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Volumn 16, Issue 1, 2015, Pages 60-70

DNA secondary structure at chromosomal fragile sites in human disease

Author keywords

Cancer; DNA fragility; DNA secondary structure; Fragile site; Genome instability; Neurological disease

Indexed keywords

BRCA1 PROTEIN; HISTONE H2AX;

EID: 84926298943     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/1389202916666150114223205     Document Type: Article
Times cited : (50)

References (141)
  • 1
    • 81455144644 scopus 로고    scopus 로고
    • Conformational changes of non-B DNA
    • Choi J, Majima T, Conformational changes of non-B DNA. Chem. Soc. Rev., 2011, 40, 5893-5909.
    • (2011) Chem. Soc. Rev , vol.40 , pp. 5893-5909
    • Choi, J.1    Majima, T.2
  • 2
    • 34249907843 scopus 로고    scopus 로고
    • Non-B DNA conformations, mutagenesis and disease
    • Wells RD, Non-B DNA conformations, mutagenesis and disease. Trends Biochem. Sci., 2007, 32, 271-278.
    • (2007) Trends Biochem. Sci , vol.32 , pp. 271-278
    • Wells, R.D.1
  • 4
    • 84877921309 scopus 로고    scopus 로고
    • The yin and yang of repair mechanisms in DNA structure-induced genetic instability
    • Vasquez, K.M.; Wang, G. The yin and yang of repair mechanisms in DNA structure-induced genetic instability. Mutat. Res., 2013, 743-744, 118-131.
    • (2013) Mutat. Res , vol.743-744 , pp. 118-131
    • Vasquez, K.M.1    Wang, G.2
  • 5
    • 78651103642 scopus 로고    scopus 로고
    • Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression
    • Ray, B.K.; Dhar, S.; Shakya, A.; Ray, A. Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression. Proc. Natl. Acad. Sci. U S A., 2010, 108, 103-108.
    • (2010) Proc. Natl. Acad. Sci. U S A , vol.108 , pp. 103-108
    • Ray, B.K.1    Dhar, S.2    Shakya, A.3    Ray, A.4
  • 7
    • 0029588611 scopus 로고
    • Identification of transcriptionally induced Z-DNA segments in the human c-myc gene
    • Wolfl, S.; Wittig, B.; Rich, A. Identification of transcriptionally induced Z-DNA segments in the human c-myc gene. Biochim. Biophys. Acta., 1995, 1264, 294-302.
    • (1995) Biochim. Biophys. Acta , vol.1264 , pp. 294-302
    • Wolfl, S.1    Wittig, B.2    Rich, A.3
  • 8
    • 0024437912 scopus 로고
    • Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours
    • Boehm, T.; Mengle-Gaw, L.; Kees, U.R.; Spurr, N.; Lavenir, I.; Forster, A.; Rabbitts, T.H. Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours. EMBO J., 1989, 8, 2621-2631.
    • (1989) EMBO J , vol.8 , pp. 2621-2631
    • Boehm, T.1    Mengle-Gaw, L.2    Kees, U.R.3    Spurr, N.4    Lavenir, I.5    Forster, A.6    Rabbitts, T.H.7
  • 9
    • 79958724230 scopus 로고    scopus 로고
    • Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy
    • Sinclair, P.B.; Parker, H.; An, Q.; Rand, V.; Ensor, H.; Harrison, C.J.; Strefford, J.C. Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy. Hum. Mol. Gene., 2011, 20, 2591-2602.
    • (2011) Hum. Mol. Gene , vol.20 , pp. 2591-2602
    • Sinclair, P.B.1    Parker, H.2    An, Q.3    Rand, V.4    Ensor, H.5    Harrison, C.J.6    Strefford, J.C.7
  • 10
    • 0025933719 scopus 로고
    • Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae
    • Nag, D.K.; Petes, T.D. Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae. Genetics, 1991, 129, 669-673.
    • (1991) Genetics , vol.129 , pp. 669-673
    • Nag, D.K.1    Petes, T.D.2
  • 12
    • 0035902483 scopus 로고    scopus 로고
    • Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
    • Zhou, Z.H.; Akgun, E.; Jasin, M. Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences. Proc. Natl. Acad. Sci. U S A, 2001, 98, 8326-8333.
    • (2001) Proc. Natl. Acad. Sci. U S A , vol.98 , pp. 8326-8333
    • Zhou, Z.H.1    Akgun, E.2    Jasin, M.3
  • 13
    • 0037173105 scopus 로고    scopus 로고
    • Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells
    • Tanaka, H.; Tapscott, S.J.; Trask, B.J.; Yao, M.C.; Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells. Proc. Natl. Acad. Sci. U S A, 2002, 99, 8772-8777.
    • (2002) Proc. Natl. Acad. Sci. U S A , vol.99 , pp. 8772-8777
    • Tanaka, H.1    Tapscott, S.J.2    Trask, B.J.3    Yao, M.C.4
  • 14
    • 0242637353 scopus 로고    scopus 로고
    • Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism
    • Cunningham, L.A.; Cote, A.G.; Cam-Ozdemir, C.; Lewis, S.M. Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism. Mol. Cell. Biol., 2003, 23, 8740-8750.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 8740-8750
    • Cunningham, L.A.1    Cote, A.G.2    Cam-Ozdemir, C.3    Lewis, S.M.4
  • 15
    • 0034234453 scopus 로고    scopus 로고
    • Regions of genomic instability on 22q11 and 11q23 as the etiology for the recurrent constitutional t(11;22)
    • Kurahashi, H.; Shaikh, T.H.; Hu, P.; Roe, B.A.; Emanuel, B.S.; Budarf, M.L. Regions of genomic instability on 22q11 and 11q23 as the etiology for the recurrent constitutional t(11;22). Hum. Mol. Genet., 2000, 9, 1665-1670.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 1665-1670
    • Kurahashi, H.1    Shaikh, T.H.2    Hu, P.3    Roe, B.A.4    Emanuel, B.S.5    Budarf, M.L.6
  • 17
    • 0035509701 scopus 로고    scopus 로고
    • Long AT-rich palindromes and the constitutional t(11;22) breakpoint
    • Kurahashi, H.; Emanuel, B.S. Long AT-rich palindromes and the constitutional t(11;22) breakpoint. Hum. Mol. Genet., 2001, 10, 2605-2617.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 2605-2617
    • Kurahashi, H.1    Emanuel, B.S.2
  • 19
    • 1542287213 scopus 로고    scopus 로고
    • A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
    • Raghavan, S.C.; Swanson, P.C.; Wu, X.; Hsieh, C.L.; Lieber, M.R. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature, 2004, 428, 88-93.
