메뉴 건너뛰기




Volumn 133, Issue 7, 2010, Pages 2032-2044

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

Author keywords

alpha synuclein; dopamine; neurodegenerative diseases; Parkinson's disease; SNARE proteins

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; SNARE PROTEIN; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN 1;

EID: 77954379317     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq132     Document Type: Article
Times cited : (228)

References (42)
  • 1
    • 0036850725 scopus 로고    scopus 로고
    • Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
    • Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 2002; 22: 9340-9351
    • (2002) J Neurosci , vol.22 , pp. 9340-9351
    • Allen, B.1    Ingram, E.2    Takao, M.3    Smith, M.J.4    Jakes, R.5    Virdee, K.6
  • 2
    • 67349213205 scopus 로고    scopus 로고
    • Synaptic degeneration in Alzheimer's disease
    • Arendt T. Synaptic degeneration in Alzheimer's disease. Acta Neuropathol 2009; 118: 167-179
    • (2009) Acta Neuropathol , vol.118 , pp. 167-179
    • Arendt, T.1
  • 3
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, et al. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998; 152: 879-884
    • (1998) Am J Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6
  • 4
    • 51649089030 scopus 로고    scopus 로고
    • Alphasynuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation
    • Bellucci A, Collo G, Sarnico I, Battistin L, Missale C, Spano P. Alphasynuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation. J Neurochem 2008; 106: 560-577
    • (2008) J Neurochem , vol.106 , pp. 560-577
    • Bellucci, A.1    Collo, G.2    Sarnico, I.3    Battistin, L.4    Missale, C.5    Spano, P.6
  • 6
    • 63849332293 scopus 로고    scopus 로고
    • Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV α-synucleinopathy
    • Chung CY, Koprich JB, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV α-synucleinopathy. J Neurosci 2009; 29: 3365-3373
    • (2009) J Neurosci , vol.29 , pp. 3365-3373
    • Chung, C.Y.1    Koprich, J.B.2    Siddiqi, H.3    Isacson, O.4
  • 7
    • 0031728689 scopus 로고    scopus 로고
    • Synthetic filaments assembled from C-terminally truncated α-synuclein
    • Crowther RA, Jakes R, Spillantini MG, Goedert M. Synthetic filaments assembled from C-terminally truncated α-synuclein. FEBS Lett 1998; 436: 309-312
    • (1998) FEBS Lett , vol.436 , pp. 309-312
    • Crowther, R.A.1    Jakes, R.2    Spillantini, M.G.3    Goedert, M.4
  • 9
    • 58749107499 scopus 로고    scopus 로고
    • A rapid Percoll gradient procedure for preparation of synaptosomes
    • Dunkley PR, Jarvie PE, Robinson PJ. A rapid Percoll gradient procedure for preparation of synaptosomes. Nat Protoc 2008; 3: 1718-1728
    • (2008) Nat Protoc , vol.3 , pp. 1718-1728
    • Dunkley, P.R.1    Jarvie, P.E.2    Robinson, P.J.3
  • 12
    • 34548833278 scopus 로고    scopus 로고
    • Imaging synaptic vesicle exocytosis and endocytosis with FM dyes
    • Gaffield MA, Betz WJ. Imaging synaptic vesicle exocytosis and endocytosis with FM dyes. Nat Protoc 2006; 1: 2916-2921
    • (2006) Nat Protoc , vol.1 , pp. 2916-2921
    • Gaffield, M.A.1    Betz, W.J.2
  • 13
    • 0036121191 scopus 로고    scopus 로고
    • Aconitase: Sensitive target and measure of superoxide
    • Gardner PR. Aconitase: sensitive target and measure of superoxide. Methods Enzymol 2002; 349: 9-23.
    • (2002) Methods Enzymol , vol.349 , pp. 9-23
    • Gardner, P.R.1
  • 14
    • 0035409575 scopus 로고    scopus 로고
    • Alpha-synuclein and neurodegenerative diseases
    • Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001; 2: 492-501.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 492-501
    • Goedert, M.1
  • 15
    • 70449532484 scopus 로고    scopus 로고
    • A stable proportion of Lewy body-bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    • Greffard S, Verny M, Bonnet AM, Seilhear D, Hauw JJ, Duyckaerts C. A stable proportion of Lewy body-bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol Aging 2010; 31: 99-103.
    • (2010) Neurobiol Aging , vol.31 , pp. 99-103
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Seilhear, D.4    Hauw, J.J.5    Duyckaerts, C.6
  • 16
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O. Biochemical aspects of Parkinson's disease. Neurology 1998; 51: S2-9.
    • (1998) Neurology , vol.51
    • Hornykiewicz, O.1
  • 17
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
    • Ibanez P, Bonnet AM, Débarges B, Lohmann E, Tison F, Pollak P, et al. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004; 364: 1169-1171
    • (2004) Lancet , vol.364 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.M.2    Débarges, B.3    Lohmann, E.4    Tison, F.5    Pollak, P.6
  • 18
    • 0033372818 scopus 로고    scopus 로고
    • Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey and rat
    • Kay AR, Alfonso A, Alford S, Cline HT, Holgado AM, Sakmann B, et al. Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey and rat. Neuron 1999; 24: 809-817
    • (1999) Neuron , vol.24 , pp. 809-817
    • Kay, A.R.1    Alfonso, A.2    Alford, S.3    Cline, H.T.4    Holgado, A.M.5    Sakmann, B.6
  • 19
    • 27644518292 scopus 로고    scopus 로고
    • Monitoring activity and inhibition of 26S proteasome with fluorogenic peptide substrate
