Docosahexaenoic acid reduces amyloid β production via multiple pleiotropic mechanisms

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14028-14039

  Grimm, Marcus O W ^a   Kuchenbecker, Johanna ^a   Grosgen, Sven ^a   Burg, Verena K ^a   Hundsdorfer, Benjamin ^a   Rothhaar, Tatjana L ^a   Friess, Petra ^a   De Wilde, Martijn C ^b   Broersen, Laus M ^b   Penke, Botond ^c   Peter, Maria ^d   Vígh, Laszlo ^d   Grimm, Heike S ^a   Hartmann, Tobias ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b DANONE RESEARCH   (Netherlands)

^c UNIVERSITY OF SZEGED   (Hungary)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID DEPOSITION; AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; CHOLESTEROL METABOLISM; DE NOVO SYNTHESIS; DOCOSAHEXAENOIC ACID; IN-VITRO; IN-VIVO; MOLECULAR MECHANISM; MULTIPLE EFFECT; PLASMA MEMBRANES; PLEIOTROPIC EFFECTS; PROTEIN LEVEL; PROTEIN STABILITY; SECRETASES;

CELL MEMBRANES; CHOLESTEROL; FATTY ACIDS; NEURODEGENERATIVE DISEASES; POLYUNSATURATED FATTY ACIDS; PROTEINS;

GLYCOPROTEINS;

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; DOCOSAHEXAENOIC ACID; GAMMA SECRETASE; PRESENILIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CROSS LINKING; DRUG ACTIVITY; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMAL FEED; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; CHOLESTEROL; DOCOSAHEXAENOIC ACIDS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPIDS; MALE; MICE; MICE, INBRED C57BL; PRESENILIN-1; RISK;

EID: 79954592687     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182329     Document Type: Article

References (83)

