The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics

ChemBioChem

Volumn 14, Issue 15, 2013, Pages 1943-1948

  Pester, Oxana ^a,b   Götz, Alexander ^a   Multhaup, Gerd ^c   Scharnagl, Christina ^a   Langosch, Dieter ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Amide exchange; Amyloid precursor proteins; Membrane proteins; Molecular dynamics; Transmembrane domains

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CARBONYL DERIVATIVE; GAMMA SECRETASE; MEMBRANE PROTEIN; OLIGOMER; PRESENILIN; PROTEINASE; SIGNAL PEPTIDE;

ALZHEIMER DISEASE; AMINO ACID COMPOSITION; ARTICLE; CIRCULAR DICHROISM; DIMERIZATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTON TRANSPORT;

ALZHEIMER'S DISEASE; AMIDE EXCHANGE; AMYLOID PRECURSOR PROTEINS; MEMBRANE PROTEINS; MOLECULAR DYNAMICS; TRANSMEMBRANE DOMAINS;

AMYLOID BETA-PROTEIN PRECURSOR; CELL MEMBRANE; HUMANS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84885412461     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300322     Document Type: Article

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