    • (2004) Nature , vol.428 , pp. 88-93
    • Raghavan, S.C.1    Swanson, P.C.2    Wu, X.3    Hsieh, C.L.4    Lieber, M.R.5
  • 23
    • 33747871340 scopus 로고    scopus 로고
    • The involvement of non-B DNA structures in gross chromosomal rearrangements
    • Bacolla, A.; Wojciechowska, M.; Kosmider, B.; Larson, J.E.; Wells, R.D. The involvement of non-B DNA structures in gross chromosomal rearrangements. DNA Repair, 2006, 5, 1161-1170.
    • (2006) DNA Repair , vol.5 , pp. 1161-1170
    • Bacolla, A.1    Wojciechowska, M.2    Kosmider, B.3    Larson, J.E.4    Wells, R.D.5
  • 24
    • 65249186097 scopus 로고    scopus 로고
    • Non-B DNA conformations as determinants of mutagenesis and human disease
    • Bacolla, A.; Wells, R.D. Non-B DNA conformations as determinants of mutagenesis and human disease. Mol. Carcinogenesis, 2009, 48, 273-285.
    • (2009) Mol. Carcinogenesis , vol.48 , pp. 273-285
    • Bacolla, A.1    Wells, R.D.2
  • 25
    • 77955791569 scopus 로고    scopus 로고
    • G-quadruplex nucleic acids and human disease
    • Wu, Y.; Brosh, R.M, Jr., G-quadruplex nucleic acids and human disease. FEBS. J., 2010, 277, 3470-3488.
    • (2010) FEBS. J , vol.277 , pp. 3470-3488
    • Wu, Y.1    Brosh, R.M.2
  • 26
    • 84864690009 scopus 로고    scopus 로고
    • Unraveling cell typespecific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
    • Besnard, E.; Babled, A.; Lapasset, L.; Milhavet, O.; Parrinello, H.; Dantec, C.; Marin, J.M.; Lemaitre, J.M. Unraveling cell typespecific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat. Struct. Mol. Biol., 2012, 19, 837-844.
    • (2012) Nat. Struct. Mol. Biol , vol.19 , pp. 837-844
    • Besnard, E.1    Babled, A.2    Lapasset, L.3    Milhavet, O.4    Parrinello, H.5    Dantec, C.6    Marin, J.M.7    Lemaitre, J.M.8
  • 28
    • 79957556530 scopus 로고    scopus 로고
    • DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase
    • Paeschke, K.; Capra, J.A.; Zakian, V.A. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell, 2011, 145, 678-691.
    • (2011) Cell , vol.145 , pp. 678-691
    • Paeschke, K.1    Capra, J.A.2    Zakian, V.A.3
  • 29
    • 0025877846 scopus 로고
    • Inhibition of telomerase by G-quartet DNA structures
    • Zahler, A.M.; Williamson, J.R.; Cech, T.R.; Prescott, D.M. Inhibition of telomerase by G-quartet DNA structures. Nature, 1991, 350, 718-720.
    • (1991) Nature , vol.350 , pp. 718-720
    • Zahler, A.M.1    Williamson, J.R.2    Cech, T.R.3    Prescott, D.M.4
  • 30
    • 79961029908 scopus 로고    scopus 로고
    • DNA secondary structures and epigenetic determinants of cancer genome evolution
    • De, S.; Michor, F. DNA secondary structures and epigenetic determinants of cancer genome evolution. Nat. Struct. Mol. Biol., 2011, 18, 950-955.
    • (2011) Nat. Struct. Mol. Biol , vol.18 , pp. 950-955
    • De, S.1    Michor, F.2
  • 31
    • 84903650357 scopus 로고    scopus 로고
    • Tandem repeats and G-rich sequences are enriched at human CNV breakpoints
    • Bose, P.; Hermetz, K.E.; Conneely, K.N.; Rudd, M.K. Tandem repeats and G-rich sequences are enriched at human CNV breakpoints. PloS One, 2014, 9, e101607.
    • (2014) Plos One , vol.9
    • Bose, P.1    Hermetz, K.E.2    Conneely, K.N.3    Rudd, M.K.4
  • 32
    • 84875981640 scopus 로고    scopus 로고
    • The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni-and multimolecular RNA G-quadruplex structures
    • Reddy, K.; Zamiri, B.; Stanley, S.Y.; Macgregor, R.B, Jr., Pearson CE, The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni-and multimolecular RNA G-quadruplex structures. J. Biol. Chem., 2013, 288, 9860-9866.
    • (2013) J. Biol. Chem , vol.288 , pp. 9860-9866
    • Reddy, K.1    Zamiri, B.2    Stanley, S.Y.3    Macgregor, R.B.4    Pearson, C.E.5
  • 36
    • 80051549115 scopus 로고    scopus 로고
    • Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement
    • Kobayashi, H.; Abe, K.; Matsuura, T.; Ikeda, Y.; Hitomi, T.; Akechi, Y.; Habu, T.; Liu, W.; Okuda, H.; Koizumi, A. Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am. J. Hum. Genet., 2011, 89, 121-130.
    • (2011) Am. J. Hum. Genet , vol.89 , pp. 121-130
    • Kobayashi, H.1    Abe, K.2    Matsuura, T.3    Ikeda, Y.4    Hitomi, T.5    Akechi, Y.6    Habu, T.7    Liu, W.8    Okuda, H.9    Koizumi, A.10
  • 40
    • 0036578758 scopus 로고    scopus 로고
    • Evidence of cisacting factors in replication-mediated trinucleotide repeat instability in primate cells
    • Cleary, J.D.; Nichol, K.; Wang, Y.H. Pearson CE, Evidence of cisacting factors in replication-mediated trinucleotide repeat instability in primate cells. Nat. Genet, 2002, 31, 37-46.