1. AD International, World Alzheimer Report (2009) in Alzheimer's Disease International Consortium (Prince, M., and Jackson, J. eds) pp. 1-20, Alzheimer's Disease International, London
2. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766
4. Sisodia, S. S., and St George-Hyslop, P. H. (2002) Nat. Rev. Neurosci. 3, 281-290
5. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
6. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., Zhao, J., McConlogue, L., and John, V. (1999) Nature 402, 537-540
7. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-441
8. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 6382-6387
9. Kim, S. H., Ikeuchi, T., Yu, C., and Sisodia, S. S. (2003) J. Biol. Chem. 278, 33992-34002
10. Wakabayashi, T., and De Strooper, B. (2008) Physiology 23, 194-204
11. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767
12. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927
13. Allinson, T. M., Parkin, E. T., Condon, T. P., Schwager, S. L., Sturrock, E. D., Turner, A. J., and Hooper, N. M. (2004) Eur. J. Biochem. 271, 2539-2547
14. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) Nature 359, 322-325
15. Haass, C., Hung, A. Y., Schlossmacher, M. G., Teplow, D. B., and Selkoe, D. J. (1993) J. Biol. Chem. 268, 3021-3024
16. Kamphuis, P. J., and Scheltens, P. (2010) J. Alzheimers Dis. 20, 765-775
17. Scheltens, P., Kamphuis, P. J., Verhey, F. R., Olde Rikkert, M. G., Wurtman, R. J., Wilkinson, D., Twisk, J. W., and Kurz, A. (2010) Alzheimers Dement. 6, 1-10.e1
18. Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., and Salem, N., Jr. (2001) J. Lipid Res. 42, 1257-1265
19. Bazan, N. G., and Scott, B. L. (1990) Ups J. Med. Sci. Suppl. 48, 97-107
20. Ansari, K. A., and Shoeman, D. W. (1990) Neurochem. Res. 15, 7-11
21. Horrocks, L. A., and Farooqui, A. A. (2004) Prostaglandins Leukot. Essent. Fatty Acids 70, 361-372
22. Söderberg, M., Edlund, C., Kristensson, K., and Dallner, G. (1991) Lipids 26, 421-425
23. Tully, A. M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., Lawlor, B., Coakley, D., and Gibney, M. J. (2003) Br. J. Nutr. 89, 483-489
24. Barberger-Gateau, P., Letenneur, L., Deschamps, V., Pérès, K., Dartigues, J. F., and Renaud, S. (2002) BMJ 325, 932-933
25. Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., and Schneider, J. (2003) Arch. Neurol. 60, 940-946
26. Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W., and Wolf, P. A. (2006) Arch. Neurol. 63, 1545-1550
27. Albanese, E., Dangour, A. D., Uauy, R., Acosta, D., Guerra, M., Guerra, S. S., Huang, Y., Jacob, K. S., de Rodriguez, J. L., Noriega, L. H., Salas, A., Sosa, A. L., Sousa, R. M., Williams, J., Ferri, C. P., and Prince, M. J. (2009) Am. J. Clin. Nutr. 90, 392-400
28. van Gelder, B. M., Tijhuis, M., Kalmijn, S., and Kromhout, D. (2007) Am. J. Clin. Nutr. 85, 1142-1147
29. Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L. O., and Palmblad, J. (2006) Arch. Neurol. 63, 1402-1408
30. Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., and Yamashima, T. (2006) Neurosci. Res. 56, 159-164
31. Chiu, C. C., Su, K. P., Cheng, T. C., Liu, H. C., Chang, C. J., Dewey, M. E., Stewart, R., and Huang, S. Y. (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 1538-1544
32. van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olderikkert, M. G., Beekman, A. T., and de Groot, C. P. (2008) Neurology 71, 430-438
33. Lukiw, W. J., Cui, J. G., Marcheselli, V. L., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C. N., and Bazan, N. G. (2005) J. Clin. Invest. 115, 2774-2783
34. Perez, S. E., Berg, B. M., Moore, K. A., He, B., Counts, S. E., Fritz, J. J., Hu, Y. S., Lazarov, O., Lah, J. J., and Mufson, E. J. (2010) J. Neurosci. Res. 88, 1026-1040
35. Oksman, M., Iivonen, H., Hogyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L., Lütjohann, D., Hartmann, T., and Tanila, H. (2006) Neurobiol. Dis. 23, 563-572
36. Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Jr., Ashe, K. H., Frautschy, S. A., and Cole, G. M. (2004) Neuron 43, 633-645
37. Hooijmans, C. R., Rutters, F., Dederen, P. J., Gambarota, G., Veltien, A., van Groen, T., Broersen, L. M., Lütjohann, D., Heerschap, A., Tanila, H., and Kiliaan, A. J. (2007) Neurobiol. Dis. 28, 16-29
38. Lien, E. L. (2009) Prostaglandins Leukot. Essent. Fatty Acids 81, 125-132
39. Cole, G. M., Ma, Q. L., and Frautschy, S. A. (2009) Prostaglandins Leukot. Essent. Fatty Acids 81, 213-221
40. Reeves, P. G., Nielsen, F. H., and Fahey, G. C., Jr. (1993) J. Nutr. 123, 1939-1951
41. Ida, N., Hartmann, T., Pantel, J., Schröder, J., Zerfass, R., Förstl, H., Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914
42. Livak, K. J., and Schmittgen, T. D. (2001) Methods 25, 402-408
43. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985) Anal. Biochem. 150, 76-85
44. Grimm, M. O., Grimm, H. S., Tomic, I., Beyreuther, K., Hartmann, T., and Bergmann, C. (2008) J. Biol. Chem. 283, 11302-11311
