-
1
-
-
0019419823
-
Insulin degradation by insulin target cells
-
Goldstein, B. J. and Livingston, J. N. (1981) Insulin degradation by insulin target cells. Metabolism 30, 825-835.
-
(1981)
Metabolism
, vol.30
, pp. 825-835
-
-
Goldstein, B.J.1
Livingston, J.N.2
-
2
-
-
0019260391
-
Immunochemical studies on the insulin-degrading enzyme from pig and rat skeletal muscle
-
Yokono, K., Imamura, Y., Shii, K., Mizuno, N., Sakai, H. and Baba, S. (1980) Immunochemical studies on the insulin-degrading enzyme from pig and rat skeletal muscle. Diabetes 29, 856-859.
-
(1980)
Diabetes
, vol.29
, pp. 856-859
-
-
Yokono, K.1
Imamura, Y.2
Shii, K.3
Mizuno, N.4
Sakai, H.5
Baba, S.6
-
3
-
-
0022473263
-
Purification and characterization of insulin-degrading enzyme from human erythrocytes
-
Shii, K., Yokono, K., Baba, S. and Roth, R. A. (1986) Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes 35, 675-683.
-
(1986)
Diabetes
, vol.35
, pp. 675-683
-
-
Shii, K.1
Yokono, K.2
Baba, S.3
Roth, R.A.4
-
4
-
-
0022656170
-
Degradation of insulin by insulin-degrading enzyme and biological characteristics of its fragments
-
Yonezawa, K., Yokono, K., Yaso, S., Hari, J., Amano, K., Kawase, Y., Sakamoto, T., Shii, K., Imamura, Y. and Baba, S. (1986) Degradation of insulin by insulin-degrading enzyme and biological characteristics of its fragments. Endocrinology 118, 1989-1996.
-
(1986)
Endocrinology
, vol.118
, pp. 1989-1996
-
-
Yonezawa, K.1
Yokono, K.2
Yaso, S.3
Hari, J.4
Amano, K.5
Kawase, Y.6
Sakamoto, T.7
Shii, K.8
Imamura, Y.9
Baba, S.10
-
5
-
-
0022445076
-
Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease
-
Shii, K. and Roth, R. A. (1986) Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease. Proc. Natl. Acad. Sci. USA 83, 4147-4151.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4147-4151
-
-
Shii, K.1
Roth, R.A.2
-
6
-
-
0023164755
-
125I]insulin with a cytosolic insulin-degrading enzyme: Detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody
-
125I]insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. Endocrinology 120, 829-831.
-
(1987)
Endocrinology
, vol.120
, pp. 829-831
-
-
Hari, J.1
Shii, K.2
Roth, R.A.3
-
7
-
-
0034284938
-
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
-
Fakhrai-Rad, H., Nikoshkov, A., Kamel, A., Fernstrom, M., Zierath, J. R., Norgren, S., Luthman, H. and Galli, J. (2000) Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Hum. Mol. Genet. 9, 2149-2158.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2149-2158
-
-
Fakhrai-Rad, H.1
Nikoshkov, A.2
Kamel, A.3
Fernstrom, M.4
Zierath, J.R.5
Norgren, S.6
Luthman, H.7
Galli, J.8
-
8
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
Farris, W., Mansourian, S., Leissring, M. A., Eckman, E. A., Bertram, L., Eckman, C. B., Tanzi, R. E. and Selkoe, D. J. (2004) Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am. J. Pathol. 164, 1425-1434.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
9
-
-
0028176821
-
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
-
Kurochkin, I. V. and Goto, S. (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345, 33-37.
-
(1994)
FEBS Lett.
, vol.345
, pp. 33-37
-
-
Kurochkin, I.V.1
Goto, S.2
-
10
-
-
0031044352
-
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
-
McDermott, J. R. and Gibson, A. M. (1997) Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem. Res. 22, 49-56.
-
(1997)
Neurochem. Res.
, vol.22
, pp. 49-56
-
-
McDermott, J.R.1
Gibson, A.M.2
-
11
-
-
1842367306
-
Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells
-
Qiu, W. Q., Ye, Z., Kholodenko, D., Seubert, P. and Selkoe, D. J. (1997) Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem 272, 6641-6646.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6641-6646
-
-
Qiu, W.Q.1
Ye, Z.2
Kholodenko, D.3
Seubert, P.4
Selkoe, D.J.5
-
12
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B. and Selkoe, D. J. (1998) Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J. Biol. Chem. 273, 32730-32738.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
13
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J. and Guenette, S. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. USA 100, 4162-4167.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
14
-
-
0037947406
-
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
-
Miller, B. C., Eckman, E. A., Sambamurti, K., Dobbs, N., Chow, K. M., Eckman, C. B., Hersh, L. B. and Thiele, D. L. (2003) Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc. Natl. Acad. Sci. USA 100, 6221-6226.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6221-6226
-
-
Miller, B.C.1
Eckman, E.A.2
Sambamurti, K.3
Dobbs, N.4
Chow, K.M.5
Eckman, C.B.6
Hersh, L.B.7
Thiele, D.L.8
-
15
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring, M. A., Farris, W., Chang, A. Y., Walsh, D. M., Wu, X., Sun, X., Frosch, M. P. and Selkoe, D. J. (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087-1093.