    • (2002) Nat. Genet , vol.31 , pp. 37-46
    • Cleary, J.D.1    Nichol, K.2    Wang, Y.H.3    Pearson, C.E.4
  • 41
    • 0242549824 scopus 로고    scopus 로고
    • DNA repair and trinucleotide repeat instability
    • Lahue, R.S.; Slater, D.L. DNA repair and trinucleotide repeat instability. Front. Biosci., 2003, 8, s653-665.
    • (2003) Front. Biosci , vol.8 , pp. 653-665
    • Lahue, R.S.1    Slater, D.L.2
  • 42
    • 0028362201 scopus 로고
    • The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure
    • Fry, M.; Loeb, L.A. The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure. Proc. Natl. Acad. Sci. U S A., 1994, 91, 4950-4954.
    • (1994) Proc. Natl. Acad. Sci. U S A , vol.91 , pp. 4950-4954
    • Fry, M.1    Loeb, L.A.2
  • 43
    • 0029053371 scopus 로고
    • Trinucleotide repeats that expand in human disease form hairpin structures in vitro
    • Gacy, A.M.; Goellner, G.; Juranic, N.; Macura, S.; McMurray, C.T. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell, 1995, 81, 533-540.
    • (1995) Cell , vol.81 , pp. 533-540
    • Gacy, A.M.1    Goellner, G.2    Juranic, N.3    Macura, S.4    McMurray, C.T.5
  • 44
    • 0028874391 scopus 로고
    • CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro
    • Usdin, K.; Woodford, K.J. CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro. Nucleic Acids Res., 1995, 23, 4202-4209.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4202-4209
    • Usdin, K.1    Woodford, K.J.2
  • 45
    • 0030725454 scopus 로고    scopus 로고
    • Trinucleotide repeats affect DNA replication in vivo
    • Samadashwily, G.M.; Raca, G.; Mirkin, S.M. Trinucleotide repeats affect DNA replication in vivo. Nat. Genet, 1997, 17, 298-304.
    • (1997) Nat. Genet , vol.17 , pp. 298-304
    • Samadashwily, G.M.1    Raca, G.2    Mirkin, S.M.3
  • 46
    • 84864340143 scopus 로고    scopus 로고
    • DNA triplex structures in neurodegenerative disorder, Friedreich's ataxia
    • Rajeswari, M.R. DNA triplex structures in neurodegenerative disorder, Friedreich's ataxia. J. Biosci., 2012, 37, 519-532.
    • (2012) J. Biosci , vol.37 , pp. 519-532
    • Rajeswari, M.R.1
  • 47
    • 77955574156 scopus 로고    scopus 로고
    • AGG interruptions in (CGG)(n) DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro
    • Jarem, D.A.; Huckaby, L.V.; Delaney, S. AGG interruptions in (CGG)(n) DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro. Biochemistry, 2010, 49, 6826-6837.
    • (2010) Biochemistry , vol.49 , pp. 6826-6837
    • Jarem, D.A.1    Huckaby, L.V.2    Delaney, S.3
  • 48
    • 0032562132 scopus 로고    scopus 로고
    • Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation
    • Pearson, C.E.; Eichler, E.E.; Lorenzetti, D.; Kramer, S.F.; Zoghbi, H.Y.; Nelson, D.L.; Sinden, R.R. Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation. Biochemistry, 1998, 37, 2701-2708.
    • (1998) Biochemistry , vol.37 , pp. 2701-2708
    • Pearson, C.E.1    Eichler, E.E.2    Lorenzetti, D.3    Kramer, S.F.4    Zoghbi, H.Y.5    Nelson, D.L.6    Sinden, R.R.7
  • 49
    • 0034175916 scopus 로고    scopus 로고
    • Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures
    • Weisman-Shomer, P.; Cohen, E.; Fry, M. Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures. Nucleic Acids Res., 2000, 28, 1535-1541.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1535-1541
    • Weisman-Shomer, P.1    Cohen, E.2    Fry, M.3
  • 50
    • 0035369401 scopus 로고    scopus 로고
    • Fragile and unstable chromosomes in cancer, causes and consequences
    • Richards, R.I. Fragile and unstable chromosomes in cancer, causes and consequences. Trends in Genetics, TIG 2001, 17, 339-345.
    • (2001) Trends in Genetics, TIG , vol.17 , pp. 339-345
    • Richards, R.I.1
  • 51
    • 30144439370 scopus 로고    scopus 로고
    • Common fragile sites
    • Glover, T.W. Common fragile sites. Cancer Lett., 2006, 232, 4-12.
    • (2006) Cancer Lett , vol.232 , pp. 4-12
    • Glover, T.W.1
  • 52
    • 0027337930 scopus 로고
    • DNA polymerase epsilon, aphidicolin inhibition and the relationship between polymerase and exonuclease activity
    • Cheng, C.H.; Kuchta, R.D. DNA polymerase epsilon, aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry, 1993, 32, 8568-8574.
    • (1993) Biochemistry , vol.32 , pp. 8568-8574
    • Cheng, C.H.1    Kuchta, R.D.2
  • 53
    • 0021278143 scopus 로고
    • DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
    • Glover, T.W.; Berger, C.; Coyle, J.; Echo, B. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Gene., 1984, 67, 136-142.
    • (1984) Hum. Gene , vol.67 , pp. 136-142
    • Glover, T.W.1    Berger, C.2    Coyle, J.3    Echo, B.4
  • 54
    • 77956539396 scopus 로고    scopus 로고
    • DNA instability at chromosomal fragile sites in cancer
    • Dillon, L.W.; Burrow, A.A.; Wang, Y.H. DNA instability at chromosomal fragile sites in cancer. Curr. Genom., 2010, 11, 326-337.
    • (2010) Curr. Genom , vol.11 , pp. 326-337
    • Dillon, L.W.1    Burrow, A.A.2    Wang, Y.H.3
  • 58
    • 0025905795 scopus 로고
    • Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk, A.J.; Pieretti, M.; Sutcliffe, J.S.; Fu, Y.H.; Kuhl, D.P.; Pizzuti, A.; Reiner, O.; Richards, S.; Victoria, M.F.; Zhang, F.P. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 1991, 65, 905-914.
