-
1
-
-
68649095434
-
Parkinson's disease: the dual hit theory revisited
-
Hawkes CH, Del Tredici K, Braak H, (2009) Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci 1170: 615-622.
-
(2009)
Ann N Y Acad Sci
, vol.1170
, pp. 615-622
-
-
Hawkes, C.H.1
Del Tredici, K.2
Braak, H.3
-
2
-
-
77949906891
-
Lewy body pathology in fetal grafts
-
Chu Y, Kordower JH, (2010) Lewy body pathology in fetal grafts. Ann N Y Acad Sci 1184: 55-67.
-
(2010)
Ann N Y Acad Sci
, vol.1184
, pp. 55-67
-
-
Chu, Y.1
Kordower, J.H.2
-
3
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW, (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14: 504-506.
-
(2008)
Nat Med
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
4
-
-
79958227103
-
Signs of Degeneration in 12-22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson's Disease
-
Kurowska Z, Englund E, Widner H, Lindvall O, Li JY, et al. (2011) Signs of Degeneration in 12-22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson's Disease. Journal of Parkinson's Disease 1: 83-92.
-
(2011)
Journal of Parkinson's Disease
, vol.1
, pp. 83-92
-
-
Kurowska, Z.1
Englund, E.2
Widner, H.3
Lindvall, O.4
Li, J.Y.5
-
5
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li JY, Englund E, Holton JL, Soulet D, Hagell P, et al. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14: 501-503.
-
(2008)
Nat Med
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
-
6
-
-
77949820437
-
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
-
Li JY, Englund E, Widner H, Rehncrona S, Bjorklund A, et al. (2010) Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov Disord 25: 1091-1096.
-
(2010)
Mov Disord
, vol.25
, pp. 1091-1096
-
-
Li, J.Y.1
Englund, E.2
Widner, H.3
Rehncrona, S.4
Bjorklund, A.5
-
7
-
-
77957939093
-
Are synucleinopathies prion-like disorders?
-
Angot E, Steiner JA, Hansen C, Li JY, Brundin P, (2010) Are synucleinopathies prion-like disorders? Lancet Neurol 9: 1128-1138.
-
(2010)
Lancet Neurol
, vol.9
, pp. 1128-1138
-
-
Angot, E.1
Steiner, J.A.2
Hansen, C.3
Li, J.Y.4
Brundin, P.5
-
8
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, et al. (1997) Alpha-synuclein in Lewy bodies. Nature 388: 839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
-
9
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, et al. (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364: 1167-1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
-
10
-
-
34147109175
-
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
-
Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, et al. (2007) Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology 68: 916-922.
-
(2007)
Neurology
, vol.68
, pp. 916-922
-
-
Fuchs, J.1
Nilsson, C.2
Kachergus, J.3
Munz, M.4
Larsson, E.M.5
-
11
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Krüger R, Kuhn W, Muller T, Woitalla D, Graeber M, et al. (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106-108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
-
12
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
-
13
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, et al. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302: 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
-
14
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, et al. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55: 164-173.
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
-
15
-
-
77951185469
-
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
-
Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, et al. (2010) Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet 74: 97-109.
-
(2010)
Ann Hum Genet
, vol.74
, pp. 97-109
-
-
Edwards, T.L.1
Scott, W.K.2
Almonte, C.3
Burt, A.4
Powell, E.H.5
-
16
-
-
79251565507
-
Heat-shock protein 70 modulates toxic extracellular {alpha}-synuclein oligomers and rescues trans-synaptic toxicity
-
Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, et al. (2010) Heat-shock protein 70 modulates toxic extracellular {alpha}-synuclein oligomers and rescues trans-synaptic toxicity. Faseb J 25: 326-336.
-
(2010)
Faseb J
, vol.25
, pp. 326-336
-
-
Danzer, K.M.1
Ruf, W.P.2
Putcha, P.3
Joyner, D.4
Hashimoto, T.5
-
17
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
-
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, et al. (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106: 13010-13015.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
-
18
-
-
77952648551
-
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
-
Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, et al. (2010) Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 30: 6838-6851.
