Three-dimensional structure of human γ-secretase

Nature

Volumn 512, Issue 7513, 2014, Pages 166-170

  Lu, Peilong ^a,b   Bai, Xiao Chen ^c   Ma, Dan ^a,b   Xie, Tian ^a,b   Yan, Chuangye ^b,d   Sun, Linfeng ^a,b   Yang, Guanghui ^b,d   Zhao, Yanyu ^a,b   Zhou, Rui ^a,b   Scheres, Sjors H W ^c   Shi, Yigong ^a,b  

^a TSINGHUA UNIVERSITY   (China)

^b Tsinghua University   (China)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d Peking University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLUTAMYL HYDROLASE; GAMMA SECRETASE; NICASTRIN;

BRAIN; ELECTRON MICROSCOPY; ENZYME ACTIVITY; MEMBRANE; NERVOUS SYSTEM DISORDER; SUBSTRATE; THREE-DIMENSIONAL MODELING;

ARTICLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME STRUCTURE; EXTRACELLULAR DOMAIN; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; THREE DIMENSIONAL IMAGING;

AMYLOID PRECURSOR PROTEIN SECRETASES; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 84904560883     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13567     Document Type: Article

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