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.1    Pieretti, M.2    Sutcliffe, J.S.3    Fu, Y.H.4    Kuhl, D.P.5    Pizzuti, A.6    Reiner, O.7    Richards, S.8    Victoria, M.F.9    Zhang, F.P.10
  • 59
    • 34548724996 scopus 로고    scopus 로고
    • Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat
    • Sofola, O.A.; Jin, P.; Botas, J.; Nelson, D.L. Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat. Hum. Mol. Gene., 2007, 16, 2326-2332.
    • (2007) Hum. Mol. Gene , vol.16 , pp. 2326-2332
    • Sofola, O.A.1    Jin, P.2    Botas, J.3    Nelson, D.L.4
  • 60
    • 0342424768 scopus 로고    scopus 로고
    • Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome, evidence for a common mechanism of chromosome breakage
    • Jones, C.; Mullenbach, R.; Grossfeld, P.; Auer, R.; Favier, R.; Chien, K.; James, M.; Tunnacliffe, A.; Cotter, F. Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome, evidence for a common mechanism of chromosome breakage. Hum. Mol. Gene., 2000, 9, 1201-1208.
    • (2000) Hum. Mol. Gene , vol.9 , pp. 1201-1208
    • Jones, C.1    Mullenbach, R.2    Grossfeld, P.3    Auer, R.4    Favier, R.5    Chien, K.6    James, M.7    Tunnacliffe, A.8    Cotter, F.9
  • 61
    • 62749093260 scopus 로고    scopus 로고
    • The expression of folate sensitive fragile sites in patients with bipolar disorder
    • Demirhan, O.; Tastemir, D.; Sertdemir, Y. The expression of folate sensitive fragile sites in patients with bipolar disorder. Yonsei, Med. J., 2009, 50, 137-141.
    • (2009) Yonsei, Med. J , vol.50 , pp. 137-141
    • Demirhan, O.1    Tastemir, D.2    Sertdemir, Y.3
  • 62
    • 78650019788 scopus 로고    scopus 로고
    • Genomic and epigenomic instability, fragile sites, schizophrenia and autism
    • Smith, C.L.; Bolton, A.; Nguyen, G. Genomic and epigenomic instability, fragile sites, schizophrenia and autism. Curr. Genomics, 2011, 11, 447-469.
    • (2011) Curr. Genomics , vol.11 , pp. 447-469
    • Smith, C.L.1    Bolton, A.2    Nguyen, G.3
  • 63
    • 60549094865 scopus 로고    scopus 로고
    • Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites
    • Burrow, A.A.; Williams, L.E.; Pierce, L.C.; Wang, Y.H. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites. BMC Genomics, 2009, 10, 59.
    • (2009) BMC Genomics , vol.10
    • Burrow, A.A.1    Williams, L.E.2    Pierce, L.C.3    Wang, Y.H.4
  • 64
    • 33748623634 scopus 로고    scopus 로고
    • Common fragile sites as targets for chromosome rearrangements
    • Arlt, M.F.; Durkin, S.G.; Ragland, R.L.; Glover, T.W. Common fragile sites as targets for chromosome rearrangements. DNA Repair, 2006, 5, 1126-1135.
    • (2006) DNA Repair , vol.5 , pp. 1126-1135
    • Arlt, M.F.1    Durkin, S.G.2    Ragland, R.L.3    Glover, T.W.4
  • 65
    • 13344279424 scopus 로고    scopus 로고
    • The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    • Ohta, M.; Inoue, H.; Cotticelli, M.G.; Kastury, K.; Baffa, R.; Palazzo, J.; Siprashvili, Z.; Mori, M.; McCue, P.; Druck, T. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 1996, 84, 587-597.
    • (1996) Cell , vol.84 , pp. 587-597
    • Ohta, M.1    Inoue, H.2    Cotticelli, M.G.3    Kastury, K.4    Baffa, R.5    Palazzo, J.6    Siprashvili, Z.7    Mori, M.8    McCue, P.9    Druck, T.10
  • 67
    • 84895929884 scopus 로고    scopus 로고
    • A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas
    • Gao, G.; Kasperbauer, J.L.; Tombers, N.M.; Wang, V.; Mayer, K.; Smith, D.I. A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas. Genes, Chromosomes & Cancer, 2014, 53, 392-401.
    • (2014) Genes, Chromosomes &Amp; Cancer , vol.53 , pp. 392-401
    • Gao, G.1    Kasperbauer, J.L.2    Tombers, N.M.3    Wang, V.4    Mayer, K.5    Smith, D.I.6
  • 68
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson, M.A.; Lee, J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett., 2007, 252, 157-170.
    • (2007) Cancer Lett , vol.252 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 69
    • 84983724714 scopus 로고    scopus 로고
    • Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis
    • Jiang, S.; Yang, Z.; Li, W.; Li, X.; Wang, Y.; Zhang, J.; Xu, C.; Chen, P.J.; Hou, J.; McCrae, M.A. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PloS One, 2012, 7, e40363.
    • (2012) Plos One , vol.7
    • Jiang, S.1    Yang, Z.2    Li, W.3    Li, X.4    Wang, Y.5    Zhang, J.6    Xu, C.7    Chen, P.J.8    Hou, J.9    McCrae, M.A.10
  • 71
    • 54249105939 scopus 로고    scopus 로고
    • Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions
    • Dall, K.L.; Scarpini, C.G.; Roberts, I.; Winder, D.M.; Stanley, M.A.; Muralidhar, B.; Herdman, M.T.; Pett, M.R.; Coleman, N. Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions. Cancer Res., 2008, 68, 8249-8259.
    • (2008) Cancer Res , vol.68 , pp. 8249-8259
    • Dall, K.L.1    Scarpini, C.G.2    Roberts, I.3    Winder, D.M.4    Stanley, M.A.5    Muralidhar, B.6    Herdman, M.T.7    Pett, M.R.8    Coleman, N.9
  • 72
    • 62549166628 scopus 로고    scopus 로고
    • Identification of human papillomavirus type 16 integration sites in high-grade precancerous cervical lesions
    • Matovina, M.; Sabol, I.; Grubisic, G.; Gasperov, N.M.; Grce, M. Identification of human papillomavirus type 16 integration sites in high-grade precancerous cervical lesions. Gynecol. Oncol., 2009, 113, 120-127.