-
(2010)
J Neurosci
, vol.30
, pp. 6838-6851
-
-
Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
Garbis, S.D.4
Ntzouni, M.5
-
19
-
-
79551519276
-
Alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, et al. (2011) Alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 121: 715-725.
-
(2011)
J Clin Invest
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.L.3
Steiner, J.A.4
Pieri, L.5
-
20
-
-
77951885732
-
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
-
Jang A, Lee HJ, Suk JE, Jung JW, Kim KP, et al. (2010) Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem 113: 1263-1274.
-
(2010)
J Neurochem
, vol.113
, pp. 1263-1274
-
-
Jang, A.1
Lee, H.J.2
Suk, J.E.3
Jung, J.W.4
Kim, K.P.5
-
21
-
-
77950571596
-
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
-
Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, et al. (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 285: 9262-9272.
-
(2010)
J Biol Chem
, vol.285
, pp. 9262-9272
-
-
Lee, H.J.1
Suk, J.E.2
Patrick, C.3
Bae, E.J.4
Cho, J.H.5
-
22
-
-
84862609075
-
Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
-
Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, et al. (2012) Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. The Journal of experimental medicine.
-
(2012)
The Journal of Experimental Medicine
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
-
23
-
-
80053613574
-
Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
-
Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, et al. (2011) Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72: 57-71.
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Riddle, D.M.5
-
24
-
-
70349223775
-
Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology
-
Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B, (2009) Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology. J Neurochem 111: 192-203.
-
(2009)
J Neurochem
, vol.111
, pp. 192-203
-
-
Danzer, K.M.1
Krebs, S.K.2
Wolff, M.3
Birk, G.4
Hengerer, B.5
-
25
-
-
72149119358
-
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
-
Luk KC, Song C, O'Brien P, Stieber A, Branch JR, et al. (2009) Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A 106: 20051-20056.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20051-20056
-
-
Luk, K.C.1
Song, C.2
O'Brien, P.3
Stieber, A.4
Branch, J.R.5
-
26
-
-
78049376559
-
Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases
-
Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M, (2010) Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem 285: 34885-34898.
-
(2010)
J Biol Chem
, vol.285
, pp. 34885-34898
-
-
Nonaka, T.1
Watanabe, S.T.2
Iwatsubo, T.3
Hasegawa, M.4
-
27
-
-
77949706598
-
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation
-
Waxman EA, Giasson BI, (2010) A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. J Neurochem 113: 374-388.
-
(2010)
J Neurochem
, vol.113
, pp. 374-388
-
-
Waxman, E.A.1
Giasson, B.I.2
-
28
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
Mougenot AL, Nicot S, Bencsik A, Morignat E, Verchere J, et al. (2011) Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging.
-
(2011)
Neurobiol Aging
-
-
Mougenot, A.L.1
Nicot, S.2
Bencsik, A.3
Morignat, E.4
Verchere, J.5
-
29
-
-
44749083979
-
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
-
Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, et al. (2008) Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol 40: 1835-1849.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1835-1849
-
-
Lee, H.J.1
Suk, J.E.2
Bae, E.J.3
Lee, J.H.4
Paik, S.R.5
-
30
-
-
0035920226
-
Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein
-
Sung JY, Kim J, Paik SR, Park JH, Ahn YS, et al. (2001) Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J Biol Chem 276: 27441-27448.
-
(2001)
J Biol Chem
, vol.276
, pp. 27441-27448
-
-
Sung, J.Y.1
Kim, J.2
Paik, S.R.3
Park, J.H.4
Ahn, Y.S.5
-
31
-
-
84862649620
-
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons
-
Decressac M, Mattsson B, Lundblad M, Weikop P, Bjorklund A, (2011) Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons. Neurobiol Dis: in press.
-
(2011)
Neurobiol Dis: In Press
-
-
Decressac, M.1
Mattsson, B.2
Lundblad, M.3
Weikop, P.4
Bjorklund, A.5
-
32
-
-
0030248550
-
The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum
-
Barker RA, Dunnett SB, Faissner A, Fawcett JW, (1996) The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Experimental neurology 141: 79-93.