    • Kisselev AF, Goldberg AL. Monitoring activity and inhibition of 26S proteasome with fluorogenic peptide substrate. Methods Enzymol 2005; 398: 364-378
    • (2005) Methods Enzymol , vol.398 , pp. 364-378
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 20
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007; 27: 1405-1410
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 21
  • 22
    • 33751113009 scopus 로고    scopus 로고
    • α-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
    • Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, et al. α-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci 2006; 26: 11915-11922
    • (2006) J Neurosci , vol.26 , pp. 11915-11922
    • Larsen, K.E.1    Schmitz, Y.2    Troyer, M.D.3    Mosharov, E.4    Dietrich, P.5    Quazi, A.Z.6
  • 23
    • 20744442130 scopus 로고    scopus 로고
    • A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of Parkinson disease
    • Liu CW, Giasson BI, Lewis KA, Lee VM, DeMartino GN, Thomas PJ. A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 2005; 280: 22670-22678
    • (2005) J Biol Chem , vol.280 , pp. 22670-22678
    • Liu, C.W.1    Giasson, B.I.2    Lewis, K.A.3    Lee, V.M.4    Demartino, G.N.5    Thomas, P.J.6
  • 24
    • 0028880456 scopus 로고
    • Complexins: Cytosolic proteins that regulate SNAP receptor function
    • McMahon HT, Missler M, Li C, Südhof TC. Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 1995; 83: 111-119
    • (1995) Cell , vol.83 , pp. 111-119
    • McMahon, H.T.1    Missler, M.2    Li, C.3    Südhof, T.C.4
  • 26
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87: 493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1    Sathasivam, K.2    Seller, M.3    Cozens, B.4    Harper, A.5    Hetherington, C.6
  • 27
    • 39749123263 scopus 로고    scopus 로고
    • Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    • Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, et al. Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008; 131: 642-650
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1    Uchihara, T.2    Nakamura, A.3    Mori, F.4    Kakita, A.5    Wakabayashi, K.6
  • 30
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. Mutation in α-synuclein gene identified in families with Parkinson's disease. Science 1997; 276: 2045-2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5    Dutra, A.6
  • 31
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ. Alzheimer's disease is a synaptic failure. Science 2002; 298: 789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 32
    • 0034712918 scopus 로고    scopus 로고
    • Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-ß conformation
    • Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA. Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-ß conformation. Proc Natl Acad Sci USA 2000; 97: 4897-4902
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4897-4902
    • Serpell, L.C.1    Berriman, J.2    Jakes, R.3    Goedert, M.4    Crowther, R.A.5
  • 33
    • 1842454976 scopus 로고    scopus 로고
    • Does α-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    • Sidhu A, Wersinger C, Vernier P. Does α-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J 2004; 18: 637-647
    • (2004) FASEB J , vol.18 , pp. 637-647
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 35
    • 0035789203 scopus 로고    scopus 로고
    • Deletion of the alpha-synuclein locus in a sub-population of C57BL/6J inbred mice
    • Specht CG, Schoepfer R. Deletion of the alpha-synuclein locus in a sub-population of C57BL/6J inbred mice. BMC Neurosci 2001; 2: 11-19.
    • (2001) BMC Neurosci , vol.2 , pp. 11-19
    • Specht, C.G.1    Schoepfer, R.2
  • 36
    • 77954377128 scopus 로고    scopus 로고
    • Tau and alpha-synuclein interaction in neurodegenerative diseases
    • Spillantini MG, Speretta E, Goedert M, Magnani E. Tau and alpha-synuclein interaction in neurodegenerative diseases. Neurodeg Dis 2007; 4 (Suppl 1): 185.
    • (2007) Neurodeg Dis , vol.4 , Issue.SUPPL. 1 , pp. 185
    • Spillantini, M.G.1    Speretta, E.2    Goedert, M.3    Magnani, E.4
  • 39
    • 0242666359 scopus 로고    scopus 로고
    • Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
    • Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG. Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J Biol Chem 2003; 278: 44405-44411
    • (2003) J Biol Chem , vol.278 , pp. 44405-44411
    • Tofaris, G.K.1    Razzaq, A.2    Ghetti, B.3    Lilley, K.S.4    Spillantini, M.G.5
  • 40
    • 33646097224 scopus 로고    scopus 로고
    • Pathological changes in dopaminergic neurons in mice transgenic for human α-synuclein (1-120): Implications for Lewy body disorders
    • Tofaris GK, Reitböck PG, Humby T, Lambourne SL, O'Connell M, Ghetti B, et al. Pathological changes in dopaminergic neurons in mice transgenic for human α-synuclein (1-120): implications for Lewy body disorders. J Neurosci 2006; 26: 3942-3950
    • (2006) J Neurosci , vol.26 , pp. 3942-3950
    • Tofaris, G.K.1    Reitböck, P.G.2    Humby, T.3    Lambourne, S.L.4    O'Connell, M.5    Ghetti, B.6
  • 42
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease A mechanism of pathogenic and therapeutic significance
    • Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease. A mechanism of pathogenic and therapeutic significance. Ann NY Acad Sci 2008; 1147: 93-104.
    • (2008) Ann NY Acad Sci , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.