jr., P.T.3
  • 61
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A, Schmitz Y, Farinas I, et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000;25:239-252.
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3
  • 62
    • 79956296370 scopus 로고    scopus 로고
    • Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
    • Anwar S, Peters O, Millership S, et al. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci 2011;31:7264-7274.
    • (2011) J Neurosci , vol.31 , pp. 7264-7274
    • Anwar, S.1    Peters, O.2    Millership, S.3
  • 63
    • 0037109727 scopus 로고    scopus 로고
    • Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    • Cabin DE, Shimazu K, Murphy D, et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 2002;22:8797-8807.
    • (2002) J Neurosci , vol.22 , pp. 8797-8807
    • Cabin, D.E.1    Shimazu, K.2    Murphy, D.3
  • 64
    • 34547467082 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    • Caudle WM, Richardson JR, Wang MZ, et al. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J Neurosci 2007;27:8138-8148.
    • (2007) J Neurosci , vol.27 , pp. 8138-8148
    • Caudle, W.M.1    Richardson, J.R.2    Wang, M.Z.3
  • 65
    • 77954379317 scopus 로고    scopus 로고
    • SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
    • Garcia-Reitbock P, Anichtchik O, Bellucci A, et al. SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain 2010;133:2032-2044.
    • (2010) Brain , vol.133 , pp. 2032-2044
    • Garcia-Reitbock, P.1    Anichtchik, O.2    Bellucci, A.3
  • 66
    • 33751113009 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
    • Larsen KE, Schmitz Y, Troyer MD, et al. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci 2006;26:11915-11922.
    • (2006) J Neurosci , vol.26 , pp. 11915-11922
    • Larsen, K.E.1    Schmitz, Y.2    Troyer, M.D.3
  • 67
    • 73549085595 scopus 로고    scopus 로고
    • Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    • Nemani VM, Lu W, Berge V, et al. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 2010;65:66-79.
    • (2010) Neuron , vol.65 , pp. 66-79
    • Nemani, V.M.1    Lu, W.2    Berge, V.3
  • 68
    • 77953796839 scopus 로고    scopus 로고
    • A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    • Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci 2010;30:8083-8095.
    • (2010) J Neurosci , vol.30 , pp. 8083-8095
    • Scott, D.A.1    Tabarean, I.2    Tang, Y.3    Cartier, A.4    Masliah, E.5    Roy, S.6
  • 69
    • 82855172161 scopus 로고    scopus 로고
    • Redistribution of DAT/alpha-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease
    • Bellucci A, Navarria L, Falarti E, et al. Redistribution of DAT/alpha-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease. PLoS One 2011;6(12):e27959.
    • (2011) PLoS One , vol.6 , Issue.12
    • Bellucci, A.1    Navarria, L.2    Falarti, E.3
  • 70
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007;27:1405-1410.
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 71
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131:642-650.
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3
  • 72
    • 70449532484 scopus 로고    scopus 로고
    • A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    • Greffard S, Verny M, Bonnet AM, Seilhean D, Hauw JJ, Duyckaerts C. A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol Aging 2010;31:99-103.
    • (2010) Neurobiol Aging , vol.31 , pp. 99-103
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Seilhean, D.4    Hauw, J.J.5    Duyckaerts, C.6
  • 73
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O. Biochemical aspects of Parkinson's disease. Neurology 1998;51(2 Suppl 2):S2-S9.
    • (1998) Neurology , vol.51 , Issue.2 SUPPL 2
    • Hornykiewicz, O.1
  • 74
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991;114:2283-2301.
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 75
    • 0342981758 scopus 로고    scopus 로고
    • Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
    • Ma SY, Roytta M, Rinne JO, Collan Y, Rinne UK. Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts. J Neurol Sci 1997;151:83-87.
    • (1997) J Neurol Sci , vol.151 , pp. 83-87
    • Ma, S.Y.1    Roytta, M.2    Rinne, J.O.3    Collan, Y.4    Rinne, U.K.5
  • 76
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004;44:601-607.
