Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease

Volumn 25, Issue 3, 2007, Pages 686-696

  Vingtdeux, Valérie ^a,b   Hamdane, Malika ^a,b   Bégard, Séverine ^a,b   Loyens, Anne ^a,b   Delacourte, André ^a,b   Beauvillain, Jean Claude ^a,b   Buée, Luc ^a,b   Marambaud, Philippe ^c   Sergeant, Nicolas ^a  

^a JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^b UNIV LILLE   (France)

^c FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Alkalizing drugs; Alzheimer's disease; Amyloid precursor protein; APP intracellular domain; Gamma secretase; Lysosome

Indexed keywords

AMYLOID PROTEIN; GAMMA SECRETASE; METALLOPROTEINASE; NERVE CELL ADHESION MOLECULE; NOTCH1 RECEPTOR; PROTEASOME;

ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; CELL STRAIN COS1; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYSOSOME; NEUROBLASTOMA; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALKALIES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CADHERINS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; LYSOSOMES; MACROLIDES; NEUROBLASTOMA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; SOLUBILITY; TRANSFECTION;

EID: 33847322057     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.09.019     Document Type: Article

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