Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

EMBO Journal

Volumn 33, Issue 21, 2014, Pages 2492-2506

  Chen, Chia Yi ^a   Malchus, Nicole S ^a   Hehn, Beate ^a   Stelzer, Walter ^b   Avci, Dönem ^a   Langosch, Dieter ^b   Lemberg, Marius K ^a  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

E3 ubiquitin protein ligase; GxGD intramembrane protease; protein homeostasis; rhomboid pseudoprotease

Indexed keywords

DERLIN 1 PROTEIN; DOXYCYCLINE; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; PEPTIDASE; PROTEIN P97; SIGNAL PEPTIDE; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CELL SURFACE RECEPTOR; DERL1 PROTEIN, HUMAN; DNA BINDING PROTEIN; PROTEASOME; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RNF139 PROTEIN, HUMAN; SERINE PROTEINASE; TRANSCRIPTION FACTOR; TYPE I SIGNAL PEPTIDASE;

ARTICLE; CELL FRACTIONATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GLYCOSYLATION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TARGETING; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY;

DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RECEPTORS, CELL SURFACE; SERINE ENDOPEPTIDASES; TRANSCRIPTION FACTORS;

EID: 84922219279     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488208     Document Type: Article

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