β-Amyloid precursor protein mutants respond to γ-secretase modulators

Journal of Biological Chemistry

Volumn 285, Issue 23, 2010, Pages 17798-17810

  Page, Richard M ^a   Gutsmiedl, Amelie ^a   Fukumori, Akio ^a   Winkler, Edith ^a   Haass, Christian ^a   Steiner, Harald ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CLEAVAGE MECHANISM; CLEAVAGE SITES; COMPLEX MECHANISMS; MODE OF ACTION; POTENT COMPOUNDS; SECRETASES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; AMINO ACIDS; BINDING ENERGY; ORGANIC ACIDS; PEPTIDES;

GLYCOPROTEINS;

AGENTS AFFECTING METABOLISM; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-39]; AMYLOID BETA PROTEIN[1-41]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA; GAMMA SECRETASE; GAMMA SECRETASE MODULATOR; GLYCINE; PHENYLALANINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA TRANSFECTION; DRUG MECHANISM; DRUG PROTEIN BINDING; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MASS SPECTROMETRY; MUTAGENESIS; MUTANT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN SECRETION;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL-FREE SYSTEM; HUMANS; IMMUNOASSAY; MODELS, BIOLOGICAL; MUTATION; PEPTIDE HYDROLASES; PEPTIDES; PHENYLALANINE; PROTEIN BINDING;

EID: 77952947184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.103283     Document Type: Article

References (47)