    • (2009) Gynecol. Oncol , vol.113 , pp. 120-127
    • Matovina, M.1    Sabol, I.2    Grubisic, G.3    Gasperov, N.M.4    Grce, M.5
  • 73
    • 77951060421 scopus 로고    scopus 로고
    • DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells
    • Gandhi, M.; Dillon, L.W.; Pramanik, S.; Nikiforov, Y.E.; Wang, Y.H. DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells. Oncogene, 2010, 29, 2272-2280.
    • (2010) Oncogene , vol.29 , pp. 2272-2280
    • Gandhi, M.1    Dillon, L.W.2    Pramanik, S.3    Nikiforov, Y.E.4    Wang, Y.H.5
  • 74
    • 77953278318 scopus 로고    scopus 로고
    • Secondary structure formation and DNA instability at fragile site FRA16B
    • Burrow, A.A.; Marullo, A.; Holder, L.R.; Wang, Y.H. Secondary structure formation and DNA instability at fragile site FRA16B. Nucleic Acids Res., 2010, 38, 2865-2877.
    • (2010) Nucleic Acids Res , vol.38 , pp. 2865-2877
    • Burrow, A.A.1    Marullo, A.2    Holder, L.R.3    Wang, Y.H.4
  • 75
    • 33744807443 scopus 로고    scopus 로고
    • DNA structures, repeat expansions and human hereditary disorders
    • Mirkin, S.M. DNA structures, repeat expansions and human hereditary disorders. Curr. Opin. Struct. Biol., 2006, 16, 351-358.
    • (2006) Curr. Opin. Struct. Biol , vol.16 , pp. 351-358
    • Mirkin, S.M.1
  • 76
    • 0034017208 scopus 로고    scopus 로고
    • CGG/CCG repeats exhibit orientation-dependent instability and orientationindependent fragility in Saccharomyces cerevisiae
    • Balakumaran, B.S.; Freudenreich, C.H.; Zakian, V.A. CGG/CCG repeats exhibit orientation-dependent instability and orientationindependent fragility in Saccharomyces cerevisiae. Hum. Mol. Gene., 2000, 9, 93-100.
    • (2000) Hum. Mol. Gene , vol.9 , pp. 93-100
    • Balakumaran, B.S.1    Freudenreich, C.H.2    Zakian, V.A.3
  • 77
    • 34547205070 scopus 로고    scopus 로고
    • An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. Cervisiae
    • Zhang, H.; Freudenreich, C.H. An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cervisiae. Mol. Cell, 2007, 27, 367-379.
    • (2007) Mol. Cell , vol.27 , pp. 367-379
    • Zhang, H.1    Freudenreich, C.H.2
  • 78
    • 84911915086 scopus 로고    scopus 로고
    • Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes
    • Savelyeva, L.; Brueckner, L.M. Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes. Cellular and molecular life sciences , CMLS, 2014, 71, 4561-4575.
    • (2014) Cellular and Molecular Life Sciences , CMLS , vol.71 , pp. 4561-4575
    • Savelyeva, L.1    Brueckner, L.M.2
  • 79
    • 84875269728 scopus 로고    scopus 로고
    • Role of DNA secondary structures in fragile site breakage along human chromosome 10
    • Dillon, L.W.; Pierce, L.C.; Ng, M.C.; Wang, Y.H. Role of DNA secondary structures in fragile site breakage along human chromosome 10. Hum. Mol. Gene., 2013, 22, 1443-1456.
    • (2013) Hum. Mol. Gene , vol.22 , pp. 1443-1456
    • Dillon, L.W.1    Pierce, L.C.2    Ng, M.C.3    Wang, Y.H.4
  • 80
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction
    • Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res., 2003, 31, 3406-3415.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1
  • 81
    • 33846928449 scopus 로고    scopus 로고
    • G-quadruplexes in promoters throughout the human genome
    • Huppert, J.L.; Balasubramanian, S. G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res., 2007, 35, 406-413.
    • (2007) Nucleic Acids Res , vol.35 , pp. 406-413
    • Huppert, J.L.1    Balasubramanian, S.2
  • 82
    • 84864056018 scopus 로고    scopus 로고
    • Potential Gquadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility
    • Katapadi, V.K.; Nambiar, M.; Raghavan, S.C. Potential Gquadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility. Genomics, 2012, 100, 72-80.
    • (2012) Genomics , vol.100 , pp. 72-80
    • Katapadi, V.K.1    Nambiar, M.2    Raghavan, S.C.3
  • 83
    • 84861883036 scopus 로고    scopus 로고
    • A genome-wide analysis of common fragile sites, What features determine chromosomal instability in the human genome
    • Fungtammasan, A.; Walsh, E.; Chiaromonte, F.; Eckert, K.A.; Makova, K.D. A genome-wide analysis of common fragile sites, What features determine chromosomal instability in the human genome? Genome. Res., 2012, 22, 993-1005.
    • (2012) Genome. Res , vol.22 , pp. 993-1005
    • Fungtammasan, A.1    Walsh, E.2    Chiaromonte, F.3    Eckert, K.A.4    Makova, K.D.5
  • 84
    • 77950355795 scopus 로고    scopus 로고
    • DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D
    • Shah, S.N.; Opresko, P.L.; Meng, X.; Lee, M.Y.; Eckert, K.A. DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res., 2010, 38, 1149-1162.
    • (2010) Nucleic Acids Res , vol.38 , pp. 1149-1162
    • Shah, S.N.1    Opresko, P.L.2    Meng, X.3    Lee, M.Y.4    Eckert, K.A.5
  • 85
    • 0037074013 scopus 로고    scopus 로고
    • ATR regulates fragile site stability
    • Casper, A.M.; Nghiem, P.; Arlt, M.F.; Glover, T.W. ATR regulates fragile site stability. Cell, 2002, 111, 779-789.
