Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 6763-6774

  Lemmin, Thomas ^a,b   Dimitrov, Mitko ^a   Fraering, Patrick C ^a   Dal Peraro, Matteo ^a,b  

^a EPFL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CYTOLOGY;

AMYLOID PRECURSOR PROTEINS; DYNAMIC CHARACTERIZATION; HELICAL STRUCTURES; NEUROTOXICITY; PROTEOLYTIC CLEAVAGE; PROTEOLYTIC PROCESSING; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANES;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN 38; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; DODECYLPHOSPHORYLCHOLINE; GAMMA SECRETASE; GLYCEROL DERIVATIVE; GLYCINE; LIPID; LYSOMYRISTOYLPHOSPHATIDYL GLYCEROL; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ALZHEIMER DISEASE; ARTICLE; BILAYER MEMBRANE; COMPUTER MODEL; ELECTRON NUCLEAR DOUBLE RESONANCE; MICELLE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

AMYLOID; AMYLOID PRECURSOR PROTEIN; DOUBLE ELECTRON-ELECTRON RESONANCE (DEER); ELECTRON PARAMAGNETIC RESONANCE (EPR) SPECTROSCOPY; MASS SPECTROMETRY (MS); METADYNAMICS; MOLECULAR DYNAMICS; SECRETASES;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL MEMBRANE; COMPUTER SIMULATION; HUMANS; MODELS, CHEMICAL; MUTATION; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS;

EID: 84896692890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.470781     Document Type: Article

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