1. Haass, C., and Selkoe, D. J. (2007) Nat. Rev. Mol. Cell. Biol. 8, 101-112
2. Steiner, H., Fluhrer, R., and Haass, C. (2008) J. Biol. Chem. 283, 29627-29631
3. Tolia, A., and De Strooper, B. (2009) Semin. Cell. Dev. Biol. 20, 211-218
4. Wolfe, M. S. (2009) Semin. Cell. Dev. Biol. 20, 219-224
5. Steiner, H. (2008) Curr. Alzheimer Res. 5, 147-157
6. Lleó, A., Berezovska, O., Herl, L., Raju, S., Deng, A., Bacskai, B. J., Frosch, M. P., Irizarry, M., and Hyman, B. T. (2004) Nat. Med. 10, 1065-1066
7. Berezovska, O., Lleo, A., Herl, L. D., Frosch, M. P., Stern, E. A., Bacskai, B. J., and Hyman, B. T. (2005) J. Neurosci. 25, 3009-3017
8. Tesco, G., Ginestroni, A., Hiltunen, M., Kim, M., Dolios, G., Hyman, B. T., Wang, R., Berezovska, O., and Tanzi, R. E. (2005) J. Neurochem. 95, 446-456
9. Herl, L., Thomas, A. V., Lill, C. M., Banks, M., Deng, A., Jones, P. B., Spoelgen, R., Hyman, B. T., and Berezovska, O. (2009) Mol. Cell. Neurosci. 41, 166-174
10. Uemura, K., Lill, C. M., Li, X., Peters, J. A., Ivanov, A., Fan, Z., DeStrooper, B., Bacskai, B. J., Hyman, B. T., and Berezovska, O. (2009) PLoS One 4, e7893
11. Tomita, T. (2009) Expert Rev. Neurother. 9, 661-679
12. Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Golde, T. E., and Koo, E. H. (2003) J. Biol. Chem. 278, 30748-30754
13. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kang, D. E., Marquez-Sterling, N., Golde, T. E., and Koo, E. H. (2001) Nature 414, 212-216
14. Kukar, T., Murphy, M. P., Eriksen, J. L., Sagi, S. A., Weggen, S., Smith, T. E., Ladd, T., Khan, M. A., Kache, R., Beard, J., Dodson, M., Merit, S., Ozols, V. V., Anastasiadis, P. Z., Das, P., Fauq, A., Koo, E. H., and Golde, T. E. (2005) Nat. Med. 11, 545-550
15. Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G., Hirotani, N., Horikoshi, Y., Kametani, F., Maeda, M., Saido, T. C., Wang, R., and Ihara, Y. (2005) J. Neurosci. 25, 436-445
16. Takami, M., Nagashima, Y., Sano, Y., Ishihara, S., Morishima-Kawashima, M., Funamoto, S., and Ihara, Y. (2009) J. Neurosci. 29, 13042-13052
17. Munter, L. M., Voigt, P., Harmeier, A., Kaden, D., Gottschalk, K. E., Weise, C., Pipkorn, R., Schaefer, M., Langosch, D., and Multhaup, G. (2007) EMBO J. 26, 1702-1712
18. Kukar, T. L., Ladd, T. B., Bann, M. A., Fraering, P. C., Narlawar, R., Maharvi, G. M., Healy, B., Chapman, R., Welzel, A. T., Price, R. W., Moore, B., Rangachari, V., Cusack, B., Eriksen, J., Jansen-West, K., Verbeeck, C., Yager, D., Eckman, C., Ye, W., Sagi, S., Cottrell, B. A., Torpey, J., Rosenberry, T. L., Fauq, A., Wolfe, M. S., Schmidt, B., Walsh, D. M., Koo, E. H., and Golde, T. E. (2008) Nature 453, 925-929
19. Sato, T., Kienlen-Campard, P., Ahmed, M., Liu, W., Li, H., Elliott, J. I., Aimoto, S., Constantinescu, S. N., Octave, J. N., and Smith, S. O. (2006) Biochemistry 45, 5503-5516
20. Hung, L. W., Ciccotosto, G. D., Giannakis, E., Tew, D. J., Perez, K., Masters, C. L., Cappai, R., Wade, J. D., and Barnham, K. J. (2008) J. Neurosci. 28, 11950-11958
21. Harmeier, A., Wozny, C., Rost, B. R., Munter, L. M., Hua, H., Georgiev, O., Beyermann, M., Hildebrand, P. W., Weise, C., Schaffner, W., Schmitz, D., and Multhaup, G. (2009) J. Neurosci. 29, 7582-7590
22. Eggert, S., Midthune, B., Cottrell, B., and Koo, E. H. (2009) J. Biol. Chem. 284, 28943-28952
23. Kienlen-Campard, P., Tasiaux, B., Van Hees, J., Li, M., Huysseune, S., Sato, T., Fei, J. Z., Aimoto, S., Courtoy, P. J., Smith, S. O., Constantinescu, S. N., and Octave, J. N. (2008) J. Biol. Chem. 283, 7733-7744
24. Page, R. M., Baumann, K., Tomioka, M., Pérez-Revuelta, B. I., Fukumori, A., Jacobsen, H., Flohr, A., Luebbers, T., Ozmen, L., Steiner, H., and Haass, C. (2008) J. Biol. Chem. 283, 677-683
25. Czirr, E., Cottrell, B. A., Leuchtenberger, S., Kukar, T., Ladd, T. B., Esselmann, H., Paul, S., Schubenel, R., Torpey, J. W., Pietrzik, C. U., Golde, T. E., Wiltfang, J., Baumann, K., Koo, E. H., and Weggen, S. (2008) J. Biol. Chem. 283, 17049-17054
26. Beel, A. J., Barrett, P., Schnier, P. D., Hitchcock, S. A., Bagal, D., Sanders, C. R., and Jordan, J. B. (2009) Biochemistry 48, 11837-11839
27. Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Ozols, V., Fauq, A., Golde, T. E., and Koo, E. H. (2003) J. Biol. Chem. 278, 31831-31837
28. Winkler, E., Hobson, S., Fukumori, A., Dümpelfeld, B., Luebbers, T., Baumann, K., Haass, C., Hopf, C., and Steiner, H. (2009) Biochemistry 48, 1183-1197
29. Shirotani, K., Tomioka, M., Kremmer, E., Haass, C., and Steiner, H. (2007) Neurobiol. Dis. 27, 102-107
30. Yamasaki, A., Eimer, S., Okochi, M., Smialowska, A., Kaether, C., Baumeister, R., Haass, C., and Steiner, H. (2006) J. Neurosci. 26, 3821-3828
31. Wang, J., Brunkan, A. L., Hecimovic, S., Walker, E., and Goate, A. (2004) Neurobiol. Dis. 15, 654-666
32. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell. Biol. 5, 486-488
33. Wiltfang, J., Smirnov, A., Schnierstein, B., Kelemen, G., Matthies, U., Klafki, H. W., Staufenbiel, M., Hüther, G., Rüther, E., and Kornhuber, J. (1997) Electrophoresis 18, 527-532
34. Kumar-Singh, S., De Jonghe, C., Cruts, M., Kleinert, R., Wang, R., Mercken, M., De Strooper, B., Vanderstichele, H., Löfgren, A., Vanderhoeven, I., Backhovens, H., Vanmechelen, E., Kroisel, P. M., and Van Broeckhoven, C. (2000) Hum. Mol. Genet. 9, 2589-2598
35. Eckman, C. B., Mehta, N. D., Crook, R., Perez-tur, J., Prihar, G., Pfeiffer, E., Graff-Radford, N., Hinder, P., Yager, D., Zenk, B., Refolo, L. M., Prada, C. M., Younkin, S. G., Hutton, M., and Hardy, J. (1997) Hum. Mol. Genet. 6, 2087-2089
36. Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) Nature 349, 704-706
37. Lichtenthaler, S. F., Wang, R., Grimm, H., Uljon, S. N., Masters, C. L., and Beyreuther, K. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3053-3058
38. Tan, J., Mao, G., Cui, M. Z., Kang, S. C., Lamb, B., Wong, B. S., Sy, M. S., and Xu, X. (2008) J. Neurochem. 107, 722-733
39. Guardia-Laguarta, C., Pera, M., Clarimón, J., Molinuevo, J. L., Sánchez-Valle, R., Lladó, A., Coma, M., Gómez-Isla, T., Blesa, R., Ferrer, I., and Lleó, A. (2010) J. Neuropathol. Exp. Neurol. 69, 53-59
40. Murrell, J., Farlow, M., Ghetti, B., and Benson, M. D. (1991) Science 254, 97-99
41. Narlawar, R., Baumann, K., Czech, C., and Schmidt, B. (2007) Bioorg. Med. Chem. Lett. 17, 5428-5431
42. Eriksen, J. L., Sagi, S. A., Smith, T. E., Weggen, S., Das, P., McLendon, D. C., Ozols, V. V., Jessing, K. W., Zavitz, K. H., Koo, E. H., and Golde, T. E. (2003) J. Clin. Invest. 112, 440-449
43. Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2003) J. Biol. Chem. 278, 18664-18670
44. Beher, D., Clarke, E. E., Wrigley, J. D., Martin, A. C., Nadin, A., Churcher, I., and Shearman, M. S. (2004) J. Biol. Chem. 279, 43419-43426
45. Grant, M. A., Lazo, N. D., Lomakin, A., Condron, M. M., Arai, H., Yamin, G., Rigby, A. C., and Teplow, D. B. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 16522-16527
46. Ren, Z., Schenk, D., Basi, G. S., and Shapiro, I. P. (2007) J. Biol. Chem. 282, 35350-35360
47. Scheuermann, S., Hambsch, B., Hesse, L., Stumm, J., Schmidt, C., Beher, D., Bayer, T. A., Beyreuther, K., and Multhaup, G. (2001) J. Biol. Chem. 276, 33923-33929