    • (2002) Cell , vol.111 , pp. 779-789
    • Casper, A.M.1    Nghiem, P.2    Arlt, M.F.3    Glover, T.W.4
  • 86
    • 4544333154 scopus 로고    scopus 로고
    • Chromosomal instability at common fragile sites in Seckel syndrome
    • Casper, A.M.; Durkin, S.G.; Arlt, M.F.; Glover, T.W. Chromosomal instability at common fragile sites in Seckel syndrome. Am. J. Hum. Genet., 2004, 75, 654-660.
    • (2004) Am. J. Hum. Genet , vol.75 , pp. 654-660
    • Casper, A.M.1    Durkin, S.G.2    Arlt, M.F.3    Glover, T.W.4
  • 87
    • 47749141560 scopus 로고    scopus 로고
    • ATR, an essential regulator of genome integrity
    • Cimprich, K.A.; Cortez D. ATR, an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol., 2008, 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 88
    • 77649183106 scopus 로고    scopus 로고
    • ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment
    • Wan, C.; Kulkarni, A.; Wang, Y.H. ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. Mutat. Res., 2010, 686, 39-46.
    • (2010) Mutat.Res , vol.686 , pp. 39-46
    • Wan, C.1    Kulkarni, A.2    Wang, Y.H.3
  • 89
    • 41649120947 scopus 로고    scopus 로고
    • Interplay between ATM and ATR in the regulation of common fragile site stability
    • Ozeri-Galai, E.; Schwartz, M.; Rahat, A.; Kerem, B. Interplay between ATM and ATR in the regulation of common fragile site stability. Oncogene, 2008, 27, 2109-2117.
    • (2008) Oncogene , vol.27 , pp. 2109-2117
    • Ozeri-Galai, E.1    Schwartz, M.2    Rahat, A.3    Kerem, B.4
  • 90
    • 3242712112 scopus 로고    scopus 로고
    • BRCA1 is required for common-fragile-site stability via its G 2/M checkpoint function
    • Arlt, M.F.; Xu, B.; Durkin, S.G.; Casper, A.M.; Kastan, M.B.; Glover, T.W. BRCA1 is required for common-fragile-site stability via its G 2/M checkpoint function. Mol. Cell. Biol., 2004, 24, 6701-6709.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 6701-6709
    • Arlt, M.F.1    Xu, B.2    Durkin, S.G.3    Casper, A.M.4    Kastan, M.B.5    Glover, T.W.6
  • 91
    • 33746495515 scopus 로고    scopus 로고
    • Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
    • Durkin, S.G.; Arlt, M.F.; Howlett, N.G.; Glover, T.W. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene, 2006, 25, 4381-4388.
    • (2006) Oncogene , vol.25 , pp. 4381-4388
    • Durkin, S.G.1    Arlt, M.F.2    Howlett, N.G.3    Glover, T.W.4
  • 93
    • 33947145194 scopus 로고    scopus 로고
    • Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
    • Zhu, M.; Weiss, R.S. Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol. Biol. Cell, 2007, 18, 1044-1055.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1044-1055
    • Zhu, M.1    Weiss, R.S.2
  • 95
    • 14644391577 scopus 로고    scopus 로고
    • The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability
    • Howlett, N.G.; Taniguchi, T.; Durkin, S.G.; D'Andrea, A.D.; Glover, T.W. The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum. Mol. Gene., 2005, 14, 693-701.
    • (2005) Hum. Mol. Gene , vol.14 , pp. 693-701
    • Howlett, N.G.1    Taniguchi, T.2    Durkin, S.G.3    D'andrea, A.D.4    Glover, T.W.5
  • 97
    • 67649198018 scopus 로고    scopus 로고
    • Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication
    • Rey, L.; Sidorova, J.M.; Puget, N.; Boudsocq, F.; Biard, D.S.; Monnat, R.J, Jr., Cazaux, C.; Hoffmann, J.S. Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Mol. Cell Biol., 2009, 29, 3344-3354.
    • (2009) Mol. Cell Biol , vol.29 , pp. 3344-3354
    • Rey, L.1    Sidorova, J.M.2    Puget, N.3    Boudsocq, F.4    Biard, D.S.5    Monnat, R.J.6    Cazaux, C.7    Hoffmann, J.S.8
  • 98
    • 84876398028 scopus 로고    scopus 로고
    • Rev3, the catalytic subunit of Polzeta, is required for maintaining fragile site stability in human cells
    • Bhat, A.; Andersen, P.L.; Qin, Z.; Xiao, W. Rev3, the catalytic subunit of Polzeta, is required for maintaining fragile site stability in human cells. Nucleic Acids Res., 2013, 41, 2328-2339.
    • (2013) Nucleic Acids Res , vol.41 , pp. 2328-2339
    • Bhat, A.1    Andersen, P.L.2    Qin, Z.3    Xiao, W.4
  • 99
    • 84872104689 scopus 로고    scopus 로고
    • Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication
    • Walsh, E.; Wang, X.; Lee, M.Y.; Eckert, K.A. Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. J. Mol. Biol., 2013, 425, 232-243.
    • (2013) J. Mol. Biol , vol.425 , pp. 232-243
    • Walsh, E.1    Wang, X.2    Lee, M.Y.3    Eckert, K.A.4
  • 100
    • 0037245862 scopus 로고    scopus 로고
    • An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo, V.; Shechter, D.; Lupardus, P.J.; Cimprich, K.A.; Gottesman, M.; Gautier, J. An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell, 2003, 11, 203-213.
    • (2003) Mol. Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 101
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L.; Elledge, S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 2003, 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 103
    • 0027939024 scopus 로고
    • Interactions of human replication protein A with oligonucleotides
    • Kim, C.; Paulus, B.F.; Wold, M.S. Interactions of human replication protein A with oligonucleotides. Biochemistry, 1994, 33, 14197-14206.
    • (1994) Biochemistry , vol.33 , pp. 14197-14206
    • Kim, C.1    Paulus, B.F.2    Wold, M.S.3
  • 104
    • 84889589443 scopus 로고    scopus 로고
    • Naked replication forks break apRPArt
    • Fernandez-Capetillo, O.; Nussenzweig, A. Naked replication forks break apRPArt. Cell, 2013, 155, 979-980.