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1    Biskup, S.2    Leitner, P.3
  • 77
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    • Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004;44:595-600.
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisan-Ruiz, C.1    Jain, S.2    Evans, E.W.3
  • 79
    • 50049104725 scopus 로고    scopus 로고
    • Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
    • Healy DG, Falchi M, O'Sullivan SS, et al. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol 2008;7:583-590.
    • (2008) Lancet Neurol , vol.7 , pp. 583-590
    • Healy, D.G.1    Falchi, M.2    O'Sullivan, S.S.3
  • 80
    • 70350461833 scopus 로고    scopus 로고
    • LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles
    • Yue Z. LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles. FEBS J 2009;276:6445-6454.
    • (2009) FEBS J , vol.276 , pp. 6445-6454
    • Yue, Z.1
  • 81
    • 80053152848 scopus 로고    scopus 로고
    • Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
    • Liu Z, Hamamichi S, Lee BD, et al. Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet 2011;20:3933-3942.
    • (2011) Hum Mol Genet , vol.20 , pp. 3933-3942
    • Liu, Z.1    Hamamichi, S.2    Lee, B.D.3
  • 82
    • 28044460070 scopus 로고    scopus 로고
    • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    • West AB, Moore DJ, Biskup S, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 2005;102:16842-16847.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16842-16847
    • West, A.B.1    Moore, D.J.2    Biskup, S.3
  • 83
    • 77953395313 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
    • Greggio E, Cookson MR. Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro 2009;1(1):e000002.
    • (2009) ASN Neuro , vol.1 , Issue.1
    • Greggio, E.1    Cookson, M.R.2
  • 84
    • 70149124508 scopus 로고    scopus 로고
    • R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    • Tong Y, Pisani A, Martella G, et al. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A 2009;106:14622-14627.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14622-14627
    • Tong, Y.1    Pisani, A.2    Martella, G.3
  • 85
    • 77957794336 scopus 로고    scopus 로고
    • Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    • Melrose HL, Dachsel JC, Behrouz B, et al. Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 2010;40:503-517.
    • (2010) Neurobiol Dis , vol.40 , pp. 503-517
    • Melrose, H.L.1    Dachsel, J.C.2    Behrouz, B.3
  • 86
    • 72149087091 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    • Lin X, Parisiadou L, Gu XL, et al. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron 2009;64:807-827.
    • (2009) Neuron , vol.64 , pp. 807-827
    • Lin, X.1    Parisiadou, L.2    Gu, X.L.3
  • 87
    • 76149134717 scopus 로고    scopus 로고
    • Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    • Li X, Patel JC, Wang J, et al. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J Neurosci 2010;30:1788-1797.
    • (2010) J Neurosci , vol.30 , pp. 1788-1797
    • Li, X.1    Patel, J.C.2    Wang, J.3
  • 88
    • 67649813448 scopus 로고    scopus 로고
    • Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    • Li Y, Liu W, Oo TF, et al. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci 2009;12(7):826-828.
    • (2009) Nat Neurosci , vol.12 , Issue.7 , pp. 826-828
    • Li, Y.1    Liu, W.2    Oo, T.F.3
  • 89
    • 79960587095 scopus 로고    scopus 로고
    • Genetic LRRK2 models of Parkinson's disease: dissecting the pathogenic pathway and exploring clinical applications
    • Yue Z, Lachenmayer ML. Genetic LRRK2 models of Parkinson's disease: dissecting the pathogenic pathway and exploring clinical applications. Mov Disord 2011;26:1386-1397.
    • (2011) Mov Disord , vol.26 , pp. 1386-1397
    • Yue, Z.1    Lachenmayer, M.L.2
  • 90
    • 79953758383 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss, reduced neurite complexity, and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
    • Ramonet D, Daher JP, Lin BM, et al. Dopaminergic neuronal loss, reduced neurite complexity, and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One 2011;6(4):e18568.