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
16
-
-
13644266898
-
Age- and region-dependent alterations in Abeta-degrading enzymes: Implications for Abeta-induced disorders
-
Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y. and LaFerla, F. M. (2005) Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol. Aging 26, 645-654.
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 645-654
-
-
Caccamo, A.1
Oddo, S.2
Sugarman, M.C.3
Akbari, Y.4
LaFerla, F.M.5
-
17
-
-
27944440133
-
Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: A potential Alzheimer's disease spiral
-
Shinall, H., Song, E. S. and Hersh, L. B. (2005) Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. Biochemistry 44, 15345-15350.
-
(2005)
Biochemistry
, vol.44
, pp. 15345-15350
-
-
Shinall, H.1
Song, E.S.2
Hersh, L.B.3
-
18
-
-
0037219221
-
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
-
Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L. W., Kovacina, K. S. and Craft, S. (2003) Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am. J. Pathol. 162, 313-319.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 313-319
-
-
Cook, D.G.1
Leverenz, J.B.2
McMillan, P.J.3
Kulstad, J.J.4
Ericksen, S.5
Roth, R.A.6
Schellenberg, G.D.7
Jin, L.W.8
Kovacina, K.S.9
Craft, S.10
-
19
-
-
0030002245
-
Insulin-degrading enzyme
-
Authier, F., Posner, B. I. and Bergeron, J. J. (1996) Insulin-degrading enzyme. Clin. Invest. Med. 19, 149-160.
-
(1996)
Clin. Invest. Med.
, vol.19
, pp. 149-160
-
-
Authier, F.1
Posner, B.I.2
Bergeron, J.J.3
-
20
-
-
17844382678
-
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein
-
Farris, W., Leissring, M. A., Hemming, M. L., Chang, A. Y. and Selkoe, D. J. (2005) Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry 44, 6513-6525.
-
(2005)
Biochemistry
, vol.44
, pp. 6513-6525
-
-
Farris, W.1
Leissring, M.A.2
Hemming, M.L.3
Chang, A.Y.4
Selkoe, D.J.5
-
21
-
-
0021353578
-
Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity
-
Goldfine, I. D., Williams, J. A,. Bailey, A. C., Wong, K. Y., Iwamoto, Y., Yokono, K., Baba, S. and Roth, R. A. (1984) Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity. Diabetes. 33, 64-72.
-
(1984)
Diabetes
, vol.33
, pp. 64-72
-
-
Goldfine, I.D.1
Williams, J.A.2
Bailey, A.C.3
Wong, K.Y.4
Iwamoto, Y.5
Yokono, K.6
Baba, S.7
Roth, R.A.8
-
22
-
-
0020201977
-
Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes
-
Yokono, K., Roth, R. A. and Baba, S. (1982) Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes. Endocrinology 111, 1102-1108.
-
(1982)
Endocrinology
, vol.111
, pp. 1102-1108
-
-
Yokono, K.1
Roth, R.A.2
Baba, S.3
-
23
-
-
0031550507
-
Overexpression of insulin degrading enzyme: Cellular localization and effects on insulin signaling
-
Seta, K. A. and Roth, R. A. (1997) Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling. Biochem. Biophys. Res. Commun. 231, 167-171.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.231
, pp. 167-171
-
-
Seta, K.A.1
Roth, R.A.2
-
24
-
-
33646363798
-
Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures
-
Lynch, J. A., George, A. M., Eisenhauer, P. B., Conn, K., Gao, W., Carreras, I., Wells, J. M., McKee A, Ullman, M. D. and Fine, R. E. (2006) Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J. Neurosci. Res. 83, 1262-1270.
-
(2006)
J. Neurosci. Res.
, vol.83
, pp. 1262-1270
-
-
Lynch, J.A.1
George, A.M.2
Eisenhauer, P.B.3
Conn, K.4
Gao, W.5
Carreras, I.6
Wells, J.M.7
McKee, A.8
Ullman, M.D.9
Fine, R.E.10
|