-
(1996)
Experimental Neurology
, vol.141
, pp. 79-93
-
-
Barker, R.A.1
Dunnett, S.B.2
Faissner, A.3
Fawcett, J.W.4
-
33
-
-
0029047361
-
Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats
-
Duan WM, Widner H, Brundin P, (1995) Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats. Experimental brain research Experimentelle Hirnforschung 104: 227-242.
-
(1995)
Experimental Brain Research Experimentelle Hirnforschung
, vol.104
, pp. 227-242
-
-
Duan, W.M.1
Widner, H.2
Brundin, P.3
-
34
-
-
0345102465
-
Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts
-
Emgard M, Karlsson J, Hansson O, Brundin P, (1999) Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts. Experimental neurology 160: 279-288.
-
(1999)
Experimental Neurology
, vol.160
, pp. 279-288
-
-
Emgard, M.1
Karlsson, J.2
Hansson, O.3
Brundin, P.4
-
35
-
-
79960285197
-
Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
-
Kordower JH, Dodiya HB, Kordower AM, Terpstra B, Paumier K, et al. (2011) Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis 43: 552-557.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 552-557
-
-
Kordower, J.H.1
Dodiya, H.B.2
Kordower, A.M.3
Terpstra, B.4
Paumier, K.5
-
36
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, et al. (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24: 197-211.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
-
37
-
-
34547727312
-
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
-
Braak H, Sastre M, Del Tredici K, (2007) Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 114: 231-241.
-
(2007)
Acta Neuropathol
, vol.114
, pp. 231-241
-
-
Braak, H.1
Sastre, M.2
Del Tredici, K.3
-
38
-
-
33749669607
-
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
-
Croisier E, Graeber MB, (2006) Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathol 112: 517-530.
-
(2006)
Acta Neuropathol
, vol.112
, pp. 517-530
-
-
Croisier, E.1
Graeber, M.B.2
-
39
-
-
0037313281
-
Glial involvement in diffuse Lewy body disease
-
Terada S, Ishizu H, Yokota O, Tsuchiya K, Nakashima H, et al. (2003) Glial involvement in diffuse Lewy body disease. Acta Neuropathol 105: 163-169.
-
(2003)
Acta Neuropathol
, vol.105
, pp. 163-169
-
-
Terada, S.1
Ishizu, H.2
Yokota, O.3
Tsuchiya, K.4
Nakashima, H.5
-
40
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
-
Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, et al. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Annals of neurology 44: 415-422.
-
(1998)
Annals of Neurology
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
Galvin, J.E.2
Baba, M.3
Giasson, B.4
Tomita, T.5
-
41
-
-
44749090147
-
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
-
Lee HJ, Suk JE, Bae EJ, Lee SJ, (2008) Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem Biophys Res Commun 372: 423-428.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 423-428
-
-
Lee, H.J.1
Suk, J.E.2
Bae, E.J.3
Lee, S.J.4
-
42
-
-
80051985178
-
GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease
-
Decressac M, Ulusoy A, Mattsson B, Georgievska B, Romero-Ramos M, et al. (2011) GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease. Brain 134: 2302-2311.
-
(2011)
Brain
, vol.134
, pp. 2302-2311
-
-
Decressac, M.1
Ulusoy, A.2
Mattsson, B.3
Georgievska, B.4
Romero-Ramos, M.5
-
43
-
-
0036430191
-
Production methods for gene transfer vectors based on adeno-associated virus serotypes
-
Grimm D, (2002) Production methods for gene transfer vectors based on adeno-associated virus serotypes. Methods 28: 146-157.
-
(2002)
Methods
, vol.28
, pp. 146-157
-
-
Grimm, D.1
-
44
-
-
0033022953
-
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
-
Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, et al. (1999) Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6: 973-985.
-
(1999)
Gene Ther
, vol.6
, pp. 973-985
-
-
Zolotukhin, S.1
Byrne, B.J.2
Mason, E.3
Zolotukhin, I.4
Potter, M.5
-
45
-
-
0022648056
-
Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells
-
Brundin P, Isacson O, Gage FH, Bjorklund A, (1986) Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain Res 389: 77-84.
-
(1986)
Brain Res
, vol.389
, pp. 77-84
-
-
Brundin, P.1
Isacson, O.2
Gage, F.H.3
Bjorklund, A.4
|