    • (2013) Cell , vol.155 , pp. 979-980
    • Fernandez-Capetillo, O.1    Nussenzweig, A.2
  • 106
    • 38749136967 scopus 로고    scopus 로고
    • Werner syndrome helicase activity is essential in maintaining fragile site stability
    • Pirzio, L.M.; Pichierri, P.; Bignami, M.; Franchitto, A. Werner syndrome helicase activity is essential in maintaining fragile site stability. J. Cell. Biol., 2008, 180, 305-314.
    • (2008) J. Cell. Biol , vol.180 , pp. 305-314
    • Pirzio, L.M.1    Pichierri, P.2    Bignami, M.3    Franchitto, A.4
  • 107
    • 84881413905 scopus 로고    scopus 로고
    • Blooming resolvase at chromosomal fragile sites
    • Pellicioli, A.; Muzi-Falconi, M. A blooming resolvase at chromosomal fragile sites. Nat. Cell Biol., 2013, 15, 883-885.
    • (2013) Nat. Cell Biol , vol.15 , pp. 883-885
    • Pellicioli, A.1    Muzi-Falconi, M.A.2
  • 108
    • 0037435026 scopus 로고    scopus 로고
    • Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle
    • Pichierri, P.; Rosselli, F.; Franchitto, A. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene, 2003, 22, 1491-1500.
    • (2003) Oncogene , vol.22 , pp. 1491-1500
    • Pichierri, P.1    Rosselli, F.2    Franchitto, A.3
  • 109
    • 79953171864 scopus 로고    scopus 로고
    • Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells
    • Bacolla, A.; Wang, G.; Jain, A.; Chuzhanova, N.A.; Cer, R.Z.; Collins, J.R.; Cooper, D.N.; Bohr, V.A.; Vasquez, K.M. Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. J. Biol. Chem., 2011, 286, 10017-10026.
    • (2011) J. Biol. Chem , vol.286 , pp. 10017-10026
    • Bacolla, A.1    Wang, G.2    Jain, A.3    Chuzhanova, N.A.4    Cer, R.Z.5    Collins, J.R.6    Cooper, D.N.7    Bohr, V.A.8    Vasquez, K.M.9
  • 110
    • 84859492258 scopus 로고    scopus 로고
    • The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase delta
    • Kamath-Loeb, A.S.; Shen, J.C.; Schmitt, M.W.; Loeb, L.A. The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase delta. J.Biol. Chem., 2012, 287, 12480-12490.
    • (2012) J.Biol. Chem , vol.287 , pp. 12480-12490
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Schmitt, M.W.3    Loeb, L.A.4
  • 111
    • 84876958248 scopus 로고    scopus 로고
    • Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
    • Lu, X.; Parvathaneni, S.; Hara, T.; Lal, A.; Sharma, S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol. Cancer, 2013, 12, 29.
    • (2013) Mol. Cancer , vol.12
    • Lu, X.1    Parvathaneni, S.2    Hara, T.3    Lal, A.4    Sharma, S.5
  • 112
    • 84881471113 scopus 로고    scopus 로고
    • ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis
    • Naim, V.; Wilhelm, T.; Debatisse, M.; Rosselli, F. ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. Nat. Cell Biol., 2013, 15, 1008-1015.
    • (2013) Nat. Cell Biol , vol.15 , pp. 1008-1015
    • Naim, V.1    Wilhelm, T.2    Debatisse, M.3    Rosselli, F.4
  • 114
    • 84899476646 scopus 로고    scopus 로고
    • Structure-specific endonucleases, guardians of fragile site stability
    • Minocherhomji, S.; Hickson, I.D. Structure-specific endonucleases, guardians of fragile site stability. Trends in Cell Biol., 2014, 24, 321-327.
    • (2014) Trends in Cell Biol , vol.24 , pp. 321-327
    • Minocherhomji, S.1    Hickson, I.D.2
  • 115
    • 84901280865 scopus 로고    scopus 로고
    • MUS81-EME2 promotes replication fork restart
    • Pepe, A.; West, S.C. MUS81-EME2 promotes replication fork restart. Cell Reports, 2014, 7, 1048-1055.
    • (2014) Cell Reports , vol.7 , pp. 1048-1055
    • Pepe, A.1    West, S.C.2
  • 116
    • 84903581320 scopus 로고    scopus 로고
    • CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity
    • Wang, H.; Li, Y.; Truong, L.N.; Shi, L.Z.; Hwang, P.Y.; He, J.; Do, J.; Cho, M.J.; Li, H.; Negrete, A. CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity. Mol. Cell, 2014, 56, 1012-1021.
    • (2014) Mol. Cell , vol.56 , pp. 1012-1021
    • Wang, H.1    Li, Y.2    Truong, L.N.3    Shi, L.Z.4    Hwang, P.Y.5    He, J.6    Do, J.7    Cho, M.J.8    Li, H.9    Negrete, A.10
  • 117
    • 84888145447 scopus 로고    scopus 로고
    • The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability
    • Mason, J.M.; Das, I.; Arlt, M.; Patel, N.; Kraftson, S.; Glover, T.W.; Sekiguchi, J.M. The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. Hum. Mol. Gene., 2013, 22, 4901-4913.
    • (2013) Hum. Mol. Gene , vol.22 , pp. 4901-4913
    • Mason, J.M.1    Das, I.2    Arlt, M.3    Patel, N.4    Kraftson, S.5    Glover, T.W.6    Sekiguchi, J.M.7
  • 118
    • 84875847199 scopus 로고    scopus 로고
    • Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations
    • Inagaki, H.; Ohye, T.; Kogo, H.; Tsutsumi, M.; Kato, T.; Tong, M.; Emanuel, B.S.; Kurahashi, H. Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations. Nat. Commun, 2013, 4, 1592.
    • (2013) Nat. Commun , vol.4
    • Inagaki, H.1    Ohye, T.2    Kogo, H.3    Tsutsumi, M.4    Kato, T.5    Tong, M.6    Emanuel, B.S.7    Kurahashi, H.8
  • 119
    • 81855198087 scopus 로고    scopus 로고
    • All tangled up, how cells direct, manage and exploit topoisomerase function
    • Vos, S.M.; Tretter, E.M.; Schmidt, B.H.; Berger, J.M. All tangled up, how cells direct, manage and exploit topoisomerase function. Nat. Rev. Mol. Cell Biol., 2011, 12, 827-841.
