Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 6, 2010, Pages 2693-2698

  Hern, Jonathan A ^a,c   Baig, Asma H ^a,b   Mashanov, Gregory I ^a   Birdsall, Berry ^a   Corrie, John E T ^a   Lazareno, Sebastian ^b   Molloy, Justin E ^a   Birdsall, Nigel J M ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Acetylcholine receptor; Dimerization; G protein coupled receptor; Receptor clustering; Receptor mobility

Indexed keywords

DIMER; MUSCARINIC M1 RECEPTOR; OLIGOMER; BENZENESULFONIC ACID DERIVATIVE; CARBOCYANINE; CY3B N HYDROXYSUCCINIMIDE ESTER; CY3B N-HYDROXYSUCCINIMIDE ESTER; DRUG DERIVATIVE; FLUORESCENT DYE; MUSCARINIC RECEPTOR BLOCKING AGENT; PIRENZEPINE; TELENZEPINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL SURFACE; CHO CELL; DIFFUSION; DISSOCIATION; FLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; ANIMAL; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN MULTIMERIZATION; RADIOASSAY; TIME;

ANIMALS; BENZENESULFONATES; BINDING, COMPETITIVE; CARBOCYANINES; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENT DYES; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; PIRENZEPINE; PROTEIN MULTIMERIZATION; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M1; TIME FACTORS; TRANSFECTION;

EID: 77249150932     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907915107     Document Type: Article

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