45. Cordy, J. M., Hussain, I., Dingwall, C., Hooper, N. M., and Turner, A. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11735-11740
46. Woods, A. J., White, D. P., Caswell, P. T., and Norman, J. C. (2004) EMBO J. 23, 2531-2543
47. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
48. Cladera, J. L., and Bryant, P. J. (1985) Dev. Genet. 6, 27-37
49. Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K., and Müller-Hill, B. (1987) Nature 325, 733-736
50. Kang, J., and Müller-Hill, B. (1990) Biochem. Biophys. Res. Commun. 166, 1192-1200
51. Rapoport, S. I., Rao, J. S., and Igarashi, M. (2007) Prostaglandins Leukot. Essent. Fatty Acids 77, 251-261
52. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464
53. Frears, E. R., Stephens, D. J., Walters, C. E., Davies, H., and Austen, B. M. (1999) Neuroreport 10, 1699-1705
54. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861
55. Lu, F., Li, X., Suo, A. Q., and Zhang, J. W. (2010) Chin. Med. J. 123, 1864-1870
56. Solomon, A., Sippola, R., Soininen, H., Wolozin, B., Tuomilehto, J., Laatikainen, T., and Kivipelto, M. (2010) Neurodegener. Dis. 7, 180-182
57. Pappolla, M. A., Bryant-Thomas, T. K., Herbert, D., Pacheco, J., Fabra Garcia, M., Manjon, M., Girones, X., Henry, T. L., Matsubara, E., Zambon, D., Wolozin, B., Sano, M., Cruz-Sanchez, F. F., Thal, L. J., Petanceska, S. S., and Refolo, L. M. (2003) Neurology 61, 199-205
58. Guardia-Laguarta, C., Coma, M., Pera, M., Clarimón, J., Sereno, L., Agulló, J. M., Molina-Porcel, L., Gallardo, E., Deng, A., Berezovska, O., Hyman, B. T., Blesa, R., Gómez-Isla, T., and Lleó, A. (2009) J. Neurochem. 110, 220-230
59. Liu, W. W., Todd, S., Coulson, D. T., Irvine, G. B., Passmore, A. P., McGuinness, B., McConville, M., Craig, D., and Johnston, J. A. (2009) J. Neurochem. 108, 341-349
60. Schneider, A., Schulz-Schaeffer, W., Hartmann, T., Schulz, J. B., and Simons, M. (2006) Neurobiol. Dis. 23, 573-577
61. Simons, K., and Ikonen, E. (1997) Nature 387, 569-572
62. Hur, J. Y., Welander, H., Behbahani, H., Aoki, M., Frånberg, J., Winblad, B., Frykman, S., and Tjernberg, L. O. (2008) FEBS J. 275, 1174-1187
63. Tun, H., Marlow, L., Pinnix, I., Kinsey, R., and Sambamurti, K. (2002) J. Mol. Neurosci. 19, 31-35
64. Vetrivel, K. S., Meckler, X., Chen, Y., Nguyen, P. D., Seidah, N. G., Vassar, R., Wong, P. C., Fukata, M., Kounnas, M. Z., and Thinakaran, G. (2009) J. Biol. Chem. 284, 3793-3803
65. Ehehalt, R., Keller, P., Haass, C., Thiele, C., and Simons, K. (2003) J. Cell Biol. 160, 113-123
66. Sakurai, T., Kaneko, K., Okuno, M., Wada, K., Kashiyama, T., Shimizu, H., Akagi, T., Hashikawa, T., and Nukina, N. (2008) J. Cell Biol. 183, 339-352
67. Cheng, H., Vetrivel, K. S., Drisdel, R. C., Meckler, X., Gong, P., Leem, J. Y., Li, T., Carter, M., Chen, Y., Nguyen, P., Iwatsubo, T., Tomita, T., Wong, P. C., Green, W. N., Kounnas, M. Z., and Thinakaran, G. (2009) J. Biol. Chem. 284, 1373-1384
68. Wahrle, S., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2002) Neurobiol. Dis. 9, 11-23
69. Shie, F. S., Jin, L. W., Cook, D. G., Leverenz, J. B., and LeBoeuf, R. C. (2002) Neuroreport 13, 455-459
70. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M., and Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737
71. Hunt, C. E., and Turner, A. J. (2009) FEBS J. 276, 1845-1859
72. Green, K. N., Martinez-Coria, H., Khashwji, H., Hall, E. B., Yurko-Mauro, K. A., Ellis, L., and LaFerla, F. M. (2007) J. Neurosci. 27, 4385-4395
73. Abad-Rodriguez, J., Ledesma, M. D., Craessaerts, K., Perga, S., Medina, M., Delacourte, A., Dingwall, C., De Strooper, B., and Dotti, C. G. (2004) J. Cell Biol. 167, 953-960
74. Grimm, M. O., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J. A., De Strooper, B., Müller, U., Shen, J., and Hartmann, T. (2005) Nat. Cell Biol. 7, 1118-1123
75. Langelier, B., Linard, A., Bordat, C., Lavialle, M., and Heberden, C. (2010) J. Cell. Biochem. 110, 1356-1364
76. Shaikh, S. R., Locascio, D. S., Soni, S. P., Wassall, S. R., and Stillwell, W. (2009) Biochim. Biophys. Acta 1788, 2421-2426
77. Shaikh, S. R., Rockett, B. D., Salameh, M., and Carraway, K. (2009) J. Nutr. 139, 1632-1639
78. Raza Shaikh, S. (2010) Prostaglandins Leukot. Essent. Fatty Acids 82, 159-164
79. Marquer, C., Devauges, V., Cossec, J. C., Liot, G., Lecart, S., Saudou, F., Duyckaerts, C., Leveque-Fort, S., and Potier, M. C. (2011) FASEB J., 10.1096/fj.10-168633
80. Tate, B. A., and Mathews, P. M. (2006) Sci. Aging Knowledge Environ. 2006, re2
81. Simons, M., Schwärzler, F., Lütjohann, D., von Bergmann, K., Beyreuther, K., Dichgans, J., Wormstall, H., Hartmann, T., and Schulz, J. B. (2002) Ann. Neurol. 52, 346-350
82. Sparks, D. L., Sabbagh, M. N., Connor, D. J., Lopez, J., Launer, L. J., Browne, P., Wasser, D., Johnson-Traver, S., Lochhead, J., and Ziolwolski, C. (2005) Arch. Neurol. 62, 753-757
83. Feldman, H. H., Doody, R. S., Kivipelto, M., Sparks, D. L., Waters, D. D., Jones, R. W., Schwam, E., Schindler, R., Hey-Hadavi, J., DeMicco, D. A., and Breazna, A. (2010) Neurology 74, 956-964