Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

Journal of Cell Science

Volumn 122, Issue 20, 2009, Pages 3703-3714

  Goodger, Zoë V ^a   Rajendran, Lawrence ^a,b   Trutzel, Annette ^a   Kohli, Bernhard M ^a   Nitsch, Roger M ^a   Konietzko, Uwe ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

AICD; Amyloid precursor protein; Endocytosis; Nuclear signaling; Retrograde transport

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ARTICLE; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; ENDOSOME; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MICROTUBULE; NERVE CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; ENDOCYTOSIS; ENDOSOMES; GENE KNOCKOUT TECHNIQUES; HUMANS; INTRACELLULAR SPACE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 70350370474     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.048090     Document Type: Article

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