Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Nature Communications

Volumn 4, Issue , 2013, Pages

  Dimitrov, Mitko ^a   Alattia, Jean René ^a   Lemmin, Thomas ^a   Lehal, Rajwinder ^a   Fligier, Andrzej ^a   Houacine, Jemila ^a   Hussain, Ishrut ^b   Radtke, Freddy ^a   Dal Peraro, Matteo ^a   Beher, Dirk ^a,b   Fraering, Patrick C ^a  

^a EPFL   (Switzerland)

^b MERCK SERONO S A   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH1 RECEPTOR;

AMINO ACID; DISEASE INCIDENCE; MEMBRANE; MUTATION; PATHOLOGY; SIMULATION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME METABOLISM; GENE MUTATION; HUMAN; PROTEIN DOMAIN; PROTEIN PROCESSING; SIMULATION;

EID: 84881366852     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms     Document Type: Article

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