    • (2011) PLoS One , vol.6 , Issue.4
    • Ramonet, D.1    Daher, J.P.2    Lin, B.M.3
  • 91
    • 80054933395 scopus 로고    scopus 로고
    • The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
    • Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 2011;12:1063-1070.
    • (2011) Nat Immunol , vol.12 , pp. 1063-1070
    • Liu, Z.1    Lee, J.2    Krummey, S.3    Lu, W.4    Cai, H.5    Lenardo, M.J.6
  • 92
    • 77956441086 scopus 로고    scopus 로고
    • Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
    • Lee BD, Shin JH, VanKampen J, et al. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med 2010;16:998-1000.
    • (2010) Nat Med , vol.16 , pp. 998-1000
    • Lee, B.D.1    Shin, J.H.2    VanKampen, J.3
  • 93
    • 0034672304 scopus 로고    scopus 로고
    • Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV, and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
    • Bjorklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV, and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Res 2000;886:82-98.
    • (2000) Brain Res , vol.886 , pp. 82-98
    • Bjorklund, A.1    Kirik, D.2    Rosenblad, C.3    Georgievska, B.4    Lundberg, C.5    Mandel, R.J.6
  • 94
    • 0036202813 scopus 로고    scopus 로고
    • Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra
    • Klein RL, King MA, Hamby ME, Meyer EM. Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Hum Gene Ther 2002;13:605-612.
    • (2002) Hum Gene Ther , vol.13 , pp. 605-612
    • Klein, R.L.1    King, M.A.2    Hamby, M.E.3    Meyer, E.M.4
  • 95
    • 0036550101 scopus 로고    scopus 로고
    • Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
    • Kirik D, Rosenblad C, Burger C, et al. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci 2002;22:2780-2791.
    • (2002) J Neurosci , vol.22 , pp. 2780-2791
    • Kirik, D.1    Rosenblad, C.2    Burger, C.3
  • 96
    • 0345269757 scopus 로고    scopus 로고
    • Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease
    • Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Bjorklund A. Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proc Natl Acad Sci U S A 2003;100:2884-2889.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2884-2889
    • Kirik, D.1    Annett, L.E.2    Burger, C.3    Muzyczka, N.4    Mandel, R.J.5    Bjorklund, A.6
  • 97
    • 0041625923 scopus 로고    scopus 로고
    • Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein
    • Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V. Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain Pathol 2003;13:364-372.
    • (2003) Brain Pathol , vol.13 , pp. 364-372
    • Lauwers, E.1    Debyser, Z.2    Van Dorpe, J.3    De Strooper, B.4    Nuttin, B.5    Baekelandt, V.6
  • 98
    • 0036679197 scopus 로고    scopus 로고
    • alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P. alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci U S A 2002;99:10813-10818.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 99
    • 16844379844 scopus 로고    scopus 로고
    • Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease
    • Maingay M, Romero-Ramos M, Kirik D. Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease. CNS Spectr 2005;10:235-244.
    • (2005) CNS Spectr , vol.10 , pp. 235-244
    • Maingay, M.1    Romero-Ramos, M.2    Kirik, D.3
  • 100
    • 33947127695 scopus 로고    scopus 로고
    • Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
    • Eslamboli A, Romero-Ramos M, Burger C, et al. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain 2007;130:799-815.
    • (2007) Brain , vol.130 , pp. 799-815
    • Eslamboli, A.1    Romero-Ramos, M.2    Burger, C.3
  • 101
    • 33747441863 scopus 로고    scopus 로고
    • Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression
    • Maingay M, Romero-Ramos M, Carta M, Kirik D. Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. Neurobiol Dis 2006;23:522-532.
    • (2006) Neurobiol Dis , vol.23 , pp. 522-532
    • Maingay, M.1    Romero-Ramos, M.2    Carta, M.3    Kirik, D.4
  • 102
    • 84856570373 scopus 로고    scopus 로고
    • Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons
    • Decressac M, Mattsson B, Lundblad M, Weikop P, Bjorklund A. Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons. Neurobiol Dis 2012;45:939-953.
