Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

Nature

Volumn 504, Issue 7479, 2013, Pages 301-305

  Manolaridis, Ioannis ^a   Kulkarni, Kiran ^a,f   Dodd, Roger B ^a,g   Ogasawara, Satoshi ^b,c   Zhang, Ziguo ^a   Bineva, Ganka ^d   O'Reilly, Nicola ^d   Hanrahan, Sarah J ^a   Thompson, Andrew J ^a   Cronin, Nora ^a   Iwata, So ^b,c,e   Barford, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f NATIONAL CHEMICAL LABORATORY   (India)

^g ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; NUCLEOPHILE; PHOSPHATASE; PROTEIN CAAX; PROTEIN KINASE; PROTEIN RCE1; PROTEINASE; RAS PROTEIN; TRIPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID; BIOCHEMISTRY; ENZYME ACTIVITY; GENE EXPRESSION; LIPID; MEMBRANE; METABOLISM; PHYSIOLOGY; PROTEIN; SIGNALING;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FEMALE; METHANOCOCCUS MARIPALUDIS; METHYLATION; MOUSE; NONHUMAN; NUCLEAR LAMINA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FARNESYLATION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PRENYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARCHAEAL PROTEINS; BIOCATALYSIS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI PROTEINS; GLUTAMIC ACID; HUMANS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; METHANOCOCCUS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PRENYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EUKARYOTA; MAMMALIA; METHANOCOCCUS MARIPALUDIS;

EID: 84890441584     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12754     Document Type: Article

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