γ-secretase associated with lipid rafts: Multiple interactive pathways in the stepwise processing ofβ-carboxylterminal fragment

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5109-5121

  Matsumura, Nobutaka ^a   Takami, Mako ^b   Okochi, Masayasu ^c   Wada Kakuda, Satoko ^b   Fujiwara, Hitomi ^b   Tagami, Shinji ^c   Funamoto, Satoru ^b,d   Ihara, Yasuo ^b,d   Morishima Kawashima, Maho ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

CARBOXYL-TERMINAL; LIPID RAFT; MOLECULAR MECHANISM; SECRETASES; STEPWISE PROCESSING;

PROTEINS;

AMYLOID BETA PROTEIN; GAMMA SECRETASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; HYDROLYSIS; IMMUNOPRECIPITATION; LIPID RAFT; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TANDEM MASS SPECTROMETRY;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN; AMYLOID Β-PROTEIN; LIPID RAFT; MEMBRANE; SECRETASES; Γ-SECRETASE;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL; OLIGOPEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84894423032     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.510131     Document Type: Article

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