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 827-841
    • Vos, S.M.1    Tretter, E.M.2    Schmidt, B.H.3    Berger, J.M.4
  • 120
    • 0021724284 scopus 로고
    • Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing
    • Been, M.D.; Champoux, J.J. Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing. J. Mol. Biol., 1984, 180, 515-531.
    • (1984) J. Mol. Biol , vol.180 , pp. 515-531
    • Been, M.D.1    Champoux, J.J.2
  • 121
    • 0028242701 scopus 로고
    • Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage
    • Froelich-Ammon, S.J.; Gale, K.C.; Osheroff, N. Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage. J. Biol. Chem., 1994, 269, 7719-7725.
    • (1994) J. Biol. Chem , vol.269 , pp. 7719-7725
    • Froelich-Ammon, S.J.1    Gale, K.C.2    Osheroff, N.3
  • 122
    • 56049098748 scopus 로고    scopus 로고
    • Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase IIalpha
    • Jonstrup, A.T.; Thomsen, T.; Wang, Y.; Knudsen, B.R.; Koch, J.; Andersen, A.H. Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase IIalpha. Nucleic Acids Res., 2008, 36, 6165-6174.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6165-6174
    • Jonstrup, A.T.1    Thomsen, T.2    Wang, Y.3    Knudsen, B.R.4    Koch, J.5    Andersen, A.H.6
  • 123
    • 77952581077 scopus 로고    scopus 로고
    • Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites
    • Arlt, M.F.; Glover, T.W.; Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites. DNA Repair, 2010, 9, 678-689.
    • (2010) DNA Repair , vol.9 , pp. 678-689
    • Arlt, M.F.1    Glover, T.W.2
  • 124
    • 84255198334 scopus 로고    scopus 로고
    • Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
    • Helmrich, A.; Ballarino, M.; Tora, L. Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol. Cell, 2011, 44, 966-977.
    • (2011) Mol. Cell , vol.44 , pp. 966-977
    • Helmrich, A.1    Ballarino, M.2    Tora, L.3
  • 125
    • 84868091320 scopus 로고    scopus 로고
    • Topoisomerase II-and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis
    • Hashash, N.; Johnson, A.L.; Cha, R.S. Topoisomerase II-and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis. PLoS Gene., 2012, 8, e1002978.
    • (2012) Plos Gene , vol.8
    • Hashash, N.1    Johnson, A.L.2    Cha, R.S.3
  • 127
    • 79959885574 scopus 로고    scopus 로고
    • Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites
    • Ozeri-Galai, E.; Lebofsky, R.; Rahat, A.; Bester, A.C.; Bensimon, A.; Kerem, B. Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Molecular cell, 2011, 43, 122-131.
    • (2011) Molecular Cell , vol.43 , pp. 122-131
    • Ozeri-Galai, E.1    Lebofsky, R.2    Rahat, A.3    Bester, A.C.4    Bensimon, A.5    Kerem, B.6
  • 130
    • 34548775695 scopus 로고    scopus 로고
    • A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro
    • Grabczyk, E.; Mancuso, M.; Sammarco, M.C. A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro. Nucleic Acids Res., 2007, 35, 5351-5359.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5351-5359
    • Grabczyk, E.1    Mancuso, M.2    Sammarco, M.C.3
  • 133
    • 79951904498 scopus 로고    scopus 로고
    • Toxicity at trinucleotide repeats, double bubble is trouble
    • Lin, Y.; Wilson, J.H. Transcription-induced DNA toxicity at trinucleotide repeats, double bubble is trouble. Cell Cycle, 2011, 10, 611-618.
    • (2011) Cell Cycle , vol.10 , pp. 611-618
    • Lin, Y.1    Wilson, J.H.2    Transcription-Induced, D.3
  • 136
    • 84892149837 scopus 로고    scopus 로고
    • To switch or not to switch, at the origin of repeat expansion disease
    • Mirkin, E.V.; Mirkin, S.M. To switch or not to switch, at the origin of repeat expansion disease. Mol. cell, 2014, 53, 1-3.
    • (2014) Mol. Cell , vol.53 , pp. 1-3
    • Mirkin, E.V.1    Mirkin, S.M.2
  • 137
    • 84922089150 scopus 로고    scopus 로고
    • Interplay between genetic and epigenetic factors governs common fragile site instability in cancer
    • Ozeri-Galai E, Tur-Sinai M, Bester AC, Kerem B, Interplay between genetic and epigenetic factors governs common fragile site instability in cancer. Cell. Mol. Life Sci. , CMLS, 2014, 71, 4495-4506.
    • (2014) Cell. Mol. Life Sci. , CMLS , vol.71 , pp. 4495-4506
    • Ozeri-Galai, E.1    Tur-Sinai, M.2    Bester, A.C.3    Kerem, B.4
  • 138
    • 0037206935 scopus 로고    scopus 로고
    • Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double Current Genomics
    • 2015, Vol. 16, No. 1 Thys et al. minutes and other chromosomal rearrangements
    • Coquelle A, Rozier L, Dutrillaux B, Debatisse M, Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double Current Genomics, 2015, Vol. 16, No. 1 Thys et al. minutes and other chromosomal rearrangements. Oncogene, 2002, 21, 7671-7679.
    • (2002) Oncogene , Issue.21 , pp. 7671-7679
    • Coquelle, A.1    Rozier, L.2    Dutrillaux, B.3    Debatisse, M.4
  • 140
    • 84912016575 scopus 로고    scopus 로고
    • Replication fork recovery and regulation of common fragile sites stability
    • Franchitto, A.; Pichierri, P. Replication fork recovery and regulation of common fragile sites stability. Cell. mol. life sci., CMLS, 2014, 71, 4507-4517.
    • (2014) Cell. Mol. Life Sci., CMLS , vol.71 , pp. 4507-4517
    • Franchitto, A.1    Pichierri, P.2
  • 141
    • 84884835877 scopus 로고    scopus 로고
    • Genome instability at common fragile sites, searching for the cause of their instability
    • Franchitto, A. Genome instability at common fragile sites, searching for the cause of their instability. BioMed. Res. Int., 2013, 2013, 730714.
    • (2013) Biomed. Res. Int , vol.2013
    • Franchitto, A.1


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