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Volumn 34, Issue 10, 2001, Pages 790-797

Follow the protons: A low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; PROTON; SOLVENT;

EID: 0034778987     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar000184m     Document Type: Article
Times cited : (185)

References (37)
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    • Sörensen, S.P.L.1
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    • 0001723532 scopus 로고
    • The use of isotope effects in the detailed analysis of catalytic mechanisms of enzymes
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    • 0021372195 scopus 로고
    • Kinetic isotope effects and tunneling in cyclic double and triple proton-transfer between acetic acid and methanol in tetrahydrofuran studied by dynamic H-1 and H-2 NMR spectroscopy
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 869-879
    • Gerritzen, D.1    Limbach, H.H.2
  • 37
    • 0003077005 scopus 로고    scopus 로고
    • A provisional patent application to this effect has been submitted. By using pepstatin as the prototype in the synthesis of tightbinding inhibitors, medicinal chemists may have been trapped in a false minimum


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.