Understanding intramembrane proteolysis: From protein dynamics to reaction kinetics

Trends in Biochemical Sciences

Volumn 40, Issue 6, 2015, Pages 318-327

  Langosch, D ^a   Scharnagl, C ^a   Steiner, H ^b   Lemberg, M K ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Conformational dynamics; Intramembrane proteolysis protease; Presenilin; Rhomboid; Transmembrane helix; secretase

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; LIPID; MEMBRANE PROTEIN; PRESENILIN; PROTEINASE; RHOMBOID PROTEASE; SIGNAL PEPTIDE PEPTIDASE; SIGNAL PEPTIDE PEPTIDASE LIKE PROTEASE; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE; SECRETASE;

ALPHA HELIX; ALZHEIMER DISEASE; CATALYSIS; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; ENZYME SUBSTRATE; HINGE REGION; HUMAN; INTRAMEMBRANE PROTEOLYSIS; LIPID BILAYER; MEMBRANE; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; TRANSMEMBRANE DOMAIN; CELL MEMBRANE; CHEMISTRY; KINETICS; METABOLISM;

AMYLOID PRECURSOR PROTEIN SECRETASES; CELL MEMBRANE; HUMANS; KINETICS; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PROTEOLYSIS;

EID: 84929514064     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2015.04.001     Document Type: Review

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