    • (2012) Neurobiol Dis , vol.45 , pp. 939-953
    • Decressac, M.1    Mattsson, B.2    Lundblad, M.3    Weikop, P.4    Bjorklund, A.5
  • 103
    • 84856440571 scopus 로고    scopus 로고
    • Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-alpha-synuclein and the pesticide, rotenone
    • Mulcahy P, O'Doherty A, Paucard A, O'Brien T, Kirik D, Dowd E. Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-alpha-synuclein and the pesticide, rotenone. Neuroscience 2012;203:170-179.
    • (2012) Neuroscience , vol.203 , pp. 170-179
    • Mulcahy, P.1    O'Doherty, A.2    Paucard, A.3    O'Brien, T.4    Kirik, D.5    Dowd, E.6
  • 104
    • 1642499508 scopus 로고    scopus 로고
    • Localized striatal delivery of GDNF as a treatment for Parkinson disease
    • Kirik D, Georgievska B, Bjorklund A. Localized striatal delivery of GDNF as a treatment for Parkinson disease. Nat Neurosci 2004;7:105-110.
    • (2004) Nat Neurosci , vol.7 , pp. 105-110
    • Kirik, D.1    Georgievska, B.2    Bjorklund, A.3
  • 105
    • 5144225578 scopus 로고    scopus 로고
    • Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
    • Lo Bianco C, Deglon N, Pralong W, Aebischer P. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 2004;17:283-289.
    • (2004) Neurobiol Dis , vol.17 , pp. 283-289
    • Lo Bianco, C.1    Deglon, N.2    Pralong, W.3    Aebischer, P.4
  • 106
    • 80051985178 scopus 로고    scopus 로고
    • GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease
    • Decressac M, Ulusoy A, Mattsson B, et al. GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease. Brain 2011;134:2302-2311.
    • (2011) Brain , vol.134 , pp. 2302-2311
    • Decressac, M.1    Ulusoy, A.2    Mattsson, B.3
  • 107
    • 33749453510 scopus 로고    scopus 로고
    • Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease
    • Vercammen L, Van der Perren A, Vaudano E, et al. Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. Mol Ther 2006;14:716-723.
    • (2006) Mol Ther , vol.14 , pp. 716-723
    • Vercammen, L.1    Van der Perren, A.2    Vaudano, E.3
  • 108
    • 10644281090 scopus 로고    scopus 로고
    • Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease
    • Lo Bianco C, Schneider BL, Bauer M, et al. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci U S A 2004;101:17510-17515.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17510-17515
    • Lo Bianco, C.1    Schneider, B.L.2    Bauer, M.3
  • 109
    • 0037461309 scopus 로고    scopus 로고
    • Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment
    • Ravina BM, Fagan SC, Hart RG, et al. Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology 2003;60:1234-1240.
    • (2003) Neurology , vol.60 , pp. 1234-1240
    • Ravina, B.M.1    Fagan, S.C.2    Hart, R.G.3
  • 110
    • 3042755065 scopus 로고    scopus 로고
    • Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease
    • Diguet E, Fernagut PO, Wei X, et al. Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease. Eur J Neurosci 2004;19:3266-3276.
    • (2004) Eur J Neurosci , vol.19 , pp. 3266-3276
    • Diguet, E.1    Fernagut, P.O.2    Wei, X.3
  • 111
    • 85047104504 scopus 로고    scopus 로고
    • Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment
    • author reply, 158-159.
    • Diguet E, Gross CE, Bezard E, Tison F, Stefanova N, Wenning GK. Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology 2004;62:158; author reply, 158-159.
    • (2004) Neurology , vol.62 , pp. 158
    • Diguet, E.1    Gross, C.E.2    Bezard, E.3    Tison, F.4    Stefanova, N.5    Wenning, G.K.6
  • 112
    • 0023185342 scopus 로고
    • Equipoise and the ethics of clinical research
    • Freedman B. Equipoise and the ethics of clinical research. N Engl J Med 1987;317:141-145.
    • (1987) N Engl J Med , vol.317 , pp. 141-145
    • Freedman, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.